Sqstm1 (sequestosome 1) - Rat Genome Database

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Gene: Sqstm1 (sequestosome 1) Mus musculus
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Symbol: Sqstm1
Name: sequestosome 1
RGD ID: 736485
MGI Page MGI
Description: Enables several functions, including ionotropic glutamate receptor binding activity; modification-dependent protein binding activity; and molecular condensate scaffold activity. Involved in several processes, including aggrephagy; brown fat cell proliferation; and positive regulation of long-term synaptic potentiation. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in several cellular components, including aggresome; autolysosome; and sperm midpiece. Is active in intracellular non-membrane-bounded organelle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Paget's disease of bone. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 3; distal myopathy with rimmed vacuoles; frontotemporal dementia and/or amyotrophic lateral sclerosis 3; and neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset. Orthologous to human SQSTM1 (sequestosome 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A17; A170; OSF; OSF-6; Osi; oxidative stress induced; p6; p62; S; sequestosome-1; STAP; STONE14; ubiquitin-binding protein p62
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,090,979 - 50,105,303 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,090,193 - 50,101,654 (-)EnsemblGRCm39 Ensembl
GRCm381150,200,152 - 50,210,820 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,199,366 - 50,210,827 (-)EnsemblGRCm38mm10GRCm38
MGSCv371150,013,654 - 50,024,292 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361150,043,575 - 50,054,213 (-)NCBIMGSCv36mm8
Celera1154,760,561 - 54,771,199 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1130.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (EXP,ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (EXP)
(20S)-ginsenoside Rg3  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1,4-benzoquinone  (ISO)
1-monopalmitoylglycerol  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(chloromethyl)pyridine  (ISO)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
2-butoxyethanol  (EXP)
2-deoxy-D-glucose  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (ISO)
2-tert-butylhydroquinone  (ISO)
20-hydroxyecdysone  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (EXP,ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-methoxy-TEMPO  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
7beta-aminocephalosporanic acid  (ISO)
abamectin  (ISO)
ABT-737  (ISO)
acarbose  (EXP)
acetaldehyde  (ISO)
acetylcholine  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (EXP,ISO)
Aescin  (EXP,ISO)
aflatoxin B1  (EXP)
AICA ribonucleotide  (ISO)
Ajugasterone C  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alginic acid  (EXP)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
aloxistatin  (EXP,ISO)
alpha,alpha-trehalose  (EXP,ISO)
alpha-amanitin  (EXP)
alpha-D-galactose  (EXP,ISO)
alpha-pinene  (ISO)
Alpinetin  (EXP,ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
amiodarone  (ISO)
ammonium chloride  (ISO)
ammonium hexachloroplatinate  (ISO)
andrographolide  (ISO)
Anemoside B4  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimonite  (ISO)
antimycin A  (EXP,ISO)
antirheumatic drug  (ISO)
aprepitant  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
astemizole  (ISO)
astragaloside IV  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP,ISO)
avobenzone  (ISO)
azathioprine  (ISO)
bafilomycin A1  (EXP,ISO)
Bafilomycin B1  (EXP)
BAPTA  (EXP)
Bardoxolone methyl  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (EXP,ISO)
berberine  (ISO)
beta-naphthoflavone  (ISO)
beta-thujaplicin  (EXP)
bexarotene  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
brazilin  (ISO)
Brusatol  (ISO)
buprofezin  (ISO)
butachlor  (EXP)
butane-2,3-dione  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camptothecin  (ISO)
cannabidiol  (EXP,ISO)
capivasertib  (ISO)
carbamazepine  (ISO)
carbon disulfide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carglumic acid  (EXP)
CCCP  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
cerium trichloride  (ISO)
chenodeoxycholic acid  (EXP,ISO)
CHIR 99021  (EXP,ISO)
chloroacetaldehyde  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
cholic acid  (EXP)
chromium(6+)  (EXP,ISO)
ciglitazone  (ISO)
ciprofibrate  (EXP)
cisplatin  (EXP,ISO)
Citreoviridin  (EXP,ISO)
clofibrate  (EXP)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
