(+)-catechin multiple interactions ISO RGD:3000 6480464 Catechin inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:23365609 (+)-catechin multiple interactions EXP 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 (+)-epicatechin-3-O-gallate multiple interactions EXP 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 (-)-epigallocatechin 3-gallate multiple interactions EXP 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 (R)-lipoic acid decreases secretion EXP 6480464 Thioctic Acid results in decreased secretion of LEP protein CTD PMID:21351249 (R)-lipoic acid decreases expression ISO RGD:3000 6480464 Thioctic Acid results in decreased expression of LEP mRNA, Thioctic Acid results in decreased expression of LEP protein CTD PMID:21351249 (R)-lipoic acid decreases expression EXP 6480464 Thioctic Acid results in decreased expression of LEP mRNA CTD PMID:21351249 (S)-nicotine increases expression ISO RGD:3000 6480464 Nicotine results in increased expression of LEP protein CTD PMID:23623838 , PMID:29155039 (S)-nicotine decreases response to substance ISO RGD:3000 6480464 Nicotine results in decreased susceptibility to LEP protein CTD PMID:23623838 1,4-bis(2-ethylhexyl) sulfosuccinate multiple interactions EXP 6480464 Dioctyl Sulfosuccinic Acid results in increased expression of and results in increased secretion of LEP protein CTD PMID:30728429 1,4-bis(2-ethylhexyl) sulfosuccinate increases expression EXP 6480464 Dioctyl Sulfosuccinic Acid results in increased expression of LEP mRNA CTD PMID:30728429 1,8-cineole multiple interactions EXP 6480464 Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of CTTN protein] more ... CTD PMID:31483951 1-(3-chlorophenyl)piperazine multiple interactions EXP 6480464 1-(3-chlorophenyl)piperazine inhibits the reaction [Corticosterone results in decreased expression of LEP protein] more ... CTD PMID:28186389 1-naphthyl isothiocyanate affects expression ISO RGD:3000 6480464 1-Naphthylisothiocyanate affects the expression of LEP protein CTD PMID:25051504 15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactions ISO RGD:69123 6480464 [Dexamethasone co-treated with 15-deoxy-delta(12, 14)-prostaglandin J2] results in decreased secretion of LEP protein CTD PMID:11092516 15-deoxy-Delta(12,14)-prostaglandin J2 increases secretion ISO RGD:69123 6480464 15-deoxy-delta(12, 14)-prostaglandin J2 results in increased secretion of LEP protein CTD PMID:11092516 17alpha-ethynylestradiol decreases expression ISO RGD:3000 6480464 Ethinyl Estradiol results in decreased expression of LEP protein CTD PMID:25051504 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of LEP mRNA CTD PMID:18359623 17beta-estradiol increases expression ISO RGD:3000 6480464 Estradiol results in increased expression of LEP mRNA CTD PMID:26164745 17beta-estradiol multiple interactions ISO RGD:69123 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[Estradiol co-treated with LEP protein] results in decreased activity of CASP3 protein] more ... CTD PMID:23850738 17beta-hydroxy-5alpha-androstan-3-one decreases expression ISO RGD:69123 6480464 Dihydrotestosterone results in decreased expression of LEP mRNA CTD PMID:18801408 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 2 more ... CTD PMID:23618531 more ... 2,2',4,4',5,5'-hexachlorobiphenyl increases expression EXP 6480464 2 more ... CTD PMID:24978599 2,2',4,4'-Tetrabromodiphenyl ether increases expression EXP 6480464 2 more ... CTD PMID:24559133 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO RGD:3000 6480464 2 more ... CTD PMID:27291303 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Dietary Fats affects the susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of LEP protein more ... CTD PMID:19063610 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of LEP mRNA CTD PMID:21570461 , PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:3000 6480464 [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of AGRP mRNA more ... CTD PMID:15977195 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA CTD PMID:19063610 2,4-dinitrophenol multiple interactions EXP 6480464 [2, 4-Dinitrophenol co-treated with Dietary Fats] affects the expression of LEP mRNA CTD PMID:24872412 2,6-di-tert-butyl-4-methylphenol multiple interactions EXP 6480464 Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] CTD PMID:16822543 2-acetamidofluorene increases expression ISO RGD:3000 6480464 2-Acetylaminofluorene results in increased expression of LEP protein CTD PMID:25051504 2-amino-2-deoxy-D-galactopyranose multiple interactions EXP 6480464 [LEP gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL12B mRNA more ... CTD PMID:19913045 2-amino-2-deoxy-D-galactopyranose increases response to substance EXP 6480464 LEP gene mutant form results in increased susceptibility to Galactosamine CTD PMID:19913045 2-amino-2-deoxy-D-glucopyranose 6-phosphate decreases expression EXP 6480464 glucosamine 6-phosphate results in decreased expression of LEP mRNA CTD PMID:19427183 2-aminopurine multiple interactions EXP 6480464 2-Aminopurine affects the reaction [LEP protein affects the expression of ADGRE1 mRNA] more ... CTD PMID:24150608 2-arachidonoylglycerol multiple interactions EXP 6480464 [Dietary Fats co-treated with LEP protein] results in increased chemical synthesis of glyceryl 2-arachidonate CTD PMID:27071101 2-deoxy-D-glucose multiple interactions ISO RGD:3000 6480464 [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein CTD PMID:10780946 2-deoxy-D-glucose decreases secretion ISO RGD:3000 6480464 Deoxyglucose results in decreased secretion of LEP protein CTD PMID:10780946 2-hydroxypropanoic acid affects expression ISO RGD:69123 6480464 Lactic Acid affects the expression of LEP mRNA CTD PMID:30851411 2-methyl-4-chlorophenoxybutyric acid multiple interactions ISO RGD:3000 6480464 [2-amino-3-chloro-1, 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 2-trans,6-trans,10-trans-geranylgeranyl diphosphate multiple interactions EXP 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA], geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased secretion of LEP protein] CTD PMID:19254925 24,25-Dihydroxyvitamin D decreases expression ISO RGD:69123 6480464 24, 25-Dihydroxyvitamin D 3 results in decreased expression of LEP protein CTD PMID:18379402 3',5'-cyclic AMP increases abundance ISO RGD:69123 6480464 LEP protein results in increased abundance of Cyclic AMP CTD PMID:11342529 3',5'-cyclic AMP multiple interactions EXP 6480464 3-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile inhibits the reaction [Cyclic AMP analog results in increased expression of LEP mRNA] CTD PMID:27381457 3',5'-cyclic AMP increases expression EXP 6480464 Cyclic AMP analog results in increased expression of LEP mRNA CTD PMID:27381457 3,3',4,4',5-pentachlorobiphenyl multiple interactions EXP 6480464 [3 more ... CTD PMID:28973532 3,3',5,5'-tetrabromobisphenol A increases expression EXP 6480464 tetrabromobisphenol A results in increased expression of LEP mRNA CTD PMID:30496566 3,4-methylenedioxymethamphetamine affects expression ISO RGD:3000 6480464 N-Methyl-3, 4-methylenedioxyamphetamine affects the expression of LEP protein CTD PMID:17910739 3,5-diethoxycarbonyl-1,4-dihydrocollidine decreases expression EXP 6480464 3 more ... CTD PMID:20512997 3-aminobenzamide increases expression ISO RGD:3000 6480464 3-aminobenzamide results in increased expression of LEP mRNA CTD PMID:18815186 3-chloropropane-1,2-diol decreases expression ISO RGD:3000 6480464 alpha-Chlorohydrin results in decreased expression of LEP mRNA CTD PMID:20409345 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:69123 6480464 4 more ... CTD PMID:19186324 more ... 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA more ... CTD PMID:23086663 more ... 4,4'-sulfonyldiphenol increases secretion EXP 6480464 bis(4-hydroxyphenyl)sulfone results in increased secretion of LEP protein CTD PMID:25111128 , PMID:31820560 4,4'-sulfonyldiphenol decreases methylation EXP 6480464 bis(4-hydroxyphenyl)sulfone results in decreased methylation of LEP promoter CTD PMID:33297965 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 bis(4-hydroxyphenyl)sulfone affects the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:27241191 4,4'-sulfonyldiphenol decreases expression ISO RGD:69123 6480464 bis(4-hydroxyphenyl)sulfone results in decreased expression of LEP mRNA CTD PMID:27685785 4-hydroxy-17beta-estradiol increases abundance ISO RGD:69123 6480464 LEP protein results in increased abundance of 4-hydroxyestradiol CTD PMID:24631339 4-hydroxy-TEMPO multiple interactions ISO RGD:3000 6480464 tempol inhibits the reaction [LEP protein results in decreased activity of PON1 protein] CTD PMID:15829432 4-hydroxybenzoic acid decreases expression ISO RGD:69123 6480464 4-hydroxybenzoic acid results in decreased expression of LEP mRNA CTD PMID:22956630 4-hydroxyphenyl retinamide decreases expression EXP 6480464 Fenretinide results in decreased expression of LEP mRNA CTD PMID:28973697 4-nonylphenol increases expression ISO RGD:3000 6480464 4-nonylphenol results in increased expression of LEP protein CTD PMID:24388992 5-aza-2'-deoxycytidine decreases methylation ISO RGD:69123 6480464 Decitabine results in decreased methylation of LEP promoter CTD PMID:17502362 5-aza-2'-deoxycytidine multiple interactions ISO RGD:69123 6480464 trichostatin A promotes the reaction [Decitabine results in increased expression of LEP mRNA] CTD PMID:17502362 5-aza-2'-deoxycytidine increases expression ISO RGD:69123 6480464 [Decitabine results in increased expression of LEP mRNA] which results in increased expression of MMP13 mRNA, Decitabine results in increased expression of LEP mRNA CTD PMID:17502362 8-Br-cAMP multiple interactions ISO RGD:69123 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]] more ... CTD PMID:19849856 8-Br-cAMP decreases response to substance ISO RGD:69123 6480464 LEP protein results in decreased susceptibility to 8-Bromo Cyclic Adenosine Monophosphate CTD PMID:19849856 9-cis-retinoic acid multiple interactions ISO RGD:3000 6480464 [Alitretinoin co-treated with Clofibrate] results in increased expression of LEP protein CTD PMID:9751766 AACOCF3 multiple interactions EXP 6480464 arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA] CTD PMID:19063610 acarbose decreases expression ISO RGD:3000 6480464 Acarbose results in decreased expression of LEP protein CTD PMID:18290871 acetaldehyde multiple interactions EXP 6480464 Acetaldehyde inhibits the reaction [LEP protein results in increased expression of ADIPOR2 protein] more ... CTD PMID:15130784 , PMID:17949463 acetylsalicylic acid multiple interactions ISO RGD:3000 6480464 [lipopolysaccharide, Helicobacter pylori co-treated with Aspirin] results in increased expression of LEP protein CTD PMID:15024038 actinomycin D multiple interactions ISO RGD:3000 6480464 Dactinomycin inhibits the reaction [LEP protein results in increased expression of COL1A2 mRNA] CTD PMID:12704794 Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate] decreases response to substance ISO RGD:69123 6480464 adenosine-3', 5'-cyclic phosphorothioate results in decreased susceptibility to LEP protein CTD PMID:11342529 Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate] multiple interactions ISO RGD:69123 6480464 adenosine-3' more ... CTD PMID:11342529 aflatoxin B1 increases methylation ISO RGD:69123 6480464 Aflatoxin B1 results in increased methylation of LEP gene CTD PMID:27153756 AH23848 multiple interactions ISO RGD:69123 6480464 AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA], AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 aldehydo-D-glucosamine 6-phosphate decreases expression EXP 6480464 glucosamine 6-phosphate results in decreased expression of LEP mRNA CTD PMID:19427183 aldehydo-D-glucose multiple interactions ISO RGD:69123 6480464 Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species], LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 aldehydo-D-glucose multiple interactions EXP 6480464 [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased abundance of Glucose CTD PMID:27712037 aldehydo-D-glucose increases secretion ISO RGD:3000 6480464 Glucose results in increased secretion of LEP protein CTD PMID:10780946 aldehydo-D-glucose increases expression ISO RGD:3000 6480464 Glucose results in increased expression of LEP mRNA, Glucose results in increased expression of LEP protein CTD PMID:10780946 more ... aldehydo-D-glucose increases response to substance ISO RGD:69123 6480464 Glucose results in increased susceptibility to LEP protein CTD PMID:11342529 aldehydo-D-glucose multiple interactions ISO RGD:3000 6480464 1 more ... CTD PMID:10780946 more ... all-trans-retinoic acid multiple interactions ISO RGD:69123 6480464 Tretinoin results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:32929351 all-trans-retinol multiple interactions ISO RGD:3000 6480464 LEP gene mutant form promotes the reaction [Vitamin A results in increased expression of UCP1 mRNA] CTD PMID:16493122 allopurinol multiple interactions ISO RGD:3000 6480464 Allopurinol inhibits the reaction [Fructose results in increased expression of LEP protein] CTD PMID:22426011 AM-251 multiple interactions EXP 6480464 AM 251 inhibits the reaction [LEP gene mutant form results in decreased expression of POMC mRNA] more ... CTD PMID:27071101 Amibegron decreases expression ISO RGD:3000 6480464 amibegron results in decreased expression of LEP mRNA CTD PMID:9718277 Amibegron multiple interactions ISO RGD:3000 6480464 3-(2-ethylphenoxy)-1-(1 more ... CTD PMID:9718277 amlodipine decreases expression ISO RGD:69123 6480464 Amlodipine results in decreased expression of LEP, Amlodipine results in decreased expression of LEP protein CTD PMID:18199500 , PMID:19059660 ammonium chloride affects expression ISO RGD:3000 6480464 Ammonium Chloride affects the expression of LEP mRNA CTD PMID:16483693 anandamide decreases abundance ISO RGD:69123 6480464 LEP protein results in decreased abundance of anandamide CTD PMID:16154199 anandamide multiple interactions EXP 6480464 Dietary Fats inhibits the reaction [LEP protein results in decreased abundance of anandamide] CTD PMID:29967158 anandamide decreases abundance EXP 6480464 LEP protein results in decreased abundance of anandamide CTD PMID:29967158 anandamide decreases activity ISO RGD:69123 6480464 LEP protein results in decreased activity of anandamide CTD PMID:16154199 anandamide decreases transport ISO RGD:69123 6480464 LEP protein results in decreased transport of anandamide CTD PMID:16154199 androst-4-ene-3,17-dione multiple interactions ISO RGD:3000 6480464 LEP protein inhibits the reaction [CGA protein results in increased secretion of Androstenedione] CTD PMID:14657608 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:69123 6480464 pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA], pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 apigenin increases expression EXP 6480464 Apigenin results in increased expression of LEP mRNA, Apigenin results in increased expression of LEP protein CTD PMID:18359623 apocynin multiple interactions EXP 6480464 acetovanillone inhibits the reaction [LEP protein affects the abundance of Calcium] more ... CTD PMID:16380530 arachidonic acid multiple interactions EXP 6480464 Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA] CTD PMID:19063610 arsane affects expression ISO RGD:69123 6480464 Arsenic affects the expression of LEP protein CTD PMID:20940111 arsane multiple interactions ISO RGD:69123 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of LEP mRNA CTD PMID:32525701 arsenic atom affects expression ISO RGD:69123 6480464 Arsenic affects the expression of LEP protein CTD PMID:20940111 arsenic atom multiple interactions ISO RGD:69123 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of LEP mRNA CTD PMID:32525701 arsenite(3-) decreases methylation ISO RGD:69123 6480464 arsenite results in decreased methylation of LEP promoter CTD PMID:23974009 arsenous acid multiple interactions ISO RGD:69123 6480464 Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein, Fenofibrate inhibits the reaction [Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein] CTD PMID:32929351 aspartame decreases expression ISO RGD:3000 6480464 Aspartame results in decreased expression of LEP protein CTD PMID:11890951 aspartame multiple interactions EXP 6480464 [Fats more ... CTD PMID:23783067 atorvastatin calcium multiple interactions ISO RGD:3000 6480464 Atorvastatin affects the reaction [Fructose results in increased expression of LEP protein] CTD PMID:21122807 ATP multiple interactions ISO RGD:3000 6480464 [[Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate] which results in increased secretion of LEP protein, [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein CTD PMID:10780946 Aurothioglucose multiple interactions EXP 6480464 [Sodium Glutamate co-treated with Aurothioglucose] results in increased expression of LEP mRNA, [Sodium Glutamate co-treated with Aurothioglucose] results in increased expression of LEP protein CTD PMID:9794456 Aurothioglucose increases expression EXP 6480464 Aurothioglucose results in increased expression of LEP mRNA, Aurothioglucose results in increased expression of LEP protein CTD PMID:15809509 more ... azoxystrobin multiple interactions EXP 6480464 [azoxystrobin co-treated with Dietary Fats] affects the expression of LEP protein CTD PMID:24726979 Bardoxolone methyl multiple interactions EXP 6480464 bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased susceptibility to LEP protein], bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:27417254 benzo[a]pyrene affects methylation ISO RGD:69123 6480464 Benzo(a)pyrene affects the methylation of LEP intron CTD PMID:30157460 Benzyl parahydroxybenzoate increases expression EXP 6480464 benzylparaben results in increased expression of LEP mRNA CTD PMID:22956630 Benzyl parahydroxybenzoate decreases expression ISO RGD:69123 6480464 benzylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 beta-D-glucosamine 6-sulfate decreases expression EXP 6480464 glucosamine 6-O-sulfate results in decreased expression of LEP mRNA CTD PMID:19520133 beta-naphthoflavone decreases expression ISO RGD:69123 6480464 beta-Naphthoflavone results in decreased expression of LEP mRNA CTD PMID:32858204 bezafibrate decreases expression ISO RGD:69123 6480464 Bezafibrate results in decreased expression of LEP CTD PMID:10726910 bezafibrate multiple interactions EXP 6480464 Bezafibrate inhibits the reaction [Sodium Glutamate results in increased expression of LEP protein] CTD PMID:21549692 bezafibrate decreases expression ISO RGD:3000 6480464 Bezafibrate results in decreased expression of LEP mRNA CTD PMID:11216866 , PMID:11473052 bezafibrate multiple interactions ISO RGD:3000 6480464 Bezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of LEP protein] CTD PMID:17379010 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of LEP mRNA, Diethylhexyl Phthalate results in increased expression of LEP protein CTD PMID:22588786 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:3000 6480464 Diethylhexyl Phthalate results in decreased expression of LEP protein CTD PMID:33309551 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:3000 6480464 [Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of LEP mRNA, [Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of LEP protein CTD PMID:33166671 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:29175711 , PMID:30660623 bis(2-ethylhexyl) phthalate increases expression ISO RGD:69123 25330351 bis(2-ethylhexyl) phthalate increased expression of LEP in adipose tissue (rat) RGD bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of LEP more ... CTD PMID:18359623 more ... bisphenol A increases expression ISO RGD:3000 6480464 bisphenol A results in increased expression of LEP mRNA CTD PMID:34947998 bisphenol A multiple interactions ISO RGD:3000 6480464 bisphenol A results in increased expression of and results in increased secretion of LEP protein CTD PMID:32339907 bisphenol A increases secretion EXP 6480464 bisphenol A results in increased secretion of LEP protein CTD PMID:31820560 bisphenol A decreases secretion ISO RGD:3000 6480464 bisphenol A results in decreased secretion of LEP protein CTD PMID:31697385 bisphenol A decreases expression ISO RGD:3000 6480464 bisphenol A results in decreased expression of LEP mRNA CTD PMID:30816183 , PMID:32528016 bisphenol A decreases expression ISO RGD:69123 6480464 bisphenol A results in decreased expression of LEP mRNA, bisphenol A results in decreased expression of LEP protein CTD PMID:24349194 more ... bisphenol A increases expression ISO RGD:69123 6480464 bisphenol A results in increased expression of LEP mRNA, bisphenol A results in increased expression of LEP protein CTD PMID:25878060 more ... bisphenol A multiple interactions ISO RGD:69123 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[bisphenol A co-treated with LEP protein] results in decreased activity of CASP3 protein] more ... CTD PMID:23850738 bisphenol A multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:23493373 more ... Bisphenol A diglycidyl ether increases expression EXP 6480464 2, 2-bis(4-glycidyloxyphenyl)propane results in increased expression of LEP mRNA CTD PMID:22763116 Bisphenol A diglycidyl ether multiple interactions EXP 6480464 2 more ... CTD PMID:32408695 Bisphenol B increases secretion EXP 6480464 bisphenol B results in increased secretion of LEP protein CTD PMID:31820560 bisphenol F increases secretion EXP 6480464 bisphenol F results in increased secretion of LEP protein CTD PMID:31820560 bleomycin A2 increases expression EXP 6480464 Bleomycin results in increased expression of LEP protein CTD PMID:29175452 boric acid multiple interactions EXP 6480464 boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA], boric acid results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:28285642 boron atom multiple