Csf3 (colony stimulating factor 3 (granulocyte)) - Rat Genome Database

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Gene: Csf3 (colony stimulating factor 3 (granulocyte)) Mus musculus
Symbol: Csf3
Name: colony stimulating factor 3 (granulocyte)
RGD ID: 731416
Description: Enables granulocyte colony-stimulating factor receptor binding activity. Acts upstream of or within positive regulation of myeloid cell differentiation. Predicted to be located in endocytic vesicle lumen and extracellular region. Predicted to be active in extracellular space. Is expressed in aorta-gonad-mesonephros; brain; head; liver; and yolk sac. Human ortholog(s) of this gene implicated in several diseases, including allergic cutaneous vasculitis; artery disease (multiple); ischemia (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to human CSF3 (colony stimulating factor 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Csf; Csfg; G-CS; G-CSF; granulocyte colony-stimulating factor; MGI-; MGI-IG
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391198,591,287 - 98,594,457 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,592,089 - 98,594,455 (+)EnsemblGRCm39 Ensembl
GRCm381198,700,183 - 98,703,631 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,701,263 - 98,703,629 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,562,627 - 98,564,943 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,517,403 - 98,519,719 (+)NCBIMGSCv36mm8
Celera11108,355,655 - 108,357,971 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.45NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
agranulocytosis  (ISO)
allergic cutaneous vasculitis  (ISO)
anemia  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
anterior ischemic optic neuropathy  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aplastic anemia  (ISO)
Arthralgia  (ISO)
asthma  (IEP,ISO)
B-cell lymphoma  (ISO)
bacterial pneumonia  (ISO)
bilirubin metabolic disorder  (ISO)
Bone Marrow Neoplasms  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiac Fibrosis  (ISO)
Carotid Artery Injuries  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cognitive disorder  (ISO)
congestive heart failure  (ISO)
cystitis  (ISO)
diarrhea  (ISO)
dilated cardiomyopathy  (ISO)
Disease Susceptibility  (ISO)
Drug-Induced Agranulocytosis  (ISO)
Drug-induced Neutropenia  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Endotoxemia  (ISO)
Enterobacteriaceae Infections  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
gastrointestinal system disease  (ISO)
Head and Neck Neoplasms  (ISO)
Headache  (ISO)
heart disease  (ISO)
hepatic veno-occlusive disease  (ISO)
Hodgkin's lymphoma  (ISO)
Hyperalgesia  (ISO)
Hypertrophy  (ISO)
Infarction  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (ISO)
leiomyosarcoma  (ISO)
Leukocytosis  (ISO)
leukopenia  (ISO)
Limb Ischemia  (ISO)
liver disease  (ISO)
Liver Injury  (ISO)
Liver Neoplasms  (ISO)
localized scleroderma  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
Lymphoma, AIDS-Related  (ISO)
melanoma  (ISO)
mental depression  (ISO)
middle cerebral artery infarction  (ISO)
mucositis  (ISO)
multiple myeloma  (ISO)
Muscle Weakness  (ISO)
muscular disease  (ISO)
myeloid leukemia  (ISO)
myocardial infarction  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasms, Second Primary  (ISO)
nervous system disease  (ISO)
neutropenia  (ISO)
Neutrophilia  (ISO)
non-Hodgkin lymphoma  (ISO)
Optic Nerve Injuries  (ISO)
Pain  (ISO)
pancytopenia  (ISO)
peripheral nervous system disease  (ISO)
pleurisy  (ISO)
Poisoning  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Sepsis  (ISO)
Septic Peritonitis  (ISO)
Skin Neoplasms  (ISO)
Soft Tissue Neoplasms  (ISO)
Somatosensory Disorders  (ISO)
Spinal Cord Injuries  (ISO)
Spontaneous Abortions  (ISO)
Staphylococcal Infections  (ISO)
Staphylococcal Pneumonia  (ISO)
Stevens-Johnson syndrome  (ISO)
