LEP (leptin) - Rat Genome Database

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Gene: LEP (leptin) Homo sapiens
Analyze
Symbol: LEP
Name: leptin
RGD ID: 69123
HGNC Page HGNC:6553
Description: Enables leptin receptor binding activity. Involved in several processes, including positive regulation of signal transduction; regulation of cytokine production; and regulation of lymphocyte proliferation. Predicted to be located in cytosol. Predicted to be active in extracellular space. Implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Biomarker of several diseases, including alcohol dependence; bone disease (multiple); fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: FLJ94114; LEPD; leptin (murine obesity homolog); leptin (obesity homolog, mouse); OB; obese protein; obese, mouse, homolog of; obesity factor; OBS
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Candidate Gene For: BW191_H BW101_H BW258_H BW257_H BW256_H SLEP5_H SLEP9_H
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387128,241,278 - 128,257,629 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7128,241,278 - 128,257,629 (+)EnsemblGRCh38hg38GRCh38
GRCh377127,881,331 - 127,897,682 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367127,668,567 - 127,684,917 (+)NCBINCBI36Build 36hg18NCBI36
Build 347127,475,281 - 127,491,632NCBI
Celera7122,684,619 - 122,700,967 (+)NCBICelera
Cytogenetic Map7q32.1NCBI
HuRef7122,242,298 - 122,258,647 (+)NCBIHuRef
CHM1_17127,814,632 - 127,830,980 (+)NCBICHM1_1
T2T-CHM13v2.07129,552,743 - 129,569,093 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27127,264,455 - 127,280,803 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISS)
abdominal obesity-metabolic syndrome 1  (ISS)
acute pancreatitis  (ISO)
acute promyelocytic leukemia  (EXP)
adult respiratory distress syndrome  (IDA)
alcohol dependence  (IDA,IEP)
alcoholic liver cirrhosis  (IDA)
Alzheimer's disease  (EXP,IEP,ISO)
asthma  (IEP)
autistic disorder  (EXP)
autoimmune hepatitis  (EXP)
bacterial pneumonia  (ISO)
Body Weight Changes  (ISO)
Brain Injuries  (ISO)
breast cancer  (IEP)
Breast Neoplasms  (EXP)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis C  (IEP)
chronic obstructive pulmonary disease  (IAGP,IEP)
Colonic Neoplasms  (EXP)
congenital leptin deficiency  (IAGP)
congestive heart failure  (ISO)
Crohn's disease  (EXP)
cystic fibrosis  (IEP)
diabetes mellitus  (IAGP)
Diabetic Nephropathies  (ISO)
Dyslipidemias  (IEP)
End Stage Liver Disease  (IEP)
end stage renal disease  (IEP)
Experimental Arthritis  (EXP)
Experimental Diabetes Mellitus  (EXP,ISO)
Experimental Liver Cirrhosis  (EXP,ISO)
Experimental Mammary Neoplasms  (ISO)
familial hyperlipidemia  (ISO)
fatty liver disease  (EXP,IEP)
Female Infertility  (EXP)
Femoral Fractures  (ISO)
Fetal Growth Retardation  (ISO)
gastric ulcer  (EXP)
gestational diabetes  (EXP,IEP)
glucose intolerance  (EXP,ISO)
hepatocellular carcinoma  (IAGP,IEP)
hepatocellular clear cell carcinoma  (IEP)
Hepatomegaly  (EXP)
heroin dependence  (EXP)
Huntington's disease  (ISO)
Hypercapnia  (IEP)
Hypercholesterolemia  (EXP,ISO)
hyperglycemia  (EXP)
hyperinsulinism  (EXP,ISO)
Hyperphagia  (EXP)
Hyperplasia  (EXP)
hypertension  (EXP,IAGP,ISO)
Hypertriglyceridemia  (ISO)
hypogonadism  (EXP,ISO)
Hypoventilation  (IEP)
Inflammation  (EXP)
Insulin Resistance  (EXP,IEP,ISO)
Kidney Reperfusion Injury  (ISO)
Knee Osteoarthritis  (IEP)
lipid metabolism disorder  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (IEP)
Metabolic Syndrome  (EXP,IEP,ISO)
morbid obesity  (EXP)
Myocardial Reperfusion Injury  (ISO)
Nerve Degeneration  (EXP)
non-alcoholic fatty liver disease  (EXP,IEP)
obesity  (EXP,IAGP,IEA,IEP,ISO)
obstructive sleep apnea  (IEP)
Oral Ulcer  (EXP)
osteoarthritis  (IEP)
osteoporosis  (IDA,IEP,ISO)
Parkinson's disease  (ISO)
pleomorphic xanthoastrocytoma  (IAGP)
Pneumococcal Pneumonia  (ISO)
polycystic ovary syndrome  (EXP)
Polydipsia  (EXP)
Polyuria  (EXP)
pre-eclampsia  (ISO)
primary biliary cholangitis  (IEP)
