LOC101968976 (leptin) - Rat Genome Database

Name: LOC101968976
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer VCMap Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: LOC101968976 (leptin) Ictidomys tridecemlineatus

Analyze

Symbol:

LOC101968976

Name:

leptin

RGD ID:

12679583

Description:

ENCODES a protein that exhibits growth factor activity (ortholog); hormone activity (ortholog); peptide hormone receptor binding (ortholog); INVOLVED IN adipose tissue development (ortholog); aorta development (ortholog); bile acid metabolic process (ortholog); PARTICIPATES IN altered energy homeostasis pathway; altered leptin system pathway; energy homeostasis pathway; ASSOCIATED WITH acute pancreatitis (ortholog); acute promyelocytic leukemia (ortholog); adult respiratory distress syndrome (ortholog); FOUND IN cytosol (ortholog); extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Lep

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LEP (leptin)	NCBI	Ortholog
Mus musculus (house mouse):	Lep (leptin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Lep (leptin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Lep (leptin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LEP (leptin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LEP (leptin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LEP (leptin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LOC103226854 (leptin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lep (leptin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	54,282,689 - 54,287,494 (+)	NCBI
SpeTri2.0	NW_004936479	15,394,966 - 15,411,334 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute pancreatitis (ISO)

acute promyelocytic leukemia (ISO)

adult respiratory distress syndrome (ISO)

alcohol dependence (ISO)

alcoholic liver cirrhosis (ISO)

Alzheimer's disease (ISO)

asthma (ISO)

autistic disorder (ISO)

autoimmune hepatitis (ISO)

bacterial pneumonia (ISO)

Body Weight Changes (ISO)

Brain Injuries (ISO)

breast cancer (ISO)

Breast Neoplasms (ISO)

Choroidal Neovascularization (ISO)

Chronic Hepatitis C (ISO)

chronic obstructive pulmonary disease (ISO)

Colonic Neoplasms (ISO)

congenital leptin deficiency (ISO)

congestive heart failure (ISO)

Crohn's disease (ISO)

cystic fibrosis (ISO)

diabetes mellitus (ISO)

Diabetic Nephropathies (ISO)

Dyslipidemias (ISO)

End Stage Liver Disease (ISO)

end stage renal disease (ISO)

Experimental Arthritis (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Cirrhosis (ISO)

familial hyperlipidemia (ISO)

fatty liver disease (ISO)

Female Infertility (ISO)

Femoral Fractures (ISO)

Fetal Growth Retardation (ISO)

gastric ulcer (ISO)

gestational diabetes (ISO)

glucose intolerance (ISO)

hepatocellular carcinoma (ISO)

hepatocellular clear cell carcinoma (ISO)

Hepatomegaly (ISO)

heroin dependence (ISO)

Huntington's disease (ISO)

Hypercapnia (ISO)

Hypercholesterolemia (ISO)

hyperglycemia (ISO)

hyperinsulinism (ISO)

Hyperphagia (ISO)

Hyperplasia (ISO)

hypertension (ISO)

Hypertriglyceridemia (ISO)

hypogonadism (ISO)

Hypoventilation (ISO)

Inflammation (ISO)

Insulin Resistance (ISO)

Kidney Reperfusion Injury (ISO)

Knee Osteoarthritis (ISO)

lipid metabolism disorder (ISO)

lung disease (ISO)

lung non-small cell carcinoma (ISO)

Mammary Neoplasms, Experimental (ISO)

Metabolic Syndrome (ISO)

morbid obesity (ISO)

Myocardial Reperfusion Injury (ISO)

Nerve Degeneration (ISO)

non-alcoholic fatty liver disease (ISO)

obesity (ISO)

obstructive sleep apnea (ISO)

Oral Ulcer (ISO)

osteoarthritis (ISO)

osteoporosis (ISO)

Parkinson's disease (ISO)

pleomorphic xanthoastrocytoma (ISO)

Pneumococcal Pneumonia (ISO)

polycystic ovary syndrome (ISO)

Polydipsia (ISO)

Polyuria (ISO)

pre-eclampsia (ISO)

primary biliary cholangitis (ISO)

Prostatic Neoplasms (ISO)

proteinuria (ISO)

renal cell carcinoma (ISO)

Reperfusion Injury (ISO)

rhinitis (ISO)

Sepsis (ISO)

short bowel syndrome (ISO)

Spinal Cord Injuries (ISO)

Tachycardia (ISO)

type 2 diabetes mellitus (ISO)

visual epilepsy (ISO)

Weight Gain (ISO)

