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Gene: Gclm (glutamate-cysteine ligase, modifier subunit) Mus musculus
Symbol: Gclm
Name: glutamate-cysteine ligase, modifier subunit
Description: Exhibits glutamate-cysteine ligase catalytic subunit binding activity and protein heterodimerization activity. Predicted to contribute to glutamate-cysteine ligase activity. Involved in several processes, including cellular response to leukemia inhibitory factor; glutathione biosynthetic process; and positive regulation of glutamate-cysteine ligase activity. Localizes to the glutamate-cysteine ligase complex. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Is expressed in several structures, including alimentary system; liver; nervous system; urinary system; and yolk sac. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; cysteine metabolic pathway; glutamic acid/glutamate metabolic pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,1-dichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI649393; expressed sequence AI649393; gamma-ECS regulatory subunit; gamma-glutamylcysteine synthetase regulatory subunit; Gcmc; GCS light chain; Glclr; glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory; glutamate--cysteine ligase modifier subunit; glutamate--cysteine ligase regulatory subunit
Homo sapiens (human) : GCLM (glutamate-cysteine ligase modifier subunit)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gclm (glutamate cysteine ligase, modifier subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gclm (glutamate-cysteine ligase modifier subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : GCLM (glutamate-cysteine ligase modifier subunit)
Canis lupus familiaris (dog) : GCLM (glutamate-cysteine ligase modifier subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gclm (glutamate-cysteine ligase modifier subunit)
Sus scrofa (pig) : GCLM (glutamate-cysteine ligase modifier subunit)
Chlorocebus sabaeus (green monkey) : GCLM (glutamate-cysteine ligase modifier subunit)
Heterocephalus glaber (naked mole-rat) : Gclm (glutamate-cysteine ligase modifier subunit)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl3122,245,557 - 122,270,732 (+)Ensembl
GRCm383122,245,487 - 122,267,215 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv373121,948,510 - 121,969,566 (+)NCBIGRCm37mm9NCBIm37
MGSCv363122,237,614 - 122,258,670 (+)NCBImm8
MGSCv363122,610,732 - 122,631,895 (+)NCBImm8
Celera3128,652,324 - 128,664,005 (+)NCBICelera
Cytogenetic Map3 G1NCBI
cM Map352.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Gclm
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735691
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.