Becn1 (beclin 1) - Rat Genome Database

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Gene: Becn1 (beclin 1) Heterocephalus glaber
Analyze
Symbol: Becn1
Name: beclin 1
RGD ID: 18927361
Description: ENCODES a protein that exhibits ubiquitin protein ligase binding (ortholog); INVOLVED IN autophagosome assembly (ortholog); autophagy (ortholog); cellular response to aluminum ion (ortholog); PARTICIPATES IN autophagy pathway; inositol metabolic pathway; mitochondrial autophagy pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute necrotizing pancreatitis (ortholog); alcoholic cardiomyopathy (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: beclin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,385,756 - 1,405,714 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,386,154 - 1,406,314 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (ISO)
acute necrotizing pancreatitis  (ISO)
alcoholic cardiomyopathy  (ISO)
alcoholic hepatitis  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anterior ischemic optic neuropathy  (ISO)
Barrett's esophagus  (ISO)
Brain Hypoxia-Ischemia  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Burns  (ISO)
Cardiomegaly  (ISO)
Cerebral Hemorrhage  (ISO)
Chronic Intermittent Hypoxia  (ISO)
Closed Head Injuries  (ISO)
Colonic Neoplasms  (ISO)
congestive heart failure  (ISO)
degenerative disc disease  (ISO)
depressive disorder  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
end stage renal disease  (ISO)
epilepsy  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Seizures  (ISO)
glaucoma  (ISO)
glioblastoma  (ISO)
Heat Stroke  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
ischemia  (ISO)
Kidney Reperfusion Injury  (ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
Lung Neoplasms  (ISO)
Machado-Joseph disease  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neointima  (ISO)
Nerve Degeneration  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (ISO)
paraplegia  (ISO)
Parkinsonism  (ISO)
perinatal necrotizing enterocolitis  (ISO)
peritonitis  (ISO)
polycystic kidney disease  (ISO)
Reperfusion Injury  (ISO)
schizophrenia  (ISO)
Spinal Cord Injuries  (ISO)
Spinal Cord Reperfusion Injury  (ISO)
status epilepticus  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (ISO)
Temporomandibular Joint Disorders  (ISO)
Temporomandibular Joint Osteoarthritis  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
viral encephalitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta metabolic process  (IEA)
apoptotic process  (IEA)
autophagosome assembly  (IEA,ISO)
autophagosome maturation  (IEA)
autophagy  (IEA,ISO)
cell division  (IEA)
cellular response to aluminum ion  (ISO)
cellular response to amino acid starvation  (ISO)
cellular response to copper ion  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to glucose starvation  (IEA)
cellular response to hydrogen peroxide  (ISO)
cellular response to nitrogen starvation  (IEA)
cellular response to oxygen-glucose deprivation  (ISO)
circadian rhythm  (ISO)
cytoplasmic pattern recognition receptor signaling pathway  (IEA)
defense response to virus  (IEA)
early endosome to late endosome transport  (IEA)
engulfment of apoptotic cell  (IEA)
JNK cascade  (ISO)
late endosome to vacuole transport  (IEA)
lysosome organization  (IEA)
macroautophagy  (IEA,ISO)
mitophagy  (IEA)
mitotic metaphase chromosome alignment  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of autophagosome assembly  (IEA)
negative regulation of autophagy  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of lysosome organization  (ISO)
negative regulation of programmed cell death  (IEA)
neuron development  (IEA)
p38MAPK cascade  (ISO)
phosphatidylinositol-3-phosphate biosynthetic process  (IEA)
positive regulation of attachment of mitotic spindle microtubules to kinetochore  (IEA)
positive regulation of autophagosome assembly  (ISO)
positive regulation of autophagy  (IEA,ISO)
positive regulation of cardiac muscle hypertrophy  (IEA)
positive regulation of intrinsic apoptotic signaling pathway  (IEA)
positive regulation of stress granule assembly  (ISO)
protein-containing complex assembly  (IEA)
receptor catabolic process  (IEA)
regulation of autophagy  (IEA)
regulation of catalytic activity  (ISO)
regulation of cytokinesis  (IEA)
regulation of macroautophagy  (IEA)
response to hypoxia  (ISO)
response to iron(II) ion  (ISO)
response to lead ion  (ISO)
response to mitochondrial depolarisation  (IEA)
response to nutrient levels  (ISO)
response to other organism  (IEA)
response to vitamin E  (ISO)
response to xenobiotic stimulus  (ISO)
SMAD protein signal transduction  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Becn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,385,756 - 1,405,714 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,386,154 - 1,406,314 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
BECN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,810,132 - 42,824,282 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,810,134 - 42,833,350 (-)EnsemblGRCh38hg38GRCh38
GRCh371740,962,150 - 40,976,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,215,678 - 38,229,807 (-)NCBINCBI36Build 36hg18NCBI36
Build 341738,215,677 - 38,229,807NCBI
Celera1737,618,135 - 37,632,364 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1736,726,539 - 36,740,774 (-)NCBIHuRef
CHM1_11741,197,767 - 41,211,922 (-)NCBICHM1_1
T2T-CHM13v2.01743,667,271 - 43,682,705 (-)NCBIT2T-CHM13v2.0
Becn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,179,084 - 101,193,112 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,176,778 - 101,193,112 (-)EnsemblGRCm39 Ensembl
GRCm3811101,288,258 - 101,302,286 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,285,952 - 101,302,286 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,149,581 - 101,163,581 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611102,067,439 - 102,081,397 (-)NCBIMGSCv36mm8