Weight Loss (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of protein kinase C activity (IEA)

adipose tissue development (IEA,ISO)

adult feeding behavior (IEA)

angiogenesis (IEA)

aorta development (IEA,ISO)

bile acid metabolic process (IEA,ISO)

bone growth (IEA)

bone mineralization involved in bone maturation (ISO)

cardiac muscle hypertrophy (ISO)

cellular response to insulin stimulus (IEA,ISO)

cellular response to L-ascorbic acid (ISO)

cellular response to leptin stimulus (IEA)

cellular response to retinoic acid (ISO)

central nervous system neuron development (IEA,ISO)

cholesterol metabolic process (IEA,ISO)

circadian rhythm (ISO)

determination of adult lifespan (IEA,ISO)

eating behavior (IEA,ISO)

elastin metabolic process (IEA,ISO)

energy reserve metabolic process (ISO)

fatty acid beta-oxidation (IEA,ISO)

fatty acid catabolic process (ISO)

female pregnancy (ISO)

glucose homeostasis (IEA,ISO)

glucose metabolic process (IEA,ISO)

glycerol biosynthetic process (ISO)

hormone metabolic process (IEA,ISO)

insulin secretion (IEA,ISO)

intestinal absorption (IEA)

intracellular signal transduction (ISO)

leptin-mediated signaling pathway (IEA,ISO)

leukocyte tethering or rolling (ISO)

lipid metabolic process (IEA,ISO)

negative regulation of apoptotic process (ISO)

negative regulation of appetite (IEA)

negative regulation of appetite by leptin-mediated signaling pathway (ISO)

negative regulation of autophagy (IEA)

negative regulation of cartilage development (ISO)

negative regulation of glucagon secretion (IEA)

negative regulation of glucose import (IEA)

negative regulation of glutamine transport (ISO)

negative regulation of insulin receptor signaling pathway (ISO)

negative regulation of lipid storage (ISO)

negative regulation of metabolic process (ISO)

negative regulation of transcription by RNA polymerase II (IEA)

negative regulation of vasoconstriction (ISO)

ovulation from ovarian follicle (ISO)

phagocytosis (IEA)

placenta development (IEA)

positive regulation of cell population proliferation (ISO)

positive regulation of cold-induced thermogenesis (IEA)

positive regulation of cytokine production (ISO)

positive regulation of developmental growth (IEA)

positive regulation of fat cell apoptotic process (ISO)

positive regulation of follicle-stimulating hormone secretion (ISO)

positive regulation of hepatic stellate cell activation (ISO)

positive regulation of insulin receptor signaling pathway (ISO)

positive regulation of interleukin-12 production (IEA)

positive regulation of interleukin-6 production (IEA)

positive regulation of interleukin-8 production (IEA)

positive regulation of ion transport (ISO)

positive regulation of luteinizing hormone secretion (ISO)

positive regulation of MAPK cascade (IEA,ISO)

positive regulation of myeloid cell differentiation (ISO)

positive regulation of p38MAPK cascade (IEA)

positive regulation of peroxisome proliferator activated receptor signaling pathway (ISO)

positive regulation of phosphatidylinositol 3-kinase signaling (IEA)

positive regulation of protein import into nucleus (IEA)

positive regulation of protein kinase B signaling (IEA)

positive regulation of protein phosphorylation (IEA)

positive regulation of reactive oxygen species metabolic process (ISO)

positive regulation of receptor signaling pathway via JAK-STAT (IEA,ISO)

positive regulation of T cell proliferation (IEA)

positive regulation of TOR signaling (IEA)

positive regulation of tumor necrosis factor production (IEA)

positive regulation of tyrosine phosphorylation of STAT protein (ISO)

prostaglandin secretion (IEA)

regulation of angiogenesis (IEA)

regulation of blood pressure (ISO)

regulation of bone remodeling (IEA)

regulation of brown fat cell differentiation (IEA)

regulation of catalytic activity (IEA,ISO)

regulation of cell cycle (IEA)

regulation of cytokine production involved in inflammatory response (IEA)

regulation of endothelial cell proliferation (IEA)

regulation of fat cell differentiation (IEA,ISO)

regulation of gluconeogenesis (IEA,ISO)

regulation of insulin secretion (IEA,ISO)

regulation of intestinal cholesterol absorption (IEA,ISO)

regulation of lipid biosynthetic process (IEA,ISO)

regulation of lipoprotein lipid oxidation (ISO)

regulation of metabolic process (IEA,ISO)

regulation of natural killer cell activation (IEA)

regulation of natural killer cell mediated cytotoxicity (IEA)

regulation of natural killer cell proliferation (IEA)

regulation of nitric-oxide synthase activity (IEA)

regulation of protein localization to nucleus (IEA,ISO)

regulation of protein phosphorylation (IEA)

regulation of steroid biosynthetic process (IEA,ISO)

response to activity (ISO)

response to dietary excess (IEA,ISO)

response to estradiol (ISO)

response to ethanol (ISO)

response to hypoxia (ISO)

response to insulin (IEA,ISO)

response to nutrient (ISO)

response to nutrient levels (ISO)

response to vitamin E (ISO)

sexual reproduction (IEA)

signal transduction (IEA)