interactions ISO RGD:3000 6480464 Boron inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA] CTD PMID:36419211 BQ 123 multiple interactions EXP 6480464 cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein affects the abundance of Calcium] more ... CTD PMID:16380530 bromodichloromethane increases expression EXP 6480464 bromodichloromethane results in increased expression of LEP mRNA CTD PMID:23640861 bromodichloromethane multiple interactions EXP 6480464 bromodichloromethane promotes the reaction [Dietary Fats results in increased expression of LEP mRNA] more ... CTD PMID:23438451 , PMID:24211274 bromodichloromethane decreases response to substance EXP 6480464 LEP gene mutant form results in decreased susceptibility to bromodichloromethane CTD PMID:23640861 bucladesine decreases expression EXP 6480464 Bucladesine results in decreased expression of LEP mRNA CTD PMID:9002984 Butylparaben increases expression EXP 6480464 butylparaben results in increased expression of LEP mRNA CTD PMID:22956630 Butylparaben decreases expression ISO RGD:69123 6480464 butylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 butyric acid multiple interactions EXP 6480464 Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein] CTD PMID:29751049 cadmium atom multiple interactions ISO RGD:69123 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LEP mRNA CTD PMID:35301059 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of LEP mRNA, Cadmium Chloride results in decreased expression of LEP protein CTD PMID:23921151 cadmium dichloride multiple interactions ISO RGD:69123 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LEP mRNA CTD PMID:35301059 cadmium dichloride decreases expression ISO RGD:69123 6480464 Cadmium Chloride results in decreased expression of LEP mRNA CTD PMID:19847775 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of LEP protein CTD PMID:27634282 cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride co-treated with methylmercuric chloride] results in increased expression of LEP protein more ... CTD PMID:23921151 , PMID:27814245 caffeine decreases expression EXP 6480464 Caffeine results in decreased expression of LEP mRNA CTD PMID:23727198 caffeine decreases expression ISO RGD:69123 6480464 Caffeine results in decreased expression of LEP mRNA CTD PMID:26367767 caffeine multiple interactions ISO RGD:69123 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA], Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] CTD PMID:26367767 caffeine decreases expression ISO RGD:3000 6480464 Caffeine results in decreased expression of LEP mRNA, Caffeine results in decreased expression of LEP protein CTD PMID:23727198 , PMID:26367767 calcitriol decreases abundance EXP 6480464 LEP protein results in decreased abundance of Calcitriol CTD PMID:14657008 calcium atom multiple interactions EXP 6480464 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium] more ... CTD PMID:16380530 , PMID:20107083 calcium atom multiple interactions ISO RGD:3000 6480464 Calcium deficiency inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 calcium atom affects secretion ISO RGD:3000 6480464 Calcium deficiency affects the secretion of LEP protein CTD PMID:10780946 calcium atom affects expression ISO RGD:3000 6480464 Calcium affects the expression of LEP mRNA CTD PMID:15913539 calcium atom decreases abundance EXP 6480464 LEP protein results in decreased abundance of Calcium CTD PMID:14657008 calcium atom affects abundance EXP 6480464 LEP protein affects the abundance of Calcium CTD PMID:16380530 calcium atom increases transport EXP 6480464 LEP protein results in increased transport of Calcium CTD PMID:20107083 calcium(0) multiple interactions EXP 6480464 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium] more ... CTD PMID:16380530 , PMID:20107083 calcium(0) multiple interactions ISO RGD:3000 6480464 Calcium deficiency inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 calcium(0) affects secretion ISO RGD:3000 6480464 Calcium deficiency affects the secretion of LEP protein CTD PMID:10780946 calcium(0) affects expression ISO RGD:3000 6480464 Calcium affects the expression of LEP mRNA CTD PMID:15913539 calcium(0) decreases abundance EXP 6480464 LEP protein results in decreased abundance of Calcium CTD PMID:14657008 calcium(0) affects abundance EXP 6480464 LEP protein affects the abundance of Calcium CTD PMID:16380530 calcium(0) increases transport EXP 6480464 LEP protein results in increased transport of Calcium CTD PMID:20107083 candesartan multiple interactions ISO RGD:69123 6480464 candesartan promotes the reaction [Ramipril results in increased expression of LEP], Ramipril promotes the reaction [candesartan results in increased expression of LEP] CTD PMID:17483542 candesartan increases response to substance ISO RGD:3000 6480464 LEP protein results in increased susceptibility to candesartan CTD PMID:21287150 candesartan decreases expression ISO RGD:69123 6480464 candesartan results in decreased expression of LEP CTD PMID:19059660 cannabidiol multiple interactions EXP 6480464 Cannabidiol analog inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:30382123 capsaicin decreases expression EXP 6480464 Capsaicin results in decreased expression of LEP protein CTD PMID:17295509 , PMID:19798065 capsaicin multiple interactions ISO RGD:3000 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein] more ... CTD PMID:20359164 , PMID:22150557 capsaicin increases expression ISO RGD:3000 6480464 Capsaicin results in increased expression of LEP mRNA, Capsaicin results in increased expression of LEP protein CTD PMID:16278290 , PMID:22150557 capsazepine multiple interactions EXP 6480464 capsazepine inhibits the reaction [Olanzapine results in increased expression of LEP protein] CTD PMID:32652086 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon results in increased expression of LEP protein CTD PMID:20381574 carvacrol multiple interactions ISO RGD:3000 6480464 carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 CCCP decreases response to substance ISO RGD:69123 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased susceptibility to LEP protein CTD PMID:11342529 CCCP multiple interactions ISO RGD:69123 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 cerulenin affects response to substance EXP 6480464 LEP protein affects the susceptibility to Cerulenin CTD PMID:11289036 CGP 52608 multiple interactions ISO RGD:69123 6480464 CGP 52608 promotes the reaction [RORA protein binds to LEP gene] CTD PMID:28238834 CGS-21680 multiple interactions ISO RGD:69123 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] CTD PMID:26367767 chlorohydrocarbon multiple interactions EXP 6480464 [LEP protein co-treated with Hydrocarbons more ... CTD PMID:31313498 chloroquine multiple interactions EXP 6480464 Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of LEP protein] CTD PMID:22341560 chlorpromazine increases expression ISO RGD:3000 6480464 Chlorpromazine results in increased expression of LEP protein CTD PMID:17512020 chlorpyrifos decreases expression ISO RGD:3000 6480464 Chlorpyrifos results in decreased expression of LEP protein CTD PMID:33994353 chlorpyrifos increases expression ISO RGD:69123 6480464 Chlorpyrifos results in increased expression of LEP mRNA CTD PMID:30879083 choline multiple interactions EXP 6480464 [3 more ... CTD PMID:24384915 more ... chromium atom decreases expression ISO RGD:3000 6480464 Chromium results in decreased expression of LEP protein CTD PMID:17114815 chromium atom increases expression ISO RGD:3000 6480464 Chromium deficiency results in increased expression of LEP mRNA, Chromium deficiency results in increased expression of LEP protein CTD PMID:19846803 chromium atom multiple interactions EXP 6480464 [Linoleic Acids, Conjugated co-treated with Chromium] results in decreased expression of LEP protein CTD PMID:16933788 cisplatin affects expression ISO RGD:3000 6480464 Cisplatin affects the expression of LEP protein CTD PMID:25051504 clofibrate multiple interactions EXP 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA] CTD PMID:17585979 clofibrate multiple interactions ISO RGD:3000 6480464 [alitretinoin co-treated with Clofibrate] results in increased expression of LEP protein CTD PMID:9751766 clozapine affects response to substance ISO RGD:69123 6480464 LEP protein affects the susceptibility to Clozapine CTD PMID:17502770 clozapine increases expression ISO RGD:3000 6480464 Clozapine results in increased expression of LEP protein CTD PMID:16402076 cobalt dichloride increases expression ISO RGD:69123 6480464 cobaltous chloride results in increased expression of LEP mRNA CTD PMID:12032628 cobalt dichloride multiple interactions EXP 6480464 2 more ... CTD PMID:32408695 cobalt dichloride increases expression ISO RGD:3000 6480464 cobaltous chloride results in increased expression of LEP mRNA CTD PMID:12032628 cobalt dichloride increases secretion ISO RGD:3000 6480464 cobaltous chloride results in increased secretion of LEP protein CTD PMID:12032628 cobalt dichloride increases secretion ISO RGD:69123 6480464 cobaltous chloride results in increased secretion of LEP protein CTD PMID:12032628 cobalt dichloride increases secretion EXP 6480464 cobaltous chloride results in increased secretion of LEP protein CTD PMID:22019852 colforsin daropate hydrochloride decreases secretion EXP 6480464 Colforsin results in decreased secretion of LEP protein CTD PMID:27381457 colforsin daropate hydrochloride multiple interactions ISO RGD:69123 6480464 Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] CTD PMID:26367767 colforsin daropate hydrochloride decreases expression EXP 6480464 Colforsin results in decreased expression of LEP mRNA CTD PMID:27381457 , PMID:9002984 conjugated linoleic acid multiple interactions EXP 6480464 [Linoleic Acids, Conjugated co-treated with Chromium] results in decreased expression of LEP protein CTD PMID:16933788 conjugated linoleic acid decreases expression EXP 6480464 Linoleic Acids, Conjugated results in decreased expression of LEP protein CTD PMID:16933788 conjugated linoleic acid increases expression EXP 6480464 Linoleic Acids, Conjugated results in increased expression of LEP protein CTD PMID:17322064 corn oil multiple interactions ISO RGD:3000 6480464 Corn Oil inhibits the reaction [Glucose results in increased expression of LEP protein] CTD PMID:29165388 corticosterone decreases expression EXP 6480464 Corticosterone results in decreased expression of LEP protein CTD PMID:28186389 corticosterone multiple interactions EXP 6480464 1-(3-chlorophenyl)piperazine inhibits the reaction [Corticosterone results in decreased expression of LEP protein] more ... CTD PMID:28186389 , PMID:29751049 crocidolite asbestos decreases expression EXP 6480464 Asbestos, Crocidolite results in decreased expression of LEP mRNA CTD PMID:23917077 cycloheximide multiple interactions EXP 6480464 LEP protein inhibits the reaction [Cycloheximide results in decreased expression of LEPR