Prostatic Neoplasms  (EXP)
proteinuria  (EXP)
renal cell carcinoma  (IEP)
Reperfusion Injury  (ISO)
rhinitis  (IDA)
Sepsis  (ISO)
short bowel syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Tachycardia  (EXP)
type 2 diabetes mellitus  (EXP,IAGP,ISO)
visual epilepsy  (EXP)
Weight Gain  (EXP)
Weight Loss  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (ISO)
(R)-mevalonic acid  (ISO)
(S)-nicotine  (ISO)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1,8-cineole  (ISO)
1-(3-chlorophenyl)piperazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrophenol  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (ISO)
2-aminopurine  (ISO)
2-arachidonoylglycerol  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (EXP)
2-methyl-4-chlorophenoxybutyric acid  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
24,25-Dihydroxyvitamin D  (EXP)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-aminobenzamide  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxy-17beta-estradiol  (EXP)
4-hydroxy-TEMPO  (ISO)
4-hydroxybenzoic acid  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP)
8-Br-cAMP  (EXP)
9-cis-retinoic acid  (ISO)
AACOCF3  (ISO)
acarbose  (ISO)
acetaldehyde  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (EXP)
aflatoxin B1  (EXP)
AH23848  (EXP)
aldehydo-D-glucosamine 6-phosphate  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (ISO)
allopurinol  (ISO)
AM-251  (ISO)
Amibegron  (ISO)
amlodipine  (EXP)
ammonium chloride  (ISO)
anandamide  (EXP,ISO)
androst-4-ene-3,17-dione  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apigenin  (ISO)
apocynin  (ISO)
arachidonic acid  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
aspartame  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
Aurothioglucose  (ISO)
azoxystrobin  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (EXP)
Benzyl parahydroxybenzoate  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-naphthoflavone  (EXP)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
BQ 123  (ISO)
bromodichloromethane  (ISO)
bucladesine  (ISO)
Butylparaben  (EXP,ISO)
butyric acid  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
candesartan  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbon nanotube  (ISO)
carvacrol  (ISO)
CCCP  (EXP)
cerulenin  (ISO)
CGP 52608  (EXP)
CGS-21680  (EXP)
chlorohydrocarbon  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium atom  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
conjugated linoleic acid  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cyromazine  (ISO)
D-glucose  (EXP,ISO)
dantrolene  (ISO)
DDE  (EXP,ISO)
DDT  (EXP)
dehydroepiandrosterone  (ISO)
deoxycholic acid  (ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
diazoxide  (ISO)
dibenziodolium  (EXP)
dibutylstannane  (ISO)
diethylstilbestrol  (ISO)
diiodine  (ISO)
dioxygen  (EXP,ISO)
dipyridamole  (ISO)
disodium selenite  (ISO)
dobutamine  (EXP,ISO)
DPCPX  (ISO)
edelfosine  (ISO)
efavirenz  (EXP)
elemental selenium  (EXP)
Elemicin  (ISO)
enalapril  (ISO)
ethambutol  (ISO)
ethanol  (ISO)
ethionamide  (ISO)
Ethyl icosapentate  (ISO)
ethylparaben  (EXP)
fenofibrate  (EXP,ISO)
fenoterol  (EXP)
fenvalerate  (ISO)
ferroheme b  (ISO)
flufenamic acid  (ISO)
flutamide  (ISO)
fonofos  (EXP)
fructose  (ISO)
furan  (ISO)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (ISO)
Ganoderic acid A  (ISO)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
gingerol  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glycine  (ISO)
heme b  (ISO)
hesperidin  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP)
imidacloprid  (ISO)
indinavir  (EXP,ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
iodide salt  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isoflavones  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
kainic acid  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lanthanum atom  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
Licarin A  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