T cell differentiation (IEA)

tyrosine phosphorylation of STAT protein (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (ISO)

extracellular region (IEA)

extracellular space (IEA,ISO)

Molecular Function

cytokine activity (IEA)

DNA binding (IEA)

growth factor activity (ISO)

hormone activity (IEA,ISO)

leptin receptor binding (IEA)

peptide hormone receptor binding (ISO)

protein binding (ISO)

signaling receptor binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

altered energy homeostasis pathway (ISO)

altered leptin system pathway (ISO)

energy homeostasis pathway (ISO)

hypoxia inducible factor pathway (ISO)

leptin system pathway (ISO)

References

Genomics

Comparative Map Data

LOC101968976
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	54,282,689 - 54,287,494 (+)	NCBI
SpeTri2.0	NW_004936479	15,394,966 - 15,411,334 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LEP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	128,241,278 - 128,257,629 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	7	128,241,278 - 128,257,629 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	127,881,331 - 127,897,682 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	127,668,567 - 127,684,917 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	7	127,475,281 - 127,491,632	NCBI
Celera	7	122,684,619 - 122,700,967 (+)	NCBI
Cytogenetic Map	7	q32.1	NCBI
HuRef	7	122,242,298 - 122,258,647 (+)	NCBI		HuRef
CHM1_1	7	127,814,632 - 127,830,980 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	129,552,743 - 129,569,093 (+)	NCBI
CRA_TCAGchr7v2	7	127,264,455 - 127,280,803 (+)	NCBI

Lep
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	29,060,220 - 29,073,875 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	6	29,060,219 - 29,073,876 (+)	Ensembl
GRCm38	6	29,060,221 - 29,073,876 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	29,060,220 - 29,073,877 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	29,010,221 - 29,023,876 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	6	29,010,231 - 29,023,886 (+)	NCBI			mm8
Celera	6	29,063,769 - 29,077,429 (+)	NCBI		Celera
Cytogenetic Map	6	A3.3	NCBI
cM Map	6	12.3	NCBI

Lep
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	57,661,127 - 57,675,262 (+)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	4	57,661,131 - 57,675,262 (+)	Ensembl
Rnor_6.0	4	56,337,695 - 56,351,818 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	56,337,695 - 56,351,818 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	56,085,079 - 56,099,209 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	55,943,837 - 55,945,938 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	4	56,185,364 - 56,197,221 (+)	NCBI
Celera	4	52,770,132 - 52,784,148 (+)	NCBI		Celera
RH 3.4 Map	4	309.5	RGD
Cytogenetic Map	4	q22	NCBI

Lep
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955479	9,274,516 - 9,279,472 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955479	9,266,604 - 9,276,568 (+)	NCBI	ChiLan1.0	ChiLan1.0

LEP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	7	132,884,994 - 132,901,519 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	132,885,011 - 132,901,519 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	7	120,230,896 - 120,248,602 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

LEP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	8,115,396 - 8,130,946 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	8,116,122 - 8,131,395 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	7,802,696 - 7,807,108 (-)	NCBI
ROS_Cfam_1.0	14	7,880,580 - 7,897,895 (-)	NCBI
ROS_Cfam_1.0 Ensembl	14	7,883,040 - 7,897,890 (-)	Ensembl
UMICH_Zoey_3.1	14	8,087,574 - 8,091,986 (-)	NCBI
UNSW_CanFamBas_1.0	14	7,828,397 - 7,832,809 (-)	NCBI
UU_Cfam_GSD_1.0	14	7,975,126 - 7,979,538 (-)	NCBI

LEP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	20,106,868 - 20,123,447 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	20,106,867 - 20,124,071 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	21,200,988 - 21,231,275 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103226854
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	97,056,913 - 97,071,161 (+)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	21	97,057,529 - 97,071,220 (+)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666042	6,335,426 - 6,349,076 (-)	NCBI	Vero_WHO_p1.0