stomatitis  (ISO)
Stroke  (ISO)
Systemic Vasculitis  (ISO)
thrombocytopenia  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (ISO)
urinary bladder cancer  (ISO)
Uterine Neoplasms  (ISO)
Ventricular Dysfunction, Left  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3,5-trinitro-1,3,5-triazinane  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
7,12-dimethyltetraphene  (EXP)
7-ketocholesterol  (ISO)
acrylamide  (EXP)
agomelatine  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
aripiprazole  (ISO)
arsenous acid  (ISO)
asbestos  (EXP,ISO)
azathioprine  (ISO)
benzalkonium chloride  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
cannabidiol  (ISO)
carbon nanotube  (EXP)
chenodeoxycholic acid  (EXP)
choline  (EXP,ISO)
cisplatin  (EXP)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
creatine  (ISO)
crocidolite asbestos  (EXP,ISO)
crotonaldehyde  (ISO)
Cuprizon  (ISO)
deoxycholic acid  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dichlorine  (EXP,ISO)
dinitrogen  (ISO)
dioxygen  (EXP)
diuron  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
Erionite  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furosemide  (ISO)
gemcitabine  (ISO)
Genipin  (EXP)
genistein  (EXP)
gentamycin  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
heparin  (ISO)
hesperetin  (ISO)
hydrogen peroxide  (ISO)
inositol  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese(II) chloride  (ISO)
mangiferin  (EXP)
mercury dichloride  (EXP)
methotrexate  (ISO)
mirex  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nickel dichloride  (ISO)
o-anisidine  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentanal  (ISO)
pentane-2,3-dione  (ISO)
phenethyl isothiocyanate  (EXP)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
polymyxin B2  (EXP)
pomalidomide  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
raloxifene  (ISO)
ranitidine  (ISO)
resveratrol  (EXP,ISO)
serpentine asbestos  (EXP,ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
sodium tungstate  (ISO)
succimer  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurocholic acid  (EXP)
terameprocol  (EXP)
tetrachloromethane  (EXP)
thalidomide  (ISO)
theophylline  (ISO)
titanium dioxide  (EXP,ISO)
tremolite asbestos  (EXP)
tributylstannane  (EXP)
trichloroethene  (ISO)
troglitazone  (ISO)
valproic acid  (EXP)
verteporfin  (EXP)
XL147  (EXP)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Effects of granulocyte colony-stimulating factor (G-CSF) on bleomycin-induced lung injury of varying severity. Adachi K, etal., Toxicol Pathol. 2003 Nov-Dec;31(6):665-73.
2. Granulocyte colony-stimulating factor enhances host defenses against bacterial pneumonia following peritonitis in nonneutropenic rats. Attalah HL, etal., Crit Care Med. 2002 Sep;30(9):2107-14.
3. Granulocyte colony-stimulating factor enhances alpha-naphthylthiourea-induced pulmonary hypertension. Azoulay E, etal., J Appl Physiol (1985). 2003 May;94(5):2027-33. Epub 2003 Jan 10.
4. Suppression of the granulocyte colony-stimulating factor response to Escherichia coli challenge by alcohol intoxication. Bagby GJ, etal., Alcohol Clin Exp Res. 1998 Nov;22(8):1740-5.
5. Treatment of adjuvant arthritis with granulocyte-colony stimulating factor and peptide derived from heat shock protein 65. Brendolan A, etal., Cell Immunol. 2003 Jan;221(1):6-14.
6. Granulocyte colony-stimulating factor serum and urine concentrations in neutropenic neonates before and after intravenous administration of recombinant granulocyte colony-stimulating factor. Calhoun DA, etal., Pediatrics. 2000 Feb;105(2):392-7.
7. Neuroprotective effects of recombinant human granulocyte colony-stimulating factor (G-CSF) in a rat model of anterior ischemic optic neuropathy (rAION). Chang CH, etal., Exp Eye Res. 2014 Jan;118:109-16. doi: 10.1016/j.exer.2013.11.012. Epub 2013 Dec 5.