coenzyme Q10  (EXP)
colforsin daropate hydrochloride  (ISO)
colistin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
corosolic acid  (EXP,ISO)
cortisol  (ISO)
Corynoxine B  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cryptotanshinone  (ISO)
cucurbitacin E  (ISO)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (EXP,ISO)
cylindrospermopsin  (EXP)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
dactolisib  (ISO)
dapagliflozin  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP,ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (EXP,ISO)
Diallyltetrasulfane  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenzofuran  (ISO)
dibutyl phthalate  (EXP)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
diethyl maleate  (EXP,ISO)
diisononyl phthalate  (ISO)
dimethyl fumarate  (EXP)
dinitrogen  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (EXP)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
diuron  (ISO)
Doramectin  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
embelin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
epichlorohydrin  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
excitatory amino acid agonist  (ISO)
fenofibrate  (EXP,ISO)
fenthion  (EXP)
fenvalerate  (ISO)
ferrostatin-1  (ISO)
fingolimod hydrochloride  (ISO)
flavokawain B  (ISO)
flufenoxuron  (EXP)
fluoxetine  (EXP)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (ISO)
fumonisin B1  (EXP)
furosemide  (ISO)
Fusaric acid  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (ISO)
galactose  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
gefitinib  (ISO)
Genipin  (EXP)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
ginsenoside Rb1  (ISO)
ginsenoside Rg2  (EXP,ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycerol 2-phosphate  (ISO)
glycidol  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhizinic acid  (ISO)
gossypetin  (ISO)
graphene oxide  (EXP,ISO)
graphite  (EXP,ISO)
GW 4064  (EXP)
hexadecanoic acid  (EXP,ISO)
hexamethylene diisocyanate  (ISO)
Honokiol  (ISO)
HU-308  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroquinone  (ISO)
hydroxychloroquine  (EXP,ISO)
hypochlorous acid  (EXP)
ifosfamide  (ISO)
indometacin  (ISO)
inositol  (ISO)
iodixanol  (ISO)
iohexol  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(III) citrate  (ISO)
isoflavones  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
kainic acid  (ISO)
ketamine  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-leucine  (EXP)
lactulose  (EXP,ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP,ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
liquiritigenin  (ISO)
liquiritin  (ISO)
lithium chloride  (EXP)
LY294002  (EXP,ISO)
lycopene  (EXP)
Maduramicin  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP,ISO)
melatonin  (EXP,ISO)
melibiose  (EXP)
menadione  (EXP,ISO)
mercury dibromide  (ISO)
mesalamine  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methidathion  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylmercury(1+)  (ISO)
metronidazole  (EXP)
miconazole  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
mirtazapine  (EXP,ISO)
mitoxantrone  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
morusin  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methylformamide  (EXP)
N-methylnicotinate  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nefazodone  (ISO)
neomycin  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP,ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nimesulide  (ISO)
NMN zwitterion  (ISO)
Nonidet P-40  (ISO)
notoginsenoside R1  (EXP)
obeticholic acid  (EXP)
ochratoxin A  (ISO)
octadecanoic acid  (EXP)
octreotide  (EXP)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oligomycin A  (ISO)
organoselenium compound  (ISO)
osimertinib  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-cresol  (ISO)
Paeonol  (ISO)
paracetamol  (EXP,ISO)
paraformaldehyde macromolecule  (EXP)
paraquat  (EXP,ISO)
patulin  (ISO)
PCB138  (ISO)
pectolinarigenin  (ISO)
pentachlorophenol  (EXP)
pepstatin A  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
Plantamajoside  (ISO)
plumbagin  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
potassium iodide  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prodigiosin  (ISO)
progesterone  (ISO)
promethazine  (ISO)
pterostilbene  (EXP,ISO)
puerarin  (ISO)
Pyridostigmine bromide  (ISO)
pyrovalerone  (ISO)
quercetin  (ISO)
quinolinic acid  (ISO)
rac-1-monopalmitoylglycerol  (ISO)
rac-lactic acid  (ISO)
radon atom  (EXP)
radon(0)  (EXP)
raloxifene  (ISO)
