Lep (leptin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Lep (leptin) Mus musculus
Analyze
Symbol: Lep
Name: leptin
RGD ID: 69124
MGI Page MGI
Description: Enables DNA binding activity and hormone activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cytokine production; and positive regulation of signal transduction. Acts upstream of or within several processes, including determination of adult lifespan; monocarboxylic acid metabolic process; and regulation of protein localization. Located in cytoplasm and extracellular space. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; early conceptus; and reproductive system. Used to study abdominal obesity-metabolic syndrome (multiple); obesity; steatotic liver disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (leptin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ob; obese; obesity factor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39629,060,220 - 29,073,875 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl629,060,219 - 29,073,876 (+)EnsemblGRCm39 Ensembl
GRCm38629,060,221 - 29,073,876 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl629,060,220 - 29,073,877 (+)EnsemblGRCm38mm10GRCm38
MGSCv37629,010,221 - 29,023,876 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36629,010,231 - 29,023,886 (+)NCBIMGSCv36mm8
Celera629,063,769 - 29,077,429 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (IAGP)
abdominal obesity-metabolic syndrome 1  (IAGP)
acute pancreatitis  (ISO)
acute promyelocytic leukemia  (ISO)
adult respiratory distress syndrome  (ISO)
alcohol dependence  (IDA,IEP,ISO)
alcoholic liver cirrhosis  (IDA)
Alzheimer's disease  (ISO)
asthma  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
bacterial pneumonia  (IMP)
Body Weight Changes  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis C  (IEP)
chronic obstructive pulmonary disease  (ISO)
Colonic Neoplasms  (ISO)
congenital leptin deficiency  (ISO)
congestive heart failure  (IMP)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IAGP)
Dyslipidemias  (IEP)
End Stage Liver Disease  (IEP)
end stage renal disease  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (IMP,ISO)
Experimental Liver Cirrhosis  (IMP,ISO)
Experimental Mammary Neoplasms  (ISO)
familial hyperlipidemia  (ISO)
Female Infertility  (ISO)
Femoral Fractures  (ISO)
Fetal Growth Retardation  (ISO)
gastric ulcer  (ISO)
gestational diabetes  (ISO)
glucose intolerance  (ISO)
hepatocellular carcinoma  (IAGP,IEP)
hepatocellular clear cell carcinoma  (ISO)
Hepatomegaly  (ISO)
heroin dependence  (ISO)
Huntington's disease  (ISO)
Hypercapnia  (ISO)
Hypercholesterolemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperphagia  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
hypogonadism  (ISO)
Hypoventilation  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
Kidney Reperfusion Injury  (ISO)
Knee Osteoarthritis  (ISO)
lipid metabolism disorder  (ISO)
lung disease  (IDA)
lung non-small cell carcinoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IAGP,IEP,ISO)
Metabolic Syndrome  (ISO)
morbid obesity  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nerve Degeneration  (ISO)
obesity  (IAGP,IDA,IMP,ISO)
obstructive sleep apnea  (ISO)
Oral Ulcer  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
Parkinson's disease  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Pneumococcal Pneumonia  (IMP)
polycystic ovary syndrome  (ISO)
Polydipsia  (ISO)
Polyuria  (ISO)
pre-eclampsia  (ISO)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
rhinitis  (ISO)
Sepsis  (ISO)
short bowel syndrome  (ISO)
Spinal Cord Injuries  (ISO)
steatotic liver disease  (IAGP,IEP,ISO)
Tachycardia  (ISO)
type 2 diabetes mellitus  (IAGP,ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(+)-epicatechin-3-O-gallate  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-lipoic acid  (EXP,ISO)
(S)-nicotine  (ISO)
1,4-bis(2-ethylhexyl) sulfosuccinate  (EXP)
1,8-cineole  (EXP)
1-(3-chlorophenyl)piperazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrophenol  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (EXP)
2-aminopurine  (EXP)
2-arachidonoylglycerol  (EXP)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-4-chlorophenoxybutyric acid  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
24,25-Dihydroxyvitamin D  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3-aminobenzamide  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxybenzoic acid  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nonylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
AACOCF3  (EXP)
acarbose  (ISO)
acetaldehyde  (EXP)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
aflatoxin B1  (ISO)
AH23848  (ISO)
aldehydo-D-glucosamine 6-phosphate  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
allopurinol  (ISO)
alpha-Zearalanol  (ISO)
AM-251  (EXP)
Amibegron  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
anandamide  (EXP,ISO)
androst-4-ene-3,17-dione  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (EXP)
apocynin  (EXP)
arachidonic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (EXP,ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
Aurothioglucose  (EXP)
azoxystrobin  (EXP)
Bardoxolone methyl  (EXP)
benzo[a]pyrene  (ISO)
Benzyl parahydroxybenzoate  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (EXP)
beta-naphthoflavone  (ISO)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
Bisphenol B  (EXP)
bisphenol F  (EXP)
bleomycin A2  (EXP)
boric acid  (EXP)
boron atom  (ISO)
BQ 123  (EXP)
bromodichloromethane  (EXP)
bucladesine  (EXP)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP,ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
candesartan  (ISO)
cannabidiol  (EXP)
capsaicin  (EXP,ISO)
capsazepine  (EXP)
carbon nanotube  (EXP)
carvacrol  (ISO)
CCCP  (ISO)
cerulenin  (EXP)
CGP 52608  (ISO)
CGS-21680  (ISO)
chlorohydrocarbon  (EXP)
chloroquine  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chromium atom  (EXP,ISO)
chrysin  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
conjugated linoleic acid  (EXP)
corn oil  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (EXP)
cycloheximide  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cyromazine  (ISO)
D-glucose  (EXP,ISO)
dantrolene  (ISO)
DDE  (EXP,ISO)
DDT  (ISO)
dehydroepiandrosterone  (ISO)
deoxycholic acid  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazoxide  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP)
dibutylstannane  (EXP)
diethyl hydrogen phosphate  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
diiodine  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (EXP,ISO)
dipyridamole  (ISO)
disodium selenite  (EXP)
dobutamine  (EXP,ISO)
DPCPX  (ISO)
edelfosine  (EXP)
efavirenz  (ISO)
elemental boron  (ISO)
elemental selenium  (ISO)
Elemicin  (EXP)
enalapril  (EXP)
ethambutol  (ISO)
ethanol  (EXP,ISO)
ethionamide  (ISO)
Ethyl icosapentate  (EXP)
ethylparaben  (ISO)
fenofibrate  (ISO)
fenoterol  (ISO)
fenvalerate  (ISO)
flufenamic acid  (EXP)
flutamide  (ISO)
fonofos  (ISO)
fructose  (EXP,ISO)
furan  (ISO)
gallocatechin  (EXP)
gamma-hexachlorocyclohexane  (ISO)
Ganoderic acid A  (EXP)
gemcitabine  (ISO)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
gingerol  (EXP)
glucagon  (EXP)
glucose  (EXP,ISO)
glycine  (EXP)
hesperidin  (ISO)
hexadecanoic acid  (EXP)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
indinavir  (EXP,ISO)
indometacin  (ISO)
inulin  (ISO)
iodide salt  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoflavones  (ISO)
isoprenaline  (EXP,ISO)
isoscutellarein  (EXP)
isotretinoin  (ISO)
kaempferol  (EXP)
kainic acid  (EXP)
ketamine  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lamivudine  (EXP)
lanthanum atom  (EXP)
lead(0)  (ISO)
Licarin A  (EXP)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
loganin  (EXP)
lopinavir  (ISO)
LY294002  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
melatonin  (ISO)
menadione  (ISO)
mercury dichloride  (EXP,ISO)
metformin  (EXP)
methacholine chloride  (EXP)
methadone  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
methylmercury chloride  (EXP)
methylparaben  (ISO)
metronidazole  (EXP)
metyrapone  (ISO)
mevalonic acid  (EXP)
MK-2206  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP,ISO)
monosodium L-glutamate  (EXP,ISO)
morin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
naproxen  (ISO)
naringin  (EXP,ISO)
nelfinavir  (EXP,ISO)
neomycin  (EXP)
nevirapine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nicotinic acid  (EXP,ISO)
nitric oxide  (ISO)
Nonylphenol  (EXP)
norwogonin  (EXP)
NS-398  (ISO)
olanzapine  (EXP,ISO)
oleanolic acid  (EXP)
oleic acid  (EXP,ISO)
omaveloxolone  (EXP)
orlistat  (EXP,ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (ISO)
permethrin  (EXP)
phencyclidine  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phloretin  (EXP)
phlorizin  (EXP)
phosphatidylcholine  (EXP)
phosphoramidon  (ISO)
pioglitazone  (ISO)
piperine  (ISO)
pirimicarb  (ISO)
pirinixic acid  (EXP)
pitavastatin  (EXP)
pitavastatin(1-)  (EXP)
pluronic P-123  (ISO)
Poloxamer  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP)
prochloraz  (ISO)
progesterone  (EXP,ISO)
propranolol  (ISO)
propylparaben  (EXP,ISO)
prostaglandin E2  (ISO)
Ptaquiloside  (EXP)
Pyridostigmine bromide  (EXP)
pyruvic acid  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
ramipril  (ISO)
reactive oxygen species  (ISO)
rebaudioside A  (EXP)
reserpine  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (EXP)
ritonavir  (ISO)
rotenone  (ISO)
roxarsone  (ISO)
ruthenium red  (EXP)
rutin  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
saquinavir  (EXP)
SB 203580  (ISO)
selenium atom  (ISO)
serpentine asbestos  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
SKF-96365 hydrochloride  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium perchlorate  (ISO)
Sophocarpine  (ISO)
stavudine  (ISO)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (EXP,ISO)
sumatriptan  (ISO)
superoxide  (EXP,ISO)
terbufos  (ISO)
terbutaline  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (EXP)
thioacetamide  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (EXP)
triazophos  (ISO)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triflumizole  (EXP,ISO)
triphenyl phosphate  (EXP)
triptonide  (EXP)
troglitazone  (EXP,ISO)
U-73122  (EXP)
ursolic acid  (EXP)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vitamin E  (ISO)
wogonin  (EXP)
wortmannin  (EXP)
xanthone  (ISO)
zidovudine  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc molecular entity  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase C activity  (IBA,ISO,ISS)
adipose tissue development  (IGI)
adult feeding behavior  (IDA)
angiogenesis  (IEA,ISO)
aorta development  (IMP)
bile acid metabolic process  (IDA)
bone growth  (IMP)
bone mineralization involved in bone maturation  (IEA,ISO)
cardiac muscle hypertrophy  (IEA,ISO)
cell surface receptor signaling pathway via JAK-STAT  (IDA)
cellular response to insulin stimulus  (IDA)
cellular response to L-ascorbic acid  (IEA,ISO)
cellular response to leptin stimulus  (ISO,ISS)
cellular response to retinoic acid  (IEA,ISO)
central nervous system neuron development  (IMP)
cholesterol metabolic process  (IGI)
circadian rhythm  (IEA,ISO)
determination of adult lifespan  (IGI)
eating behavior  (IGI)
elastin metabolic process  (IMP)
energy homeostasis  (IDA)
energy reserve metabolic process  (IBA,IEA,ISO)
fatty acid beta-oxidation  (IGI)
fatty acid catabolic process  (ISO)
female pregnancy  (IEA,ISO)
glucose homeostasis  (IGI)
glucose metabolic process  (IMP)
glycerol biosynthetic process  (IEA,ISO)
hormone metabolic process  (IMP)
insulin secretion  (IGI)
intestinal absorption  (ISO,ISS)
intracellular signal transduction  (IEA,ISO)
leptin-mediated signaling pathway  (IDA,ISO)
leukocyte tethering or rolling  (IEA,ISO)
lipid metabolic process  (IBA,IMP)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of appetite  (IDA)
negative regulation of appetite by leptin-mediated signaling pathway  (IBA,ISO,ISS)
negative regulation of autophagy  (IMP,ISO)
negative regulation of cartilage development  (IEA,ISO)
negative regulation of D-glucose import  (ISO,ISS)
negative regulation of glucagon secretion  (IDA)
negative regulation of glutamine transport  (IEA,ISO)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of lipid storage  (IEA,ISO)
negative regulation of metabolic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA)
negative regulation of vasoconstriction  (IEA,ISO)
ovulation from ovarian follicle  (IEA,ISO)
phagocytosis  (IDA,ISO)
placenta development  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of cytokine production  (ISO)
positive regulation of developmental growth  (IEA,ISO)
positive regulation of fat cell apoptotic process  (IEA,ISO)
positive regulation of follicle-stimulating hormone secretion  (IEA,ISO)
positive regulation of hepatic stellate cell activation  (IEA,ISO)
positive regulation of insulin receptor signaling pathway  (IEA,ISO)
positive regulation of interleukin-12 production  (IDA)
positive regulation of interleukin-6 production  (IDA,ISO,ISS)
positive regulation of interleukin-8 production  (ISO,ISS)
positive regulation of luteinizing hormone secretion  (IEA,ISO)
positive regulation of MAPK cascade  (IDA,ISO)
positive regulation of monoatomic ion transport  (IEA,ISO)
positive regulation of myeloid cell differentiation  (IDA)
positive regulation of p38MAPK cascade  (IBA,ISO,ISS)