8. Co-delivery of G-CSF and EPO released from fibrin gel for therapeutic neovascularization in rat hindlimb ischemia model. Chen F, etal., Microcirculation. 2013 Jul;20(5):416-24. doi: 10.1111/micc.12037.
9. Expression of granulocyte colony-stimulating factor is induced in injured rat carotid arteries and mediates vascular smooth muscle cell migration. Chen X, etal., Am J Physiol Cell Physiol. 2005 Jan;288(1):C81-8. Epub 2004 Sep 22.
10. Granulocyte colony-stimulating factor exacerbates cardiac fibrosis after myocardial infarction in a rat model of permanent occlusion. Cheng Z, etal., Cardiovasc Res. 2008 Dec 1;80(3):425-34. doi: 10.1093/cvr/cvn202. Epub 2008 Jul 31.
11. Granulocyte colony stimulating factor neuroprotective effects on spinal motoneurons after ventral root avulsion. De Freria CM, etal., Synapse. 2012 Feb;66(2):128-41. doi: 10.1002/syn.20993. Epub 2011 Nov 3.
12. Effects of granulocyte colony stimulating factor in a nonneutropenic rodent model of Escherichia coli peritonitis. Dunne JR, etal., J Surg Res. 1996 Mar;61(2):348-54.
13. Granulocyte colony stimulating factor exacerbates antineutrophil cytoplasmic antibody vasculitis. Freeley SJ, etal., Ann Rheum Dis. 2013 Jun;72(6):1053-8. doi: 10.1136/annrheumdis-2012-202160. Epub 2012 Oct 19.
14. Therapy for neutropenia in hairy cell leukemia with recombinant human granulocyte colony-stimulating factor. Glaspy JA, etal., Ann Intern Med. 1988 Nov 15;109(10):789-95.
15. Granulocyte colony-stimulating factor after intensive consolidation chemotherapy in acute myeloid leukemia: results of a randomized trial of the Groupe Ouest-Est Leucemies Aigues Myeloblastiques. Harousseau JL, etal., J Clin Oncol. 2000 Feb;18(4):780-7.
16. Hemorrhagic shock induces G-CSF expression in bronchial epithelium. Hierholzer C, etal., Am J Physiol. 1997 Nov;273(5 Pt 1):L1058-64.
17. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
18. Granulocyte colony stimulating factor attenuates hyperoxia-induced lung injury by down-modulating inflammatory responses in neonatal rats. Jeon GW, etal., Yonsei Med J. 2011 Jan 1;52(1):65-73.
19. [Effects of granulocyte colony-stimulating factor on hepatocyte apoptosis in acute liver failure: experiment with rats]. Kang W, etal., Zhonghua Yi Xue Za Zhi. 2008 Apr 8;88(14):980-4.
20. G-CSF during Escherichia coli versus Staphylococcus aureus pneumonia in rats has fundamentally different and opposite effects. Karzai W, etal., Am J Respir Crit Care Med. 1999 May;159(5 Pt 1):1377-82.
21. Leukocytoclastic vasculitis in patients with severe congenital neutropenia. Kilic SS, etal., J Trop Pediatr. 2010 Oct;56(5):359-62. doi: 10.1093/tropej/fmp140. Epub 2010 Jan 25.
22. Induction of granulocyte colony-stimulating factor mRNA by focal cerebral ischemia and cortical spreading depression. Kleinschnitz C, etal., Brain Res Mol Brain Res. 2004 Nov 24;131(1-2):73-8.
23. Delayed granulocyte colony-stimulating factor treatment in rats attenuates mechanical allodynia induced by chronic constriction injury of the sciatic nerve. Koda M, etal., Spine (Phila Pa 1976). 2014 Feb 1;39(3):192-7. doi: 10.1097/BRS.0000000000000108.
24. Granulocyte-colony stimulating factor inhibits neuronal apoptosis in a rat model of diabetic cerebral ischemia. Lan X, etal., Tohoku J Exp Med. 2008 Oct;216(2):117-26.