reserpine  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
Rhein  (ISO)
rifampicin  (ISO)
Riluzole  (ISO)
Ro 31-8220  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
salubrinal  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SB-239063  (ISO)
SCH772984  (ISO)
Securinine  (ISO)
selenium atom  (ISO)
sepantronium  (ISO)
sertraline  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (EXP,ISO)
Soman  (ISO)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP)
sulforaphane  (EXP,ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (EXP)
swainsonine  (EXP,ISO)
syringic acid  (ISO)
syringin  (ISO)
T-2 toxin  (EXP,ISO)
tamoxifen  (EXP,ISO)
taurine  (EXP,ISO)
taurocholic acid  (EXP)
Temsirolimus  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thiamine(1+) chloride  (EXP,ISO)
thioacetamide  (ISO)
thiram  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
titanium dioxide  (ISO)
toosendanin  (ISO)
topotecan  (ISO)
trametinib  (ISO)
trans-piceid  (ISO)
triacsin C  (ISO)
tributylstannane  (EXP,ISO)
tricalcium bis(phosphate)  (EXP)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
trimethyltin  (ISO)
troglitazone  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (EXP,ISO)
tyloxapol  (EXP)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vancomycin  (EXP)
venetoclax  (ISO)
venlafaxine hydrochloride  (ISO)
vincristine  (ISO)
vismodegib  (ISO)
vitamin D  (ISO)
wortmannin  (EXP)
XAV939  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP,ISO)
zinc pyrithione  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aerobic respiration  (IAGP)
abnormal behavior  (IEA)
abnormal bone mineralization  (IAGP)
abnormal bone ossification  (IAGP)
abnormal bone remodeling  (IAGP)
abnormal bone structure  (IAGP)
abnormal brown adipose tissue thermogenesis  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal forestomach morphology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal mitochondrial ATP synthesis coupled electron transport  (IAGP)
abnormal mitochondrial crista morphology  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast morphology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal respiratory electron transport chain  (IAGP)
abnormal trabecular bone morphology  (IAGP)
absent cerebral cortex pyramidal cells  (IAGP)
absent hippocampus pyramidal cells  (IAGP)
axon degeneration  (IAGP)
decreased bone trabecular spacing  (IAGP)
decreased circulating glucose level  (IEA)
decreased core body temperature  (IAGP)
decreased energy expenditure  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased liver function  (IAGP)
decreased locomotor activity  (IAGP)
decreased mean corpuscular hemoglobin  (IEA)
decreased osteoclast cell number  (IAGP)
decreased oxygen consumption  (IAGP)
decreased Purkinje cell number  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
disorganized mitochondrial cristae  (IAGP)
enlarged liver  (IAGP)
esophagus hyperplasia  (IAGP)
hepatic steatosis  (IAGP)
hyperglycemia  (IAGP)
hyperkeratosis  (IAGP)
hypoglycemia  (IAGP)
impaired glucose tolerance  (IAGP)
increased abdominal adipose tissue amount  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased body length  (IEA)
increased body weight  (IAGP)
increased bone mineral density of femur  (IAGP)
increased bone trabecula number  (IAGP)
increased bone volume  (IAGP)
increased brown fat cell lipid droplet size  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating leptin level  (IAGP)
increased food intake  (IAGP)
increased lean body mass  (IAGP)
increased neuron apoptosis  (IAGP)
increased neuron number  (IAGP)
increased osteoclast cell number  (IAGP)
increased susceptibility to age related obesity  (IAGP)
increased total body fat amount  (IAGP)
increased white fat cell size  (IAGP)
insulin resistance  (IAGP)
limb grasping  (IAGP)
lordokyphosis  (IAGP)
obese  (IAGP)
oxidative stress  (IAGP)
postnatal growth retardation  (IAGP)
premature aging  (IAGP)
premature death  (IAGP)
rough coat  (IAGP)
tremors  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons. Castillo K, etal., Autophagy. 2013 Sep;9(9):1308-20. doi: 10.4161/auto.25188. Epub 2013 Jun 6.
2. The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications. Durcan TM and Fon EA, Genes Dev. 2015 May 15;29(10):989-99. doi: 10.1101/gad.262758.115.
3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
4. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
5. Angiotensin-(1-7) inhibits autophagy in the brain of spontaneously hypertensive rats. Jiang T, etal., Pharmacol Res. 2013 May;71:61-8. doi: 10.1016/j.phrs.2013.03.001. Epub 2013 Mar 15.
6. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
7. Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration. Kitaoka Y, etal., Cell Death Dis. 2013 Oct 17;4:e860. doi: 10.1038/cddis.2013.391.
8. Mitochondria and mitophagy: the yin and yang of cell death control. Kubli DA and Gustafsson AB, Circ Res. 2012 Oct 12;111(9):1208-21. doi: 10.1161/CIRCRESAHA.112.265819.
9. Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone. Laurin N, etal., Am J Hum Genet. 2002 Jun;70(6):1582-8. Epub 2002 Apr 30.
10. Acute hyperglycemia together with hematoma of high-glucose blood exacerbates neurological injury in a rat model of intracerebral hemorrhage. Liu RY, etal., Neurosci Bull. 2014 Feb;30(1):90-8. doi: 10.1007/s12264-013-1371-6. Epub 2013 Jul 25.
11. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. MGD IEA MGD IEA
14. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Mouse MP Annotation Import Pipeline RGD automated import pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8806656   PMID:9125146   PMID:9405250   PMID:10349636   PMID:10458914   PMID:10464095   PMID:11042159   PMID:11076861   PMID:11162503   PMID:11544199   PMID:11852044   PMID:12477932  
PMID:12520002   PMID:12745069   PMID:14610273   PMID:14960283   PMID:15102471   PMID:15345747   PMID:15379887   PMID:15489334   PMID:15761153   PMID:15890008   PMID:16141072   PMID:16141073  
PMID:16252010   PMID:16286508   PMID:16517408   PMID:16602821   PMID:16702235   PMID:16874300   PMID:16877352   PMID:17092936   PMID:17296612   PMID:17389358   PMID:18083104   PMID:18174161  
PMID:18287559   PMID:18346199   PMID:18346206   PMID:18382763   PMID:18394557   PMID:18524774   PMID:18598672   PMID:18765443   PMID:19004011   PMID:19071211   PMID:19201866   PMID:19207582  
PMID:19250911   PMID:19257822   PMID:19282458   PMID:19365810   PMID:19765191   PMID:19780870   PMID:19850933   PMID:20036720   PMID:20059953   PMID:20154642   PMID:20173742   PMID:20206555  
PMID:20378532   PMID:20421418   PMID:20452972   PMID:20495340   PMID:20577052   PMID:20604804   PMID:20616007   PMID:20716775   PMID:20808911   PMID:20814419   PMID:20890124   PMID:20974803  
PMID:21041446   PMID:21119005   PMID:21173155   PMID:21185285   PMID:21193837   PMID:21195346   PMID:21220332   PMID:21220506   PMID:21267068   PMID:21317241   PMID:21482715   PMID:21498569  
PMID:21515589   PMID:21536669   PMID:21551061   PMID:21574998   PMID:21576355   PMID:21628417   PMID:21628531   PMID:21677750   PMID:21687634   PMID:21715324   PMID:21746920   PMID:21757726  
PMID:21872578   PMID:21873635   PMID:21878516   PMID:21909099   PMID:21981924   PMID:22033522   PMID:22049074   PMID:22082874   PMID:22167182   PMID:22222206   PMID:22396390   PMID:22658522  
PMID:22761437   PMID:22792322   PMID:22854957   PMID:22863802   PMID:22904094   PMID:22952826   PMID:22988430   PMID:23093667   PMID:23147249   PMID:23148214   PMID:23257354   PMID:23274085  
PMID:23295856   PMID:23333919   PMID:23392225   PMID:23479732   PMID:23542691   PMID:23563314   PMID:23591541   PMID:23637164   PMID:23754749   PMID:23759924   PMID:23954414   PMID:23974797  
PMID:24011591   PMID:24027277   PMID:24035364   PMID:24124537   PMID:24178293   PMID:24220501   PMID:24300375   PMID:24339057   PMID:24374573   PMID:24376899   PMID:24394643   PMID:24492006  
PMID:24566496   PMID:24614889   PMID:24675871   PMID:24683544   PMID:24713655   PMID:24825920   PMID:24879152   PMID:24888590   PMID:24925527   PMID:24954904   PMID:25002027   PMID:25002530  
PMID:25015291   PMID:25026213   PMID:25040165   PMID:25044020   PMID:25049227   PMID:25052093   PMID:25163928   PMID:25198012   PMID:25242226   PMID:25305080   PMID:25412696   PMID:25450619  
PMID:25483963   PMID:25484084   PMID:25484342   PMID:25497209   PMID:25501661   PMID:25533346   PMID:25585051   PMID:25605500   PMID:25609235   PMID:25675818   PMID:25723488   PMID:25915474  
PMID:26012548   PMID:26115514   PMID:26133577   PMID:26162509   PMID:26208452   PMID:26222436   PMID:26231202   PMID:26235979   PMID:26282199   PMID:26284655   PMID:26286116   PMID:26325428  