Lep
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624783	7,708,588 - 7,721,727 (-)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624783	7,708,820 - 7,721,610 (-)	NCBI	HetGla_female_1.0		hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005319415	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

XM_005319415 ⟹ XP_005319472

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	54,282,689 - 54,287,494 (+)	NCBI
SpeTri2.0	NW_004936479	15,394,966 - 15,411,334 (+)	NCBI

Sequence:

show sequence

AATCCCCGGTGCCAGCAGCTGCGAGGCCCAAGAAGCACATCCTGGGGAGGAAAATGCGCTGTGG
ACGCCTGTGCCAGTTCCTGTGGCTTTGGCCCTATCTGTCTTATGTTCAAGCTGTGCCCATCCGA
AAAGTCCAGGATGACACCAAAACCCTCATCAAGACTATTGTCACCAGGATCAATGACATTTCAC
ACACGCAGTCGGTGTCCTCCAAGCAGAGGGTCACTGGTTTGGACTTCATTCCTGGGCTTCACCC
GGTCCTGAGTTTGTCCAAAATGGACCAGACATTGGCAGTCTACCAACAGATCCTCACCAGTCTG
CCTTCCCAAAATGTGATGCAAATATCTAATGACCTGGAGAACCTCCGGGACCTTCTCCGCCTGC
TGGCTTCCTCCAAGAGCTGCCCTCTGCCCCAGACCAGTGGTCTGGAGACTCTAGAGAGCCTGGA
TGGTGTCCTGGAAGCCTCTCTCTATTCCACAGAGGTAGTGGCTCTGAGCAGGCTGCAAGGGTCT
CTACAGGGGATGCTGAGGCAGCTGGACTTCAGCCCCAGATGCTGAAGCCTTGAGCGCTGCTCTT
CCCCCAAGGAGCATGGAGAAGGAAGAAACCTTGGCTTCCAGGTGACTGGAGGAGAAGAGAGCTT
TGTATGGACATCCTTTATCCAGGACTCTGTCCATGTCTCTCCCTCCTCTAATCCACCCTTCCAA
AGGCGAAGACTCCACGTTGCTTGAAACCAAAGATATATATACACATGATTCCTCGCTCGCTGAA
AGGGGGTCCATCCAGCAGAGTGGATTGTTGCTGTGATTCTCGCCAAATTCTTCAGCCATCGACC
AGAGTCATCCTGTCCTCTCCCCATTCCATCTCCCTCTCTGCTTGCTTCAGGGCAATCCAGGGTG
ATTTTAGGAGTGGGGTGGGCAGAGCCTCTGGATCTTTTCAGAAACAAGTTTCTATTTGAGAATT
CTAGGGAGCACCATGAAGGCTACGTCCACACACAGCTAGAAACTCCCAAGCAACACACGTTGGA
AGAACTTATTTATTGATTATGTATTTTACTCTGAATGGATGTAAAGCAAAGCACCAGCTTTTCC
ATGCTTTGGGGTCAGCAAGGGCTGCACATGCCCCTGGGATGTTGTTTCCAATCCCATCCATGAG
TCTGGCTGAGGCAAACCCACTTTGAGTGACTAGAAGGTTGGGATTGTCTAAGCAAGAGTCAGCC
GGGTGGTTCTCAAGTTAGTTCTGTAGTGACTGCTTTTGTTTCTATTGTGAATGACTTTACAGTA
TAGTGTTTGCAATGACATAGCCCTAAGGGCTGGGTTATTTTAAAAAGAAGATGAATTTCATCAA
GTGTAATGTGAATCGTATGTACCCCAGGGTGGGGGATGTGTTAGAAACAGGGTAGGATCCAGAT
GTTATTTTCTGAATAACATTTGTGTGGTAGGCTTTTGGGAAAGGGTAAAGTCATCTTGTTTTCT
ACAACCACACTAGGGTGGTTTCAATGCAAAGAACAAACAAGATGACTTCTGAAGGGGGACTGTG
AGGTTTTCTAGGCACCCATGGAGGGAGGGTGCTGAAGGAGAAGGCCATTTGTTGGGGGTAGTGA
TGAGCTCAGGGAGTGAGGGTCCCACACTTATGACAGTGTGTCACTGGTGTGACCCTCTAAGTAT
TCCAGGGTTGATCCCACACTGGATTTATAACATGGCAGTGGCCTTATTGTGGGTTGCATGTCAA
ATTGTGGTTCTCATCTGATTGGTTCAGCCAAAGCAAGGCCATGTTTTCCACCCATTCTGTGGGG
ATTTTTAGTCCAGTGGGAAAGGAAAATCCTTTAGCAGATGGTCCTAAGCCCTGGGACTTCTGGG
TTAGTGCCAGGGCCCCTGGCCAGACTGTAGGACTGCCCTTCAGCTGGAGGTCATGTTCAGGCAG