25. Therapeutic angiogenesis with intramuscular injection of low-dose recombinant granulocyte-colony stimulating factor. Lee M, etal., Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2535-41. Epub 2005 Oct 13.
26. Improvement of heart allograft acceptability associated with recruitment of CD4+CD25+ T cells in peripheral blood by recipient treatment with granulocyte colony-stimulating factor. Liang HL, etal., Transplant Proc. 2008 Jun;40(5):1604-11. doi: 10.1016/j.transproceed.2008.02.078.
27. Granulocyte colony-stimulating factor improves survival rate and reduces concentrations of bacteria, endotoxin, tumor necrosis factor, and endothelin-1 in fulminant intra-abdominal sepsis in rats. Lundblad R, etal., Crit Care Med. 1996 May;24(5):820-6.
28. In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis in mouse. Luo X, etal., PLoS One. 2010 Apr 13;5(4):e10149.
29. Granulocyte colony-stimulating factor prevents progression of monocrotaline-induced pulmonary arterial hypertension in rats. Maruyama H, etal., Circ J. 2007 Jan;71(1):138-43.
30. Relationship between the cAMP levels in leukocytes and the cytokine balance in patients surviving gram negative bacterial pneumonia. Matsumoto T, etal., J Clin Biochem Nutr. 2011 Mar;48(2):134-41. Epub 2011 Feb 26.
31. MGDs mouse GO annotations MGD data from the GO Consortium
33. Treatment of relapsed adult acute lymphoblastic leukemia with fludarabine and cytosine arabinoside followed by granulocyte colony-stimulating factor (FLAG-GCSF). Montillo M, etal., Leuk Lymphoma. 1997 May;25(5-6):579-83.
34. Increased migration of neutrophils to granulocyte-colony stimulating factor in rat carrageenin-induced pleurisy: roles of complement, bradykinin, and inducible cyclooxygenase-2. Ogino M, etal., Inflamm Res. 1996 Jul;45(7):335-46.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. Effect of recombinant human granulocyte colony stimulating factor on granulocytopenia induced by cytotoxic chemotherapy in patients with multiple myeloma. Poglod R, etal., Mater Med Pol. 1995 Jul-Sep;27(3):83-9.
37. G-CSF suppresses allergic pulmonary inflammation, downmodulating cytokine, chemokine and eosinophil production. Queto T, etal., Life Sci. 2011 May 9;88(19-20):830-8. Epub 2011 Mar 21.
38. Mouse MP Annotation Import Pipeline RGD automated import pipeline
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. Levels of serum granulocyte colony-stimulating factor in patients with chronic myeloid leukemia. Saitoh H and Shibata A, Leuk Lymphoma. 1993 Nov;11(5-6):443-6.
41. Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia. Schabitz WR, etal., Stroke. 2003 Mar;34(3):745-51. Epub 2003 Feb 13.
42. IFN/RBV treatment induced neutropenia and its correction with neupogen in patients with hepatitis C. Sharvadze L, etal., Georgian Med News. 2007 Jun;(147):52-5.
43. Enhancement in cognitive function recovery by granulocyte-colony stimulating factor in a rodent model of traumatic brain injury. Sikoglu EM, etal., Behav Brain Res. 2014 Feb 1;259:354-6. doi: 10.1016/j.bbr.2013.11.008. Epub 2013 Nov 14.
44. Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis. Smaldone MC, etal., Urology. 2009 Feb;73(2):421-6. Epub 2008 Oct 9.
45. Granulocyte colony-stimulating factor protects the brain against experimental stroke via inhibition of apoptosis and inflammation. Solaroglu I, etal., Neurol Res. 2009 Mar;31(2):167-72. doi: 10.1179/174313209X393582.
46. The effects of recombinant human granulocyte-colony stimulating factor on vascular dysfunction and splanchnic ischaemia-reperfusion injury. Squadrito F, etal., Br J Pharmacol. 1997 Jan;120(2):333-9.