positive regulation of peroxisome proliferator activated receptor signaling pathway  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA,IDA,ISO,ISS)
positive regulation of protein import into nucleus  (IDA)
positive regulation of protein modification process  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of reactive oxygen species metabolic process  (IEA,ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IBA,IDA,ISO)
positive regulation of T cell proliferation  (IEA,ISO)
positive regulation of TOR signaling  (IBA,IEA,ISO)
positive regulation of tumor necrosis factor production  (IDA)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
prostaglandin secretion  (ISO,ISS)
regulation of angiogenesis  (ISO,ISS)
regulation of blood pressure  (IEA,ISO)
regulation of bone remodeling  (IMP)
regulation of brown fat cell differentiation  (IDA)
regulation of catalytic activity  (IMP)
regulation of cell cycle  (IDA,ISO,ISS)
regulation of cytokine production involved in inflammatory response  (ISO,ISS)
regulation of endothelial cell proliferation  (ISO,ISS)
regulation of fat cell differentiation  (IGI)
regulation of gluconeogenesis  (IMP)
regulation of insulin secretion  (IMP)
regulation of intestinal cholesterol absorption  (IDA)
regulation of lipid biosynthetic process  (IGI)
regulation of lipoprotein lipid oxidation  (IEA,ISO)
regulation of metabolic process  (IMP)
regulation of natural killer cell activation  (ISO,ISS)
regulation of natural killer cell mediated cytotoxicity  (ISO,ISS)
regulation of natural killer cell proliferation  (ISO,ISS)
regulation of nitric-oxide synthase activity  (IDA,ISO)
regulation of protein localization to nucleus  (IMP)
regulation of protein phosphorylation  (IDA)
regulation of steroid biosynthetic process  (IMP)
response to activity  (IEA,ISO)
response to dietary excess  (IGI,IMP,ISO)
response to estradiol  (IEA,ISO)
response to ethanol  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to insulin  (IBA,IMP)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
response to vitamin E  (IEA,ISO)
sexual reproduction  (IMP,ISO)
signal transduction  (IEA)
T cell differentiation  (IMP)
tyrosine phosphorylation of STAT protein  (IBA,IDA)

Cellular Component
cytoplasm  (IDA)
cytosol  (IEA,ISO)
extracellular region  (IEA,TAS)
extracellular space  (IBA,IDA,IEP,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal acute inflammation  (IAGP)
abnormal adipose tissue amount  (IAGP)
abnormal adipose tissue development  (IAGP)
abnormal adipose tissue morphology  (IAGP)
abnormal arteriole morphology  (IAGP)
abnormal behavior  (IAGP)
abnormal body size  (IAGP)
abnormal body temperature  (IAGP)
abnormal body weight  (IAGP)
abnormal bone marrow morphology  (IAGP)
abnormal branching of the mammary ductal tree  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cell cycle  (IAGP)
abnormal chemokine secretion  (IAGP)
abnormal circulating cholesterol level  (IAGP)
abnormal circulating corticosterone level  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal circulating hormone level  (IAGP)
abnormal circulating insulin level  (IAGP)
abnormal circulating pancreatic peptide level  (IAGP)
abnormal circulating testosterone level  (IAGP)
abnormal coat appearance  (IEA)
abnormal colon goblet cell morphology  (IAGP)
abnormal cortical plate morphology  (IAGP)
abnormal corticosterone level  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal eating behavior  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal energy expenditure  (IAGP)
abnormal enzyme/coenzyme level  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epididymal fat pad morphology  (IAGP)
abnormal estrous cycle  (IAGP)
abnormal excitatory postsynaptic currents  (IAGP)
abnormal eye posterior chamber depth  (IEA)
abnormal fat cell morphology  (IAGP)
abnormal fat pad morphology  (IAGP)
abnormal fatty acids level  (IAGP)
abnormal fertility/fecundity  (IAGP)
abnormal food intake  (IAGP)
abnormal frequency of paradoxical sleep  (IAGP)
abnormal gland physiology  (IAGP)
abnormal gluconeogenesis  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal glucose tolerance  (IAGP)
abnormal glycogen homeostasis  (IAGP)
abnormal gonadal fat pad morphology  (IAGP)
abnormal hepatocyte physiology  (IAGP)
abnormal hormone level  (IAGP)
abnormal inhibitory postsynaptic currents  (IAGP)
abnormal insulin secretion  (IAGP)
abnormal interstitial cell of Cajal morphology  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal intestinal mucosa morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal lipid level  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver size  (IAGP)
abnormal liver weight  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal maternal nurturing  (IAGP)
abnormal metabolism  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal muscle contractility  (IAGP)
abnormal muscle morphology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal nucleotide metabolism  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal oxygen consumption  (IAGP)
abnormal pain threshold  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal pancreatic beta cell physiology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal podocyte morphology  (IAGP)
abnormal postnatal growth  (IAGP)
abnormal protein level  (IAGP)
abnormal respiratory electron transport chain  (IAGP)
abnormal response to cardiac infarction  (IAGP)
abnormal retina inner nuclear layer morphology  (IEA)
abnormal retina vasculature morphology  (IAGP)
abnormal skeletal muscle fiber type ratio  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal sleep pattern  (IAGP)
abnormal sympathetic nervous system physiology  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
abnormal urine catecholamine level  (IAGP)
abnormal urine color  (IAGP)
abnormal urine homeostasis  (IAGP)
abnormal vagina orifice morphology  (IAGP)
abnormal vascular wound healing  (IAGP)
abnormal white adipose tissue amount  (IAGP)
abnormal white adipose tissue morphology  (IAGP)
abnormal white fat cell morphology  (IAGP)
absent corpus luteum  (IAGP)
albuminuria  (IAGP)
allodynia  (IAGP)
atherosclerotic lesions  (IAGP)
decreased activity of thyroid gland  (IAGP)
decreased body fat mass  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body temperature  (IAGP)
decreased body weight  (IAGP)
decreased bone mass  (IAGP)
decreased carbon dioxide production  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cardiac muscle triglyceride level  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased circulating adiponectin level  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating corticosterone level  (IAGP)
decreased circulating follicle stimulating hormone level  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating growth hormone level  (IAGP)
decreased circulating HDL cholesterol level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating LDL cholesterol level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating luteinizing hormone level  (IAGP)
decreased circulating prolactin level  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased circulating tumor necrosis factor level  (IAGP)
decreased core body temperature  (IAGP)
decreased embryonic neuroepithelial cell proliferation  (IAGP)
decreased embryonic neuroepithelium thickness  (IAGP)
decreased energy expenditure  (IAGP)
decreased epididymal fat pad weight  (IAGP)
decreased exploration in new environment  (IEA)
decreased fat cell size  (IAGP)
decreased fatty acid beta-oxidation  (IAGP)
decreased food intake  (IAGP)
decreased gonadal fat pad weight  (IAGP)
decreased grip strength  (IEA)
decreased heart rate  (IEA)
decreased heart weight  (IEA)
decreased inguinal fat pad weight  (IAGP)
decreased insulin secretion  (IAGP)
decreased lean body mass  (IAGP)
decreased length of long bones  (IAGP)
decreased liver cholesterol level  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased liver weight  (IAGP)
decreased locomotor activity  (IAGP)
decreased mesenteric fat pad weight  (IAGP)
decreased nerve conduction velocity  (IAGP)
decreased neuron number  (IAGP)
decreased NK cell number  (IAGP)
decreased oxygen consumption  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased pituitary hormone level  (IAGP)
decreased primary ovarian follicle number  (IAGP)
decreased respiratory quotient  (IAGP)
decreased retroperitoneal fat pad weight  (IAGP)
decreased secondary ovarian follicle number  (IAGP)
decreased seminal vesicle weight  (IAGP)
decreased skeletal muscle fiber size  (IAGP)
decreased skeletal muscle mass  (IAGP)
decreased somatotroph cell number  (IAGP)
decreased spleen weight  (IEA)
decreased splenocyte number  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased susceptibility to diet-induced hepatic steatosis  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased susceptibility to hepatic steatosis  (IAGP)
decreased susceptibility to weight gain  (IAGP)
decreased T cell proliferation  (IAGP)
decreased testis weight  (IAGP)
decreased total retina thickness  (IEA)
decreased triglyceride level  (IAGP)
decreased vertical activity  (IEA)
decreased white adipose tissue amount  (IAGP)
decreased white fat cell number  (IAGP)
disorganized pancreatic islets  (IAGP)
enhanced fertility  (IAGP)
enlarged kidney  (IAGP)
enlarged pancreatic islets  (IAGP)
expanded mesangial matrix  (IAGP)
female infertility  (IAGP)
fragmentation of sleep/wake states  (IAGP)
glomerulosclerosis  (IAGP)
heart left ventricle hypertrophy  (IAGP)
hepatic steatosis  (IAGP)
hyperalgesia  (IAGP)
hyperglycemia  (IAGP)
hyperlipidemia  (IAGP)
hypersecretion of corticosterone  (IAGP)
hypertension  (IAGP)
hypoglycemia  (IAGP)
hypotension  (IAGP)
impaired adaptive thermogenesis  (IAGP)
impaired glucose tolerance  (IAGP)
improved glucose tolerance  (IAGP)
increased adipocyte glucose uptake  (IAGP)
increased adrenocorticotropin level  (IAGP)
increased anxiety-related response  (IEA)
increased blood urea nitrogen level  (IAGP)
increased body fat mass  (IEA)
increased body length  (IAGP)
increased body weight  (IAGP)
increased bone mass  (IAGP)
increased brown adipose tissue amount  (IAGP)
increased brown fat cell lipid droplet size  (IAGP)
increased cardiac stroke volume  (IEA)
increased cholesterol level  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating HDL cholesterol level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating LDL cholesterol level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased circulating VLDL cholesterol level  (IAGP)
increased cornea thickness  (IEA)
increased defecation amount  (IAGP)
increased fasting circulating glucose level  (IAGP)
increased fat cell size  (IAGP)
increased fatty acids level  (IAGP)
increased fluid intake  (IAGP)
increased food intake  (IAGP)
increased gonadal fat pad weight  (IAGP)
increased growth rate  (IAGP)
increased heart weight  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased inguinal fat pad weight  (IAGP)
increased insulin secretion  (IAGP)
increased insulin sensitivity  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased interscapular fat pad weight  (IAGP)
increased kidney weight  (IAGP)
increased lean body mass  (IAGP)
increased Leydig cell number  (IAGP)
increased liver cholesterol level  (IAGP)
increased liver glycogen level  (IAGP)
increased liver triglyceride level  (IAGP)
increased liver weight  (IAGP)
increased macrophage cell number  (IAGP)
increased metastatic potential  (IAGP)
increased muscle cell glucose uptake  (IAGP)
increased myocardial fiber size  (IAGP)
increased oxygen consumption  (IAGP)
increased pancreas weight  (IAGP)
increased pancreatic alpha cell number  (IAGP)
increased pancreatic beta cell mass  (IAGP)
increased pancreatic beta cell number  (IAGP)
increased pancreatic islet number  (IAGP)
increased percent body fat/body weight  (IAGP)
increased pituitary hormone level  (IAGP)
increased renal glomerulus basement membrane thickness  (IAGP)
increased seminal vesicle weight  (IAGP)
increased sperm number  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to weight gain  (IAGP)
increased thermal nociceptive threshold  (IAGP)
increased total body fat amount  (IAGP)
increased total fat pad weight  (IAGP)
increased trabecular bone thickness  (IAGP)
increased triglyceride level  (IAGP)
increased urine adrenaline level  (IAGP)
increased urine glucose level  (IAGP)
increased white adipose tissue amount  (IAGP)
increased white fat cell number  (IAGP)
increased white fat cell size  (IAGP)
infertility  (IAGP)
insulin resistance  (IAGP)
liver fibrosis  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
macrovesicular hepatic steatosis  (IAGP)
male infertility  (IAGP)
mesangiolysis  (IAGP)
obese  (IAGP)
osteopetrosis  (IAGP)
oxidative stress  (IAGP)
pale liver  (IAGP)
pancreatic islet hyperplasia  (IAGP)
polydipsia  (IAGP)
polyphagia  (IAGP)
polyuria  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prolonged diestrus  (IAGP)
prolonged estrous cycle  (IAGP)
prolonged estrus  (IAGP)
prolonged QRS complex duration  (IEA)
reduced female fertility  (IAGP)
reduced male fertility  (IAGP)
renal glomerulus hypertrophy  (IAGP)
renal interstitial fibrosis  (IAGP)
short femur  (IAGP)
short humerus  (IAGP)
short tibia  (IEA)
small liver  (IAGP)
small pancreatic islets  (IAGP)
weight loss  (IAGP)
white spotting  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver. Aizawa-Abe M, etal., Physiol Genomics. 2013 Sep 3;45(17):786-93. doi: 10.1152/physiolgenomics.00040.2013. Epub 2013 Jun 25.
