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Gene: Ddit4 (DNA-damage-inducible transcript 4) Mus musculus
Symbol: Ddit4
Name: DNA-damage-inducible transcript 4
Description: ENCODES a protein that exhibits 14-3-3 protein binding; INVOLVED IN cellular response to dexamethasone stimulus; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of glycolytic process; PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH abnormal cell morphology; abnormal retinal vasculature morphology; decreased retinal apoptosis; ASSOCIATED WITH leukemia (ortholog); mouth disease (ortholog); Nerve Degeneration (ortholog); FOUND IN mitochondrion; cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 17beta-estradiol
Type: protein-coding
Also known as: 5830413E08Rik; AA415483; dexamethasone-induced gene 2 protein; dig2; DNA damage-inducible transcript 4 protein; DNA-damage-inducible transcript 4 protein; HIF-1 responsive protein RTP801; HIF-1 responsive RTP801; protein regulated in development and DNA damage response 1; REDD-1; REDD1; Rtp801
Homo sapiens (human) : DDIT4 (DNA damage inducible transcript 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ddit4 (DNA-damage-inducible transcript 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddit4 (DNA damage inducible transcript 4)
Pan paniscus (bonobo/pygmy chimpanzee) : DDIT4 (DNA damage inducible transcript 4)
Canis lupus familiaris (dog) : DDIT4 (DNA damage inducible transcript 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ddit4 (DNA damage inducible transcript 4)
Sus scrofa (pig) : DDIT4 (DNA damage inducible transcript 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381059,949,675 - 59,951,770 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371059,412,423 - 59,414,518 (-)NCBIGRCm37mm9NCBIm37
MGSCv361059,345,032 - 59,347,127 (-)NCBImm8
Celera1061,046,891 - 61,048,986 (-)NCBICelera
Cytogenetic Map10 B4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ddit4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733067
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.