47. Granulocyte colony-stimulating factor attenuates early ventricular expansion after experimental myocardial infarction. Sugano Y, etal., Cardiovasc Res. 2005 Feb 1;65(2):446-56.
48. Antithyroid drug-induced agranulocytosis: how has granulocyte colony-stimulating factor changed therapy? Tajiri J and Noguchi S, Thyroid. 2005 Mar;15(3):292-7.
49. Implantation of fibroblasts transfected with human granulocyte colony-stimulating factor cDNA into mice as a model of cytokine-supplement gene therapy. Tani K, etal., Blood. 1989 Sep;74(4):1274-80.
50. Granulocyte colony-stimulating factor administration reverses cadmium-associated inhibition of hepatocyte regeneration. Theocharis SE, etal., Eur J Gastroenterol Hepatol. 1996 Aug;8(8):805-9.
51. Anti-apoptotic effects of human granulocyte colony-stimulating factor (G-CSF) on retinal ganglion cells after optic nerve crush are PI3K/AKT-dependent. Tsai RK, etal., Exp Eye Res. 2010 May;90(5):537-45. doi: 10.1016/j.exer.2010.01.004. Epub 2010 Feb 6.
52. Identification of mammalian noggin and its expression in the adult nervous system. Valenzuela DM, etal., J Neurosci 1995 Sep;15(9):6077-84.
53. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
54. Effect of nartograstim, a recombinant human granulocyte colony-stimulating factor on elastase-induced emphysema in rats. Yoshimatsu A, etal., Arzneimittelforschung. 2009;59(5):248-53. doi: 10.1055/s-0031-1296393.
55. The neutrophil/Th1 lymphocyte balance and the therapeutic effect of granulocyte colony-stimulating factor in TNBS-induced colitis of rat strains. Yoshimitsu M, etal., J Interferon Cytokine Res. 2006 May;26(5):291-300.
56. Protective effect of granulocyte colony-stimulating factor on intracerebral hemorrhage in rat. Zhang L, etal., Neurochem Res. 2009 Jul;34(7):1317-23. doi: 10.1007/s11064-008-9911-6. Epub 2009 Jan 24.
57. Granulocyte colony-stimulating factor treatment ameliorates liver injury and improves survival in rats with D-galactosamine-induced acute liver failure. Zhang L, etal., Toxicol Lett. 2011 Jul 4;204(1):92-9. doi: 10.1016/j.toxlet.2011.04.016. Epub 2011 Apr 27.
58. Acute ethanol intoxication inhibits neutrophil beta2-integrin expression in rats during endotoxemia. Zhang P, etal., Alcohol Clin Exp Res. 1998 Feb;22(1):135-41.
59. Granulocyte colony-stimulating factor treatment prevents cognitive impairment following status epilepticus in rats. Zhang Y, etal., Biol Pharm Bull. 2010;33(4):572-9.
60. Brain repair by hematopoietic growth factors in a rat model of stroke. Zhao LR, etal., Stroke. 2007 Sep;38(9):2584-91. Epub 2007 Jul 26.