2. Genetic polymorphisms of IL-23R (rs7517847) and LEP (rs7799039) among Egyptian patients with hepatocellular carcinoma. Amer T, etal., Arch Physiol Biochem. 2017 Dec;123(5):279-285. doi: 10.1080/13813455.2017.1320680. Epub 2017 Apr 28.
3. Characterization of changes in leptin and leptin receptors in a rat model of preeclampsia. Anderson CM, etal., Am J Obstet Gynecol. 2005 Jul;193(1):267-72.
4. Airway inflammation in obstructive sleep apnea: is leptin the missing link? Antonopoulou S, etal., Respir Med. 2008 Oct;102(10):1399-405. Epub 2008 Jul 7.
5. The relationship between serum adiponectin and steatosis in patients with chronic hepatitis C genotype-4. Ashour E, etal., Clin Lab. 2010;56(3-4):103-10.
6. Leptin administration affects growth and skeletal development in a rat intrauterine growth restriction model: Preliminary study. Bar-El Dadon S, etal., Nutrition. 2011 Feb 23.
7. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
8. The effect of high fat diet-induced obesity on cardiovascular toxicity in wistar albino rats. Bhandari U, etal., Hum Exp Toxicol. 2010 Nov 12.
9. Increased numbers of motor activity peaks during light cycle are associated with reductions in adrenergic alpha(2)-receptor levels in a transgenic Huntington's disease rat model. Bode FJ, etal., Behav Brain Res. 2009 Dec 14;205(1):175-82. Epub 2009 Jun 30.
10. The passive coping Roman Low Avoidance rat, a non-obese rat model for insulin resistance. Boersma GJ, etal., Physiol Behav. 2009 Jun 22;97(3-4):353-8. Epub 2009 Mar 16.
11. Gender differences in the adipose secretome system in chronic obstructive pulmonary disease (COPD): A pivotal role of leptin. Breyer MK, etal., Respir Med. 2011 Feb 28.
12. Leptin reduces ovariectomy-induced bone loss in rats. Burguera B, etal., Endocrinology. 2001 Aug;142(8):3546-53.
13. Serum leptin and leptin resistance correlations with NAFLD in patients with type 2 diabetes. Cernea S, etal., Diabetes Metab Res Rev. 2018 Nov;34(8):e3050. doi: 10.1002/dmrr.3050. Epub 2018 Sep 13.
14. Serum adiponectin and leptin levels in Taiwanese breast cancer patients. Chen DC, etal., Cancer Lett. 2006 Jun 8;237(1):109-14. Epub 2005 Jul 12.
15. Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. Chen WS, etal., Mol Cell Biol. 2009 Jun;29(11):3151-62. Epub 2009 Mar 16.
16. Serum leptin levels depend on allergen exposure in patients with seasonal allergic rhinitis. Ciprandi G, etal., Immunol Invest. 2009;38(8):681-9.
17. Plasma ghrelin and leptin in adult cystic fibrosis patients. Cohen RI, etal., J Cyst Fibros. 2008 Sep;7(5):398-402. Epub 2008 Mar 18.
18. Adipokine Levels Versus Hepatic Histopathology in Bariatric Surgery Patients. D'Incao RB, etal., Obes Surg. 2017 Aug;27(8):2151-2158. doi: 10.1007/s11695-017-2627-4.
19. A Functional Melanocortin System May Be Required For Chronic Cns-Mediated Antidiabetic And Cardiovascular Actions Of Leptin. da Silva AA, etal., Diabetes. 2009 Jun 2.
20. Divergent effects of intracerebroventricular and peripheral leptin administration on feeding and hypothalamic neuropeptide Y in lean and obese (fa/fa) Zucker rats. Dryden S, etal., Clin Sci (Lond). 1999 Mar;96(3):307-12.
21. Evidence for a key role of leptin in osteoarthritis. Dumond H, etal., Arthritis Rheum. 2003 Nov;48(11):3118-29.
22. Leptin, visfatin, insulin resistance, and body composition change in chronic obstructive pulmonary disease. Eker S, etal., Scand J Clin Lab Invest. 2010 Feb;70(1):40-4.
23. Competitive inhibition of leptin signaling results in amelioration of liver fibrosis through modulation of stellate cell function. Elinav E, etal., Hepatology. 2009 Jan;49(1):278-86.
24. Insulin resistance, leptin and monocyte chemotactic protein-1 levels in diabetic and non-diabetic Afro-Caribbean subjects. Ezenwaka CE, etal., Arch Physiol Biochem. 2009 Feb;115(1):22-7.
25. Oral salmon calcitonin protects against impaired fasting glycemia, glucose intolerance, and obesity induced by high-fat diet and ovariectomy in rats. Feigh M, etal., Menopause. 2013 Jul;20(7):785-94. doi: 10.1097/GME.0b013e31827c58ab.
26. [Effects of decreased leptin expression on liver fibrosis]. Feng HJ, etal., Zhonghua Gan Zang Bing Za Zhi. 2010 May;18(5):342-5. doi: 10.3760/cma.j.issn.1007-3418.2010.05.008.
27. Serum leptin levels following acute experimental spinal cord injury. Gezici AR, etal., J Spinal Cord Med. 2009;32(4):416-21.
28. Leptin treatment ameliorates acute lung injury in rats with cerulein-induced acute pancreatitis. Gultekin FA, etal., World J Gastroenterol. 2007 Jun 7;13(21):2932-8.
29. Linkage exclusion analysis of two candidate regions on chromosomes 7 and 11: leptin and UCP2/UCP3 are not QTLs for obesity in US Caucasians. Guo JJ, etal., Biochem Biophys Res Commun. 2005 Jul 1;332(2):602-8.
30. Effects of periconceptional maternal alcohol intake and a postnatal high-fat diet on obesity and liver disease in male and female rat offspring. Gårdebjer EM, etal., Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E694-E704. doi: 10.1152/ajpendo.00251.2017. Epub 2017 Oct 31.
31. Genetic variations in the leptin and leptin receptor genes are associated with type 2 diabetes mellitus and metabolic traits in the Korean female population. Han HR, etal., Clin Genet. 2008 Aug;74(2):105-15. Epub 2008 Jun 28.
32. Serum immunoreactive leptin concentration and its relation to the body fat content in chronic renal failure. Heimburger O, etal., J Am Soc Nephrol. 1997 Sep;8(9):1423-30.
33. Attenuation of leptin and insulin signaling by SOCS proteins. Howard JK and Flier JS, Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28.
34. Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia. Hsu A, etal., Clin Exp Immunol. 2007 Nov;150(2):332-9. Epub 2007 Sep 5.
35. Hypothalamic leptin gene therapy prevents weight gain without long-term detrimental effects on bone in growing and skeletally mature female rats. Iwaniec UT, etal., J Bone Miner Res. 2011 Feb 16. doi: 10.1002/jbmr.365.
36. Leptin Promotes Fibroproliferative ARDS by Inhibiting Peroxisome Proliferator-activated Receptor-{gamma} Jain M, etal., Am J Respir Crit Care Med. 2011 Feb 11.
37. Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and promote survival in insulin-deficient diabetic mice. Kojima S, etal., Peptides. 2009 May;30(5):962-6. Epub 2009 Jan 22.
38. Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats. Kruger AJ, etal., Autoimmunity. 2011 Mar;44(2):137-48. Epub 2010 Aug 9.
39. Association Between Serum Leptin and Adiponectin Levels with Risk of Insulin Resistance and Impaired Glucose Tolerance in Non-diabetic Women. Lee CY, etal., Kaohsiung J Med Sci. 2009 Mar;25(3):116-25.
40. The modulating effect of the androgen receptor on craving in alcohol withdrawal of men is partially mediated by leptin. Lenz B, etal., Pharmacogenomics J. 2010 Jun;10(3):226-31. doi: 10.1038/tpj.2009.56. Epub 2009 Nov 3.
41. [Distribution of leptin expression and its effect on the recovery of sepsis-induced internal disorders]. Lin J, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 May;39(3):360-3, 417.
42. Endogenous leptin fluctuates in hepatic ischemia/reperfusion injury and represents a potential therapeutic target. Lin J, etal., World J Gastroenterol. 2010 Nov 21;16(43):5424-34.
43. Polymorphism of human leptin receptor gene is associated with type 2 diabetic patients complicated with non-alcoholic fatty liver disease in China. Lu H, etal., J Gastroenterol Hepatol. 2009 Feb;24(2):228-32. Epub 2008 Aug 17.
44. Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute Family Heart Study. Ma D, etal., Hypertension. 2009 Mar;53(3):473-9. Epub 2009 Feb 9.
45. [Association of single nucleotide polymorphisms (SNPs) in leptin receptor gene with knee osteoarthritis in the Ningxia Hui population]. Ma XJ, etal., Yi Chuan. 2013 Mar;35(3):359-64.
46. Amyloid beta lowering and cognition enhancing effects of ghrelin receptor analog [D-Lys (3)] GHRP-6 in rat model of obesity. Madhavadas S, etal., Indian J Biochem Biophys. 2014 Aug;51(4):257-62.
47. Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. Mancuso P, etal., J Immunol. 2002 Apr 15;168(8):4018-24.
48. Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia. Mancuso P, etal., J Immunol. 2011 Jan 15;186(2):1081-90. Epub 2010 Dec 10.
49. Accelerated renal disease is associated with the development of metabolic syndrome in a glucolipotoxic mouse model. Martinez-Garcia C, etal., Dis Model Mech. 2012 Sep;5(5):636-48. doi: 10.1242/dmm.009266. Epub 2012 Jul 5.
50. Central overexpression of leptin antagonist reduces wheel running and underscores importance of endogenous leptin receptor activity in energy homeostasis. Matheny M, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1254-61. Epub 2009 Sep 2.
51. Leptin signalling reduces the severity of cardiac dysfunction and remodelling after chronic ischaemic injury. McGaffin KR, etal., Cardiovasc Res. 2008 Jan;77(1):54-63. Epub 2007 Sep 20.
52. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
53. MGDs mouse GO annotations MGD data from the GO Consortium
54. MGD IEA MGD IEA
55. [Plasma leptin level in patients with bronchial asthma]. Mineev VN, etal., Klin Med (Mosk). 2009;87(7):33-7.
56. Leptin, adiponectin, and high-sensitivity C-reactive protein in relation to the metabolic syndrome in urban South African blacks with and without coronary artery disease. Ntyintyane L, etal., Metab Syndr Relat Disord. 2009 Jun;7(3):243-8.
57. Dual relation between leptin and cortisol in humans is disturbed in Alzheimer's disease. Olsson T, etal., Biol Psychiatry. 1998 Sep 1;44(5):374-6.
58. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
59. Effects of the obese gene product on body weight regulation in ob/ob mice. Pelleymounter MA, etal., Science. 1995 Jul 28;269(5223):540-3.
60. Association of serum leptin with hypoventilation in human obesity. Phipps PR, etal., Thorax. 2002 Jan;57(1):75-6.
61. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
62. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
63. Relationship between osteoporosis and adipose tissue leptin and osteoprotegerin in patients with chronic obstructive pulmonary disease. Pobeha P, etal., Bone. 2011 Mar 1.
64. Leptin Expression and Gene Methylation Patterns in Alcohol-Dependent Patients with Ethyltoxic Cirrhosis-Normalization After Liver Transplantation and Implications for Future Research. Proskynitopoulos PJ, etal., Alcohol Alcohol. 2018 Sep 1;53(5):511-517. doi: 10.1093/alcalc/agy038.
65. Mouse MP Annotation Import Pipeline RGD automated import pipeline
66. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
67. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
68. Leptin-leptin receptor are involved in angiogenesis in human hepatocellular carcinoma. Ribatti D, etal., Peptides. 2008 Sep;29(9):1596-602. doi: 10.1016/j.peptides.2008.05.011. Epub 2008 May 22.
69. Serum leptin and insulin in paediatric end-stage liver disease and following successful orthotopic liver transplantation. Roberts GA, etal., Clin Endocrinol (Oxf). 1998 Apr;48(4):401-6. doi: 10.1046/j.1365-2265.1998.00448.x.
70. Effects of apelin and leptin on renal functions following renal ischemia/reperfusion: An experimental study. Sagiroglu T, etal., Exp Ther Med. 2012 May;3(5):908-914. Epub 2012 Feb 29.
71. Pharmacology of Cimicifuga racemosa extract BNO 1055 in rats: bone, fat and uterus. Seidlova-Wuttke D, etal., Maturitas. 2003 Mar 14;44 Suppl 1:S39-50.
72. 7alpha-methyl-19-nortestosterone vs. testosterone implants for hypogonadal osteoporosis: a preclinical study in the aged male orchidectomized rat model. Sinnesael M, etal., Int J Androl. 2011 Dec;34(6 Pt 2):e601-11. doi: 10.1111/j.1365-2605.2011.01198.x. Epub 2011 Jul 26.
73. Inverse association of leptin levels with renal cell carcinoma: results from a case-control study. Spyridopoulos TN, etal., Hormones (Athens). 2009 Jan-Mar;8(1):39-46.
74. Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase. Stefanou N, etal., BMC Cancer. 2010 Aug 19;10:442. doi: 10.1186/1471-2407-10-442.
75. Leptin affects intestinal epithelial cell turnover in correlation with leptin receptor expression along the villus-crypt axis after massive small bowel resection in a rat. Sukhotnik I, etal., Pediatr Res. 2009 Dec;66(6):648-53.
76. Serum leptin, soluble leptin receptor, free leptin index and bone mineral density in patients with primary biliary cirrhosis. Szalay F, etal., Eur J Gastroenterol Hepatol. 2005 Sep;17(9):923-8.
77. Elevated serum leptin levels: a risk factor for non-small-cell lung cancer? Terzidis A, etal., Oncology. 2009;76(1):19-25. Epub 2008 Nov 24.
78. Metabolic syndrome triggered by high-fructose diet favors choroidal neovascularization and impairs retinal light sensitivity in the rat. Thierry M, etal., PLoS One. 2014 Nov 7;9(11):e112450. doi: 10.1371/journal.pone.0112450. eCollection 2014.
79. Creation and preliminary characterization of a leptin knockout rat. Vaira S, etal., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4.
80. Effect of leptin on bone metabolism in rat model of traumatic brain injury and femoral fracture. Wang L, etal., Chin J Traumatol. 2011 Feb 1;14(1):7-13.
81. Hepatic steatosis depresses alpha-1-antitrypsin levels in human and rat acute pancreatitis. Wang Q, etal., Sci Rep. 2015 Dec 4;5:17833. doi: 10.1038/srep17833.
82. Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling. Weng Z, etal., J Biol Chem. 2007 Nov 23;282(47):34479-91. Epub 2007 Sep 25.
83. Hepatitis C and the leptin system: bound leptin levels are elevated in patients with hepatitis C and decrease during antiviral therapy. Widjaja A, etal., Scand J Gastroenterol. 2001 Apr;36(4):426-31. doi: 10.1080/003655201300051333.
84. DNA Methylation of the Leptin Gene Promoter is Altered by Chronic Alcohol Exposure in an Animal Model for Alcohol Dependence. Wieting J, etal., Eur Addict Res. 2019;25(2):49-55. doi: 10.1159/000496111. Epub 2019 Jan 16.
85. [Preliminary investigation of the changes and mechanism of Leptin after myocardial ischemia/reperfusion injury]. Xue H, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2010 Nov;22(11):680-3.
86. Change in lipid components in the adipose and liver tissues of regucalcin transgenic rats with increasing age: suppression of leptin and adiponectin gene expression. Yamaguchi M and Nakagawa T, Int J Mol Med. 2007 Sep;20(3):323-8.
87. The polymorphism -2548G/A in leptin and severity of chronic obstructive pulmonary disease. Ye XW, etal., Int J Immunogenet. 2011 Feb;38(1):45-50. doi: 10.1111/j.1744-313X.2010.00968.x. Epub 2010 Sep 20.
88. Treatment of obesity hypoventilation syndrome and serum leptin. Yee BJ, etal., Respiration. 2006;73(2):209-12. Epub 2005 Sep 20.
89. Assessment of insulin sensitivity/resistance and their relations with leptin concentrations and anthropometric measures in a pregnant population with and without gestational diabetes mellitus. Yilmaz O, etal., J Diabetes Complications. 2009 Mar 6.
90. Adenovirus-mediated leptin expression normalises hypertension associated with diet-induced obesity. Zhang W, etal., J Neuroendocrinol. 2010 Mar;22(3):175-80. Epub 2010 Jan 5.
91. Propranolol Prevents Osteoporosis and up-regulates Leptin in Ovariectomized Rats. Zhang X, etal., Iran J Pharm Res. 2013 Summer;12(3):557-62.
92. The effect of di-2-ethylhexyl phthalate on inflammation and lipid metabolic disorder in rats. Zhou L, etal., Ecotoxicol Environ Saf. 2019 Apr 15;170:391-398. doi: 10.1016/j.ecoenv.2018.12.009. Epub 2018 Dec 11.
93. Effects of energy restriction and wheel running on mammary carcinogenesis and host systemic factors in a rat model. Zhu Z, etal., Cancer Prev Res (Phila). 2012 Mar;5(3):414-22. doi: 10.1158/1940-6207.CAPR-11-0454. Epub 2012 Jan 13.
Additional References at PubMed
PMID:212501   PMID:223169   PMID:350680   PMID:508700   PMID:565045   PMID:760211   PMID:834144   PMID:840297   PMID:1013161   PMID:1107122   PMID:1314241   PMID:1382044  
PMID:1384356   PMID:1415535   PMID:1433278   PMID:1475285   PMID:1499292   PMID:1499293   PMID:1540129   PMID:1550226   PMID:1575780   PMID:1646706   PMID:1686014   PMID:1794923  
PMID:1797227   PMID:2912985   PMID:3044893   PMID:3976886   PMID:4588246   PMID:4767369   PMID:5059196   PMID:5412353   PMID:6393185   PMID:6971254   PMID:7053993   PMID:7075918  
PMID:7485473   PMID:7487925   PMID:7490107   PMID:7499416   PMID:7508208   PMID:7560100   PMID:7564879   PMID:7566150   PMID:7568067   PMID:7584987   PMID:7593267   PMID:7593268  
PMID:7608151   PMID:7616850   PMID:7624352   PMID:7624777   PMID:7624778   PMID:7635205   PMID:7651535   PMID:7661115   PMID:7669033   PMID:7706460   PMID:7733267   PMID:7735347  
PMID:7784267   PMID:7800681   PMID:7815168   PMID:7824540   PMID:7835283   PMID:7876925   PMID:7876929   PMID:7889367   PMID:7891022   PMID:7906968   PMID:7914350   PMID:7928642  
PMID:7968588   PMID:7984236   PMID:7985012   PMID:7987248   PMID:8023896   PMID:8089731   PMID:8145074   PMID:8150231   PMID:8166263   PMID:8177042   PMID:8177043   PMID:8200619  
PMID:8253133   PMID:8344641   PMID:8348338   PMID:8349816   PMID:8360782   PMID:8371149   PMID:8386184   PMID:8392795   PMID:8467860   PMID:8498501   PMID:8559786   PMID:8566229  
PMID:8570651   PMID:8576190   PMID:8589726   PMID:8597582   PMID:8603777   PMID:8609847   PMID:8614460   PMID:8621378   PMID:8621612   PMID:8621615   PMID:8622953   PMID:8625929  
PMID:8632796   PMID:8633022   PMID:8643634   PMID:8643697   PMID:8645274   PMID:8647948   PMID:8650171   PMID:8653144   PMID:8661738   PMID:8661739   PMID:8662239   PMID:8663251  
PMID:8680474   PMID:8687445   PMID:8687512   PMID:8729088   PMID:8760093   PMID:8782827   PMID:8817099   PMID:8856397   PMID:8856925   PMID:8866547   PMID:8886745   PMID:8898192  
PMID:8920957   PMID:8939859   PMID:8962136   PMID:8965809   PMID:8973143   PMID:8974400   PMID:8990120   PMID:8996253   PMID:9002984   PMID:9007565   PMID:9011250   PMID:9013734  
PMID:9013739   PMID:9022071   PMID:9027475   PMID:9036533   PMID:9037192   PMID:9054925   PMID:9090387   PMID:9099705   PMID:9102398   PMID:9119224   PMID:9133562   PMID:9139806  
PMID:9166685   PMID:9173544   PMID:9177239   PMID:9177786   PMID:9192391   PMID:9200670   PMID:9202206   PMID:9207125   PMID:9225721   PMID:9231663   PMID:9245710   PMID:9249548  
PMID:9254055   PMID:9271234   PMID:9275075   PMID:9276726   PMID:9276734   PMID:9278578   PMID:9294198   PMID:9299448   PMID:9305858   PMID:9311966   PMID:9345027   PMID:9367912  
PMID:9374468   PMID:9374549   PMID:9380761   PMID:9388507   PMID:9389733   PMID:9389736   PMID:9389742   PMID:9389752   PMID:9392508   PMID:9398609   PMID:9399964   PMID:9405382  
PMID:9421367   PMID:9421392   PMID:9421394   PMID:9438411   PMID:9447943   PMID:9464852   PMID:9486972   PMID:9500540   PMID:9504329   PMID:9509396   PMID:9511737   PMID:9517901  
PMID:9519731   PMID:9559948   PMID:9564880   PMID:9568684   PMID:9575960   PMID:9575979   PMID:9590691   PMID:9618302   PMID:9623983   PMID:9627357   PMID:9636194   PMID:9654348  
PMID:9660946   PMID:9726234   PMID:9732873   PMID:9748302   PMID:9751754   PMID:9763877   PMID:9826672   PMID:9826706   PMID:9832419   PMID:9868202   PMID:9874578   PMID:9885188  
PMID:9886818   PMID:9886838   PMID:9887187   PMID:9892232   PMID:9892692   PMID:9916873   PMID:9924185   PMID:9927300   PMID:9927310   PMID:9933608   PMID:9934817   PMID:9950766  
PMID:9950797   PMID:10026188   PMID:10036303   PMID:10049703   PMID:10070008   PMID:10080923   PMID:10080944   PMID:10087446   PMID:10092045   PMID:10094576   PMID:10094957   PMID:10102052  
PMID:10198314   PMID:10216246   PMID:10218993   PMID:10321434   PMID:10329986   PMID:10342814   PMID:10342866   PMID:10348810   PMID:10349636   PMID:10359811   PMID:10395190   PMID:10395195  
PMID:10426381   PMID:10480614   PMID:10481077   PMID:10485707   PMID:10497230   PMID:10514488   PMID:10525043   PMID:10537114   PMID:10549291   PMID:10588755   PMID:10592285   PMID:10613847  
PMID:10642593   PMID:10644531   PMID:10644901   PMID:10660043   PMID:10679205   PMID:10681432   PMID:10688662   PMID:10703894   PMID:10712302   PMID:10722859   PMID:10742101   PMID:10783168  