protein] CTD PMID:31199479 cyclosporin A decreases expression ISO RGD:3000 6480464 Cyclosporine results in decreased expression of LEP protein CTD PMID:25051504 cyhalothrin increases expression ISO RGD:3000 6480464 cyhalothrin results in increased expression of LEP protein CTD PMID:27348886 cyromazine multiple interactions ISO RGD:3000 6480464 [2-amino-3-chloro-1, 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 D-glucose multiple interactions ISO RGD:3000 6480464 1 more ... CTD PMID:10780946 more ... D-glucose multiple interactions EXP 6480464 [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased abundance of Glucose CTD PMID:27712037 D-glucose increases expression ISO RGD:3000 6480464 Glucose results in increased expression of LEP mRNA, Glucose results in increased expression of LEP protein CTD PMID:10780946 more ... D-glucose increases secretion ISO RGD:3000 6480464 Glucose results in increased secretion of LEP protein CTD PMID:10780946 D-glucose increases response to substance ISO RGD:69123 6480464 Glucose results in increased susceptibility to LEP protein CTD PMID:11342529 D-glucose multiple interactions ISO RGD:69123 6480464 Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species], LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 dantrolene decreases expression ISO RGD:3000 6480464 Dantrolene results in decreased expression of LEP protein CTD PMID:25051504 DDE increases secretion EXP 6480464 Dichlorodiphenyl Dichloroethylene results in increased secretion of LEP protein CTD PMID:21044676 DDE multiple interactions ISO RGD:69123 6480464 Dichlorodiphenyl Dichloroethylene promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of LEP mRNA] CTD PMID:26200599 DDT increases expression ISO RGD:69123 6480464 DDT results in increased expression of LEP mRNA CTD PMID:25014179 dehydroepiandrosterone decreases expression ISO RGD:3000 6480464 Dehydroepiandrosterone results in decreased expression of LEP protein CTD PMID:12659879 deoxycholic acid decreases expression EXP 6480464 Deoxycholic Acid results in decreased expression of LEP mRNA CTD PMID:23911798 desferrioxamine B increases expression ISO RGD:69123 6480464 Deferoxamine results in increased expression of LEP mRNA CTD PMID:12032628 desferrioxamine B increases secretion ISO RGD:3000 6480464 Deferoxamine results in increased secretion of LEP protein CTD PMID:12032628 desferrioxamine B increases secretion ISO RGD:69123 6480464 Deferoxamine results in increased secretion of LEP protein CTD PMID:12032628 desferrioxamine B increases expression ISO RGD:3000 6480464 Deferoxamine results in increased expression of LEP mRNA CTD PMID:12032628 dexamethasone multiple interactions ISO RGD:69123 6480464 4 more ... CTD PMID:10946865 more ... dexamethasone multiple interactions EXP 6480464 [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA more ... CTD PMID:23086663 more ... dexamethasone increases secretion ISO RGD:69123 6480464 Dexamethasone results in increased secretion of LEP protein CTD PMID:10946865 dexamethasone increases expression ISO RGD:69123 6480464 Dexamethasone results in increased expression of LEP mRNA CTD PMID:10946865 , PMID:32976960 dexamethasone increases expression ISO RGD:3000 6480464 Dexamethasone results in increased expression of LEP mRNA, Dexamethasone results in increased expression of LEP protein CTD PMID:15824971 , PMID:23166830 dextran sulfate multiple interactions EXP 6480464 [Azoxymethane co-treated with Dextran Sulfate] results in increased expression of LEP mRNA, [Azoxymethane co-treated with Dextran Sulfate] results in increased expression of LEP protein CTD PMID:19931517 diarsenic trioxide multiple interactions ISO RGD:69123 6480464 Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein, Fenofibrate inhibits the reaction [Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein] CTD PMID:32929351 diazoxide multiple interactions ISO RGD:3000 6480464 Diazoxide inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 diazoxide decreases secretion ISO RGD:3000 6480464 Diazoxide results in decreased secretion of LEP protein CTD PMID:10780946 dibenziodolium multiple interactions ISO RGD:69123 6480464 diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of LEP protein] more ... CTD PMID:17668557 dibutylstannane multiple interactions EXP 6480464 [Dietary Fats co-treated with di-n-butyltin] results in increased expression of LEP protein CTD PMID:29787037 diethylstilbestrol decreases secretion EXP 6480464 Diethylstilbestrol results in decreased secretion of LEP protein CTD PMID:25111128 diethylstilbestrol multiple interactions EXP 6480464 Diethylstilbestrol inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:23493373 diiodine multiple interactions ISO RGD:3000 6480464 [Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of LEP protein CTD PMID:30090431 dioxygen increases secretion ISO RGD:69123 6480464 Oxygen deficiency results in increased secretion of LEP protein CTD PMID:12032628 dioxygen increases expression ISO RGD:69123 6480464 Oxygen deficiency results in increased expression of LEP mRNA CTD PMID:12032628 , PMID:23466666 dioxygen decreases expression EXP 6480464 Oxygen deficiency results in decreased expression of LEP mRNA, Oxygen deficiency results in decreased expression of LEP protein CTD PMID:21531777 , PMID:23539316 dipyridamole multiple interactions ISO RGD:3000 6480464 1, 3-dipropyl-8-cyclopentylxanthine inhibits the reaction [Dipyridamole results in increased expression of LEP protein] CTD PMID:10746648 dipyridamole increases expression ISO RGD:3000 6480464 Dipyridamole results in increased expression of LEP protein CTD PMID:10746648 disodium selenite decreases expression EXP 6480464 Sodium Selenite results in decreased expression of LEP mRNA CTD PMID:23274088 dobutamine decreases secretion ISO RGD:69123 6480464 Dobutamine results in decreased secretion of LEP protein CTD PMID:11022189 dobutamine decreases expression EXP 6480464 Dobutamine results in decreased expression of LEP mRNA, Dobutamine results in decreased expression of LEP protein CTD PMID:9002984 DPCPX multiple interactions ISO RGD:3000 6480464 1, 3-dipropyl-8-cyclopentylxanthine inhibits the reaction [Dipyridamole results in increased expression of LEP protein] CTD PMID:10746648 edelfosine multiple interactions EXP 6480464 edelfosine inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 efavirenz decreases expression ISO RGD:69123 6480464 efavirenz results in decreased expression of LEP mRNA CTD PMID:21619898 elemental boron multiple interactions ISO RGD:3000 6480464 Boron inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA] CTD PMID:36419211 elemental selenium decreases abundance ISO RGD:69123 6480464 LEP gene mutant form results in decreased abundance of Selenium CTD PMID:10965932 Elemicin multiple interactions EXP 6480464 [Vancomycin co-treated with Neomycin co-treated with Metronidazole co-treated with elemicin] results in increased expression of LEP mRNA CTD PMID:34979169 enalapril increases response to substance EXP 6480464 LEP protein results in increased susceptibility to Enalapril CTD PMID:20614101 ethambutol decreases expression ISO RGD:3000 6480464 Ethambutol results in decreased expression of LEP protein CTD PMID:25051504 ethanol multiple interactions ISO RGD:3000 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein more ... CTD PMID:18227024 ethanol multiple interactions EXP 6480464 [Zinc deficiency co-treated with Ethanol] results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24155903 ethionamide decreases expression ISO RGD:3000 6480464 Ethionamide results in decreased expression of LEP protein CTD PMID:25051504 Ethyl icosapentate increases expression EXP 6480464 eicosapentaenoic acid ethyl ester results in increased expression of LEP mRNA CTD PMID:10753628 Ethyl icosapentate increases secretion EXP 6480464 eicosapentaenoic acid ethyl ester results in increased secretion of LEP protein CTD PMID:10753628 Ethyl icosapentate multiple interactions EXP 6480464 Diazooxonorleucine inhibits the reaction [eicosapentaenoic acid ethyl ester results in increased expression of LEP mRNA], Diazooxonorleucine inhibits the reaction [eicosapentaenoic acid ethyl ester results in increased secretion of LEP protein] CTD PMID:10753628 ethylparaben decreases expression ISO RGD:69123 6480464 ethyl-p-hydroxybenzoate results in decreased expression of LEP mRNA CTD PMID:22956630 fenofibrate multiple interactions ISO RGD:3000 6480464 [Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA], Fenofibrate inhibits the reaction [Fructose results in increased expression of LEP mRNA] CTD PMID:26973390 fenofibrate multiple interactions ISO RGD:69123 6480464 Fenofibrate inhibits the reaction [Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein] CTD PMID:32929351 fenoterol decreases secretion ISO RGD:69123 6480464 Fenoterol results in decreased secretion of LEP protein CTD PMID:11022189 fenvalerate increases expression ISO RGD:3000 6480464 fenvalerate results in increased expression of LEP mRNA CTD PMID:30307764 flufenamic acid multiple interactions EXP 6480464 Flufenamic Acid inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 flutamide decreases expression ISO RGD:3000 6480464 Flutamide results in decreased expression of LEP protein CTD PMID:25051504 fonofos increases methylation ISO RGD:69123 6480464 Fonofos results in increased methylation of LEP promoter CTD PMID:22847954 fructose increases expression ISO RGD:3000 6480464 Fructose results in increased expression of LEP mRNA, Fructose results in increased expression of LEP protein CTD PMID:11741341 more ... fructose increases secretion ISO RGD:3000 6480464 Fructose results in increased secretion of LEP protein CTD PMID:10780946 more ... fructose multiple interactions ISO RGD:3000 6480464 [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA] more ... CTD PMID:21122807 more ... furan decreases expression ISO RGD:3000 6480464 furan results in decreased expression of LEP mRNA CTD PMID:25539665 gallocatechin multiple interactions EXP 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 gamma-hexachlorocyclohexane affects expression ISO RGD:3000 6480464 Hexachlorocyclohexane affects the expression of LEP mRNA CTD PMID:17785943 Ganoderic acid A multiple interactions EXP 6480464 [Dietary Fats co-treated with ganoderic acid A] affects the expression of LEP mRNA CTD PMID:29852127 gemcitabine decreases expression ISO RGD:69123 6480464 Gemcitabine results in decreased expression of LEP protein CTD PMID:20531411 gemfibrozil decreases expression ISO RGD:3000 6480464 Gemfibrozil results in decreased expression of LEP protein CTD PMID:25051504 gemfibrozil increases expression ISO RGD:3000 6480464 Gemfibrozil results in increased expression of LEP protein CTD PMID:25051504 genistein decreases expression EXP 6480464 Genistein results in decreased expression of LEP mRNA, Genistein results in decreased expression of LEP protein CTD PMID:18359623 genistein decreases response to substance ISO