Syt12 (synaptotagmin XII) - Rat Genome Database
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Gene: Syt12 (synaptotagmin XII) Mus musculus
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Symbol: Syt12
Name: synaptotagmin XII
RGD ID: 734414
MGI Page MGI
Description: Predicted to have several functions, including calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in long-term synaptic potentiation. Colocalizes with hippocampal mossy fiber to CA3 synapse and synaptic vesicle. Is expressed in adrenal gland and ventral grey horn. Orthologous to human SYT12 (synaptotagmin 12); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: synaptotagmin 12; synaptotagmin-12; sytXII
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,495,936 - 4,527,171 (-)NCBIGRCm39mm39
GRCm39 Ensembl194,495,936 - 4,527,475 (-)Ensembl
GRCm38194,445,908 - 4,477,143 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,445,908 - 4,477,447 (-)EnsemblGRCm38mm10GRCm38
MGSCv37194,445,908 - 4,477,143 (-)NCBIGRCm37mm9NCBIm37
MGSCv36194,445,908 - 4,477,143 (-)NCBImm8
Celera194,316,249 - 4,347,461 (-)NCBICelera
Cytogenetic Map19ANCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11514560   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16407767   PMID:17190793   PMID:21267068  
PMID:21677750   PMID:21873635   PMID:23739973  


Genomics

Comparative Map Data
Syt12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,495,936 - 4,527,171 (-)NCBIGRCm39mm39
GRCm39 Ensembl194,495,936 - 4,527,475 (-)Ensembl
GRCm38194,445,908 - 4,477,143 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,445,908 - 4,477,447 (-)EnsemblGRCm38mm10GRCm38
MGSCv37194,445,908 - 4,477,143 (-)NCBIGRCm37mm9NCBIm37
MGSCv36194,445,908 - 4,477,143 (-)NCBImm8
Celera194,316,249 - 4,347,461 (-)NCBICelera
Cytogenetic Map19ANCBI
SYT12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1167,006,778 - 67,050,863 (+)EnsemblGRCh38hg38GRCh38
GRCh381167,006,773 - 67,050,863 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371166,790,264 - 66,818,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,547,467 - 66,574,906 (+)NCBINCBI36hg18NCBI36
Build 341166,547,466 - 66,574,905NCBI
Celera1164,118,713 - 64,146,930 (+)NCBI
Cytogenetic Map11q13.2NCBI
HuRef1163,117,876 - 63,146,182 (+)NCBIHuRef
CHM1_11166,673,196 - 66,701,341 (+)NCBICHM1_1
Syt12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21201,729,307 - 201,760,192 (-)NCBI
Rnor_6.0 Ensembl1219,688,451 - 219,719,272 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01219,690,013 - 219,719,359 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01226,557,944 - 226,587,017 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41207,021,672 - 207,073,026 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11207,175,131 - 207,226,479 (-)NCBI
Celera1199,274,610 - 199,303,297 (-)NCBICelera
Cytogenetic Map1q43NCBI
Syt12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542218,357,025 - 18,374,621 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542218,359,105 - 18,381,312 (-)NCBIChiLan1.0ChiLan1.0
SYT12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11165,686,485 - 65,733,010 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1165,709,808 - 65,733,010 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01162,383,485 - 62,412,451 (+)NCBIMhudiblu_PPA_v0panPan3
SYT12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11850,334,779 - 50,358,113 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1850,336,042 - 50,351,333 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,945,117 - 48,967,963 (-)NCBI
ROS_Cfam_1.01851,285,508 - 51,308,358 (-)NCBI
UMICH_Zoey_3.11850,469,616 - 50,492,451 (-)NCBI
UNSW_CanFamBas_1.01850,044,340 - 50,067,184 (-)NCBI
UU_Cfam_GSD_1.01850,839,332 - 50,862,180 (-)NCBI
Syt12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049476,176,026 - 6,195,017 (-)NCBI
SpeTri2.0NW_0049365992,617,083 - 2,637,355 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SYT12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl25,410,624 - 5,433,929 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.125,410,605 - 5,434,492 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.224,385,504 - 4,409,321 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SYT12
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.117,222,090 - 7,248,406 (-)NCBI
ChlSab1.1 Ensembl17,221,220 - 7,248,489 (-)Ensembl
Syt12
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476719,412,314 - 19,436,939 (-)NCBI

Position Markers
BB348287  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38194,445,915 - 4,446,029UniSTSGRCm38
MGSCv37194,445,915 - 4,446,029UniSTSGRCm37
Celera194,316,256 - 4,316,370UniSTS
Cytogenetic Map19AUniSTS
Whitehead/MRC_RH16247.24UniSTS
BB448160  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38194,447,345 - 4,447,473UniSTSGRCm38
MGSCv37194,447,345 - 4,447,473UniSTSGRCm37
Celera194,317,686 - 4,317,814UniSTS
Cytogenetic Map19AUniSTS
Whitehead/MRC_RH1963.86UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120278703Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120645286Mouse
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122321310Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132362870Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132897810Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19167640035676563Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19320000035900000Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19327855120562299Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19334585237345984Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19334585237345984Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19334585237345984Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19334585237345984Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1273
Count of miRNA genes:616
Interacting mature miRNAs:777
Transcripts:ENSMUST00000059295, ENSMUST00000128114, ENSMUST00000133222, ENSMUST00000166191
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000059295   ⟹   ENSMUSP00000055237
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl194,445,908 - 4,477,447 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128114
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl194,447,717 - 4,452,151 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133222
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl194,466,055 - 4,477,156 (-)Ensembl
RefSeq Acc Id: ENSMUST00000166191
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl194,456,837 - 4,477,126 (-)Ensembl
RefSeq Acc Id: NM_134164   ⟹   NP_598925
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39194,495,936 - 4,527,171 (-)NCBI
GRCm38194,445,908 - 4,477,143 (-)ENTREZGENE
MGSCv37194,445,908 - 4,477,143 (-)RGD
Celera194,316,249 - 4,347,461 (-)RGD
cM Map19 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_598925   ⟸   NM_134164
- UniProtKB: Q920N7 (UniProtKB/Swiss-Prot),   Q14AG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000055237   ⟸   ENSMUST00000059295
Protein Domains
C2

Promoters
RGD ID:6830447
Promoter ID:MM_KWN:26015
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000070208,   OTTMUST00000070209
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36194,476,726 - 4,477,226 (-)MPROMDB
RGD ID:13678432
Promoter ID:EPDNEW_M23365
Type:multiple initiation site
Name:Syt12_1
Description:Mus musculus synaptotagmin XII , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38194,477,126 - 4,477,186EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2159601 AgrOrtholog
Ensembl Genes ENSMUSG00000049303 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000055237 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000059295 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synaptotagmin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SYT12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:171180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2159601 ENTREZGENE
NCBI Gene 171180 ENTREZGENE
PANTHER PTHR10024:SF252 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Syt12 PhenoGen
PRINTS SYNAPTOTAGMN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q14AG7 ENTREZGENE, UniProtKB/TrEMBL
  Q920N7 ENTREZGENE, UniProtKB/Swiss-Prot