PMID:10791999   PMID:10802666   PMID:10866690   PMID:10884431   PMID:10884720   PMID:10915826   PMID:10938239   PMID:10949029   PMID:10953025   PMID:10965911   PMID:10969840   PMID:10982846  
PMID:11000478   PMID:11015588   PMID:11037963   PMID:11042159   PMID:11054393   PMID:11056473   PMID:11060440   PMID:11076861   PMID:11078460   PMID:11078464   PMID:11089524   PMID:11089532  
PMID:11089558   PMID:11145598   PMID:11158938   PMID:11208527   PMID:11217851   PMID:11229420   PMID:11244463   PMID:11259650   PMID:11298451   PMID:11340336   PMID:11342605   PMID:11360153  
PMID:11360154   PMID:11369941   PMID:11375346   PMID:11387233   PMID:11423703   PMID:11427484   PMID:11431335   PMID:11440717   PMID:11445560   PMID:11459786   PMID:11481248   PMID:11533494  
PMID:11551957   PMID:11557677   PMID:11557972   PMID:11574408   PMID:11584365   PMID:11682696   PMID:11699060   PMID:11703084   PMID:11704598   PMID:11709414   PMID:11713213   PMID:11713215  
PMID:11714745   PMID:11777985   PMID:11797013   PMID:11805129   PMID:11845234   PMID:11853960   PMID:11860946   PMID:11872379   PMID:11877467   PMID:11882498   PMID:11882520   PMID:11914033  
PMID:11915020   PMID:11923308   PMID:11956242   PMID:11964566   PMID:11967222   PMID:11970899   PMID:11978737   PMID:12000791   PMID:12006366   PMID:12021050   PMID:12054158   PMID:12055606  
PMID:12058043   PMID:12067905   PMID:12068290   PMID:12085344   PMID:12091495   PMID:12107823   PMID:12114517   PMID:12114623   PMID:12126735   PMID:12127425   PMID:12130553   PMID:12136396  
PMID:12149424   PMID:12166825   PMID:12172784   PMID:12177191   PMID:12193546   PMID:12193563   PMID:12200416   PMID:12200699   PMID:12231403   PMID:12244109   PMID:12355168   PMID:12360490  
PMID:12372428   PMID:12376403   PMID:12402973   PMID:12413939   PMID:12419242   PMID:12424222   PMID:12431986   PMID:12438443   PMID:12447443   PMID:12453895   PMID:12466851   PMID:12477932  
PMID:12536362   PMID:12540594   PMID:12540600   PMID:12563024   PMID:12563025   PMID:12571077   PMID:12588883   PMID:12594516   PMID:12602920   PMID:12606383   PMID:12606510   PMID:12612907  
PMID:12618528   PMID:12623845   PMID:12660884   PMID:12668499   PMID:12671032   PMID:12697721   PMID:12702488   PMID:12702697   PMID:12730884   PMID:12734185   PMID:12765967   PMID:12770749  
PMID:12787792   PMID:12810541   PMID:12815040   PMID:12824284   PMID:12826573   PMID:12829638   PMID:12865329   PMID:12865337   PMID:12865502   PMID:12878760   PMID:12885755   PMID:12897241  
PMID:12901866   PMID:12917427   PMID:12923067   PMID:12925742   PMID:12928770   PMID:12930764   PMID:12949354   PMID:12960041   PMID:12960099   PMID:12970157   PMID:14523051   PMID:14551222  
PMID:14578283   PMID:14578285   PMID:14578302   PMID:14581480   PMID:14592964   PMID:14610251   PMID:14615386   PMID:14647064   PMID:14651995   PMID:14657008   PMID:14673160   PMID:14675208  
PMID:14676330   PMID:14679177   PMID:14679178   PMID:14683458   PMID:14707012   PMID:14722102   PMID:14729450   PMID:14741225   PMID:14741342   PMID:14742244   PMID:14749529   PMID:14752112  
PMID:14764630   PMID:14824537   PMID:14854870   PMID:14854871   PMID:14962997   PMID:14976145   PMID:14977926   PMID:14978271   PMID:14981264   PMID:14985253   PMID:14985341   PMID:14988239  
PMID:14993217   PMID:15001430   PMID:15003171   PMID:15003785   PMID:15024641   PMID:15033910   PMID:15047605   PMID:15055599   PMID:15059949   PMID:15059968   PMID:15063934   PMID:15064420  
PMID:15064421   PMID:15096593   PMID:15111494   PMID:15126241   PMID:15131020   PMID:15146238   PMID:15155574   PMID:15178437   PMID:15181014   PMID:15201286   PMID:15215189   PMID:15220189  
PMID:15231485   PMID:15240754   PMID:15256362   PMID:15271881   PMID:15280541   PMID:15289464   PMID:15306556   PMID:15306821   PMID:15319454   PMID:15331547   PMID:15331557   PMID:15358114  
PMID:15368448   PMID:15369800   PMID:15371092   PMID:15483213   PMID:15492859   PMID:15533870   PMID:15539553   PMID:15550470   PMID:15556608   PMID:15556643   PMID:15561935   PMID:15562249  
PMID:15563449   PMID:15591027   PMID:15591135   PMID:15599701   PMID:15616027   PMID:15616563   PMID:15618289   PMID:15664410   PMID:15677756   PMID:15699332   PMID:15724149   PMID:15731403  
PMID:15734486   PMID:15734493   PMID:15760936   PMID:15805118   PMID:15828130   PMID:15831785   PMID:15855344   PMID:15868135   PMID:15899045   PMID:15902306   PMID:15904868   PMID:15923630  
PMID:15923664   PMID:15925330   PMID:15941783   PMID:15942150   PMID:15965483   PMID:15983201   PMID:15994342   PMID:15994350   PMID:15995171   PMID:16020476   PMID:16037295   PMID:16037401  
PMID:16039170   PMID:16054086   PMID:16054098   PMID:16109802   PMID:16123334   PMID:16141072   PMID:16141073   PMID:16141243   PMID:16141392   PMID:16150499   PMID:16160743   PMID:16174655  
PMID:16178853   PMID:16203737   PMID:16222056   PMID:16246967   PMID:16261527   PMID:16280642   PMID:16282354   PMID:16288988   PMID:16293343   PMID:16293682   PMID:16304204   PMID:16306442  
PMID:16308421   PMID:16326714   PMID:16327801   PMID:16329991   PMID:16330324   PMID:16337133   PMID:16339484   PMID:16364907   PMID:16373670   PMID:16394172   PMID:16407534   PMID:16410783  
PMID:16410832   PMID:16414347   PMID:16431926   PMID:16436371   PMID:16436658   PMID:16438946   PMID:16442319   PMID:16443758   PMID:16446356   PMID:16455782   PMID:16455789   PMID:16469807  
PMID:16482497   PMID:16494846   PMID:16501941   PMID:16505218   PMID:16505236   PMID:16507892   PMID:16513828   PMID:16522636   PMID:16537512   PMID:16549076   PMID:16554040   PMID:16601142  
PMID:16602821   PMID:16604086   PMID:16612592   PMID:16614459   PMID:16627594   PMID:16638826   PMID:16643594   PMID:16650847   PMID:16670645   PMID:16675953   PMID:16679295   PMID:16705063  
PMID:16731822   PMID:16750430   PMID:16764953   PMID:16785512   PMID:16790840   PMID:16804058   PMID:16804073   PMID:16804078   PMID:16809344   PMID:16825198   PMID:16872559   PMID:16879220  
PMID:16899579   PMID:16936207   PMID:16950136   PMID:16951207   PMID:16955393   PMID:16981010   PMID:16982425   PMID:16995815   PMID:16998795   PMID:17003267   PMID:17003268   PMID:17003330  
PMID:17003333   PMID:17003351   PMID:17011078   PMID:17011710   PMID:17020752   PMID:17023554   PMID:17050683   PMID:17050906   PMID:17053832   PMID:17056524   PMID:17065346   PMID:17065392  
PMID:17068142   PMID:17084710   PMID:17084711   PMID:17095713   PMID:17122091   PMID:17125140   PMID:17125143   PMID:17130477   PMID:17141630   PMID:17164440   PMID:17170224   PMID:17179051  
PMID:17182038   PMID:17184856   PMID:17189835   PMID:17194443   PMID:17200717   PMID:17229941   PMID:17259372   PMID:17303660   PMID:17307368   PMID:17307705   PMID:17307725   PMID:17317774  
PMID:17327424   PMID:17347480   PMID:17354198   PMID:17362969   PMID:17363460   PMID:17369521   PMID:17379835   PMID:17386921   PMID:17400175   PMID:17416798   PMID:17420279   PMID:17440173  
PMID:17465682   PMID:17482547   PMID:17495001   PMID:17496155   PMID:17516018   PMID:17525261   PMID:17526026   PMID:17529981   PMID:17543459   PMID:17550780   PMID:17556363   PMID:17561514  
PMID:17563062   PMID:17575085   PMID:17595226   PMID:17596325   PMID:17596451   PMID:17603492   PMID:17617622   PMID:17620316   PMID:17630348   PMID:17643114   PMID:17666485   PMID:17686962  
PMID:17688465   PMID:17690315   PMID:17693256   PMID:17717599   PMID:17726024   PMID:17728393   PMID:17728716   PMID:17873059   PMID:17873881   PMID:17879067   PMID:17881125   PMID:17906221  
PMID:17906635   PMID:17909097   PMID:17917378   PMID:17932216   PMID:17932511   PMID:17935159   PMID:17952094   PMID:17962343   PMID:17965621   PMID:17974623   PMID:18006491   PMID:18029445  
PMID:18032600   PMID:18039669   PMID:18039786   PMID:18039787   PMID:18048492   PMID:18068663   PMID:18070594   PMID:18077674   PMID:18080100   PMID:18081560   PMID:18086675   PMID:18097472  
PMID:18160458   PMID:18160459   PMID:18171713   PMID:18178152   PMID:18179777   PMID:18202748   PMID:18203899   PMID:18212290   PMID:18239469   PMID:18241989   PMID:18250302   PMID:18252207  
PMID:18256806   PMID:18272929   PMID:18292187   PMID:18296638   PMID:18305141   PMID:18310351   PMID:18325632   PMID:18332096   PMID:18334608   PMID:18348717   PMID:18349116   PMID:18356830  
PMID:18359888   PMID:18362392   PMID:18367451   PMID:18369453   PMID:18375435   PMID:18375438   PMID:18381283   PMID:18382766   PMID:18396136   PMID:18408913   PMID:18420580   PMID:18426864  
PMID:18436234   PMID:18444172   PMID:18463231   PMID:18467551   PMID:18472337   PMID:18480244   PMID:18480494   PMID:18483882   PMID:18485333   PMID:18497448   PMID:18501893   PMID:18502406  
PMID:18505833   PMID:18515422   PMID:18519977   PMID:18551122   PMID:18552236   PMID:18559657   PMID:18562627   PMID:18566694   PMID:18583419   PMID:18583460   PMID:18645210   PMID:18653778  
PMID:18654634   PMID:18682832   PMID:18689498   PMID:18689499   PMID:18718531   PMID:18718905   PMID:18719660   PMID:18721461   PMID:18728232   PMID:18753616   PMID:18758446   PMID:18787108  
PMID:18790715   PMID:18803240   PMID:18815209   PMID:18818416   PMID:18829956   PMID:18832088   PMID:18835938   PMID:18840360   PMID:18843095   PMID:18845634   PMID:18847327   PMID:18854155  
PMID:18854211   PMID:18941143   PMID:18977759   PMID:18984739   PMID:18996960   PMID:19008231   PMID:19017730   PMID:19020034   PMID:19020099   PMID:19023096   PMID:19025999   PMID:19036876  
PMID:19038858   PMID:19041763   PMID:19049975   PMID:19052259   PMID:19066318   PMID:19074282   PMID:19074983   PMID:19095090   PMID:19100295   PMID:19103304   PMID:19103808   PMID:19107190  
PMID:19114551   PMID:19114642   PMID:19117545   PMID:19117547   PMID:19136651   PMID:19136654   PMID:19136718   PMID:19136964   PMID:19139561   PMID:19156541   PMID:19156569   PMID:19179437  
PMID:19188425   PMID:19188430   PMID:19193947   PMID:19204053   PMID:19211925   PMID:19214223   PMID:19219422   PMID:19223399   PMID:19233863   PMID:19254572   PMID:19286646   PMID:19289822  
PMID:19338759   PMID:19343112   PMID:19356715   PMID:19373220   PMID:19390091   PMID:19401184   PMID:19401420   PMID:19408668   PMID:19409880   PMID:19433254   PMID:19435851   PMID:19436734  
PMID:19457101   PMID:19460359   PMID:19468077   PMID:19478204   PMID:19490910   PMID:19491194   PMID:19491239   PMID:19494115   PMID:19502550   PMID:19505930   PMID:19509029   PMID:19513120  
PMID:19528970   PMID:19531256   PMID:19535678   PMID:19576209   PMID:19589781   PMID:19619509   PMID:19620723   PMID:19620781   PMID:19622746   PMID:19628573   PMID:19633656   PMID:19633657  