MGSCv3611101,104,357 - 101,118,357 (-)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
cM Map1164.58NCBI
Becn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,731,649 - 86,747,002 (-)NCBIGRCr8
mRatBN7.21086,231,387 - 86,246,742 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,231,388 - 86,246,742 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,269,132 - 91,284,493 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,743,662 - 90,759,021 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,136,830 - 86,152,190 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,209,944 - 89,225,297 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,209,940 - 89,225,297 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,008,975 - 89,024,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,317,957 - 90,333,329 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,332,322 - 90,347,231 (-)NCBI
Celera1084,949,343 - 84,964,691 (-)NCBICelera
Cytogenetic Map10q31NCBI
Becn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,616,595 - 16,625,730 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,616,595 - 16,625,731 (-)NCBIChiLan1.0ChiLan1.0
BECN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,152,390 - 22,175,667 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,042,657 - 24,065,785 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,493,619 - 14,507,809 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,719,781 - 14,733,286 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,719,781 - 14,733,286 (+)Ensemblpanpan1.1panPan2
BECN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,204,203 - 20,215,081 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,204,220 - 20,214,236 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,665,517 - 19,676,150 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,922,592 - 20,933,221 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,922,586 - 20,933,212 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,707,479 - 19,718,113 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,973,720 - 19,984,352 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,076,426 - 20,087,053 (+)NCBIUU_Cfam_GSD_1.0
Becn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,544,014 - 19,557,039 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,517,751 - 17,531,151 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,518,100 - 17,531,126 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BECN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,041,956 - 20,054,373 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,041,914 - 20,054,249 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,256,871 - 20,268,928 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BECN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,469,187 - 63,482,627 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,469,192 - 63,485,322 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,260,316 - 34,273,836 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000025457   ⟹   ENSHGLP00000025235
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247951,385,756 - 1,405,714 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000025458   ⟹   ENSHGLP00000025236
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247951,386,505 - 1,405,466 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000025459   ⟹   ENSHGLP00000025237
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247951,386,622 - 1,404,029 (+)Ensembl
RefSeq Acc Id: XM_004859306   ⟹   XP_004859363
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247951,386,154 - 1,406,314 (+)NCBI
RefSeq Acc Id: XM_013077692   ⟹   XP_012933146
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247951,386,154 - 1,406,314 (+)NCBI
RefSeq Acc Id: XM_021240236   ⟹   XP_021095895
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247951,386,168 - 1,406,314 (+)NCBI
RefSeq Acc Id: XM_021240237   ⟹   XP_021095896
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247951,390,317 - 1,406,314 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004859363 (Get FASTA)   NCBI Sequence Viewer  
  XP_012933146 (Get FASTA)   NCBI Sequence Viewer  
  XP_021095895 (Get FASTA)   NCBI Sequence Viewer  
  XP_021095896 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000025235
GenBank Protein JAO01102 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_012933146   ⟸   XM_013077692
- Peptide Label: isoform X2
- UniProtKB: A0AAX6R6X6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004859363   ⟸   XM_004859306
- Peptide Label: isoform X1
- UniProtKB: A0A0N8EU54 (UniProtKB/TrEMBL),   G5C9Z7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021095895   ⟸   XM_021240236
- Peptide Label: isoform X1
- UniProtKB: A0A0N8EU54 (UniProtKB/TrEMBL),   G5C9Z7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021095896   ⟸   XM_021240237
- Peptide Label: isoform X3
- UniProtKB: A0AAX6RGE0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000025236   ⟸   ENSHGLT00000025458
Ensembl Acc Id: ENSHGLP00000025235   ⟸   ENSHGLT00000025457
Ensembl Acc Id: ENSHGLP00000025237   ⟸   ENSHGLT00000025459


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000017981 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000025457 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.40 UniProtKB/TrEMBL
  6.10.250.3110 UniProtKB/TrEMBL
InterPro Atg6/Beclin UniProtKB/TrEMBL
  Atg6/Beclin_C_sf UniProtKB/TrEMBL
  Atg6/beclin_CC UniProtKB/TrEMBL
  Atg6_BARA UniProtKB/TrEMBL
  BH3_dom UniProtKB/TrEMBL
KEGG Report hgl:101712212 UniProtKB/TrEMBL
NCBI Gene Becn1 ENTREZGENE
PANTHER PTHR12768 UniProtKB/TrEMBL
  PTHR12768:SF6 UniProtKB/TrEMBL
Pfam APG6 UniProtKB/TrEMBL
  APG6_N UniProtKB/TrEMBL
  BH3 UniProtKB/TrEMBL
UniProt A0A0N8EU54 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6R6X6 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RGE0 ENTREZGENE, UniProtKB/TrEMBL
  G5C9Z7 ENTREZGENE, UniProtKB/TrEMBL