Lep (leptin) - Rat Genome Database

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Gene: Lep (leptin) Mus musculus
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Symbol: Lep
Name: leptin
RGD ID: 69124
MGI Page MGI
Description: Enables DNA binding activity and growth factor activity. Involved in several processes, including adult feeding behavior; positive regulation of cytokine production; and positive regulation of signal transduction. Acts upstream of or within several processes, including determination of adult lifespan; monocarboxylic acid metabolic process; and regulation of protein localization. Located in cytoplasm and extracellular space. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; early conceptus; and reproductive system. Used to study abdominal obesity-metabolic syndrome (multiple); obesity; steatotic liver disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (leptin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ob; obese; obesity factor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39629,060,220 - 29,073,875 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl629,060,219 - 29,073,876 (+)EnsemblGRCm39 Ensembl
GRCm38629,060,221 - 29,073,876 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl629,060,220 - 29,073,877 (+)EnsemblGRCm38mm10GRCm38
MGSCv37629,010,221 - 29,023,876 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36629,010,231 - 29,023,886 (+)NCBIMGSCv36mm8
Celera629,063,769 - 29,077,429 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model