PMID:19636528   PMID:19651818   PMID:19656487   PMID:19675137   PMID:19680236   PMID:19688337   PMID:19706524   PMID:19706786   PMID:19730740   PMID:19737523   PMID:19737935   PMID:19738035  
PMID:19749180   PMID:19751733   PMID:19752026   PMID:19773811   PMID:19790050   PMID:19808894   PMID:19828684   PMID:19834009   PMID:19838201   PMID:19840239   PMID:19841237   PMID:19850873  
PMID:19864403   PMID:19875640   PMID:19883618   PMID:19885945   PMID:19887048   PMID:19888448   PMID:19898815   PMID:19917283   PMID:19929143   PMID:19940178   PMID:19955656   PMID:19961738  
PMID:19966187   PMID:19996103   PMID:20007767   PMID:20032483   PMID:20060009   PMID:20068132   PMID:20068135   PMID:20074524   PMID:20074527   PMID:20097762   PMID:20100487   PMID:20103702  
PMID:20107083   PMID:20122948   PMID:20157577   PMID:20164094   PMID:20185765   PMID:20200319   PMID:20200981   PMID:20223942   PMID:20227394   PMID:20231468   PMID:20348926   PMID:20354157  
PMID:20363835   PMID:20364085   PMID:20368432   PMID:20371609   PMID:20410123   PMID:20413511   PMID:20424269   PMID:20427662   PMID:20445103   PMID:20447400   PMID:20448152   PMID:20488786  
PMID:20501669   PMID:20506495   PMID:20522600   PMID:20532036   PMID:20534724   PMID:20538900   PMID:20541607   PMID:20546737   PMID:20592471   PMID:20595619   PMID:20601111   PMID:20603014  
PMID:20613882   PMID:20616094   PMID:20620997   PMID:20624962   PMID:20634301   PMID:20634488   PMID:20649970   PMID:20660304   PMID:20660733   PMID:20664173   PMID:20702576   PMID:20707912  
PMID:20727362   PMID:20739548   PMID:20798332   PMID:20807840   PMID:20808936   PMID:20813965   PMID:20824498   PMID:20842343   PMID:20851881   PMID:20851886   PMID:20876580   PMID:20881244  
PMID:20926971   PMID:20929976   PMID:20929977   PMID:20952387   PMID:20953578   PMID:20967535   PMID:20967828   PMID:21031339   PMID:21035758   PMID:21041703   PMID:21056997   PMID:21062956  
PMID:21068004   PMID:21078910   PMID:21084751   PMID:21086065   PMID:21109190   PMID:21109192   PMID:21119198   PMID:21119640   PMID:21123564   PMID:21134353   PMID:21135134   PMID:21139688  
PMID:21145759   PMID:21151569   PMID:21169216   PMID:21183787   PMID:21187319   PMID:21209012   PMID:21209019   PMID:21216976   PMID:21233451   PMID:21234744   PMID:21266330   PMID:21267068  
PMID:21270263   PMID:21278136   PMID:21285316   PMID:21289197   PMID:21298050   PMID:21325051   PMID:21325106   PMID:21325649   PMID:21334313   PMID:21338489   PMID:21356196   PMID:21378161  
PMID:21382979   PMID:21386087   PMID:21406387   PMID:21427219   PMID:21427359   PMID:21427410   PMID:21436399   PMID:21437243   PMID:21437772   PMID:21441440   PMID:21444625   PMID:21459326  
PMID:21464907   PMID:21520064   PMID:21520275   PMID:21521746   PMID:21532591   PMID:21533112   PMID:21550356   PMID:21554665   PMID:21555864   PMID:21557698   PMID:21572010   PMID:21576825  
PMID:21593203   PMID:21606595   PMID:21616110   PMID:21623172   PMID:21640075   PMID:21669879   PMID:21670064   PMID:21673305   PMID:21690486   PMID:21704006   PMID:21731759   PMID:21737754  
PMID:21743466   PMID:21745644   PMID:21756932   PMID:21804540   PMID:21852673   PMID:21853117   PMID:21856284   PMID:21865462   PMID:21873635   PMID:21885532   PMID:21885868   PMID:21892182  
PMID:21897366   PMID:21900603   PMID:21907142   PMID:21908604   PMID:21911492   PMID:21933985   PMID:21949859   PMID:21954068   PMID:21969596   PMID:21971349   PMID:21978495   PMID:21997794  
PMID:21998599   PMID:22000926   PMID:22009939   PMID:22037453   PMID:22037645   PMID:22037765   PMID:22042484   PMID:22044999   PMID:22051061   PMID:22067317   PMID:22075916   PMID:22078933  
PMID:22080103   PMID:22083962   PMID:22094601   PMID:22095235   PMID:22118645   PMID:22135239   PMID:22144677   PMID:22160191   PMID:22166979   PMID:22167524   PMID:22187378   PMID:22197240  
PMID:22201680   PMID:22202803   PMID:22205566   PMID:22207628   PMID:22210924   PMID:22225875   PMID:22227600   PMID:22232663   PMID:22253420   PMID:22253718   PMID:22259190   PMID:22261820  
PMID:22268099   PMID:22275362   PMID:22278400   PMID:22279186   PMID:22287654   PMID:22291185   PMID:22310664   PMID:22326225   PMID:22326952   PMID:22326958   PMID:22327204   PMID:22328591  
PMID:22341640   PMID:22345430   PMID:22370560   PMID:22381575   PMID:22383686   PMID:22395110   PMID:22396530   PMID:22405860   PMID:22415881   PMID:22427537   PMID:22427681   PMID:22434078  
PMID:22438574   PMID:22451920   PMID:22456428   PMID:22466652   PMID:22474027   PMID:22493092   PMID:22495310   PMID:22503562   PMID:22504909   PMID:22522563   PMID:22535963   PMID:22541436  
PMID:22570438   PMID:22580898   PMID:22581287   PMID:22581458   PMID:22596054   PMID:22610169   PMID:22621923   PMID:22628617   PMID:22647282   PMID:22669248   PMID:22674717   PMID:22682244  
PMID:22688330   PMID:22692856   PMID:22699504   PMID:22700774   PMID:22703581   PMID:22719268   PMID:22722451   PMID:22722857   PMID:22759970   PMID:22761160   PMID:22768838   PMID:22814966  
PMID:22815920   PMID:22829877   PMID:22833425   PMID:22841822   PMID:22848520   PMID:22849606   PMID:22851489   PMID:22868909   PMID:22887758   PMID:22904304   PMID:22927639   PMID:22936178  
PMID:22936179   PMID:22958918   PMID:22958920   PMID:22969086   PMID:22975078   PMID:22993381   PMID:23016759   PMID:23024263   PMID:23024365   PMID:23028821   PMID:23040070   PMID:23044938  
PMID:23045458   PMID:23064363   PMID:23071089   PMID:23099119   PMID:23104557   PMID:23105095   PMID:23115649   PMID:23117929   PMID:23139221   PMID:23149622   PMID:23149942   PMID:23178931  
PMID:23180096   PMID:23185367   PMID:23196413   PMID:23201226   PMID:23201486   PMID:23207144   PMID:23209186   PMID:23220275   PMID:23232360   PMID:23235530   PMID:23236292   PMID:23238296  
PMID:23248313   PMID:23257357   PMID:23272114   PMID:23274884   PMID:23274897   PMID:23281369   PMID:23285079   PMID:23291629   PMID:23295202   PMID:23299243   PMID:23312282   PMID:23329815  
PMID:23347184   PMID:23349477   PMID:23349487   PMID:23357303   PMID:23359322   PMID:23385644   PMID:23396210   PMID:23413430   PMID:23416070   PMID:23417423   PMID:23423172   PMID:23423572  
PMID:23447682   PMID:23471885   PMID:23473035   PMID:23482448   PMID:23504315   PMID:23505551   PMID:23518925   PMID:23520131   PMID:23520165   PMID:23530005   PMID:23542898   PMID:23544120  
PMID:23562077   PMID:23583845   PMID:23604321   PMID:23620818   PMID:23630288   PMID:23630583   PMID:23630616   PMID:23640861   PMID:23663742   PMID:23671120   PMID:23677171   PMID:23684624  
PMID:23688013   PMID:23695216   PMID:23700320   PMID:23711960   PMID:23720771   PMID:23723060   PMID:23726997   PMID:23736543   PMID:23737551   PMID:23762342   PMID:23775767   PMID:23782941  
PMID:23803760   PMID:23825223   PMID:23826244   PMID:23832089   PMID:23835338   PMID:23836106   PMID:23841921   PMID:23855826   PMID:23858470   PMID:23860123   PMID:23861552   PMID:23868745  
PMID:23869060   PMID:23894207   PMID:23897430   PMID:23904453   PMID:23919961   PMID:23963458   PMID:23964120   PMID:23973929   PMID:24035996   PMID:24038081   PMID:24058635   PMID:24062245  
PMID:24062247   PMID:24074871   PMID:24084737   PMID:24084738   PMID:24086476   PMID:24089355   PMID:24089373   PMID:24098417   PMID:24098442   PMID:24105484   PMID:24123166   PMID:24130336  
PMID:24150608   PMID:24155240   PMID:24165127   PMID:24166765   PMID:24169547   PMID:24194600   PMID:24206663   PMID:24211274   PMID:24212090   PMID:24220642   PMID:24226772   PMID:24241534  
PMID:24248353   PMID:24251118   PMID:24263282   PMID:24268736   PMID:24270983   PMID:24271843   PMID:24273001   PMID:24293639   PMID:24297699   PMID:24302741   PMID:24307731   PMID:24312665  
PMID:24315368   PMID:24326423   PMID:24326453   PMID:24343796   PMID:24347831   PMID:24361011   PMID:24361012   PMID:24361515   PMID:24374218   PMID:24391210   PMID:24394757   PMID:24399295  
PMID:24409114   PMID:24424041   PMID:24424049   PMID:24440570   PMID:24458155   PMID:24458360   PMID:24486192   PMID:24487023   PMID:24497646   PMID:24506866   PMID:24506868   PMID:24506870  
PMID:24516558   PMID:24519936   PMID:24519944   PMID:24561619   PMID:24569592   PMID:24581479   PMID:24582795   PMID:24583133   PMID:24585709   PMID:24586592   PMID:24591047   PMID:24595352  
PMID:24597547   PMID:24599937   PMID:24614199   PMID:24639549   PMID:24645678   PMID:24667636   PMID:24675804   PMID:24680679   PMID:24685581   PMID:24690172   PMID:24694605   PMID:24695736  
PMID:24703953   PMID:24708244   PMID:24717514   PMID:24722246   PMID:24741071   PMID:24742194   PMID:24743494   PMID:24752583   PMID:24760991   PMID:24781151   PMID:24781935   PMID:24807222  
PMID:24812663   PMID:24813992   PMID:24819473   PMID:24833719   PMID:24840347   PMID:24857376   PMID:24877561   PMID:24881856   PMID:24882746   PMID:24910243   PMID:24917577   PMID:24923522  
PMID:24939734   PMID:24944269   PMID:24947355   PMID:24947615   PMID:24955894   PMID:24956382   PMID:24966213   PMID:24966903   PMID:24976513   PMID:24985145   PMID:24986598   PMID:24989835  
PMID:24990938   PMID:24993831   PMID:24995979   PMID:24996410   PMID:25003192   PMID:25038826   PMID:25043058   PMID:25047119   PMID:25057200   PMID:25060689   PMID:25068621   PMID:25071024  
PMID:25116704   PMID:25119041   PMID:25125486   PMID:25144618   PMID:25144769   PMID:25157818   PMID:25158853   PMID:25193594   PMID:25198535   PMID:25223801   PMID:25233132   PMID:25233440  
PMID:25236782   PMID:25239306   PMID:25245291   PMID:25250519   PMID:25255053   PMID:25255859   PMID:25285996   PMID:25307347   PMID:25313970   PMID:25333972   PMID:25337938   PMID:25349437  
PMID:25352638   PMID:25352997   PMID:25368096   PMID:25370851   PMID:25371201   PMID:25391656   PMID:25395359   PMID:25395617   PMID:25397888   PMID:25404345   PMID:25409143   PMID:25433105  
PMID:25447227   PMID:25453257   PMID:25464737   PMID:25466899   PMID:25480301   PMID:25501551   PMID:25510553   PMID:25516549   PMID:25516614   PMID:25521581   PMID:25524914   PMID:25537833  
PMID:25550516   PMID:25555091   PMID:25565658   PMID:25568075   PMID:25576051   PMID:25576055   PMID:25579844   PMID:25594176   PMID:25605877   PMID:25621497   PMID:25628422   PMID:25633666  
PMID:25652850   PMID:25656573   PMID:25658689   PMID:25670497   PMID:25685701   PMID:25695914   PMID:25698262   PMID:25716801   PMID:25730108   PMID:25730471   PMID:25756181   PMID:25773177  
PMID:25774551   PMID:25774553   PMID:25819761   PMID:25826747   PMID:25830704   PMID:25837594   PMID:25843719   PMID:25844899   PMID:25849138   PMID:25864946   PMID:25869131   PMID:25894829  
