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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69124
Species: Mus musculus
RGD Object: Gene
Symbol: Lep
Name: leptin
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lepincreases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of LEP proteinPMID:29987408
Lepmultiple interactionsEXP 6480464CTDLEP protein affects the reaction [Carbon Tetrachloride results in increased activity of STAT3 protein]; LEP protein affects the reaction [Carbon Tetrachloride results in increased degradation of NFKBIA protein]; LEP protein affects the reaction [Carbon Tetrachloride results in increased expression of CCND1 protein]; LEP protein affects the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; LEP protein affects the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; LEP protein affects the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; LEP protein affects the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; LEP protein affects the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; LEP protein affects the reaction [Carbon Tetrachloride results in increased localization of RELA protein]; LEP protein promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; LEP protein promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; LEP protein promotes the reaction [Carbon Tetrachloride results in increased expression of SERPINH1 mRNA]; LEP protein promotes the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]PMID:11481614 PMID:12586293 PMID:12730884
Lepincreases expressionISOLep (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in increased expression of LEP proteinPMID:27623180
Lepmultiple interactionsISOLep (Rattus norvegicus)6480464CTD[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein; [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP mRNA; [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP protein; Drugs, Chinese Herbal inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein]PMID:14758566 PMID:18227024
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