RGD:69123 6480464 Genistein results in decreased susceptibility to LEP protein CTD PMID:11342529 genistein multiple interactions ISO RGD:69123 6480464 Genistein inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species], Genistein inhibits the reaction [LEP protein results in increased expression of CCL2] CTD PMID:11342529 gentamycin increases expression ISO RGD:3000 6480464 Gentamicins results in increased expression of LEP mRNA CTD PMID:33387578 gingerol multiple interactions EXP 6480464 gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA], gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21851089 glucagon multiple interactions EXP 6480464 Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein], Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of LEP protein] CTD PMID:29988851 glucose multiple interactions ISO RGD:3000 6480464 1 more ... CTD PMID:10780946 more ... glucose multiple interactions EXP 6480464 [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased abundance of Glucose CTD PMID:27712037 glucose increases expression ISO RGD:3000 6480464 Glucose results in increased expression of LEP mRNA, Glucose results in increased expression of LEP protein CTD PMID:10780946 more ... glucose increases secretion ISO RGD:3000 6480464 Glucose results in increased secretion of LEP protein CTD PMID:10780946 glucose increases response to substance ISO RGD:69123 6480464 Glucose results in increased susceptibility to LEP protein CTD PMID:11342529 glucose multiple interactions ISO RGD:69123 6480464 Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species], LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 glycine multiple interactions EXP 6480464 Glycine affects the reaction [Sodium Glutamate affects the expression of LEP protein] CTD PMID:18930730 hesperidin decreases expression ISO RGD:3000 6480464 Hesperidin results in decreased expression of LEP protein CTD PMID:21820093 hesperidin multiple interactions ISO RGD:3000 6480464 [naringin co-treated with Hesperidin] results in decreased expression of LEP protein CTD PMID:21820093 hexadecanoic acid multiple interactions EXP 6480464 [Palmitic Acid co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of LEP mRNA more ... CTD PMID:34968464 hexadecanoic acid decreases expression EXP 6480464 Palmitic Acid results in decreased expression of LEP mRNA, Palmitic Acid results in decreased expression of LEP protein CTD PMID:34968464 hydrogen peroxide affects expression ISO RGD:69123 6480464 Hydrogen Peroxide affects the expression of LEP mRNA CTD PMID:21179406 hydrogen peroxide decreases expression ISO RGD:69123 6480464 Hydrogen Peroxide results in decreased expression of LEP mRNA CTD PMID:26339600 imidacloprid increases secretion EXP 6480464 imidacloprid results in increased secretion of LEP protein CTD PMID:27960282 imidacloprid multiple interactions EXP 6480464 Dietary Fats promotes the reaction [imidacloprid results in increased secretion of LEP protein], imidacloprid promotes the reaction [Dietary Fats results in increased secretion of LEP protein] CTD PMID:27960282 indinavir multiple interactions ISO RGD:69123 6480464 diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of LEP protein] CTD PMID:17668557 indinavir multiple interactions EXP 6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 indinavir decreases expression ISO RGD:69123 6480464 Indinavir results in decreased expression of LEP protein CTD PMID:17668557 indometacin increases expression ISO RGD:3000 6480464 Indomethacin results in increased expression of LEP protein CTD PMID:16280098 , PMID:25051504 indometacin multiple interactions ISO RGD:69123 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of LEP mRNA more ... CTD PMID:23086663 , PMID:28628672 indometacin multiple interactions ISO RGD:3000 6480464 BQ 610 inhibits the reaction [Indomethacin results in increased expression of LEP protein] more ... CTD PMID:16280098 , PMID:18181030 inulin decreases expression ISO RGD:3000 6480464 Inulin results in decreased expression of LEP protein CTD PMID:27760213 iodide salt increases expression ISO RGD:3000 6480464 Iodides deficiency results in increased expression of LEP protein CTD PMID:26795019 iron(2+) sulfate (anhydrous) increases expression ISO RGD:69123 6480464 ferrous sulfate results in increased expression of LEP mRNA CTD PMID:21540303 isoflavones increases expression ISO RGD:3000 6480464 Isoflavones results in increased expression of LEP protein CTD PMID:22155228 isoprenaline increases secretion EXP 6480464 Isoproterenol results in increased secretion of LEP protein CTD PMID:25111128 isoprenaline increases expression ISO RGD:3000 6480464 Isoproterenol results in increased expression of LEP protein CTD PMID:20307649 isoprenaline multiple interactions ISO RGD:3000 6480464 CPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEP protein] CTD PMID:20307649 isoprenaline multiple interactions ISO RGD:69123 6480464 Propranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein] CTD PMID:11022189 isoprenaline decreases secretion ISO RGD:69123 6480464 Isoproterenol results in decreased secretion of LEP protein CTD PMID:11022189 isotretinoin increases expression ISO RGD:3000 6480464 Isotretinoin results in increased expression of LEP mRNA CTD PMID:19212007 kainic acid decreases response to substance EXP 6480464 LEP protein results in decreased susceptibility to Kainic Acid CTD PMID:17993459 ketamine multiple interactions ISO RGD:69123 6480464 LEP protein promotes the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in decreased expression of BCL2 protein]] more ... CTD PMID:36907275 ketamine decreases expression ISO RGD:69123 6480464 Ketamine results in decreased expression of LEP protein CTD PMID:36907275 L-ascorbic acid decreases secretion ISO RGD:3000 6480464 Ascorbic Acid results in decreased secretion of LEP protein CTD PMID:20400526 L-ascorbic acid multiple interactions ISO RGD:3000 6480464 Ascorbic Acid inhibits the reaction [INS1 protein results in increased secretion of LEP protein] CTD PMID:20400526 L-methionine multiple interactions EXP 6480464 [3 more ... CTD PMID:24384915 more ... lamivudine multiple interactions EXP 6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA, [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 lanthanum atom multiple interactions EXP 6480464 Lanthanum promotes the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 lead(0) multiple interactions ISO RGD:69123 6480464 Lead results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24709140 Licarin A multiple interactions EXP 6480464 [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of LEP mRNA CTD PMID:29288687 lipoic acid decreases secretion EXP 6480464 Thioctic Acid results in decreased secretion of LEP protein CTD PMID:21351249 lipoic acid decreases expression ISO RGD:3000 6480464 Thioctic Acid results in decreased expression of LEP mRNA, Thioctic Acid results in decreased expression of LEP protein CTD PMID:21351249 lipoic acid decreases expression EXP 6480464 Thioctic Acid results in decreased expression of LEP mRNA CTD PMID:21351249 lipopolysaccharide multiple interactions ISO RGD:69123 6480464 [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of LEP protein CTD PMID:18437699 lipopolysaccharide increases expression ISO RGD:3000 6480464 Lipopolysaccharides results in increased expression of LEP protein CTD PMID:17379010 lipopolysaccharide multiple interactions ISO RGD:3000 6480464 Bezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of LEP protein], Lipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of LEP protein] CTD PMID:17379010 , PMID:17621560 lipopolysaccharide multiple interactions EXP 6480464 [Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein, TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein] CTD PMID:21327618 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of LEP mRNA CTD PMID:12057914 lipopolysaccharide decreases expression EXP 6480464 Lipopolysaccharides results in decreased expression of LEP mRNA CTD PMID:12057914 loganin affects expression EXP 6480464 loganin affects the expression of LEP protein CTD PMID:21864639 lopinavir multiple interactions ISO RGD:69123 6480464 diphenyleneiodonium inhibits the reaction [Lopinavir results in decreased expression of LEP protein] CTD PMID:17668557 lopinavir decreases expression ISO RGD:69123 6480464 Lopinavir results in decreased expression of LEP protein CTD PMID:17668557 LY294002 decreases expression EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of LEP mRNA CTD PMID:19254925 , PMID:21351249 LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in decreased expression of MIR122 mRNA], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased phosphorylation of FOXO1 protein] CTD PMID:29248466 LY294002 multiple interactions ISO RGD:69123 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 LY294002 decreases secretion EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased secretion of LEP protein CTD PMID:19254925 , PMID:21351249 manganese atom decreases abundance ISO RGD:69123 6480464 LEP gene mutant form results in decreased abundance of Manganese CTD PMID:10965932 manganese(0) decreases abundance ISO RGD:69123 6480464 LEP gene mutant form results in decreased abundance of Manganese CTD PMID:10965932 melatonin decreases expression ISO RGD:69123 6480464 Melatonin results in decreased expression of LEP mRNA CTD PMID:20738756 melatonin decreases expression ISO RGD:3000 6480464 Melatonin results in decreased expression of LEP protein CTD PMID:19028472 menadione multiple interactions ISO RGD:69123 6480464 1 more ... CTD PMID:16996477 menadione increases expression ISO RGD:69123 6480464 Vitamin K 3 results in increased expression of LEP mRNA CTD PMID:16996477 mercury dichloride decreases expression EXP 6480464 Mercuric Chloride results in decreased expression of LEP mRNA CTD PMID:22019852 mercury dichloride increases expression ISO RGD:3000 6480464 Mercuric Chloride results in increased expression of LEP mRNA CTD PMID:30807803 mercury dichloride decreases secretion EXP 6480464 Mercuric Chloride results in decreased secretion of LEP protein CTD PMID:22019852 metformin increases expression EXP 6480464 Metformin results in increased expression of LEP protein CTD PMID:20869956 metformin multiple interactions EXP 6480464 Metformin inhibits the reaction [Olanzapine results in increased expression of LEP protein] CTD PMID:32652086 methacholine chloride increases response to substance EXP 6480464 LEP gene mutant form results in increased susceptibility to Methacholine Chloride CTD PMID:12794034 methadone increases expression ISO RGD:69123 6480464 Methadone results in increased expression of LEP protein CTD PMID:15717844 methapyrilene decreases expression ISO RGD:3000 6480464 Methapyrilene results in decreased expression of LEP protein CTD PMID:25051504 methotrexate affects expression EXP 6480464 Methotrexate affects the expression of LEP mRNA CTD PMID:18502557 methylmercury chloride