Srpx2 (sushi-repeat-containing protein, X-linked 2) - Rat Genome Database

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Gene: Srpx2 (sushi-repeat-containing protein, X-linked 2) Mus musculus
Analyze
Symbol: Srpx2
Name: sushi-repeat-containing protein, X-linked 2
RGD ID: 1557026
MGI Page MGI
Description: Enables signaling receptor binding activity. Involved in positive regulation of cell migration involved in sprouting angiogenesis and vocalization behavior. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; limb; musculoskeletal system; peritoneum; and testis. Orthologous to human SRPX2 (sushi repeat containing protein X-linked 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110039C07Rik; SRP; SRPUL; sushi repeat-containing protein SRPX2; sushi-repeat containing protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X132,809,155 - 132,833,195 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX132,809,175 - 132,833,195 (+)EnsemblGRCm39 Ensembl
GRCm38X133,908,416 - 133,932,448 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX133,908,426 - 133,932,446 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X130,442,965 - 130,467,001 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X129,255,046 - 129,278,164 (+)NCBIMGSCv36mm8
CeleraX116,784,471 - 116,808,449 (+)NCBICelera
Cytogenetic MapXE3NCBI
cM MapX55.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12226475   PMID:12466305   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:19667118   PMID:21267068  
PMID:21677750   PMID:21873635   PMID:22159717   PMID:24006456   PMID:24179158   PMID:25855264   PMID:29920554   PMID:31362033   PMID:31907354   PMID:32661396   PMID:34762332  


Genomics

Comparative Map Data
Srpx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X132,809,155 - 132,833,195 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX132,809,175 - 132,833,195 (+)EnsemblGRCm39 Ensembl
GRCm38X133,908,416 - 133,932,448 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX133,908,426 - 133,932,446 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X130,442,965 - 130,467,001 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X129,255,046 - 129,278,164 (+)NCBIMGSCv36mm8
CeleraX116,784,471 - 116,808,449 (+)NCBICelera
Cytogenetic MapXE3NCBI
cM MapX55.47NCBI
SRPX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X100,644,199 - 100,675,788 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX100,644,195 - 100,675,788 (+)EnsemblGRCh38hg38GRCh38
GRCh37X99,899,196 - 99,930,785 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X99,785,819 - 99,812,952 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X99,705,369 - 99,732,435NCBI
CeleraX100,417,899 - 100,445,036 (+)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX89,699,083 - 89,726,241 (+)NCBIHuRef
CHM1_1X99,792,044 - 99,819,192 (+)NCBICHM1_1
T2T-CHM13v2.0X99,086,631 - 99,118,247 (+)NCBIT2T-CHM13v2.0
Srpx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X101,399,748 - 101,425,486 (+)NCBIGRCr8
mRatBN7.2X97,106,455 - 97,132,197 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX97,106,561 - 97,132,195 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX98,780,980 - 98,806,337 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X102,290,762 - 102,316,123 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X99,794,158 - 99,819,519 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X104,734,035 - 104,760,658 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX104,734,082 - 104,760,547 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X104,569,972 - 104,594,902 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X121,446,756 - 121,468,691 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX98,154,669 - 98,178,553 (+)NCBICelera
Cytogenetic MapXq32NCBI
Srpx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555036,795,734 - 6,821,119 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555036,795,793 - 6,817,779 (+)NCBIChiLan1.0ChiLan1.0
SRPX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X100,248,125 - 100,279,048 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X100,253,972 - 100,285,692 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X89,854,389 - 89,886,776 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X99,994,560 - 100,021,241 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX99,994,560 - 100,021,241 (+)Ensemblpanpan1.1panPan2
SRPX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X74,513,473 - 74,536,446 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX74,513,774 - 74,534,910 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X75,923,141 - 75,944,851 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX75,922,966 - 75,944,592 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X73,485,604 - 73,507,297 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X75,155,899 - 75,177,590 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X74,916,918 - 74,938,615 (+)NCBIUU_Cfam_GSD_1.0
Srpx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X63,671,204 - 63,697,221 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365845,855,818 - 5,880,259 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365845,855,818 - 5,879,478 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRPX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX82,336,744 - 82,363,867 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X82,336,741 - 82,363,868 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X90,178,156 - 90,205,276 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRPX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X88,954,310 - 88,982,608 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX88,957,316 - 88,982,305 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606513,884,531 - 13,916,219 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srpx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249021,944,019 - 1,964,983 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249021,944,073 - 1,967,106 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Srpx2
742 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1485
Count of miRNA genes:408
Interacting mature miRNAs:458
Transcripts:ENSMUST00000033606, ENSMUST00000113303, ENSMUST00000113304, ENSMUST00000165805
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse
13208552Wght12_mweight 12 (mouse)X94043606149782996Mouse
13208556Lgth14_mbody length 14 (mouse)X94043606149782996Mouse
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX102055848162758941Mouse
1301209Cia19_mcollagen induced arthritis 19 (mouse)Not determinedX120993165160213038Mouse
25314309Syncl5_msynaptonemal complex length 5 (mouse)X121909697152582996Mouse
10412164Cmv2_mcytomegalovirus resistance 2 (mouse)Not determinedX125685149159685269Mouse
13824981Svwq2_mseminal vesicle weight QTL 2 (mouse)X128900749153782996Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001083895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_026838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006528606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF393640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH011681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL691421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW495563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB843885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB848735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF470209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ560499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ830905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN539245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000033606   ⟹   ENSMUSP00000033606
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX132,809,175 - 132,832,563 (+)Ensembl
GRCm38.p6 EnsemblX133,908,426 - 133,931,814 (+)Ensembl
RefSeq Acc Id: ENSMUST00000113304   ⟹   ENSMUSP00000108929
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX132,809,197 - 132,833,195 (+)Ensembl
GRCm38.p6 EnsemblX133,908,448 - 133,932,446 (+)Ensembl
RefSeq Acc Id: NM_001083895   ⟹   NP_001077364
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X132,809,174 - 132,833,195 (+)NCBI
GRCm38X133,908,425 - 133,932,446 (+)NCBI
MGSCv37X130,442,965 - 130,467,001 (+)RGD
CeleraX116,784,470 - 116,808,433 (+)NCBI
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_026838   ⟹   NP_081114
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X132,809,174 - 132,833,195 (+)NCBI
GRCm38X133,908,425 - 133,932,446 (+)NCBI
MGSCv37X130,442,965 - 130,467,001 (+)RGD
CeleraX116,784,470 - 116,808,433 (+)NCBI
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006528606   ⟹   XP_006528669
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X132,809,155 - 132,832,563 (+)NCBI
GRCm38X133,908,416 - 133,932,448 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_081114   ⟸   NM_026838
- Peptide Label: precursor
- UniProtKB: Q8K1F8 (UniProtKB/Swiss-Prot),   Q3UVU0 (UniProtKB/Swiss-Prot),   B1AVI6 (UniProtKB/Swiss-Prot),   Q8K4W6 (UniProtKB/Swiss-Prot),   Q8R054 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001077364   ⟸   NM_001083895
- Peptide Label: precursor
- UniProtKB: Q8K1F8 (UniProtKB/Swiss-Prot),   Q3UVU0 (UniProtKB/Swiss-Prot),   B1AVI6 (UniProtKB/Swiss-Prot),   Q8K4W6 (UniProtKB/Swiss-Prot),   Q8R054 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006528669   ⟸   XM_006528606
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000108929   ⟸   ENSMUST00000113304
RefSeq Acc Id: ENSMUSP00000033606   ⟸   ENSMUST00000033606
Protein Domains
HYR   Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R054-F1-model_v2 AlphaFold Q8R054 1-468 view protein structure