Additional References at PubMed
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PMID:9129021   PMID:9180904   PMID:9218537   PMID:9226367   PMID:9345066   PMID:9376584   PMID:9382924   PMID:9446646   PMID:9465299   PMID:9558377   PMID:9639496   PMID:9743535  
PMID:9811459   PMID:9922384   PMID:9989983   PMID:10079103   PMID:10087300   PMID:10349636   PMID:10419886   PMID:10725249   PMID:10780854   PMID:10845903   PMID:11012764   PMID:11042159  
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PMID:20178614   PMID:20185584   PMID:20207226   PMID:20354107   PMID:20360400   PMID:20585044   PMID:20713518   PMID:20736176   PMID:20939024   PMID:21160041   PMID:21179444   PMID:21239180  
PMID:21267068   PMID:21292774   PMID:21422169   PMID:21455770   PMID:21664343   PMID:21699735   PMID:21764457   PMID:21873635   PMID:21922246   PMID:22080594   PMID:22426029   PMID:22528488  
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PMID:24253464   PMID:24470495   PMID:24518205   PMID:24585878   PMID:24990886   PMID:25160782   PMID:25563839   PMID:25623234   PMID:25624500   PMID:25865621   PMID:25908586   PMID:25976246  
PMID:26008898   PMID:26524416   PMID:26538529   PMID:26649828   PMID:26687628   PMID:26718978   PMID:26772539   PMID:26848119   PMID:27193261   PMID:27551153   PMID:27694472   PMID:28775207  
PMID:28867537   PMID:28973941   PMID:29352287   PMID:29438518   PMID:29708507   PMID:30056257   PMID:30626747   PMID:30627910   PMID:30679689   PMID:30729183   PMID:30842418   PMID:30988118  
PMID:31108101   PMID:31175224   PMID:31521664   PMID:31736098   PMID:32619702   PMID:32889566   PMID:33042110   PMID:33234677   PMID:33470903   PMID:33485710   PMID:33804138   PMID:34571009  
PMID:34883100   PMID:35243819   PMID:35364512  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391198,591,287 - 98,594,457 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,592,089 - 98,594,455 (+)EnsemblGRCm39 Ensembl
GRCm381198,700,183 - 98,703,631 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,701,263 - 98,703,629 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,562,627 - 98,564,943 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,517,403 - 98,519,719 (+)NCBIMGSCv36mm8
Celera11108,355,655 - 108,357,971 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.45NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381740,015,440 - 40,017,813 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1740,015,361 - 40,017,813 (+)EnsemblGRCh38hg38GRCh38
GRCh371738,171,693 - 38,174,066 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,425,214 - 35,427,592 (+)NCBINCBI36Build 36hg18NCBI36
Build 341735,425,213 - 35,427,591NCBI
Celera1734,831,674 - 34,834,127 (+)NCBICelera
Cytogenetic Map17q21.1NCBI
HuRef1733,965,611 - 33,968,064 (+)NCBIHuRef
CHM1_11738,407,306 - 38,409,759 (+)NCBICHM1_1
T2T-CHM13v2.01740,879,315 - 40,881,689 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21083,660,787 - 83,664,569 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,661,207 - 83,663,603 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,605,117 - 88,607,492 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01088,103,193 - 88,105,568 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01083,495,892 - 83,498,267 (+)NCBIRnor_WKY
Rnor_6.01086,616,785 - 86,619,160 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,616,785 - 86,619,157 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,413,088 - 86,415,478 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,473,990 - 87,476,365 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11087,488,359 - 87,490,732 (+)NCBI
Celera1082,409,331 - 82,411,709 (+)NCBICelera
RH 3.4 Map10850.39RGD
Cytogenetic Map10q31NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495545114,688,181 - 14,690,126 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,688,181 - 14,690,126 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11717,491,272 - 17,493,729 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,491,276 - 17,493,729 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01717,271,074 - 17,273,493 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1922,529,643 - 22,532,326 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,530,698 - 22,533,108 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,001,811 - 22,004,573 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,322,490 - 23,325,252 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,323,327 - 23,325,322 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,095,850 - 22,098,611 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,355,055 - 22,357,817 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,479,613 - 22,482,375 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440560221,929,893 - 21,934,092 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493649015,142,526 - 15,146,375 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1222,333,449 - 22,338,753 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,333,445 - 22,335,949 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,732,713 - 22,734,736 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11666,162,814 - 66,166,192 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,163,681 - 66,165,172 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607737,070,211 - 37,072,804 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247953,163,009 - 3,166,594 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,162,999 - 3,167,248 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,703,302 - 98,703,406UniSTSGRCm38