loganin  (ISO)
lopinavir  (EXP)
LY294002  (EXP,ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
melatonin  (EXP,ISO)
menadione  (EXP)
mercury dichloride  (ISO)
metformin  (ISO)
methacholine chloride  (ISO)
methadone  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (EXP)
metronidazole  (ISO)
MK-2206  (ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
morin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
naproxen  (ISO)
naringin  (ISO)
nelfinavir  (EXP,ISO)
neomycin  (ISO)
nevirapine  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP)
nicotine  (ISO)
nicotinic acid  (EXP,ISO)
nitric oxide  (EXP)
Nonylphenol  (ISO)
NS-398  (EXP)
olanzapine  (EXP,ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
orlistat  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (ISO)
permethrin  (ISO)
phencyclidine  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phloretin  (ISO)
phlorizin  (ISO)
phosphatidylcholine  (ISO)
phosphoramidon  (ISO)
pioglitazone  (ISO)
piperine  (ISO)
pirimicarb  (ISO)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
pluronic P-123  (ISO)
Poloxamer  (ISO)
potassium dichromate  (EXP)
pravastatin  (ISO)
prochloraz  (EXP)
progesterone  (EXP,ISO)
propranolol  (EXP,ISO)
propylparaben  (EXP,ISO)
prostaglandin E2  (ISO)
Ptaquiloside  (ISO)
Pyridostigmine bromide  (ISO)
pyruvic acid  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (EXP)
ramipril  (EXP)
reactive oxygen species  (EXP)
rebaudioside A  (ISO)
reserpine  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
ritonavir  (EXP)
rotenone  (EXP)
roxarsone  (EXP)
ruthenium red  (ISO)
rutin  (ISO)
S-adenosyl-L-methioninate  (EXP)
S-adenosyl-L-methionine  (EXP)
saquinavir  (ISO)
SB 203580  (EXP)
selenium atom  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium perchlorate  (ISO)
stavudine  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (ISO)
sumatriptan  (ISO)
superoxide  (EXP,ISO)
terbufos  (EXP)
terbutaline  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triflumizole  (EXP,ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
U-73122  (ISO)
ursolic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
wortmannin  (ISO)
xanthone  (ISO)
zidovudine  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP)
zinc molecular entity  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase C activity  (IBA,IDA)
adipose tissue development  (IEA,ISO)
adult feeding behavior  (IEA,ISS)
angiogenesis  (IDA)
aorta development  (IEA,ISO)
bile acid metabolic process  (IEA,ISO)
bone growth  (IEA,ISS)
bone mineralization involved in bone maturation  (IEA,ISO)
cardiac muscle hypertrophy  (IEA,ISO)
cellular response to insulin stimulus  (IEA,ISO)
cellular response to L-ascorbic acid  (IEA,ISO)
cellular response to leptin stimulus  (IDA)
cellular response to retinoic acid  (IEA,ISO)
central nervous system neuron development  (IEA,ISO)
cholesterol metabolic process  (IEA,ISO)
circadian rhythm  (IEA,ISO)
determination of adult lifespan  (IEA,ISO)
eating behavior  (IEA,ISO)
elastin metabolic process  (IEA,ISO)
energy reserve metabolic process  (IBA,IEA,ISO,TAS)
fatty acid beta-oxidation  (IEA,ISO)
fatty acid catabolic process  (IEA,ISO)
female pregnancy  (IEA,ISO)
glucose homeostasis  (IEA,ISO)
glucose metabolic process  (IEA,ISO)
glycerol biosynthetic process  (IEA,ISO)
hormone metabolic process  (IEA,ISO)
insulin secretion  (IEA,ISO)
intestinal absorption  (IDA)
intracellular signal transduction  (IEA,ISO)
leptin-mediated signaling pathway  (IEA,ISO,ISS)
leukocyte tethering or rolling  (IEA,ISO)
lipid metabolic process  (IBA,IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of appetite  (IEA,ISS)
negative regulation of appetite by leptin-mediated signaling pathway  (IBA,IEA,ISS)
negative regulation of autophagy  (IDA,IEA)
negative regulation of cartilage development  (IEA,ISO)
negative regulation of glucagon secretion  (IEA)
negative regulation of glucose import  (IDA)
negative regulation of glutamine transport  (IEA,ISO)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of lipid storage  (IEA,ISO)
negative regulation of metabolic process  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of vasoconstriction  (IEA,ISO)
ovulation from ovarian follicle  (IEA,ISO)
phagocytosis  (IEA)
placenta development  (IDA)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cold-induced thermogenesis  (IEA,ISS)
positive regulation of cytokine production  (IEA,ISO)
positive regulation of developmental growth  (IDA)
positive regulation of fat cell apoptotic process  (IEA,ISO)
positive regulation of follicle-stimulating hormone secretion  (IEA,ISO)
positive regulation of hepatic stellate cell activation  (IEA,ISO)
positive regulation of insulin receptor signaling pathway  (IEA,ISO)
positive regulation of interleukin-12 production  (IEA)
positive regulation of interleukin-6 production  (IDA,IEA)
positive regulation of interleukin-8 production  (IDA)
positive regulation of luteinizing hormone secretion  (IEA,ISO)
positive regulation of MAPK cascade  (IDA,IEA,ISO,ISS)
positive regulation of monoatomic ion transport  (IEA,ISO)
positive regulation of myeloid cell differentiation  (ISO)
positive regulation of p38MAPK cascade  (IBA,IDA)
positive regulation of peroxisome proliferator activated receptor signaling pathway  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (IBA,IDA,IEA,ISS)
positive regulation of protein import into nucleus  (IEA)
positive regulation of protein kinase B signaling  (IEA,ISS)
positive regulation of protein phosphorylation  (IDA)
positive regulation of reactive oxygen species metabolic process  (IEA,ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IBA,IDA,IEA,ISO)
positive regulation of T cell proliferation  (IDA)
positive regulation of TOR signaling  (IBA,IDA)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA,ISO)
prostaglandin secretion  (IDA)
regulation of angiogenesis  (IDA)
regulation of blood pressure  (IEA,ISO)
regulation of bone remodeling  (IEA,ISS)
regulation of brown fat cell differentiation  (IEA,ISS)
regulation of catalytic activity  (IEA,ISO)
regulation of cell cycle  (IDA,IEA)
regulation of cytokine production involved in inflammatory response  (IDA)
regulation of endothelial cell proliferation  (IDA)
regulation of fat cell differentiation  (IEA,ISO)
regulation of gluconeogenesis  (IEA,ISO)
regulation of insulin secretion  (IEA,ISO)
regulation of intestinal cholesterol absorption  (IEA,ISO)
regulation of lipid biosynthetic process  (IEA,ISO)
regulation of lipoprotein lipid oxidation  (IEA,ISO)
regulation of metabolic process  (IEA,ISO)
regulation of natural killer cell activation  (IDA)
regulation of natural killer cell mediated cytotoxicity  (IDA)
regulation of natural killer cell proliferation  (IDA)
regulation of nitric-oxide synthase activity  (IDA,IEA)
regulation of protein localization to nucleus  (IEA,ISO)
regulation of protein phosphorylation  (IEA)
regulation of steroid biosynthetic process  (IEA,ISO)
response to activity  (IEA,ISO)
response to dietary excess  (IEA,ISO)
response to estradiol  (IEA,ISO)
response to ethanol  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to insulin  (IBA,IEA,ISO)
response to nutrient  (IEA,ISO)
response to nutrient levels  (IEA,ISO)
response to vitamin E  (IEA,ISO)
sexual reproduction  (IEA,IMP)
signal transduction  (IEA)
T cell differentiation  (IEA,ISS)
tyrosine phosphorylation of STAT protein  (IBA,IEA)

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISS)
extracellular region  (IEA,TAS)
extracellular space  (IBA,IEA,IEP,ISS,TAS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver. Aizawa-Abe M, etal., Physiol Genomics. 2013 Sep 3;45(17):786-93. doi: 10.1152/physiolgenomics.00040.2013. Epub 2013 Jun 25.
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61. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
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65. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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