PMID:25941406   PMID:25955205   PMID:25968479   PMID:25980347   PMID:25986657   PMID:26000480   PMID:26016715   PMID:26038578   PMID:26042770   PMID:26068544   PMID:26070086   PMID:26071405  
PMID:26074075   PMID:26076035   PMID:26077864   PMID:26083576   PMID:26098416   PMID:26120082   PMID:26122877   PMID:26133737   PMID:26134028   PMID:26135354   PMID:26150485   PMID:26166747  
PMID:26196541   PMID:26220769   PMID:26256903   PMID:26268630   PMID:26277398   PMID:26280538   PMID:26290368   PMID:26297880   PMID:26301810   PMID:26302162   PMID:26307585   PMID:26310911  
PMID:26324179   PMID:26332085   PMID:26348837   PMID:26362633   PMID:26368306   PMID:26370912   PMID:26385979   PMID:26387534   PMID:26403688   PMID:26406372   PMID:26410445   PMID:26417690  
PMID:26468261   PMID:26472867   PMID:26474534   PMID:26481668   PMID:26492472   PMID:26496899   PMID:26521149   PMID:26527067   PMID:26529285   PMID:26530443   PMID:26552046   PMID:26567290  
PMID:26573796   PMID:26586443   PMID:26592769   PMID:26625958   PMID:26639061   PMID:26644581   PMID:26648290   PMID:26653333   PMID:26655697   PMID:26696638   PMID:26701066   PMID:26701291  
PMID:26702093   PMID:26712468   PMID:26730935   PMID:26773096   PMID:26775030   PMID:26775176   PMID:26802310   PMID:26824363   PMID:26833098   PMID:26858440   PMID:26859333   PMID:26859361  
PMID:26868294   PMID:26873633   PMID:26876182   PMID:26880786   PMID:26882989   PMID:26895791   PMID:26899548   PMID:26899873   PMID:26909311   PMID:26919869   PMID:26923074   PMID:26923837  
PMID:26926925   PMID:26934227   PMID:26943364   PMID:26973883   PMID:26976243   PMID:26985063   PMID:26997281   PMID:27003684   PMID:27052164   PMID:27064285   PMID:27075628   PMID:27087445  
PMID:27105383   PMID:27128821   PMID:27131369   PMID:27135827   PMID:27137487   PMID:27166942   PMID:27166944   PMID:27176632   PMID:27195707   PMID:27207522   PMID:27207538   PMID:27213816  
PMID:27214655   PMID:27215388   PMID:27226618   PMID:27239029   PMID:27239042   PMID:27270587   PMID:27270589   PMID:27318140   PMID:27325287   PMID:27333268   PMID:27337687   PMID:27357657  
PMID:27358174   PMID:27381457   PMID:27388216   PMID:27396327   PMID:27408775   PMID:27445662   PMID:27457618   PMID:27479085   PMID:27488462   PMID:27500833   PMID:27520373   PMID:27524617  
PMID:27544029   PMID:27545894   PMID:27555288   PMID:27564111   PMID:27566543   PMID:27568546   PMID:27568549   PMID:27569282   PMID:27571135   PMID:27573204   PMID:27573812   PMID:27575855  
PMID:27588900   PMID:27589085   PMID:27593694   PMID:27605626   PMID:27616329   PMID:27619918   PMID:27626668   PMID:27635635   PMID:27644327   PMID:27689002   PMID:27693038   PMID:27708159  
PMID:27717825   PMID:27733447   PMID:27735945   PMID:27757953   PMID:27759039   PMID:27782940   PMID:27791019   PMID:27793638   PMID:27806304   PMID:27827305   PMID:27865839   PMID:27886513  
PMID:27889607   PMID:27907040   PMID:27935966   PMID:27938665   PMID:27940965   PMID:27941791   PMID:27941793   PMID:27986616   PMID:27992530   PMID:28011645   PMID:28069950   PMID:28091609  
PMID:28096235   PMID:28100475   PMID:28105518   PMID:28107353   PMID:28112679   PMID:28122051   PMID:28153708   PMID:28165007   PMID:28186389   PMID:28190775   PMID:28193789   PMID:28256596  
PMID:28257569   PMID:28297678   PMID:28302796   PMID:28322786   PMID:28325853   PMID:28340340   PMID:28343310   PMID:28363698   PMID:28381495   PMID:28383761   PMID:28404597   PMID:28414311  
PMID:28430962   PMID:28434881   PMID:28447181   PMID:28479296   PMID:28481357   PMID:28496206   PMID:28504650   PMID:28583918   PMID:28585545   PMID:28593811   PMID:28628102   PMID:28630133  
PMID:28645653   PMID:28647369   PMID:28650457   PMID:28654087   PMID:28676689   PMID:28678840   PMID:28694473   PMID:28698385   PMID:28701693   PMID:28705795   PMID:28710369   PMID:28720716  
PMID:28737771   PMID:28739528   PMID:28743992   PMID:28751653   PMID:28753423   PMID:28753653   PMID:28765602   PMID:28768177   PMID:28798136   PMID:28814745   PMID:28822786   PMID:28844948  
PMID:28846071   PMID:28851737   PMID:28852070   PMID:28864114   PMID:28877461   PMID:28878683   PMID:28883393   PMID:28887535   PMID:28891045   PMID:28893589   PMID:28894084   PMID:28911169  
PMID:28912580   PMID:28918935   PMID:28935755   PMID:28938414   PMID:28943435   PMID:28943448   PMID:28970284   PMID:28973648   PMID:28986573   PMID:28987875   PMID:28990936   PMID:29024666  
PMID:29028997   PMID:29032894   PMID:29035364   PMID:29046435   PMID:29054053   PMID:29056532   PMID:29074858   PMID:29075020   PMID:29077881   PMID:29091029   PMID:29101357   PMID:29107284  
PMID:29122890   PMID:29123236   PMID:29129613   PMID:29132537   PMID:29158088   PMID:29183623   PMID:29204732   PMID:29208957   PMID:29217450   PMID:29217773   PMID:29223394   PMID:29233862  
PMID:29243589   PMID:29258820   PMID:29261744   PMID:29267271   PMID:29298809   PMID:29311632   PMID:29326365   PMID:29330456   PMID:29343445   PMID:29343656   PMID:29381809   PMID:29391561  
PMID:29400713   PMID:29415997   PMID:29430655   PMID:29434323   PMID:29438518   PMID:29444429   PMID:29449623   PMID:29454584   PMID:29457786   PMID:29459681   PMID:29467755   PMID:29472382  
PMID:29483571   PMID:29504576   PMID:29519872   PMID:29522093   PMID:29522896   PMID:29523796   PMID:29528284   PMID:29535089   PMID:29539416   PMID:29551634   PMID:29562231   PMID:29596828  
PMID:29601978   PMID:29660503   PMID:29668871   PMID:29688375   PMID:29713129   PMID:29724723   PMID:29728617   PMID:29750244   PMID:29761783   PMID:29763605   PMID:29765402   PMID:29785025  
PMID:29787826   PMID:29794241   PMID:29852166   PMID:29853530   PMID:29867232   PMID:29880531   PMID:29891714   PMID:29891850   PMID:29914852   PMID:29925944   PMID:29937378   PMID:29944392  
PMID:29967158   PMID:29986925   PMID:30030460   PMID:30044988   PMID:30057068   PMID:30060148   PMID:30085057   PMID:30094465   PMID:30095299   PMID:30106375   PMID:30115652   PMID:30121753  
PMID:30135249   PMID:30158241   PMID:30174230   PMID:30181160   PMID:30216355   PMID:30226474   PMID:30232001   PMID:30241328   PMID:30243722   PMID:30279144   PMID:30279163   PMID:30283080  
PMID:30285278   PMID:30287858   PMID:30290217   PMID:30312306   PMID:30324491   PMID:30340828   PMID:30353146   PMID:30374109   PMID:30376348   PMID:30389681   PMID:30400011   PMID:30423168  
PMID:30469142   PMID:30582457   PMID:30595478   PMID:30605678   PMID:30608881   PMID:30638935   PMID:30658097   PMID:30692975   PMID:30694175   PMID:30700550   PMID:30709903   PMID:30718218  
PMID:30745182   PMID:30755607   PMID:30755658   PMID:30792482   PMID:30811418   PMID:30814508   PMID:30820969   PMID:30830262   PMID:30842678   PMID:30846562   PMID:30848574   PMID:30865891  
PMID:30893596   PMID:30898698   PMID:30905621   PMID:30923189   PMID:30926645   PMID:30938715   PMID:30955890   PMID:30990585   PMID:30998833   PMID:31023717   PMID:31033478   PMID:31085646  
PMID:31110021   PMID:31147543   PMID:31150280   PMID:31167128   PMID:31167878   PMID:31211621   PMID:31227742   PMID:31231354   PMID:31233501   PMID:31245789   PMID:31249331   PMID:31251698  
PMID:31266632   PMID:31271806   PMID:31273070   PMID:31287803   PMID:31290685   PMID:31291759   PMID:31295530   PMID:31296846   PMID:31300714   PMID:31309261   PMID:31329164   PMID:31346174  
PMID:31386565   PMID:31387986   PMID:31391336   PMID:31391339   PMID:31411897   PMID:31418690   PMID:31447776   PMID:31495688   PMID:31503545   PMID:31505214   PMID:31506541   PMID:31509546  
PMID:31509948   PMID:31518570   PMID:31530849   PMID:31543404   PMID:31545149   PMID:31564684   PMID:31594848   PMID:31597091   PMID:31597753   PMID:31624249   PMID:31624901   PMID:31648235  
PMID:31729980   PMID:31805276   PMID:31840160   PMID:31882890   PMID:31891805   PMID:31894105   PMID:31907998   PMID:31917686   PMID:31919470   PMID:31953394   PMID:31961706   PMID:31961715  
PMID:31987854   PMID:31988048   PMID:32008054   PMID:32009986   PMID:32026564   PMID:32058943   PMID:32092075   PMID:32101284   PMID:32108965   PMID:32127459   PMID:32151974   PMID:32164196  
PMID:32174013   PMID:32183843   PMID:32218572   PMID:32279995   PMID:32286361   PMID:32289482   PMID:32294435   PMID:32296847   PMID:32304665   PMID:32313051   PMID:32346034   PMID:32374776  
PMID:32375030   PMID:32413335   PMID:32439965   PMID:32442405   PMID:32451485   PMID:32561946   PMID:32595967   PMID:32603429   PMID:32632162   PMID:32698042   PMID:32699414   PMID:32709874  
PMID:32747789   PMID:32780722   PMID:32818435   PMID:32840013   PMID:32840762   PMID:32879136   PMID:32895383   PMID:32900697   PMID:32900852   PMID:32917985   PMID:33002003   PMID:33003626  
PMID:33058756   PMID:33065162   PMID:33066497   PMID:33080865   PMID:33094520   PMID:33106420   PMID:33157254   PMID:33206596   PMID:33277568   PMID:33324349   PMID:33340793   PMID:33370564  
PMID:33430468   PMID:33545051   PMID:33567453   PMID:33657393   PMID:33667344   PMID:33673387   PMID:33688917   PMID:33691105   PMID:33746008   PMID:33748705   PMID:33776901   PMID:33833312  
PMID:33846639   PMID:33856409   PMID:33895552   PMID:33911083   PMID:33951475   PMID:33974562   PMID:33980692   PMID:34010595   PMID:34015269   PMID:34017133   PMID:34260928   PMID:34275474  
PMID:34326208   PMID:34425095   PMID:34433051   PMID:34462445   PMID:34475098   PMID:34489483   PMID:34496251   PMID:34606993   PMID:34610354   PMID:34622154   PMID:34673376   PMID:34728642  
PMID:34731600   PMID:34732797   PMID:34818060   PMID:34824202   PMID:34830238   PMID:34857752   PMID:34857760   PMID:34871777   PMID:34954499   PMID:34964438   PMID:34986332   PMID:34994068  
PMID:35000230   PMID:35005562   PMID:35013417   PMID:35029277   PMID:35029658   PMID:35050801   PMID:35111151   PMID:35159134   PMID:35198900   PMID:35202387   PMID:35210404   PMID:35238641  
PMID:35243212   PMID:35245436   PMID:35264794   PMID:35298439   PMID:35323110   PMID:35328627   PMID:35349825   PMID:35372810   PMID:35409202   PMID:35409324   PMID:35440636   PMID:35478031  
PMID:35674408   PMID:35719268   PMID:35729232   PMID:35793654   PMID:35917179   PMID:35932615   PMID:35933481   PMID:35948634   PMID:35962137   PMID:35977541   PMID:36028048   PMID:36046814  
PMID:36050503   PMID:36078162   PMID:36104373   PMID:36109708   PMID:36117155   PMID:36142751   PMID:36160851   PMID:36161959   PMID:36228616   PMID:36229481   PMID:36240758   PMID:36261001  
PMID:36272977   PMID:36277726   PMID:36433953   PMID:36443308   PMID:36477540   PMID:36496438   PMID:36505926   PMID:36535401   PMID:36537765   PMID:36543979   PMID:36581316   PMID:36599953  