PMID:26349538   PMID:26383973   PMID:26412716   PMID:26440898   PMID:26483381   PMID:26512112   PMID:26595272   PMID:26604141   PMID:26637326   PMID:26649827   PMID:26682926   PMID:26732762  
PMID:26746706   PMID:26764599   PMID:26764600   PMID:26773517   PMID:26878170   PMID:26902585   PMID:26905199   PMID:26919428   PMID:26929451   PMID:26942676   PMID:27103069   PMID:27180121  
PMID:27211490   PMID:27271513   PMID:27325701   PMID:27345495   PMID:27368125   PMID:27383629   PMID:27391408   PMID:27404485   PMID:27418600   PMID:27436578   PMID:27439389   PMID:27442348  
PMID:27458013   PMID:27498865   PMID:27526095   PMID:27528230   PMID:27537524   PMID:27624873   PMID:27643531   PMID:27653365   PMID:27666593   PMID:27728806   PMID:27748507   PMID:27780373  
PMID:27869116   PMID:27997827   PMID:28055010   PMID:28121484   PMID:28137967   PMID:28190767   PMID:28322253   PMID:28341848   PMID:28380258   PMID:28386022   PMID:28396396   PMID:28404643  
PMID:28413018   PMID:28512249   PMID:28513333   PMID:28527629   PMID:28619261   PMID:28634261   PMID:28724916   PMID:28820283   PMID:28904095   PMID:28951592   PMID:28978813   PMID:28988820  
PMID:29078390   PMID:29099309   PMID:29153842   PMID:29158485   PMID:29180572   PMID:29196648   PMID:29241092   PMID:29255244   PMID:29272390   PMID:29276215   PMID:29311744   PMID:29311767  
PMID:29331651   PMID:29339380   PMID:29395578   PMID:29459677   PMID:29535191   PMID:29550918   PMID:29555685   PMID:29634950   PMID:29670287   PMID:29672276   PMID:29676259   PMID:29719249  
PMID:29764981   PMID:29775594   PMID:29786968   PMID:29843805   PMID:29893844   PMID:29966650   PMID:30017357   PMID:30022074   PMID:30081710   PMID:30154079   PMID:30158642   PMID:30196744  
PMID:30215534   PMID:30428088   PMID:30451833   PMID:30475154   PMID:30498063   PMID:30581152   PMID:30704899   PMID:30740681   PMID:30818059   PMID:30913396   PMID:30952864   PMID:30954537  
PMID:30973865   PMID:30985297   PMID:31059511   PMID:31142229   PMID:31203752   PMID:31223056   PMID:31286822   PMID:31339428   PMID:31362587   PMID:31434890   PMID:31439879   PMID:31441382  
PMID:31500508   PMID:31526472   PMID:31618870   PMID:31690171   PMID:31754024   PMID:31880208   PMID:31913745   PMID:32047033   PMID:32093570   PMID:32098917   PMID:32100883   PMID:32170061  
PMID:32201259   PMID:32214786   PMID:32291905   PMID:32313051   PMID:32385399   PMID:32394328   PMID:32493884   PMID:32554809   PMID:32744119   PMID:32746697   PMID:32805647   PMID:32876528  
PMID:32968282   PMID:32975614   PMID:33044112   PMID:33077977   PMID:33106420   PMID:33222586   PMID:33227565   PMID:33296658   PMID:33341674   PMID:33397898   PMID:33436499   PMID:33462315  
PMID:33742095   PMID:33933676   PMID:33966596   PMID:34001883   PMID:34048907   PMID:34075102   PMID:34108486   PMID:34207662   PMID:34215815   PMID:34341497   PMID:34400288   PMID:34453106  
PMID:34520306   PMID:34657574   PMID:34774801   PMID:34870542   PMID:34899723   PMID:34903812   PMID:34962634   PMID:35020883   PMID:35227727   PMID:35390228   PMID:35392569   PMID:35452957  
PMID:35458235   PMID:35512463   PMID:35563822   PMID:35593053   PMID:35597240   PMID:35624155   PMID:35626041   PMID:35640762   PMID:35662390   PMID:35695893   PMID:35723871   PMID:35850054  
PMID:36167966   PMID:36179399   PMID:36184612   PMID:36198274   PMID:36238284   PMID:36417873   PMID:36439272   PMID:36628446   PMID:36634736   PMID:36685533   PMID:36754207   PMID:36899856  
PMID:37116593   PMID:37306101   PMID:37353485   PMID:37385404   PMID:37460613   PMID:37534581   PMID:37624620   PMID:37804507   PMID:37812701   PMID:37852547   PMID:37998373   PMID:38218976  
PMID:38365674  


Genomics

Comparative Map Data
Sqstm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,090,979 - 50,105,303 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,090,193 - 50,101,654 (-)EnsemblGRCm39 Ensembl
GRCm381150,200,152 - 50,210,820 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,199,366 - 50,210,827 (-)EnsemblGRCm38mm10GRCm38
MGSCv371150,013,654 - 50,024,292 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361150,043,575 - 50,054,213 (-)NCBIMGSCv36mm8
Celera1154,760,561 - 54,771,199 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1130.36NCBI