ATGAACAAGGAGGCTTGGGTTTTTCCACCACCCTGCCACAGTGTCACCGTCACATTGTTAGTAG
TGATTCTGCCCAAGGAAACTTGAATCAAAGCAATACACTTTAGACTGAGTGCCTGCTTGGTGCT
CAGCCCTGACTGGTGCTGTGGGCTAGAGAGCTCACCAAATAAACGTAAAAATCAGGGACTTGCA
TCCCCATGCTAAAAACCCCCACTCACCATGTGCCAAGGTGGATGCCTCACCAAGGTGGCACCCA
ACAGCTGAAAGCAGAGTGTTGCCTTCAGCAGGTGGAAGTGGCATGAGCTGAGGGTGACAGTGCT
CAGGAAACCCTGTTCGCACTCTGTAGCATTTATATACTTTTTAGAATGCGTTAGCCTCTATTGC
TGCATAGTACATTCTGTTAATGCAGGATAACTAAAACTGCAAAAATAAGAAAATACAGGTTGAG
TATCCCTTATCCAAAATGCTTGGTGCCAGAAGTGTTTGGATTTTGGATTTTTTTTCTCATTATT
GGAATATCCGCATATACATAATGAGTTATCTTGGGTAGGGGACCCAAATGCACACAGATAATTC
ATTTCTATTTCATAAATACCTTATATACACAGTTTGAAGGTAATTTATCCCATATTTTTAATAA
TTATGTGCATGAAATGAAGTTTCATGCTGTGGAATTTTCCACTCATGGCAACATGTCATCATTC
AAGACATTTTGGAGTTTGGAGCATTTCAGCTCTTGGATTTTCAGATAAGGGATGCTTACCCTGT
ACCCAAGACTATCACAGCCAACATGCAGAAGACCAGGCCTAGAGTCCAGCCTCTGATCCCTAGT
GTACCTCAATCCAGGTACGCTCTGTGGAGATAAACTGGAGCAAAGGGAGACCACTAGTTCTCTC
TGGAAGAGAGGGACTTGGGAGTGGATTTTGAAGGAGATGAGGAATGTGAATTGCCTGTCAGAGG
AAGCTGTTTGTTGGAAGTTTGGTGGGTGGAGATGCAGAGGTGAAAGTGTGAGCTTCGAGTGAAA
GCAACAGGTAGAGAAAGAAGAGATGGGAGGGAAAAGGATACATTGAATAGGCCCTGAGGAGCAC
AGGAGTTGGGTATTAGAGCCGAGTTTCAGGTTCTGGAGCAGATGCAGTGTGGTGGCCAGGGCCA
GTCCTGCTCTGAGGGTGGTGGCAGGTCACCTCACCCACCTCATCAGGAATTTTCTTGAGGCTTG
TTCACAAACCTGGCACAGTGGCTTCCAGAACGCGAAACTTCCCAAATGCAAATGGTTGTCTTTT
TTTCTTTTTAACAATAAAATTTTTGTTTTGTTTAAAATTTTTTTTTCAAATAAATTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005319472	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	KAG3277749	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_005319472 ⟸ XM_005319415
- UniProtKB:	I3MST8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRCGRLCQFLWLWPYLSYVQAVPIRKVQDDTKTLIKTIVTRINDISHTQSVSSKQRVTGLDFIP GLHPVLSLSKMDQTLAVYQQILTSLPSQNVMQISNDLENLRDLLRLLASSKSCPLPQTSGLETL ESLDGVLEASLYSTEVVALSRLQGSLQGMLRQLDFSPRC hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000027970	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSSTOP00000015183	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000029672	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1250.10	UniProtKB/TrEMBL
InterPro	4_helix_cytokine-like_core	UniProtKB/TrEMBL
	Leptin	UniProtKB/TrEMBL
NCBI Gene	Lep	ENTREZGENE
PANTHER	PTHR11724	UniProtKB/TrEMBL
Pfam	Leptin	UniProtKB/TrEMBL
PIRSF	Leptin	UniProtKB/TrEMBL
PRINTS	LEPTIN	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47266	UniProtKB/TrEMBL
UniProt	I3MST8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-26	LOC101968976	leptin	Lep	leptin	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)