GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Lep | multiple interactions | EXP | | 6480464 | CTD | [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of LEP mRNA; [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased abundance of Glucose | PMID:27712037 PMID:37567420 | Lep | increases expression | ISO | Lep (Rattus norvegicus) | 6480464 | CTD | Glucose results in increased expression of LEP mRNA; Glucose results in increased expression of LEP protein | PMID:10780946 PMID:18627777 PMID:24399619 PMID:29165388 | Lep | increases response to substance | ISO | LEP (Homo sapiens) | 6480464 | CTD | Glucose results in increased susceptibility to LEP protein | PMID:11342529 | Lep | increases secretion | ISO | Lep (Rattus norvegicus) | 6480464 | CTD | Glucose results in increased secretion of LEP protein | PMID:10780946 | Lep | multiple interactions | ISO | Lep (Rattus norvegicus) | 6480464 | CTD | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]; [[Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate] which results in increased secretion of LEP protein; [Glucose co-treated with INS1 protein] results in increased secretion of LEP protein; argan oil inhibits the reaction [Glucose results in increased expression of LEP protein]; Calcium deficiency inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]; Corn Oil inhibits the reaction [Glucose results in increased expression of LEP protein]; Diazoxide inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]; INS1 protein promotes the reaction [Glucose results in increased expression of LEP mRNA]; INS1 protein promotes the reaction [Glucose results in increased secretion of LEP protein]; LEP promotes the reaction [Glucose results in increased secretion of INS1 protein]; naringin inhibits the reaction [Glucose results in increased expression of LEP protein]; nickel chloride inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] | PMID:10780946 PMID:24399619 PMID:29165388 PMID:9751766 | Lep | multiple interactions | ISO | LEP (Homo sapiens) | 6480464 | CTD | Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]; LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species] | PMID:11342529 | | ||||||||||||||||||||||
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