SQSTM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385179,806,393 - 179,838,078 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5179,806,398 - 179,838,078 (+)EnsemblGRCh38hg38GRCh38
GRCh375179,233,393 - 179,265,078 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365179,180,503 - 179,197,684 (+)NCBINCBI36Build 36hg18NCBI36
Build 345179,180,502 - 179,197,681NCBI
Celera5174,858,545 - 174,890,234 (+)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5173,959,564 - 173,990,246 (+)NCBIHuRef
CHM1_15178,665,789 - 178,697,494 (+)NCBICHM1_1
T2T-CHM13v2.05180,361,589 - 180,393,289 (+)NCBIT2T-CHM13v2.0
Sqstm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,026,598 - 35,037,750 (-)NCBIGRCr8
mRatBN7.21034,525,517 - 34,536,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,525,519 - 34,536,673 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1039,200,880 - 39,212,041 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,740,133 - 7,751,294 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,194,553 - 34,205,714 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,704,728 - 35,716,316 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,704,730 - 35,716,294 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01035,463,172 - 35,474,754 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,751,300 - 35,762,630 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11035,752,706 - 35,763,676 (-)NCBI
Celera1033,874,680 - 33,885,832 (-)NCBICelera
Cytogenetic Map10q22NCBI
Sqstm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955408757,426 - 771,615 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955408757,426 - 764,989 (-)NCBIChiLan1.0ChiLan1.0
SQSTM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24174,749,439 - 174,778,646 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15172,889,121 - 172,918,185 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05174,960,727 - 174,989,946 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15182,271,070 - 182,299,093 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5182,284,436 - 182,299,093 (+)Ensemblpanpan1.1panPan2
SQSTM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1111,859,776 - 1,869,289 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl111,859,465 - 1,870,755 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha111,982,949 - 1,993,602 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0111,834,485 - 1,844,494 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl111,834,122 - 1,844,507 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1111,805,423 - 1,816,088 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0111,884,694 - 1,895,335 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0112,124,878 - 2,135,544 (-)NCBIUU_Cfam_GSD_1.0
Sqstm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213119,733,303 - 119,745,506 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936739938,745 - 955,263 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936739943,080 - 955,296 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SQSTM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl278,752,771 - 78,763,938 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1278,752,768 - 78,763,998 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2280,318,820 - 80,330,048 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SQSTM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12381,536,271 - 81,571,061 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2381,558,082 - 81,574,830 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607512,913,848 - 12,950,392 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sqstm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473342,691,841 - 42,700,916 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473342,689,454 - 42,700,916 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sqstm1
293 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1711
Count of miRNA genes:620
Interacting mature miRNAs:780
Transcripts:ENSMUST00000015981, ENSMUST00000102774, ENSMUST00000131214, ENSMUST00000136936, ENSMUST00000143379, ENSMUST00000147846, ENSMUST00000154805