MGSCv371198,564,616 - 98,564,720UniSTSGRCm37
Celera11108,357,644 - 108,357,748UniSTS
Cytogenetic Map11DUniSTS
cM Map1157.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,702,090 - 98,702,895UniSTSGRCm38
MGSCv371198,563,404 - 98,564,209UniSTSGRCm37
Celera11108,356,432 - 108,357,237UniSTS
Cytogenetic Map11DUniSTS
cM Map1157.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,703,491 - 98,703,621UniSTSGRCm38
MGSCv371198,564,805 - 98,564,935UniSTSGRCm37
Celera11108,357,833 - 108,357,963UniSTS
Cytogenetic Map11DUniSTS
cM Map1157.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,702,498 - 98,703,199UniSTSGRCm38
MGSCv371198,563,812 - 98,564,513UniSTSGRCm37
Celera11108,356,840 - 108,357,541UniSTS
Cytogenetic Map11DUniSTS
cM Map1157.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,703,056 - 98,703,420UniSTSGRCm38
MGSCv371198,564,370 - 98,564,734UniSTSGRCm37
Celera11108,357,398 - 108,357,762UniSTS
Cytogenetic Map11DUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,701,517 - 98,702,920UniSTSGRCm38
MGSCv371198,562,831 - 98,564,234UniSTSGRCm37
Celera11108,355,859 - 108,357,262UniSTS
Cytogenetic Map11DUniSTS

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
1301491Abbp4_mA/J and C57BL/6 blood pressure 4 (mouse)Not determined118869958899081597Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301153Estq3_mestradiol regulated response QTL 3 (mouse)Not determined119689769399327028Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:279
Count of miRNA genes:231
Interacting mature miRNAs:252
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSMUST00000038886   ⟹   ENSMUSP00000037762
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,592,089 - 98,594,455 (+)Ensembl
GRCm38.p6 Ensembl1198,701,263 - 98,703,629 (+)Ensembl
RefSeq Acc Id: NM_009971   ⟹   NP_034101
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391198,592,139 - 98,594,455 (+)NCBI
GRCm381198,701,313 - 98,703,629 (+)NCBI
MGSCv371198,562,627 - 98,564,943 (+)RGD
Celera11108,355,655 - 108,357,971 (+)RGD
RefSeq Acc Id: XM_006532128   ⟹   XP_006532191
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,591,722 - 98,594,457 (+)NCBI
GRCm381198,700,912 - 98,703,631 (+)NCBI
RefSeq Acc Id: XM_030245517   ⟹   XP_030101377
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,591,287 - 98,594,457 (+)NCBI
GRCm381198,700,183 - 98,703,631 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_034101   ⟸   NM_009971
- Peptide Label: precursor
- UniProtKB: P09920 (UniProtKB/Swiss-Prot),   Q0VB73 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532191   ⟸   XM_006532128
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_030101377   ⟸   XM_030245517
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000037762   ⟸   ENSMUST00000038886

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09920-F1-model_v2 AlphaFold P09920 1-208 view protein structure

RGD ID:6820666
Promoter ID:MM_KWN:9598
SO ACC ID:SO:0000170
Tissues & Cell Lines:BoneMarrow_4Hour
Mouse AssemblyChrPosition (strand)Source
MGSCv361198,562,566 - 98,563,066 (+)MPROMDB
RGD ID:6850136
Promoter ID:EP17082
Type:single initiation site
Description:Granulocyte colony stimulating factor, CSF3 or CSFG gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 113; Mammalian G-CSF
Experiment Methods:Nuclease protection; Sequencing of a full-length cDNA
Regulation:macrophages; (induced by or strongly expressed in) endotoxin
Mouse AssemblyChrPosition (strand)Source
MGSCv371198,562,658 - 98,562,718EPD
MGSCv361198,562,658 - 98,562,718EPD
RGD ID:8676512
Promoter ID:EPDNEW_M16286
Type:single initiation site
Description:Mus musculus colony stimulating factor 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381198,701,344 - 98,701,404EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1339751 AgrOrtholog
Ensembl Genes ENSMUSG00000038067 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000037762 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000038886 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GCSF/MGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-6/GCSF/MGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL6/GCSF/MGF_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12985 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR10511 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GCSF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Csf3 PhenoGen
SMART IL6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL