BECN1 (beclin 1) - Rat Genome Database
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Gene: BECN1 (beclin 1) Homo sapiens
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Symbol: BECN1
Name: beclin 1
RGD ID: 733440
HGNC Page HGNC
Description: Exhibits enzyme binding activity and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including early endosome to late endosome transport; mitophagy; and regulation of cell cycle process. Localizes to endoplasmic reticulum; endosome; and extrinsic component of membrane. Colocalizes with mitochondrion. Implicated in Machado-Joseph disease. Biomarker of several diseases, including Barrett's esophagus; adenocarcinoma (multiple); brain disease (multiple); osteoarthritis; and perinatal necrotizing enterocolitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATG6; ATG6 autophagy related 6 homolog; beclin 1 (coiled-coil, moesin-like BCL2 interacting protein); beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1 (coiled-coil, myosin-like bcl2-interacting protein); beclin 1, autophagy related; beclin-1; beclin1; coiled-coil myosin-like BCL2-interacting protein; testis secretory sperm-binding protein Li 215e; VPS30
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: BECN1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1742,810,134 - 42,833,350 (-)EnsemblGRCh38hg38GRCh38
GRCh381742,810,132 - 42,824,282 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371740,962,150 - 40,976,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,215,678 - 38,229,807 (-)NCBINCBI36hg18NCBI36
Build 341738,215,677 - 38,229,807NCBI
Celera1737,618,135 - 37,632,364 (-)NCBI
Cytogenetic Map17q21.31NCBI
HuRef1736,726,539 - 36,740,774 (-)NCBIHuRef
CHM1_11741,197,767 - 41,211,946 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Necrotizing Pancreatitis  (ISO)
Alzheimer's disease  (IEP,ISO)
amyotrophic lateral sclerosis  (ISO)
anterior ischemic optic neuropathy  (ISO)
Barrett's esophagus  (IEP,ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Burns  (ISO)
Cardiomegaly  (ISO)
Cerebral Hemorrhage  (ISO)
Chronic Intermittent Hypoxia  (ISO)
Colonic Neoplasms  (EXP)
congestive heart failure  (ISO)
degenerative disc disease  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
end stage renal disease  (ISO)
epilepsy  (ISO)
esophagus adenocarcinoma  (IEP)
Experimental Diabetes Mellitus  (ISO)
Experimental Pancreatitis, Acute  (ISO)
Experimental Seizures  (ISO)
glaucoma  (ISO)
glioblastoma  (IEP)
Head Injuries, Closed  (ISO)
Heat Stroke  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (IEP)
Hypoxia-Ischemia, Brain  (ISO)
intrahepatic cholangiocarcinoma  (IEP)
ischemia  (ISO)
Kidney Reperfusion Injury  (ISO)
Lewy body dementia  (EXP)
liver cirrhosis  (IEP)
Lung Neoplasms  (EXP)
Machado-Joseph disease  (IEP,IMP,ISO)
mental depression  (IEP,ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (EXP,ISO)
Myocardial Reperfusion Injury  (ISO)
Neointima  (ISO)
Nerve Degeneration  (ISO)
osteoarthritis  (IEP,ISO)
Osteoarthritis, Experimental  (ISO)
paraplegia  (ISO)
Parkinsonism  (ISO)
perinatal necrotizing enterocolitis  (IEP)
peritonitis  (ISO)
polycystic kidney disease  (ISO)
Reperfusion Injury  (ISO)
schizophrenia  (ISO)
Spinal Cord Injuries  (EXP,ISO)
Spinal Cord Reperfusion Injury  (ISO)
status epilepticus  (EXP,ISO)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (ISS)
Temporomandibular Joint Disorders  (ISO)
Temporomandibular Joint Osteoarthritis  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
viral encephalitis  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-Tetrandrine  (EXP)
(-)-anisomycin  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,6-dinitrotoluene  (ISO)
2-deoxy-D-glucose  (EXP)
2-hydroxyethyl methacrylate  (EXP)
2-hydroxypropanoic acid  (EXP)
3-hydroxybutyric acid  (EXP)
3-methyladenine  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
acadesine  (ISO)
actinomycin D  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
alpha-D-galactose  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antirheumatic drug  (EXP)
apigenin  (ISO)
apocynin  (ISO)
aristolochic acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP,ISO)
azinphos-methyl  (EXP)
bafilomycin A1  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (EXP)
beta-thujaplicin  (ISO)
bisphenol A  (ISO)
bortezomib  (EXP)
brazilin  (EXP)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calciol  (EXP)
calcipotriol  (EXP)
calcitriol  (EXP)
camptothecin  (EXP)
cannabidiol  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbon disulfide  (ISO)
carbon nanotube  (EXP,ISO)
carboplatin  (EXP)
carglumic acid  (ISO)
carmustine  (EXP)
carvedilol  (ISO)
CCCP  (EXP,ISO)
celastrol  (ISO)
CGS-21680  (EXP)
chloroquine  (EXP,ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
colistin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Corynoxine B  (EXP)
cucurbitacin E  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP)
D-glucose  (ISO)
DDE  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diquat  (ISO)
disodium selenite  (EXP)
divinyl sulfone  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
embelin  (EXP)
endosulfan  (ISO)
erlotinib hydrochloride  (EXP)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
ferric oxide  (ISO)
fingolimod hydrochloride  (EXP)
fisetin  (ISO)
fluoxetine  (EXP)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
galactose  (ISO)
galangin  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gingerol  (EXP)
glucose  (ISO)
glycerol 2-phosphate  (EXP)
glycochenodeoxycholic acid  (EXP)
glyphosate  (ISO)
gossypetin  (EXP)
graphene oxide  (EXP,ISO)
graphite  (EXP)
hexadecanoic acid  (EXP,ISO)
HU-308  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
hydroxamic acid  (ISO)
kainic acid  (ISO)
L-ascorbic acid 2-phosphate  (EXP)
L-leucine  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
levamisole  (ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP,ISO)
Maprotiline  (EXP)
Matrine  (EXP)
melatonin  (EXP)
menadione  (EXP)
methamidophos  (EXP)
methamphetamine  (EXP,ISO)
methotrexate  (EXP)
methylisothiazolinone  (EXP)
morphine  (EXP)
morpholines  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methylnicotinate  (EXP,ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nicotine  (EXP,ISO)
Nonidet P-40  (EXP)
oleanolic acid  (EXP)
oligopeptide  (EXP)
omethoate  (EXP)
ozone  (ISO)
p-cresol  (EXP,ISO)
p-menthan-3-ol  (EXP)
paclitaxel  (EXP)
Paeonol  (ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphoramide mustard  (ISO)
platycodin D  (EXP)
potassium iodide  (EXP)
procyanidin B2  (ISO)
promethazine  (EXP)
pyrovalerone  (EXP)
pyruvic acid  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (EXP)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
Rhein  (EXP)
rotenone  (EXP,ISO)
rottlerin  (EXP)
salubrinal  (EXP)
SB 203580  (EXP,ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
sirolimus  (EXP,ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
spironolactone  (ISO)
staurosporine  (EXP)
streptozocin  (ISO)
sulfur dioxide  (ISO)
sunitinib  (ISO)
swainsonine  (ISO)
T-2 toxin  (ISO)
temozolomide  (EXP)
tetrachloromethane  (ISO)
tetramethylpyrazine  (ISO)
thalidomide  (EXP)
Tiron  (EXP)
titanium dioxide  (EXP)
tributylstannane  (ISO)
trifloxystrobin  (EXP)
Triptolide  (ISO)
ursolic acid  (EXP)
valproic acid  (EXP)
vinclozolin  (ISO)
vitamin D  (EXP)
vitamin E  (ISO)
vorinostat  (EXP)
WIN 55212-2  (EXP)
wortmannin  (EXP,ISO)
zearalenone  (ISO)
zinc oxide  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEA,ISO)
amyloid-beta metabolic process  (IEA,ISO)
apoptotic process  (IEA)
autophagosome assembly  (IBA,ISO,ISS)
autophagy  (IDA,IEA,IMP,ISO)
autophagy of mitochondrion  (IMP)
cell division  (IEA)
cellular defense response  (TAS)
cellular response to aluminum ion  (IEA,ISO)
cellular response to amino acid starvation  (IEA,ISO)
cellular response to copper ion  (IEA,ISO)
cellular response to epidermal growth factor stimulus  (IEA,ISO)
cellular response to glucose starvation  (ISS)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to nitrogen starvation  (IBA)
defense response to virus  (IEA)
early endosome to late endosome transport  (IMP)
endocytosis  (IEA)
engulfment of apoptotic cell  (IEA)
late endosome to vacuole transport  (IBA)
lysosome organization  (IEA,ISO)
macroautophagy  (ISO,ISS,TAS)
mitophagy  (IMP)
mitotic metaphase plate congression  (IMP)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of autophagosome assembly  (IEA,ISO)
negative regulation of autophagy  (ISO)
negative regulation of cell death  (IMP,ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of lysosome organization  (IEA,ISO)
negative regulation of reactive oxygen species metabolic process  (IEA)
neuron development  (IEA,ISO)
positive regulation of attachment of mitotic spindle microtubules to kinetochore  (IMP)
positive regulation of autophagosome assembly  (IEA,ISO)
positive regulation of autophagy  (ISO)
positive regulation of cardiac muscle hypertrophy  (IEA,ISO)
positive regulation of intrinsic apoptotic signaling pathway  (IMP,ISS)
positive regulation of phosphatidylinositol 3-kinase signaling  (NAS)
protein deubiquitination  (TAS)
receptor catabolic process  (IMP)
