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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69124
Species: Mus musculus
RGD Object: Gene
Symbol: Lep
Name: leptin
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lepdecreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of LEP mRNA; Cadmium Chloride results in decreased expression of LEP proteinPMID:23921151
Lepincreases expressionEXP 6480464CTDCadmium Chloride results in increased expression of LEP proteinPMID:27634282
Lepmultiple interactionsEXP 6480464CTD[Cadmium Chloride co-treated with methylmercuric chloride] results in increased expression of LEP protein; [MT1 gene mutant form results in increased susceptibility to Cadmium Chloride] which affects the expression of LEP mRNA; [MT2 gene mutant form results in increased susceptibility to Cadmium Chloride] which affects the expression of LEP mRNA; MT1 protein affects the reaction [Cadmium Chloride results in decreased expression of LEP protein]; MT2 protein affects the reaction [Cadmium Chloride results in decreased expression of LEP protein]PMID:23921151 PMID:27814245
Lepdecreases expressionISOLEP (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of LEP mRNAPMID:19847775
Lepmultiple interactionsISOLEP (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LEP mRNAPMID:35301059
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