GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Lep | increases expression | EXP | | 6480464 | CTD | Carbon Tetrachloride results in increased expression of LEP protein | PMID:29987408 | Lep | multiple interactions | EXP | | 6480464 | CTD | LEP protein affects the reaction [Carbon Tetrachloride results in increased activity of STAT3 protein]; LEP protein affects the reaction [Carbon Tetrachloride results in increased degradation of NFKBIA protein]; LEP protein affects the reaction [Carbon Tetrachloride results in increased expression of CCND1 protein]; LEP protein affects the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; LEP protein affects the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; LEP protein affects the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; LEP protein affects the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; LEP protein affects the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; LEP protein affects the reaction [Carbon Tetrachloride results in increased localization of RELA protein]; LEP protein promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; LEP protein promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; LEP protein promotes the reaction [Carbon Tetrachloride results in increased expression of SERPINH1 mRNA]; LEP protein promotes the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] | PMID:11481614 PMID:12586293 PMID:12730884 | Lep | increases expression | ISO | Lep (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride results in increased expression of LEP protein | PMID:27623180 | Lep | multiple interactions | ISO | Lep (Rattus norvegicus) | 6480464 | CTD | [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein; [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP mRNA; [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP protein; Drugs, Chinese Herbal inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein] | PMID:14758566 PMID:18227024 | |
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