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
12910801Pwbwq14_mpost-weaning body weight QTL 14 (mouse)112719805750636094Mouse
12910804Pwbwq16_mpost-weaning body weight QTL 16 (mouse)112719805750636094Mouse
12910806Pwbwq15_mpost-weaning body weight QTL 15 (mouse)112719805750636094Mouse
12910817Pwgrq20_mpost-weaning growth rate QTL 20 (mouse)112719805750636094Mouse
12910818Ogrq5_moverall growth rate QTL 5 (mouse)112719805750636094Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
10053675Eae44b_mexperimental allergic encephalomyelitis susceptibility 44b (mouse)Not determined113995072854094448Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
1300713Vmbic10_mventral midbrain iron content 10 (mouse)Not determined114277262654081064Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
13452402Hipmt3_mhippocampal morphometry trait 3 (mouse)114797732550277325Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse

Markers in Region
AW491098  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381150,201,415 - 50,201,553UniSTSGRCm38
MGSCv371150,014,917 - 50,015,055UniSTSGRCm37
Celera1154,761,824 - 54,761,962UniSTS
Cytogenetic Map11B1.2UniSTS
Whitehead/MRC_RH11691.06UniSTS
AW475975  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381150,199,669 - 50,199,783UniSTSGRCm38
MGSCv371150,013,171 - 50,013,285UniSTSGRCm37
Celera1154,760,078 - 54,760,192UniSTS
Cytogenetic Map11B1.3UniSTS
Cytogenetic Map11B1.2UniSTS
Whitehead/MRC_RH11688.85UniSTS
AI851514  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381150,199,964 - 50,200,064UniSTSGRCm38
MGSCv371150,013,466 - 50,013,566UniSTSGRCm37
Celera1154,760,373 - 54,760,473UniSTS
Cytogenetic Map11B1.2UniSTS
Cytogenetic Map11B1.3UniSTS
Whitehead/MRC_RH11692.36UniSTS
UniSTS:236567  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381150,199,848 - 50,200,061UniSTSGRCm38
MGSCv371150,013,350 - 50,013,563UniSTSGRCm37
Celera1154,760,257 - 54,760,470UniSTS
Cytogenetic Map11B1.2UniSTS
Cytogenetic Map11B1.3UniSTS
AI845619  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381150,201,222 - 50,201,301UniSTSGRCm38
MGSCv371150,014,724 - 50,014,803UniSTSGRCm37
Celera1154,761,631 - 54,761,710UniSTS
Cytogenetic Map11B1.2UniSTS
Whitehead/MRC_RH11693.3UniSTS
Sqstm1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371150,013,803 - 50,013,983UniSTSGRCm37
Celera1154,760,710 - 54,760,890UniSTS
Cytogenetic Map11B1.2UniSTS
cM MapUN UniSTS
cM Map11 UniSTS
Sqstm1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381150,200,301 - 50,200,481UniSTSGRCm38
MGSCv371150,013,803 - 50,013,983UniSTSGRCm37
Celera1154,760,710 - 54,760,890UniSTS
Cytogenetic Map11B1.2UniSTS
Cytogenetic Map11B1.3UniSTS
cM MapUN UniSTS
cM Map11 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000015981   ⟹   ENSMUSP00000015981
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1150,090,193 - 50,101,618 (-)Ensembl
GRCm38.p6 Ensembl1150,199,366 - 50,210,791 (-)Ensembl
RefSeq Acc Id: ENSMUST00000102774   ⟹   ENSMUSP00000099835
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1150,090,979 - 50,101,654 (-)Ensembl
GRCm38.p6 Ensembl1150,200,152 - 50,210,827 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131214
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1150,093,139 - 50,096,927 (-)Ensembl
GRCm38.p6 Ensembl1150,202,312 - 50,206,100 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136936   ⟹   ENSMUSP00000120442
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1150,090,994 - 50,093,781 (-)Ensembl
GRCm38.p6 Ensembl1150,200,167 - 50,202,954 (-)Ensembl
RefSeq Acc Id: ENSMUST00000143379   ⟹   ENSMUSP00000118662
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1150,091,438 - 50,101,592 (-)Ensembl
GRCm38.p6 Ensembl1150,200,611 - 50,210,765 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147846
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1150,093,270 - 50,093,945 (-)Ensembl
GRCm38.p6 Ensembl1150,202,443 - 50,203,118 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154805
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1150,096,506 - 50,098,146 (-)Ensembl
GRCm38.p6 Ensembl1150,205,679 - 50,207,319 (-)Ensembl