regulation of catalytic activity  (IEA,ISO)
regulation of cytokinesis  (IEA,IMP)
response to drug  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to iron(II) ion  (IEA,ISO)
response to lead ion  (IEA,ISO)
response to mitochondrial depolarisation  (IMP)
response to nutrient levels  (ISO)
response to other organism  (ISO)
response to vitamin E  (IEA,ISO)
viral process  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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Additional References at PubMed
PMID:7490091   PMID:7829101   PMID:8125298   PMID:10395800   PMID:10604474   PMID:11306555   PMID:11309306   PMID:11564866   PMID:12372286   PMID:12477932   PMID:14966907   PMID:14970205  
PMID:15489334   PMID:15922724   PMID:16179260   PMID:16267277   PMID:16390869   PMID:16417406   PMID:16522639   PMID:16713569   PMID:16718815   PMID:16857678   PMID:16874027   PMID:17203225  
PMID:17236580   PMID:17272502   PMID:17337444   PMID:17355787   PMID:17438366   PMID:17441324   PMID:17441338   PMID:17446862   PMID:17550384   PMID:17589504   PMID:17595761   PMID:17643073  
PMID:17659302   PMID:17724469   PMID:17786023   PMID:17999086   PMID:18005679   PMID:18184403   PMID:18184459   PMID:18497881   PMID:18552835   PMID:18628207   PMID:18641390   PMID:18769161  
PMID:18797192   PMID:18829541   PMID:18843052   PMID:19049976   PMID:19050071   PMID:19060920   PMID:19066461   PMID:19130303   PMID:19145109   PMID:19180116   PMID:19218137   PMID:19270693  
PMID:19270696   PMID:19273585   PMID:19289499   PMID:19298526   PMID:19298604   PMID:19318089   PMID:19325567   PMID:19347031   PMID:19372752   PMID:19375507   PMID:19395874   PMID:19520853  
PMID:19535901   PMID:19535919   PMID:19556884   PMID:19635843   PMID:19641499   PMID:19680556   PMID:19713971   PMID:19762066   PMID:19778902   PMID:19798108   PMID:19921231   PMID:19959994  
PMID:20004946   PMID:20009549   PMID:20010695   PMID:20023428   PMID:20037818   PMID:20090905   PMID:20150769   PMID:20190558   PMID:20206246   PMID:20207475   PMID:20208530   PMID:20230646  
PMID:20368806   PMID:20406981   PMID:20454448   PMID:20467442   PMID:20473282   PMID:20501938   PMID:20559548   PMID:20562859   PMID:20577262   PMID:20622903   PMID:20638385   PMID:20639699  
PMID:20643123   PMID:20697744   PMID:20711182   PMID:20819940   PMID:20842118   PMID:20889974   PMID:20921139   PMID:20937944   PMID:21062745   PMID:21081164   PMID:21139567   PMID:21203962  
PMID:21209283   PMID:21239722   PMID:21241894   PMID:21327823   PMID:21353614   PMID:21358617   PMID:21420796   PMID:21444671   PMID:21499230   PMID:21537144   PMID:21543763   PMID:21556768  
PMID:21597469   PMID:21610315   PMID:21646862   PMID:21654208   PMID:21681342   PMID:21711108   PMID:21722286   PMID:21729531   PMID:21750416   PMID:21769915   PMID:21777947   PMID:21779982  
PMID:21861179   PMID:21873141   PMID:21873635   PMID:21875280   PMID:21936852   PMID:21962518   PMID:21971985   PMID:21976705   PMID:22028648   PMID:22039439   PMID:22081109   PMID:22082873  
PMID:22095288   PMID:22095667   PMID:22147978   PMID:22157765   PMID:22174682   PMID:22219388   PMID:22240664   PMID:22241963   PMID:22242123   PMID:22248718   PMID:22286270   PMID:22310240  
PMID:22314358   PMID:22335943   PMID:22392728   PMID:22393062   PMID:22493499   PMID:22498477   PMID:22622204   PMID:22627130   PMID:22648564   PMID:22650021   PMID:22674982   PMID:22733132  
PMID:22742832   PMID:22797916   PMID:22805532   PMID:22875631   PMID:22933281   PMID:23029344   PMID:23089287   PMID:23112296   PMID:23125008   PMID:23168911   PMID:23182941   PMID:23184933  
PMID:23197835   PMID:23216071   PMID:23225331   PMID:23264393   PMID:23315026   PMID:23316280   PMID:23332761   PMID:23334926   PMID:23337876   PMID:23364696   PMID:23420005   PMID:23427159  
PMID:23429496   PMID:23444126   PMID:23478334   PMID:23479509   PMID:23504944   PMID:23525201   PMID:23541952   PMID:23564079   PMID:23569248   PMID:23573264   PMID:23629966   PMID:23686476  
PMID:23703612   PMID:23722017   PMID:23737459   PMID:23787295   PMID:23790316   PMID:23801739   PMID:23812859   PMID:23822101   PMID:23827971   PMID:23877263   PMID:23878393   PMID:23880165  
PMID:23935917   PMID:23943370   PMID:23954414   PMID:23974797   PMID:24012002   PMID:24034250   PMID:24056301   PMID:24056303   PMID:24113155   PMID:24132590   PMID:24141421   PMID:24145555  
PMID:24166503   PMID:24186333   PMID:24186908   PMID:24188325   PMID:24260370   PMID:24303007   PMID:24324106   PMID:24324270   PMID:24345332   PMID:24349490   PMID:24378767   PMID:24385262  