Promoters
RGD ID:6846402
Promoter ID:MM_KWN:61842
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   MEF_B6
Transcripts:NM_001083895,   NM_026838
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X130,442,796 - 130,443,296 (+)MPROMDB
RGD ID:13681326
Promoter ID:EPDNEW_M24812
Type:initiation region
Name:Srpx2_1
Description:Mus musculus sushi-repeat-containing protein, X-linked 2 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X133,908,425 - 133,908,485EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916042 AgrOrtholog
Ensembl Genes ENSMUSG00000031253 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033606 ENTREZGENE
  ENSMUST00000033606.15 UniProtKB/Swiss-Prot
  ENSMUST00000113304 ENTREZGENE
  ENSMUST00000113304.2 UniProtKB/Swiss-Prot
Gene3D-CATH Complement Module, domain 1 UniProtKB/Swiss-Prot
InterPro DUF4174 UniProtKB/Swiss-Prot
  HYR_dom UniProtKB/Swiss-Prot
  SRPX-like UniProtKB/Swiss-Prot
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot
KEGG Report mmu:68792 UniProtKB/Swiss-Prot
MGD MGI:1916042 ENTREZGENE
NCBI Gene 68792 ENTREZGENE
PANTHER PTHR46343 UniProtKB/Swiss-Prot
  PTHR46343:SF3 UniProtKB/Swiss-Prot
Pfam DUF4174 UniProtKB/Swiss-Prot
  HYR UniProtKB/Swiss-Prot
  Sushi UniProtKB/Swiss-Prot
PhenoGen Srpx2 PhenoGen
PROSITE HYR UniProtKB/Swiss-Prot
  SUSHI UniProtKB/Swiss-Prot
SMART CCP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57535 UniProtKB/Swiss-Prot
UniProt B1AVI6 ENTREZGENE
  Q3UVU0 ENTREZGENE
  Q8K1F8 ENTREZGENE
  Q8K4W6 ENTREZGENE
  Q8R054 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B1AVI6 UniProtKB/Swiss-Prot
  Q3UVU0 UniProtKB/Swiss-Prot
  Q8K1F8 UniProtKB/Swiss-Prot
  Q8K4W6 UniProtKB/Swiss-Prot