multiple interactions EXP 6480464 [Cadmium Chloride co-treated with methylmercuric chloride] results in increased expression of LEP protein more ... CTD PMID:27814245 , PMID:33338554 methylmercury chloride decreases expression EXP 6480464 methylmercuric chloride results in decreased expression of LEP mRNA CTD PMID:29850906 methylparaben decreases expression ISO RGD:69123 6480464 methylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 metronidazole multiple interactions EXP 6480464 [Vancomycin co-treated with Neomycin co-treated with Metronidazole co-treated with elemicin] results in increased expression of LEP mRNA CTD PMID:34979169 mevalonic acid multiple interactions EXP 6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA], Mevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of LEP protein] CTD PMID:19254925 MK-2206 multiple interactions EXP 6480464 MK 2206 inhibits the reaction [8-(4-chlorophenylthio)-2'-O-methyladenosine-3', 5'-monophosphate acetoxymethyl ester analog results in increased secretion of LEP protein] CTD PMID:27381457 monocrotaline affects expression ISO RGD:3000 6480464 Monocrotaline affects the expression of LEP protein CTD PMID:25051504 monocrotaline multiple interactions EXP 6480464 [Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein, TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein] CTD PMID:21327618 monosodium L-glutamate affects expression EXP 6480464 Sodium Glutamate affects the expression of LEP protein CTD PMID:18930730 monosodium L-glutamate increases expression EXP 6480464 Sodium Glutamate results in increased expression of LEP mRNA, Sodium Glutamate results in increased expression of LEP protein CTD PMID:15809509 more ... monosodium L-glutamate multiple interactions EXP 6480464 [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats more ... CTD PMID:18930730 more ... monosodium L-glutamate increases expression ISO RGD:3000 6480464 Sodium Glutamate results in increased expression of LEP protein CTD PMID:14657608 morin multiple interactions ISO RGD:3000 6480464 morin analog inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein] CTD PMID:24854284 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO RGD:69123 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] more ... CTD PMID:11342529 , PMID:28571770 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide decreases response to substance ISO RGD:69123 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased susceptibility to LEP protein CTD PMID:11342529 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions EXP 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA] CTD PMID:19254925 N-methyl-4-phenylpyridinium multiple interactions ISO RGD:69123 6480464 LEP protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SLC25A14 mRNA] CTD PMID:19763737 N-methyl-N-nitrosourea multiple interactions EXP 6480464 Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] more ... CTD PMID:16822543 N-methyl-N-nitrosourea increases expression EXP 6480464 Methylnitrosourea results in increased expression of LEP protein CTD PMID:16822543 N-nitrosodiethylamine increases expression ISO RGD:3000 6480464 Diethylnitrosamine results in increased expression of LEP protein CTD PMID:25051504 N-nitrosodimethylamine increases expression ISO RGD:3000 6480464 Dimethylnitrosamine results in increased expression of LEP mRNA, Dimethylnitrosamine results in increased expression of LEP protein CTD PMID:15798949 naproxen multiple interactions ISO RGD:3000 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein], Naproxen inhibits the reaction [Capsaicin results in increased expression of LEP protein] CTD PMID:22150557 naringin multiple interactions ISO RGD:3000 6480464 [naringin co-treated with Hesperidin] results in decreased expression of LEP protein, naringin inhibits the reaction [Glucose results in increased expression of LEP protein] CTD PMID:21820093 , PMID:24399619 naringin multiple interactions EXP 6480464 naringin inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:22198281 nelfinavir multiple interactions ISO RGD:69123 6480464 diphenyleneiodonium inhibits the reaction [Nelfinavir results in decreased expression of LEP protein] CTD PMID:17668557 nelfinavir decreases secretion EXP 6480464 Nelfinavir results in decreased secretion of LEP protein CTD PMID:19033543 nelfinavir decreases expression ISO RGD:69123 6480464 Nelfinavir results in decreased expression of LEP protein CTD PMID:17668557 neomycin multiple interactions EXP 6480464 [Vancomycin co-treated with Neomycin co-treated with Metronidazole co-treated with elemicin] results in increased expression of LEP mRNA CTD PMID:34979169 nevirapine increases expression ISO RGD:69123 6480464 Nevirapine results in increased expression of LEP mRNA CTD PMID:21619898 nickel atom decreases expression ISO RGD:69123 6480464 Nickel results in decreased expression of LEP mRNA CTD PMID:25583101 nickel dichloride multiple interactions ISO RGD:69123 6480464 [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of LEP protein CTD PMID:18437699 nickel dichloride multiple interactions ISO RGD:3000 6480464 nickel chloride inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 nickel sulfate multiple interactions ISO RGD:69123 6480464 [macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of LEP mRNA CTD PMID:18832182 nickel sulfate increases expression ISO RGD:69123 6480464 nickel sulfate results in increased expression of LEP mRNA CTD PMID:18832182 nicotine increases expression ISO RGD:3000 6480464 Nicotine results in increased expression of LEP protein CTD PMID:23623838 , PMID:29155039 nicotine decreases response to substance ISO RGD:3000 6480464 Nicotine results in decreased susceptibility to LEP protein CTD PMID:23623838 nicotinic acid increases expression ISO RGD:69123 6480464 Niacin results in increased expression of LEP protein CTD PMID:16887123 nicotinic acid increases expression EXP 6480464 Niacin results in increased expression of LEP mRNA CTD PMID:21236357 nitric oxide multiple interactions ISO RGD:69123 6480464 LEP protein affects the reaction [IL1B protein results in increased chemical synthesis of Nitric Oxide] CTD PMID:9312173 Nonylphenol increases expression EXP 6480464 nonylphenol results in increased expression of LEP mRNA CTD PMID:18417718 NS-398 multiple interactions ISO RGD:69123 6480464 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA], N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 olanzapine increases expression ISO RGD:69123 6480464 olanzapine results in increased expression of LEP protein CTD PMID:11927762 , PMID:19512971 olanzapine increases expression EXP 6480464 Olanzapine results in increased expression of LEP protein CTD PMID:32652086 olanzapine multiple interactions EXP 6480464 capsazepine inhibits the reaction [Olanzapine results in increased expression of LEP protein] more ... CTD PMID:32652086 oleanolic acid increases expression EXP 6480464 Oleanolic Acid results in increased expression of LEP protein CTD PMID:20188082 oleic acid decreases expression EXP 6480464 Oleic Acid results in decreased expression of LEP mRNA CTD PMID:9002984 oleic acid increases expression ISO RGD:3000 6480464 Oleic Acid results in increased expression of LEP mRNA CTD PMID:23395669 oleic acid multiple interactions ISO RGD:3000 6480464 sophocarpine inhibits the reaction [Oleic Acid results in increased expression of LEP mRNA] CTD PMID:23395669 orlistat multiple interactions ISO RGD:3000 6480464 orlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:25087745 orlistat multiple interactions EXP 6480464 orlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21332399 ozone multiple interactions EXP 6480464 [LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CCL11 protein more ... CTD PMID:12794034 , PMID:27472835 ozone multiple interactions ISO RGD:3000 6480464 [Ozone co-treated with Cholesterol more ... CTD PMID:23968387 more ... ozone increases response to substance EXP 6480464 LEP gene mutant form results in increased susceptibility to Ozone, LEP protein results in increased susceptibility to Ozone CTD PMID:12794034 more ... ozone decreases secretion EXP 6480464 Ozone results in decreased secretion of LEP protein CTD PMID:27240593 ozone increases expression ISO RGD:3000 6480464 Ozone results in increased expression of LEP, Ozone results in increased expression of LEP protein CTD PMID:24103449 more ... paracetamol multiple interactions EXP 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA] CTD PMID:17585979 paracetamol decreases expression ISO RGD:69123 6480464 Acetaminophen results in decreased expression of LEP mRNA CTD PMID:26690555 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of LEP mRNA CTD PMID:17562736 paraquat affects expression ISO RGD:3000 6480464 Paraquat affects the expression of LEP mRNA CTD PMID:18198484 parathion increases methylation ISO RGD:69123 6480464 Parathion results in increased methylation of LEP promoter CTD PMID:22847954 perfluorohexanesulfonic acid multiple interactions ISO RGD:3000 6480464 [perfluorohexanesulfonic acid co-treated with Dietary Fats] results in increased expression of LEP protein more ... CTD PMID:34464680 perfluorooctane-1-sulfonic acid increases expression ISO RGD:69123 6480464 perfluorooctane sulfonic acid results in increased expression of LEP mRNA CTD PMID:28011154 perfluorooctane-1-sulfonic acid multiple interactions ISO RGD:3000 6480464 [perfluorooctane sulfonic acid co-treated with Dietary Fats] results in increased expression of LEP protein more ... CTD PMID:34464680 perfluorooctane-1-sulfonic acid affects expression ISO RGD:69123 6480464 perfluorooctane sulfonic acid affects the expression of LEP mRNA CTD PMID:30738844 perfluorooctanoic acid multiple interactions ISO RGD:3000 6480464 [perfluorooctane sulfonic acid co-treated with perfluorooctanoic acid co-treated with perfluorohexanesulfonic acid co-treated with Dietary Fats] results in increased expression of LEP protein more ... CTD PMID:34464680 perindopril decreases expression ISO RGD:3000 6480464 Perindopril results in decreased expression of LEP protein CTD PMID:18083506 permethrin multiple interactions EXP 6480464 [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein, Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein] CTD PMID:29751049 phencyclidine increases expression EXP 6480464 Phencyclidine results in increased expression of LEP mRNA CTD PMID:12105081 phenethyl caffeate decreases expression EXP 6480464 caffeic acid phenethyl ester results in decreased expression of LEP mRNA, caffeic acid phenethyl ester results in decreased expression of LEP protein CTD PMID:21467634 phenobarbital affects expression ISO RGD:3000 6480464 Phenobarbital affects the expression of LEP protein CTD PMID:25051504 phenobarbital multiple interactions ISO RGD:3000 6480464 [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP mRNA, [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP protein CTD PMID:14758566 phloretin multiple