PMID:24386307   PMID:24440703   PMID:24443581   PMID:24472739   PMID:24478461   PMID:24528868   PMID:24535641   PMID:24587252   PMID:24599950   PMID:24623173   PMID:24681041   PMID:24690321  
PMID:24705551   PMID:24716949   PMID:24733562   PMID:24755562   PMID:24760274   PMID:24785657   PMID:24879154   PMID:24879156   PMID:24885292   PMID:24941712   PMID:24956373   PMID:24969889  
PMID:24970676   PMID:24971696   PMID:24980959   PMID:24980960   PMID:25032846   PMID:25046113   PMID:25086043   PMID:25096824   PMID:25115400   PMID:25127057   PMID:25136588   PMID:25175672  
PMID:25179078   PMID:25196438   PMID:25204229   PMID:25208472   PMID:25215947   PMID:25275521   PMID:25292086   PMID:25311841   PMID:25318890   PMID:25366815   PMID:25400807   PMID:25427639  
PMID:25436332   PMID:25438055   PMID:25439234   PMID:25466963   PMID:25472497   PMID:25482163   PMID:25484083   PMID:25490155   PMID:25496667   PMID:25499913   PMID:25512258   PMID:25533187  
PMID:25565814   PMID:25594178   PMID:25596085   PMID:25607466   PMID:25620738   PMID:25631043   PMID:25639875   PMID:25649430   PMID:25669656   PMID:25689150   PMID:25693418   PMID:25708267  
PMID:25714112   PMID:25714272   PMID:25715028   PMID:25758178   PMID:25803737   PMID:25814554   PMID:25821789   PMID:25824726   PMID:25825496   PMID:25837021   PMID:25847297   PMID:25871810  
PMID:25891078   PMID:25905985   PMID:25906440   PMID:25955014   PMID:25984893   PMID:26008601   PMID:26055714   PMID:26097572   PMID:26134156   PMID:26148234   PMID:26186194   PMID:26218645  
PMID:26239434   PMID:26263979   PMID:26295339   PMID:26319552   PMID:26330555   PMID:26347139   PMID:26363527   PMID:26386349   PMID:26387716   PMID:26395023   PMID:26458502   PMID:26496610  
PMID:26506105   PMID:26510741   PMID:26549445   PMID:26549519   PMID:26573276   PMID:26582930   PMID:26590968   PMID:26617774   PMID:26654401   PMID:26673895   PMID:26682748   PMID:26708607  
PMID:26722036   PMID:26739061   PMID:26756998   PMID:26765290   PMID:26783301   PMID:26876213   PMID:26880040   PMID:26929373   PMID:26935807   PMID:26937551   PMID:26965179   PMID:26984766  
PMID:26988033   PMID:27002764   PMID:27031958   PMID:27046249   PMID:27046250   PMID:27067261   PMID:27173217   PMID:27174920   PMID:27175789   PMID:27203177   PMID:27245989   PMID:27304906  
PMID:27356955   PMID:27383850   PMID:27444698   PMID:27462784   PMID:27466513   PMID:27468561   PMID:27468577   PMID:27556506   PMID:27559856   PMID:27613096   PMID:27621469   PMID:27632526  
PMID:27638205   PMID:27655288   PMID:27683118   PMID:27693506   PMID:27696537   PMID:27715386   PMID:27744427   PMID:27853422   PMID:27857190   PMID:27929538   PMID:28059666   PMID:28070138  
PMID:28076888   PMID:28081732   PMID:28128446   PMID:28174297   PMID:28205554   PMID:28224423   PMID:28238651   PMID:28345663   PMID:28351322   PMID:28351336   PMID:28351972   PMID:28368777  
PMID:28401970   PMID:28404643   PMID:28409693   PMID:28431397   PMID:28445460   PMID:28479384   PMID:28514442   PMID:28515304   PMID:28518135   PMID:28521610   PMID:28542134   PMID:28558758  
PMID:28628118   PMID:28651493   PMID:28653874   PMID:28682313   PMID:28699106   PMID:28731147   PMID:28742203   PMID:28747345   PMID:28757208   PMID:28767174   PMID:28776671   PMID:28798234  
PMID:28846113   PMID:28876241   PMID:28964771   PMID:28977798   PMID:28982601   PMID:28983596   PMID:29022195   PMID:29079782   PMID:29157081   PMID:29185708   PMID:29251248   PMID:29278874  
PMID:29313410   PMID:29321306   PMID:29322787   PMID:29326710   PMID:29330382   PMID:29361549   PMID:29368980   PMID:29393406   PMID:29402890   PMID:29518394   PMID:29545906   PMID:29587298  
PMID:29604308   PMID:29610308   PMID:29669822   PMID:29738069   PMID:29849149   PMID:29866835   PMID:29929436   PMID:29945297   PMID:29955058   PMID:29970115   PMID:30015871   PMID:30057310  
PMID:30066884   PMID:30081711   PMID:30081750   PMID:30107804   PMID:30134829   PMID:30184615   PMID:30231667   PMID:30258449   PMID:30272335   PMID:30321575   PMID:30335599   PMID:30362635  
PMID:30383396   PMID:30458278   PMID:30504397   PMID:30581147   PMID:30626284   PMID:30654935   PMID:30661206   PMID:30686098   PMID:30701202   PMID:30729279   PMID:30807795   PMID:30827509  
PMID:30842153   PMID:30878502   PMID:30954215   PMID:30964166   PMID:30978004   PMID:31029709   PMID:31054328   PMID:31091453   PMID:31108943   PMID:31128017   PMID:31211444   PMID:31218746  
PMID:31260798   PMID:31262976   PMID:31272261   PMID:31373534   PMID:31375263   PMID:31382319   PMID:31410188   PMID:31503548   PMID:31520423   PMID:31613002   PMID:31620128   PMID:31650158  
PMID:31659150   PMID:31696776   PMID:31744816   PMID:31758957   PMID:31799599   PMID:31806350   PMID:31823702   PMID:31852899   PMID:31955515   PMID:32021240   PMID:32093773   PMID:32097085  
PMID:32187724   PMID:32204925   PMID:32296183   PMID:32384667   PMID:32428566   PMID:32428696   PMID:32473226   PMID:32513537   PMID:32674313   PMID:32772229   PMID:32814053   PMID:33202207  


Genomics

Comparative Map Data
BECN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1742,810,134 - 42,833,350 (-)EnsemblGRCh38hg38GRCh38
GRCh381742,810,132 - 42,824,282 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371740,962,150 - 40,976,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,215,678 - 38,229,807 (-)NCBINCBI36hg18NCBI36
Build 341738,215,677 - 38,229,807NCBI
Celera1737,618,135 - 37,632,364 (-)NCBI
Cytogenetic Map17q21.31NCBI
HuRef1736,726,539 - 36,740,774 (-)NCBIHuRef
CHM1_11741,197,767 - 41,211,946 (-)NCBICHM1_1
Becn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,179,084 - 101,193,112 (-)NCBIGRCm39mm39
GRCm39 Ensembl11101,176,778 - 101,193,112 (-)Ensembl
GRCm3811101,288,258 - 101,302,286 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,285,952 - 101,302,286 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,149,581 - 101,163,581 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611102,067,439 - 102,081,397 (-)NCBImm8
MGSCv3611101,104,357 - 101,118,357 (-)NCBImm8
Cytogenetic Map11DNCBI
Becn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21086,231,387 - 86,246,742 (-)NCBI
Rnor_6.0 Ensembl1089,209,940 - 89,225,297 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01089,209,944 - 89,225,297 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01089,008,975 - 89,024,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,317,957 - 90,333,329 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11090,332,322 - 90,347,231 (-)NCBI
Celera1084,949,343 - 84,964,691 (-)NCBICelera
Cytogenetic Map10q31NCBI
Becn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,616,595 - 16,625,730 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,616,595 - 16,625,731 (-)NCBIChiLan1.0ChiLan1.0
BECN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11714,719,781 - 14,733,286 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,719,781 - 14,733,286 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01714,493,619 - 14,507,809 (+)NCBIMhudiblu_PPA_v0panPan3
BECN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,204,203 - 20,215,081 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,204,220 - 20,214,236 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,665,517 - 19,676,150 (+)NCBI
ROS_Cfam_1.0920,922,592 - 20,933,221 (+)NCBI
UMICH_Zoey_3.1919,707,479 - 19,718,113 (+)NCBI
UNSW_CanFamBas_1.0919,973,720 - 19,984,352 (+)NCBI
UU_Cfam_GSD_1.0920,076,426 - 20,087,053 (+)NCBI
Becn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_ltri_2NW_02440560219,544,014 - 19,557,039 (+)NCBI
SpeTri2.0NW_00493649017,518,100 - 17,531,126 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BECN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,041,956 - 20,054,373 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,041,914 - 20,054,249 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,256,871 - 20,268,928 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BECN1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,469,187 - 63,482,627 (+)NCBI
ChlSab1.1 Ensembl1663,469,192 - 63,485,322 (+)Ensembl
Becn1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247951,386,154 - 1,406,314 (+)NCBI

Position Markers
STS-U17909  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,961,977 - 40,962,157UniSTSGRCh37
Build 361738,215,503 - 38,215,683RGDNCBI36
Celera1737,617,962 - 37,618,142RGD
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map17q21UniSTS
HuRef1736,726,366 - 36,726,546UniSTS
GeneMap99-GB4 RH Map17311.36UniSTS
RH48446  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,966,555 - 40,966,676UniSTSGRCh37
Build 361738,220,081 - 38,220,202RGDNCBI36
Celera1737,622,609 - 37,622,730RGD
Cytogenetic Map17q21UniSTS
HuRef1736,731,019 - 36,731,140UniSTS
GeneMap99-GB4 RH Map17311.36UniSTS
NCBI RH Map17511.3UniSTS
G20453  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,962,228 - 40,962,410UniSTSGRCh37
Build 361738,215,754 - 38,215,936RGDNCBI36
Celera1737,618,213 - 37,618,395RGD
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map17q21UniSTS
HuRef1736,726,617 - 36,726,799UniSTS
A005R43  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,962,228 - 40,962,410UniSTSGRCh37
Build 361738,215,754 - 38,215,936RGDNCBI36
Celera1737,618,213 - 37,618,395RGD
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map17q21UniSTS
HuRef1736,726,617 - 36,726,799UniSTS
GeneMap99-GB4 RH Map17308.5UniSTS
WI-11793  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,962,161 - 40,962,310UniSTSGRCh37
Build 361738,215,687 - 38,215,836RGDNCBI36
Celera1737,618,146 - 37,618,295RGD
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map17q21UniSTS
HuRef1736,726,550 - 36,726,699UniSTS
GeneMap99-GB4 RH Map17308.5UniSTS
Whitehead-RH Map17347.6UniSTS
RH17649  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,962,333 - 40,962,571UniSTSGRCh37
Build 361738,215,859 - 38,216,097RGDNCBI36
Celera1737,618,318 - 37,618,556RGD
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map17q21UniSTS
HuRef1736,726,722 - 36,726,960UniSTS
GeneMap99-GB4 RH Map17315.43UniSTS
RH48640  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,970,587 - 40,970,825UniSTSGRCh37
Build 361738,224,113 - 38,224,351RGDNCBI36
Celera1737,626,641 - 37,626,879RGD
Cytogenetic Map17q21UniSTS
HuRef1736,735,051 - 36,735,289UniSTS
GeneMap99-GB4 RH Map17311.36UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR30Ahsa-miR-30a-5pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assay;OtherFunctional MTI19535919
MIR30Ahsa-miR-30a-5pOncomiRDBexternal_infoNANA22157765
MIR30Ahsa-miR-30a-5pOncomiRDBexternal_infoNANA19535919
MIR30Ahsa-miR-30a-3pMirecordsexternal_info{changed}NA19535919
MIR30Dhsa-miR-30d-5pOncomiRDBexternal_infoNANA23274497

Predicted Target Of
Summary Value
Count of predictions:3365
Count of miRNA genes:1045
Interacting mature miRNAs:1285
Transcripts:ENST00000361523, ENST00000438274, ENST00000543382, ENST00000585515, ENST00000586589, ENST00000586754, ENST00000587880, ENST00000588276, ENST00000589492, ENST00000589493, ENST00000589636, ENST00000589663, ENST00000590099, ENST00000590185, ENST00000590764, ENST00000590852, ENST00000591085, ENST00000591307, ENST00000591404, ENST00000593112, ENST00000593205
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2428 2692 1503 423 1843 265 4349 2041 3242 376 1436 1607 175 1 1204 2787 5 2
Low 11 299 222 201 108 200 8 156 492 43 24 5 1 1
Below cutoff 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001313998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001313999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001314000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005257759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005257760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011525421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017025262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017025263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017025264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA427906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC016889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF077301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF139131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI496049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC296896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC354547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM005628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC776730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF511232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L38932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000361523   ⟹   ENSP00000355231
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,810,134 - 42,824,263 (-)Ensembl
RefSeq Acc Id: ENST00000438274   ⟹   ENSP00000416173
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,810,308 - 42,824,287 (-)Ensembl
RefSeq Acc Id: ENST00000543382
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,810,414 - 42,824,287 (-)Ensembl
RefSeq Acc Id: ENST00000585515
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,819,324 - 42,824,282 (-)Ensembl
RefSeq Acc Id: ENST00000586589   ⟹   ENSP00000466281
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,810,860 - 42,818,652 (-)Ensembl
RefSeq Acc Id: ENST00000586754
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,811,724 - 42,815,995 (-)Ensembl
RefSeq Acc Id: ENST00000587880   ⟹   ENSP00000465964
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,810,716 - 42,813,989 (-)Ensembl
RefSeq Acc Id: ENST00000588276   ⟹   ENSP00000466419
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,810,310 - 42,814,673 (-)Ensembl
RefSeq Acc Id: ENST00000589492
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,813,903 - 42,815,014 (-)Ensembl
RefSeq Acc Id: ENST00000589493
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,815,670 - 42,818,682 (-)Ensembl
RefSeq Acc Id: ENST00000589636   ⟹   ENSP00000467937
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,820,794 - 42,833,350 (-)Ensembl
RefSeq Acc Id: ENST00000589663   ⟹   ENSP00000468104
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,810,670 - 42,818,578 (-)Ensembl
RefSeq Acc Id: ENST00000590099   ⟹   ENSP00000465364
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,810,134 - 42,824,282 (-)Ensembl
RefSeq Acc Id: ENST00000590185
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,810,780 - 42,812,086 (-)Ensembl
RefSeq Acc Id: ENST00000590764   ⟹   ENSP00000468597
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,810,288 - 42,814,593 (-)Ensembl
RefSeq Acc Id: ENST00000590852   ⟹   ENSP00000468461
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,814,168 - 42,815,971 (-)Ensembl
RefSeq Acc Id: ENST00000591085   ⟹   ENSP00000465658
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,818,651 - 42,824,287 (-)Ensembl
RefSeq Acc Id: ENST00000591307
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,820,351 - 42,824,253 (-)Ensembl
RefSeq Acc Id: ENST00000593112
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,820,523 - 42,824,260 (-)Ensembl
RefSeq Acc Id: ENST00000593205   ⟹   ENSP00000466766
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,814,599 - 42,824,251 (-)Ensembl
RefSeq Acc Id: ENST00000612631   ⟹   ENSP00000479791
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,823,818 - 42,833,332 (-)Ensembl
RefSeq Acc Id: ENST00000617806
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1742,810,134 - 42,824,278 (-)Ensembl
RefSeq Acc Id: NM_001313998   ⟹   NP_001300927
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,810,134 - 42,824,282 (-)NCBI
CHM1_11741,197,767 - 41,211,946 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001313999   ⟹   NP_001300928
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,810,132 - 42,823,879 (-)NCBI
CHM1_11741,197,767 - 41,211,509 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001314000   ⟹   NP_001300929
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,810,134 - 42,824,282 (-)NCBI
CHM1_11741,197,767 - 41,211,946 (-)NCBI
Sequence:
RefSeq Acc Id: NM_003766   ⟹   NP_003757
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,810,134 - 42,824,282 (-)NCBI
GRCh371740,962,150 - 40,976,310 (-)ENTREZGENE
Build 361738,215,678 - 38,229,807 (-)NCBI Archive
HuRef1736,726,539 - 36,740,774 (-)ENTREZGENE
CHM1_11741,197,767 - 41,211,946 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005257759   ⟹   XP_005257816
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,810,133 - 42,824,260 (-)NCBI
GRCh371740,962,150 - 40,976,310 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005257760   ⟹   XP_005257817
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,810,132 - 42,824,260 (-)NCBI
GRCh371740,962,150 - 40,976,310 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011525421   ⟹   XP_011523723
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,810,132 - 42,824,260 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017025262   ⟹   XP_016880751
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,810,132 - 42,824,267 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017025263   ⟹   XP_016880752
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,810,133 - 42,824,267 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017025264   ⟹   XP_016880753
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,810,133 - 42,824,267 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003757   ⟸   NM_003766
- Peptide Label: isoform a
- UniProtKB: Q14457 (UniProtKB/Swiss-Prot),   A0A024R1X5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005257816   ⟸   XM_005257759
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005257817   ⟸   XM_005257760
- Peptide Label: isoform X3
- UniProtKB: W0FFG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011523723   ⟸   XM_011525421
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001300929   ⟸   NM_001314000
- Peptide Label: isoform c
- UniProtKB: Q14457 (UniProtKB/Swiss-Prot),   B4DQ36 (UniProtKB/TrEMBL),   E7EV84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300927   ⟸   NM_001313998
- Peptide Label: isoform a
- UniProtKB: Q14457 (UniProtKB/Swiss-Prot),   A0A024R1X5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300928   ⟸   NM_001313999
- Peptide Label: isoform b
- UniProtKB: Q14457 (UniProtKB/Swiss-Prot),   W0FFG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016880752   ⟸   XM_017025263
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016880751   ⟸   XM_017025262
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016880753   ⟸   XM_017025264
- Peptide Label: isoform X3
- UniProtKB: W0FFG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000416173   ⟸   ENST00000438274
RefSeq Acc Id: ENSP00000355231   ⟸   ENST00000361523
RefSeq Acc Id: ENSP00000466281   ⟸   ENST00000586589
RefSeq Acc Id: ENSP00000479791   ⟸   ENST00000612631
RefSeq Acc Id: ENSP00000465964   ⟸   ENST00000587880
RefSeq Acc Id: ENSP00000466419   ⟸   ENST00000588276
RefSeq Acc Id: ENSP00000468104   ⟸   ENST00000589663
RefSeq Acc Id: ENSP00000467937   ⟸   ENST00000589636
RefSeq Acc Id: ENSP00000465364   ⟸   ENST00000590099
RefSeq Acc Id: ENSP00000468597   ⟸   ENST00000590764
RefSeq Acc Id: ENSP00000468461   ⟸   ENST00000590852
RefSeq Acc Id: ENSP00000465658   ⟸   ENST00000591085
RefSeq Acc Id: ENSP00000466766   ⟸   ENST00000593205
Protein Domains
APG6   APG6_N   BH3

Promoters
RGD ID:6793784
Promoter ID:HG_KWN:26224
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_003766,   UC002IBO.2,   UC002IBP.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361738,229,529 - 38,230,029 (-)MPROMDB
RGD ID:7235139
Promoter ID:EPDNEW_H23316
Type:initiation region
Name:BECN1_1
Description:beclin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,824,281 - 42,824,341EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q12-21.31(chr17:39199873-45629579)x3 copy number gain See cases [RCV000052479] Chr17:39199873..45629579 [GRCh38]
Chr17:37356126..43706945 [GRCh37]
Chr17:34609652..41062728 [NCBI36]
Chr17:17q12-21.31
pathogenic
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
NM_001313998.2(BECN1):c.980+9T>C single nucleotide variant not provided [RCV000965385] Chr17:42814515 [GRCh38]
Chr17:40966533 [GRCh37]
Chr17:17q21.31
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1034 AgrOrtholog
COSMIC BECN1 COSMIC
Ensembl Genes ENSG00000126581 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000355231 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000416173 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000465364 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000465658 UniProtKB/TrEMBL
  ENSP00000465964 UniProtKB/TrEMBL
  ENSP00000466281 UniProtKB/TrEMBL
  ENSP00000466419 UniProtKB/TrEMBL
  ENSP00000466766 UniProtKB/TrEMBL
  ENSP00000467937 UniProtKB/TrEMBL
  ENSP00000468104 UniProtKB/TrEMBL
  ENSP00000468461 UniProtKB/TrEMBL
  ENSP00000468597 UniProtKB/TrEMBL
  ENSP00000479791 UniProtKB/TrEMBL
Ensembl Transcript ENST00000361523 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000438274 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000586589 UniProtKB/TrEMBL
  ENST00000587880 UniProtKB/TrEMBL
  ENST00000588276 UniProtKB/TrEMBL
  ENST00000589636 UniProtKB/TrEMBL
  ENST00000589663 UniProtKB/TrEMBL
  ENST00000590099 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000590764 UniProtKB/TrEMBL
  ENST00000590852 UniProtKB/TrEMBL
  ENST00000591085 UniProtKB/TrEMBL
  ENST00000593205 UniProtKB/TrEMBL
  ENST00000612631 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000126581 GTEx
HGNC ID HGNC:1034 ENTREZGENE
Human Proteome Map BECN1 Human Proteome Map
InterPro Atg6/Beclin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Atg6/Beclin_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Atg6/beclin_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Atg6_BARA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BECN1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8678 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 8678 ENTREZGENE
OMIM 604378 OMIM
PANTHER PTHR12768 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12768:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam APG6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APG6_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA25337 PharmGKB
UniProt A0A024R1X5 ENTREZGENE, UniProtKB/TrEMBL
  A0A087WVZ2_HUMAN UniProtKB/TrEMBL
  B4DQ36 ENTREZGENE, UniProtKB/TrEMBL
  BECN1_HUMAN UniProtKB/Swiss-Prot
  E7EV84 ENTREZGENE, UniProtKB/TrEMBL
  K7EKK2_HUMAN UniProtKB/TrEMBL
  K7EL88_HUMAN UniProtKB/TrEMBL
  K7ELY9_HUMAN UniProtKB/TrEMBL
  K7EMA2_HUMAN UniProtKB/TrEMBL
  K7EN35_HUMAN UniProtKB/TrEMBL
  K7EQQ7_HUMAN UniProtKB/TrEMBL
  K7ER46_HUMAN UniProtKB/TrEMBL
  K7ERY0_HUMAN UniProtKB/TrEMBL
  K7ES83_HUMAN UniProtKB/TrEMBL
  Q14457 ENTREZGENE
  W0FFG4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B2R6N7 UniProtKB/Swiss-Prot
  O75595 UniProtKB/Swiss-Prot
  Q9UNA8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-03 BECN1  beclin 1    beclin 1, autophagy related  Symbol and/or name change 5135510 APPROVED