PMID:36690339   PMID:36710264   PMID:36726200   PMID:36797364   PMID:36866247   PMID:36891264   PMID:36895649   PMID:36917177   PMID:36917179   PMID:36977414   PMID:37020955   PMID:37034162  
PMID:37056368   PMID:37069175   PMID:37088120   PMID:37091852   PMID:37102688   PMID:37116777   PMID:37154299   PMID:37164743   PMID:37182513   PMID:37185802   PMID:37216518   PMID:37245295  
PMID:37316538   PMID:37318951   PMID:37334306   PMID:37341148   PMID:37341495   PMID:37402735   PMID:37435939   PMID:37467572   PMID:37488474   PMID:37502436   PMID:37511290   PMID:37590136  
PMID:37605533   PMID:37652169   PMID:37681411   PMID:37777412   PMID:37786973   PMID:37823674   PMID:37863933   PMID:37907171   PMID:37989315   PMID:38031726   PMID:38056462   PMID:38090745  
PMID:38145825   PMID:38147550   PMID:38211696   PMID:38302474   PMID:38314646   PMID:38355793   PMID:38362276   PMID:38460132   PMID:38524370   PMID:38561362   PMID:38569044   PMID:38580672  
PMID:38582490   PMID:38626531   PMID:38673910   PMID:38678562   PMID:38691458   PMID:38729945   PMID:38732183   PMID:38781074   PMID:38811804   PMID:38821928   PMID:38926424   PMID:38961186  
PMID:38972757   PMID:38974903   PMID:38992049  


Genomics

Comparative Map Data
Lep
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39629,060,220 - 29,073,875 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl629,060,219 - 29,073,876 (+)EnsemblGRCm39 Ensembl
GRCm38629,060,221 - 29,073,876 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl629,060,220 - 29,073,877 (+)EnsemblGRCm38mm10GRCm38
MGSCv37629,010,221 - 29,023,876 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36629,010,231 - 29,023,886 (+)NCBIMGSCv36mm8
Celera629,063,769 - 29,077,429 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.3NCBI
LEP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387128,241,278 - 128,257,629 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7128,241,278 - 128,257,629 (+)EnsemblGRCh38hg38GRCh38
GRCh377127,881,331 - 127,897,682 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367127,668,567 - 127,684,917 (+)NCBINCBI36Build 36hg18NCBI36
Build 347127,475,281 - 127,491,632NCBI
Celera7122,684,619 - 122,700,967 (+)NCBICelera
Cytogenetic Map7q32.1NCBI
HuRef7122,242,298 - 122,258,647 (+)NCBIHuRef
CHM1_17127,814,632 - 127,830,980 (+)NCBICHM1_1
T2T-CHM13v2.07129,552,743 - 129,569,093 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27127,264,455 - 127,280,803 (+)NCBI
Lep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8458,626,529 - 58,640,663 (+)NCBIGRCr8
mRatBN7.2457,661,127 - 57,675,262 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl457,661,131 - 57,675,262 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx462,644,034 - 62,658,181 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0458,559,814 - 58,573,975 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0456,962,087 - 56,976,240 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0456,337,695 - 56,351,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl456,337,695 - 56,351,818 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0456,085,079 - 56,099,209 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4455,943,837 - 55,945,938 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1456,185,364 - 56,197,221 (+)NCBI
Celera452,770,132 - 52,784,148 (+)NCBICelera
RH 3.4 Map4309.5RGD
Cytogenetic Map4q22NCBI
Lep
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554799,274,516 - 9,279,472 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554799,266,604 - 9,276,568 (+)NCBIChiLan1.0ChiLan1.0
LEP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26165,095,350 - 165,111,990 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1717,116,521 - 17,122,242 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07120,230,896 - 120,248,602 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17132,884,994 - 132,901,519 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7132,885,011 - 132,901,519 (+)Ensemblpanpan1.1panPan2
LEP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,115,396 - 8,130,946 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,116,122 - 8,131,395 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha147,802,696 - 7,807,108 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0147,880,580 - 7,897,895 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl147,883,040 - 7,897,890 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1148,087,574 - 8,091,986 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0147,828,397 - 7,832,809 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0147,975,126 - 7,979,538 (-)NCBIUU_Cfam_GSD_1.0
Lep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511854,282,689 - 54,287,494 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647915,394,966 - 15,411,334 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647915,394,966 - 15,411,334 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LEP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1820,106,868 - 20,123,323 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11820,106,867 - 20,124,071 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21821,200,988 - 21,231,275 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LEP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12197,056,913 - 97,071,161 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2197,057,529 - 97,071,220 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660426,335,426 - 6,349,076 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lep
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247837,708,588 - 7,721,727 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247837,708,820 - 7,721,610 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lep
384 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1074
Count of miRNA genes:663
Interacting mature miRNAs:792
Transcripts:ENSMUST00000069789, ENSMUST00000169505
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
11353836Bmiq1_mbody mass index QTL 1 (mouse)6450382329751333Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
1301131Chol2_mcholesterol 2 (mouse)Not determined6132144495Mouse
1302024Skull7_mskull morphology 7 (mouse)Not determined6132144495Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
5491191Mobq2_mmultigenic obesity QTL 2 (mouse)Not determined6132144495Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
1300731Smdq3_msegregation of mitochondrial DNA QTL 3 (mouse)Not determined6424920638249325Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
15039372Nmrs22_mNAFLD-associated magnetic resonance shift 22 (mouse)6147633435476334Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse

Markers in Region
PMC187774P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38629,070,970 - 29,071,082UniSTSGRCm38
MGSCv37629,020,970 - 29,021,082UniSTSGRCm37
Celera629,074,523 - 29,074,635UniSTS
Cytogenetic Map6A3.3UniSTS
PMC23608P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38629,070,959 - 29,071,100UniSTSGRCm38
MGSCv37629,020,959 - 29,021,100UniSTSGRCm37
Celera629,074,512 - 29,074,653UniSTS
Cytogenetic Map6A3.3UniSTS
PMC316374P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38629,059,370 - 29,060,180UniSTSGRCm38
MGSCv37629,009,370 - 29,010,180UniSTSGRCm37
Celera629,062,918 - 29,063,728UniSTS
Cytogenetic Map6A3.3UniSTS
Lep  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38629,070,887 - 29,071,077UniSTSGRCm38
MGSCv37629,020,887 - 29,021,077UniSTSGRCm37
Celera629,074,440 - 29,074,630UniSTS
Cytogenetic Map6A3.3UniSTS
cM Map610.5UniSTS
Lep  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38629,070,975 - 29,071,075UniSTSGRCm38
MGSCv37629,020,975 - 29,021,075UniSTSGRCm37
Celera629,074,528 - 29,074,628UniSTS
Cytogenetic Map6A3.3UniSTS
cM Map610.5UniSTS
Lep  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38629,070,975 - 29,071,075UniSTSGRCm38
MGSCv37629,020,975 - 29,021,075UniSTSGRCm37
Celera629,074,528 - 29,074,628UniSTS
Cytogenetic Map6A3.3UniSTS
cM Map610.5UniSTS
Lep  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6A3.3UniSTS
cM Map610.5UniSTS
Lep  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38629,073,189 - 29,073,394UniSTSGRCm38
MGSCv37629,023,189 - 29,023,394UniSTSGRCm37
Celera629,076,742 - 29,076,947UniSTS
Cytogenetic Map6A3.3UniSTS
cM Map610.5UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000069789   ⟹   ENSMUSP00000067046
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl629,060,219 - 29,073,876 (+)Ensembl
GRCm38.p6 Ensembl629,060,220 - 29,073,877 (+)Ensembl
Ensembl Acc Id: ENSMUST00000169505   ⟹   ENSMUSP00000130087
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl629,065,461 - 29,070,971 (+)Ensembl
GRCm38.p6 Ensembl629,065,462 - 29,070,972 (+)Ensembl
RefSeq Acc Id: NM_008493   ⟹   NP_032519
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39629,060,220 - 29,073,875 (+)NCBI
GRCm38629,060,221 - 29,073,876 (+)NCBI
MGSCv37629,010,221 - 29,023,876 (+)RGD
Celera629,063,769 - 29,077,429 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032519   ⟸   NM_008493
- Peptide Label: precursor
- UniProtKB: P41160 (UniProtKB/Swiss-Prot),   Q544U0 (UniProtKB/TrEMBL),   E9M0G2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000130087   ⟸   ENSMUST00000169505
Ensembl Acc Id: ENSMUSP00000067046   ⟸   ENSMUST00000069789

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41160-F1-model_v2 AlphaFold P41160 1-167 view protein structure

Promoters
RGD ID:6889158
Promoter ID:EPDNEW_M8030
Type:single initiation site
Name:Lep_1
Description:Mus musculus leptin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38629,060,220 - 29,060,280EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104663 AgrOrtholog
Ensembl Genes ENSMUSG00000059201 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000069789 ENTREZGENE
  ENSMUST00000069789.12 UniProtKB/Swiss-Prot
  ENSMUST00000169505.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leptin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16846 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104663 ENTREZGENE
NCBI Gene 16846 ENTREZGENE
PANTHER LEPTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11724 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Leptin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB LEP RGD
PhenoGen Lep PhenoGen
PIRSF Leptin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS LEPTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1C9CJK6_MOUSE UniProtKB/TrEMBL
  E9M0G2 ENTREZGENE, UniProtKB/TrEMBL
  E9Q7Z0_MOUSE UniProtKB/TrEMBL
  LEP_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q544U0 ENTREZGENE, UniProtKB/TrEMBL