interactions EXP 6480464 2 more ... CTD PMID:32408695 phlorizin multiple interactions EXP 6480464 2 more ... CTD PMID:32408695 phosphatidylcholine decreases expression EXP 6480464 Phosphatidylcholines results in decreased expression of LEP mRNA CTD PMID:23911798 phosphoramidon decreases expression ISO RGD:3000 6480464 phosphoramidon results in decreased expression of LEP protein CTD PMID:16391412 pioglitazone increases expression ISO RGD:3000 6480464 pioglitazone results in increased expression of LEP protein CTD PMID:15655531 piperine multiple interactions ISO RGD:3000 6480464 piperine inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:25087745 pirimicarb multiple interactions ISO RGD:3000 6480464 [2-amino-3-chloro-1, 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 pirinixic acid multiple interactions EXP 6480464 pirinixic acid inhibits the reaction [rosiglitazone results in increased expression of LEP protein] CTD PMID:16306350 pitavastatin multiple interactions EXP 6480464 pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA] more ... CTD PMID:18323514 pitavastatin(1-) multiple interactions EXP 6480464 pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA] more ... CTD PMID:18323514 pluronic P-123 multiple interactions ISO RGD:3000 6480464 carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein], Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 pluronic P-123 increases secretion ISO RGD:3000 6480464 Poloxamer results in increased secretion of LEP protein CTD PMID:29071762 Poloxamer increases secretion ISO RGD:3000 6480464 Poloxamer results in increased secretion of LEP protein CTD PMID:29071762 Poloxamer multiple interactions ISO RGD:3000 6480464 carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein], Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 potassium dichromate increases expression ISO RGD:69123 6480464 Potassium Dichromate results in increased expression of LEP mRNA CTD PMID:11678601 pravastatin multiple interactions EXP 6480464 Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA] more ... CTD PMID:18323514 prochloraz decreases expression ISO RGD:69123 6480464 prochloraz results in decreased expression of LEP mRNA CTD PMID:30879083 progesterone decreases secretion ISO RGD:69123 6480464 Progesterone results in decreased secretion of LEP protein CTD PMID:16048798 progesterone multiple interactions ISO RGD:69123 6480464 LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased chemical synthesis of Progesterone], LEPR protein affects the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased chemical synthesis of Progesterone]] CTD PMID:19849856 progesterone increases expression EXP 6480464 Progesterone results in increased expression of LEP mRNA CTD PMID:15713686 propranolol multiple interactions ISO RGD:69123 6480464 Propranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein] CTD PMID:11022189 propranolol increases expression ISO RGD:3000 6480464 Propranolol results in increased expression of LEP protein CTD PMID:24250662 propylparaben increases expression EXP 6480464 propylparaben results in increased expression of LEP mRNA CTD PMID:22956630 propylparaben decreases expression ISO RGD:69123 6480464 propylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 prostaglandin E2 increases secretion ISO RGD:3000 6480464 Dinoprostone results in increased secretion of LEP protein CTD PMID:11060898 prostaglandin E2 increases expression ISO RGD:3000 6480464 Dinoprostone results in increased expression of LEP protein CTD PMID:11060898 prostaglandin E2 increases abundance ISO RGD:3000 6480464 LEP protein results in increased abundance of Dinoprostone CTD PMID:16015682 Ptaquiloside decreases expression EXP 6480464 ptaquiloside results in decreased expression of LEP mRNA CTD PMID:23274088 Pyridostigmine bromide multiple interactions EXP 6480464 [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein, Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein] CTD PMID:29751049 pyruvic acid increases secretion ISO RGD:3000 6480464 Pyruvic Acid results in increased secretion of LEP protein CTD PMID:10780946 pyruvic acid multiple interactions ISO RGD:3000 6480464 INS1 protein promotes the reaction [Pyruvic Acid results in increased secretion of LEP protein] CTD PMID:10780946 quercetin multiple interactions ISO RGD:3000 6480464 Quercetin inhibits the reaction [Dietary Fats results in increased expression of LEP protein] more ... CTD PMID:22426011 more ... quercetin increases expression ISO RGD:69123 6480464 Quercetin results in increased expression of LEP mRNA, Quercetin results in increased expression of LEP protein CTD PMID:22230496 quercetin decreases expression EXP 6480464 Quercetin results in decreased expression of LEP mRNA CTD PMID:19914226 quercetin decreases secretion EXP 6480464 Quercetin results in decreased secretion of LEP protein CTD PMID:19914226 quercetin multiple interactions EXP 6480464 Quercetin affects the reaction [LEP protein affects the expression of NOS2 mRNA] more ... CTD PMID:19914226 more ... rac-lactic acid affects expression ISO RGD:69123 6480464 Lactic Acid affects the expression of LEP mRNA CTD PMID:30851411 ramipril multiple interactions ISO RGD:69123 6480464 candesartan promotes the reaction [Ramipril results in increased expression of LEP], Ramipril promotes the reaction [candesartan results in increased expression of LEP] CTD PMID:17483542 ramipril decreases expression ISO RGD:69123 6480464 Ramipril results in decreased expression of LEP CTD PMID:19059660 reactive oxygen species multiple interactions ISO RGD:69123 6480464 adenosine-3' more ... CTD PMID:11342529 reactive oxygen species increases chemical synthesis ISO RGD:69123 6480464 LEP protein results in increased chemical synthesis of Reactive Oxygen Species CTD PMID:11342529 rebaudioside A multiple interactions EXP 6480464 rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA] more ... CTD PMID:25554529 reserpine increases expression EXP 6480464 Reserpine results in increased expression of LEP mRNA CTD PMID:10050748 resveratrol decreases secretion EXP 6480464 resveratrol metabolite results in decreased secretion of LEP protein, resveratrol results in decreased secretion of LEP protein CTD PMID:23717508 resveratrol multiple interactions EXP 6480464 [Dietary Fats co-treated with Resveratrol] results in increased expression of LEP mRNA more ... CTD PMID:29197120 , PMID:31881177 resveratrol multiple interactions ISO RGD:3000 6480464 [Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA], resveratrol inhibits the reaction [Fructose results in increased expression of LEP mRNA] CTD PMID:26973390 resveratrol decreases expression ISO RGD:69123 6480464 resveratrol results in decreased expression of LEP mRNA, resveratrol results in decreased expression of LEP protein CTD PMID:21713995 , PMID:23536519 resveratrol decreases expression EXP 6480464 resveratrol metabolite results in decreased expression of LEP mRNA more ... CTD PMID:23717508 more ... rifampicin increases expression ISO RGD:3000 6480464 Rifampin results in increased expression of LEP protein CTD PMID:25051504 rimonabant multiple interactions EXP 6480464 Rimonabant inhibits the reaction [Dietary Fats results in increased secretion of LEP protein] more ... CTD PMID:19030233 , PMID:26967640 ritonavir multiple interactions ISO RGD:69123 6480464 diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of LEP protein] CTD PMID:17668557 ritonavir decreases expression ISO RGD:69123 6480464 Ritonavir results in decreased expression of LEP protein CTD PMID:17668557 rotenone decreases response to substance ISO RGD:69123 6480464 Rotenone results in decreased susceptibility to LEP protein CTD PMID:11342529 rotenone multiple interactions ISO RGD:69123 6480464 Rotenone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 roxarsone decreases expression ISO RGD:69123 6480464 Roxarsone results in decreased expression of LEP mRNA CTD PMID:18414637 ruthenium red multiple interactions EXP 6480464 Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of LEP protein] CTD PMID:32652086 rutin multiple interactions ISO RGD:3000 6480464 Rutin inhibits the reaction [Fructose results in increased expression of LEP protein] CTD PMID:22426011 S-adenosyl-L-methioninate multiple interactions ISO RGD:69123 6480464 S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA], S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 S-adenosyl-L-methionine multiple interactions ISO RGD:69123 6480464 S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA], S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 saquinavir multiple interactions EXP 6480464 [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 SB 203580 multiple interactions ISO RGD:69123 6480464 SB 203580 inhibits the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]], SB 203580 inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 , PMID:19849856 SB 203580 decreases response to substance ISO RGD:69123 6480464 SB 203580 results in decreased susceptibility to LEP protein CTD PMID:19849856 selenium atom decreases abundance ISO RGD:69123 6480464 LEP gene mutant form results in decreased abundance of Selenium CTD PMID:10965932 serpentine asbestos decreases expression EXP 6480464 Asbestos, Serpentine results in decreased expression of LEP mRNA CTD PMID:23917077 silicon dioxide decreases expression ISO RGD:69123 6480464 Silicon Dioxide analog results in decreased expression of LEP mRNA CTD PMID:23806026 silicon dioxide decreases expression ISO RGD:3000 6480464 Silicon Dioxide results in decreased expression of LEP mRNA CTD PMID:32721576 simvastatin multiple interactions EXP 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA] more ... CTD PMID:19254925 simvastatin multiple interactions ISO RGD:3000 6480464 Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 simvastatin decreases secretion EXP 6480464 Simvastatin results in decreased secretion of LEP protein CTD PMID:19254925 simvastatin decreases expression EXP 6480464 Simvastatin results in decreased expression of LEP mRNA, Simvastatin results in decreased expression of LEP mRNA alternative form CTD PMID:19254925 SKF-96365 hydrochloride multiple interactions EXP 6480464 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 sodium arsenate multiple interactions ISO RGD:69123 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of LEP mRNA CTD PMID:32525701 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of LEP protein CTD PMID:28593471 , PMID:29755549 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of LEP mRNA CTD PMID:34968464 , PMID:36209798 sodium arsenite multiple interactions EXP 6480464 [Palmitic Acid co-treated with sodium arsenite] results in decreased expression of LEP mRNA more ... CTD PMID:28593471 more ... sodium arsenite affects expression EXP 6480464 sodium arsenite affects the expression of LEP mRNA, sodium arsenite affects the expression of LEP protein CTD PMID:25367288 , PMID:28206643 sodium arsenite increases expression ISO RGD:69123 6480464 sodium arsenite results in increased expression of LEP mRNA CTD PMID:25879800 sodium perchlorate multiple interactions ISO RGD:3000 6480464 [Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of LEP protein CTD PMID:30090431 stavudine decreases expression ISO RGD:69123 6480464 Stavudine results in decreased expression of LEP protein CTD PMID:17668557 steviol multiple interactions EXP 6480464 steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACACA mRNA] more ... CTD PMID:25554529 stevioside multiple interactions EXP 6480464 stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA] more ... CTD PMID:25554529 streptozocin multiple interactions ISO RGD:3000 6480464 [Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein more ... CTD PMID:24854284 streptozocin multiple interactions EXP 6480464 [Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein more ... CTD PMID:29988851 , PMID:32410268 sumatriptan multiple interactions ISO RGD:3000 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein], Sumatriptan inhibits the reaction [Capsaicin results in increased expression of LEP protein] CTD PMID:22150557 superoxide multiple interactions EXP 6480464 acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides] more ... CTD PMID:16380530 superoxide multiple interactions ISO RGD:69123 6480464 [LEP protein results in increased oxidation of Fatty Acids] which results in increased chemical synthesis of Superoxides CTD PMID:11342529 superoxide increases abundance EXP 6480464 LEP protein results in increased abundance of Superoxides CTD PMID:16380530 terbufos increases methylation ISO RGD:69123 6480464 terbufos results in increased methylation of LEP promoter CTD PMID:22847954 terbutaline decreases expression EXP 6480464 Terbutaline results in decreased expression of LEP mRNA, Terbutaline results in decreased expression of LEP protein CTD PMID:9002984 testosterone multiple interactions EXP 6480464 alpha-cyano-(3 more ... CTD PMID:24502529 testosterone affects secretion EXP 6480464 LEP protein affects the secretion of Testosterone CTD PMID:24502529 tetrachloromethane multiple interactions EXP 6480464 LEP protein affects the reaction [Carbon Tetrachloride results in increased activity of STAT3 protein] more ... CTD PMID:11481614 more ... tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of LEP protein CTD PMID:29987408 tetrachloromethane increases expression ISO RGD:3000 6480464 Carbon Tetrachloride results in increased expression of LEP protein CTD PMID:27623180 tetrachloromethane multiple interactions ISO RGD:3000 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein more ... CTD PMID:14758566 , PMID:18227024 thioacetamide decreases response to substance EXP 6480464 LEP gene mutant form results in decreased susceptibility to Thioacetamide CTD PMID:12085344 thioacetamide increases expression ISO RGD:3000 6480464 Thioacetamide results in increased expression of LEP protein CTD PMID:17621560 thioacetamide multiple interactions ISO RGD:3000 6480464 Lipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of LEP protein] CTD PMID:17621560 thioacetamide increases response to substance EXP 6480464 LEP protein results in increased susceptibility to Thioacetamide CTD PMID:12085344 thioacetamide multiple interactions EXP 6480464 [Thioacetamide co-treated with LEP protein] results in increased expression of COL1A1 mRNA more ... CTD PMID:11481614 more ... thiram multiple interactions ISO RGD:3000 6480464 [2-amino-3-chloro-1, 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of LEP mRNA CTD PMID:23131501 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of LEP mRNA CTD PMID:29264374 tributylstannane increases expression ISO RGD:69123 6480464 tributyltin results in increased expression of LEP mRNA CTD PMID:28011154 tributylstannane increases expression ISO RGD:3000 6480464 tributyltin results in increased expression of LEP protein CTD PMID:30172001 tributylstannane multiple interactions EXP 6480464 [Dietary Fats co-treated with tributyltin] results in increased expression of LEP protein CTD PMID:29787037 tributylstannane decreases expression EXP 6480464 tributyltin results in decreased expression of LEP protein CTD PMID:27310180 tributylstannane increases expression EXP 6480464 tributyltin results in increased expression of LEP protein CTD PMID:30172001 tributylstannane increases secretion ISO RGD:3000 6480464 tributyltin results in increased secretion of LEP protein CTD PMID:28161095 trichloroethene multiple interactions EXP 6480464 Trichloroethylene inhibits the reaction [Dietary Fats affects the expression of LEP mRNA] CTD PMID:29669109 trichloroethene decreases expression ISO RGD:3000 6480464 Trichloroethylene results in decreased expression of LEP mRNA CTD PMID:33387578 trichostatin A increases expression ISO RGD:69123 6480464 trichostatin A results in increased expression of LEP mRNA CTD PMID:17502362 trichostatin A multiple interactions ISO RGD:69123 6480464 trichostatin A promotes the reaction [decitabine results in increased expression of LEP mRNA] CTD PMID:17502362 triflumizole multiple interactions ISO RGD:69123 6480464 [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA, T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA] CTD PMID:23086663 triflumizole multiple interactions EXP 6480464 [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA, T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA] CTD PMID:23086663 triphenyl phosphate multiple interactions EXP 6480464 [tris(1 more ... CTD PMID:29112739 triptonide increases expression EXP 6480464 triptonide results in increased expression of LEP mRNA CTD PMID:33045310 troglitazone decreases expression ISO RGD:3000 6480464 troglitazone results in decreased expression of LEP mRNA, troglitazone results in decreased expression of LEP protein CTD PMID:11909685 more ... troglitazone decreases expression ISO RGD:69123 6480464 troglitazone results in decreased expression of LEP protein CTD PMID:10946865 , PMID:9727893 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of LEP mRNA CTD PMID:10753628 troglitazone increases secretion ISO RGD:69123 6480464 troglitazone results in increased secretion of LEP protein CTD PMID:11092516 troglitazone multiple interactions ISO RGD:69123 6480464 [Dexamethasone co-treated with troglitazone] results in decreased secretion of LEP protein more ... CTD PMID:10946865 , PMID:11092516 U-73122 multiple interactions EXP 6480464 1-(6-((3-methoxyestra-1 more ... CTD PMID:20107083 ursolic acid increases expression EXP 6480464 ursolic acid results in increased expression of LEP protein CTD PMID:20869956 vanadium atom multiple interactions ISO RGD:3000 6480464 Vanadium promotes the reaction [LEP protein results in increased expression of UCP1 protein], Vanadium promotes the reaction [LEP protein results in increased phosphorylation of STAT3 protein] CTD PMID:16195403 vanadium(0) multiple interactions ISO RGD:3000 6480464 Vanadium promotes the reaction [LEP protein results in increased expression of UCP1 protein], Vanadium promotes the reaction [LEP protein results in increased phosphorylation of STAT3 protein] CTD PMID:16195403 vancomycin multiple interactions EXP 6480464 [Vancomycin co-treated with Neomycin co-treated with Metronidazole co-treated with elemicin] results in increased expression of LEP mRNA CTD PMID:34979169 vinclozolin decreases expression ISO RGD:3000 6480464 vinclozolin results in decreased expression of LEP mRNA CTD PMID:23160963 vitamin E multiple interactions ISO RGD:3000 6480464 Vitamin E inhibits the reaction [Dietary Fats results in decreased expression of LEP mRNA], Vitamin E inhibits the reaction [Dietary Fats results in decreased expression of LEP protein] CTD PMID:20404018 wortmannin decreases expression EXP 6480464 wortmannin results in decreased expression of LEP mRNA CTD PMID:19254925 wortmannin multiple interactions EXP 6480464 wortmannin inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 wortmannin decreases secretion EXP 6480464 wortmannin results in decreased secretion of LEP protein CTD PMID:19254925 xanthone multiple interactions ISO RGD:3000 6480464 xanthone inhibits the reaction [LEP protein results in increased activity of ACE2 protein], xanthone inhibits the reaction [LEP protein results in increased expression of ACE2] CTD PMID:25205467 zidovudine decreases expression ISO RGD:69123 6480464 Zidovudine results in decreased expression of LEP protein CTD PMID:17668557 zidovudine multiple interactions EXP 6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA, [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 zinc atom decreases expression EXP 6480464 Zinc deficiency results in decreased expression of LEP protein CTD PMID:25088245 zinc atom multiple interactions EXP 6480464 [Zinc deficiency co-treated with Ethanol] results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24155903 zinc atom increases expression ISO RGD:3000 6480464 Zinc deficiency results in increased expression of LEP protein CTD PMID:20660286 zinc atom decreases expression ISO RGD:69123 6480464 Zinc results in decreased expression of LEP mRNA CTD PMID:18316168 zinc atom multiple interactions ISO RGD:69123 6480464 IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA], MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA] CTD PMID:18316168 zinc atom decreases abundance ISO RGD:69123 6480464 LEP gene mutant form results in decreased abundance of Zinc CTD PMID:10965932 zinc dichloride increases expression ISO RGD:69123 6480464 zinc chloride results in increased expression of LEP mRNA CTD PMID:21540303 zinc molecular entity multiple interactions ISO RGD:3000 6480464 Zinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein] CTD PMID:24854284 zinc sulfate decreases expression ISO RGD:3000 6480464 Zinc Sulfate deficiency results in decreased expression of LEP mRNA CTD PMID:11568307 zinc sulfate multiple interactions ISO RGD:3000 6480464 Zinc Sulfate deficiency results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:11568307 zinc(0) decreases expression EXP 6480464 Zinc deficiency results in decreased expression of LEP protein CTD PMID:25088245 zinc(0) decreases abundance ISO RGD:69123 6480464 LEP gene mutant form results in decreased abundance of Zinc CTD PMID:10965932 zinc(0) multiple interactions ISO RGD:69123 6480464 IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA], MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA] CTD PMID:18316168 zinc(0) decreases expression ISO RGD:69123 6480464 Zinc results in decreased expression of LEP mRNA CTD PMID:18316168 zinc(0) increases expression ISO RGD:3000 6480464 Zinc deficiency results in increased expression of LEP protein CTD PMID:20660286 zinc(0) multiple interactions EXP 6480464 [Zinc deficiency co-treated with Ethanol] results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24155903 ziram multiple interactions ISO RGD:3000 6480464 [2-amino-3-chloro-1, 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614