RefSeq Acc Id: NM_001290769   ⟹   NP_001277698
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391150,090,979 - 50,101,647 (-)NCBI
GRCm381150,200,152 - 50,210,820 (-)NCBI
Celera1154,760,561 - 54,771,229 (-)NCBI
Sequence:
RefSeq Acc Id: NM_011018   ⟹   NP_035148
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391150,090,979 - 50,101,647 (-)NCBI
GRCm381150,200,152 - 50,210,820 (-)NCBI
MGSCv371150,013,654 - 50,024,292 (-)RGD
Celera1154,760,561 - 54,771,229 (-)NCBI
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036156414   ⟹   XP_036012307
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391150,090,982 - 50,105,303 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_035148   ⟸   NM_011018
- Peptide Label: isoform 1
- UniProtKB: Q99JM8 (UniProtKB/Swiss-Prot),   Q64337 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001277698   ⟸   NM_001290769
- Peptide Label: isoform 2
- UniProtKB: Q64337 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000118662   ⟸   ENSMUST00000143379
RefSeq Acc Id: ENSMUSP00000015981   ⟸   ENSMUST00000015981
RefSeq Acc Id: ENSMUSP00000099835   ⟸   ENSMUST00000102774
RefSeq Acc Id: ENSMUSP00000120442   ⟸   ENSMUST00000136936
RefSeq Acc Id: XP_036012307   ⟸   XM_036156414
- Peptide Label: isoform X1
Protein Domains
PB1   UBA   ZZ-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64337-F1-model_v2 AlphaFold Q64337 1-442 view protein structure

Promoters
RGD ID:6846909
Promoter ID:MM_ACW:7341
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:SQSTM1.HSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361150,013,991 - 50,014,491 (-)MPROMDB
RGD ID:6822216
Promoter ID:MM_KWN:7227
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Liver,   MEF_B6
Transcripts:OTTMUST00000012390,   OTTMUST00000086219
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361150,016,161 - 50,017,482 (-)MPROMDB
RGD ID:6822218
Promoter ID:MM_KWN:7228
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   MEF_B6
Transcripts:OTTMUST00000086221
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361150,019,206 - 50,020,582 (-)MPROMDB
RGD ID:6822217
Promoter ID:MM_KWN:7229
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000086220
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361150,020,831 - 50,021,772 (-)MPROMDB
RGD ID:6821283
Promoter ID:MM_KWN:7230
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000015981,   OTTMUST00000012385,   OTTMUST00000012391,   OTTMUST00000086218
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361150,023,491 - 50,024,982 (+)MPROMDB
RGD ID:8674498
Promoter ID:EPDNEW_M15280
Type:multiple initiation site
Name:Sqstm1_1
Description:Mus musculus sequestosome 1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381150,210,791 - 50,210,851EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107931 AgrOrtholog
Ensembl Genes ENSMUSG00000015837 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000015981 ENTREZGENE
  ENSMUST00000015981.12 UniProtKB/Swiss-Prot
  ENSMUST00000102774 ENTREZGENE
  ENSMUST00000102774.11 UniProtKB/Swiss-Prot
  ENSMUST00000136936.2 UniProtKB/TrEMBL
  ENSMUST00000143379.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PB1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PB1_p62 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SQSTM_UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_ZZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_ZZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18412 UniProtKB/Swiss-Prot
MGD MGI:107931 ENTREZGENE
NCBI Gene 18412 ENTREZGENE
PANTHER SEQUESTOSOME 1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEQUESTOSOME-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00569 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sqstm1 PhenoGen
PROSITE PB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_ZZ_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_ZZ_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_ZZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP CAD & PB1 domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF46934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YZJ1_MOUSE UniProtKB/TrEMBL
  F6VD69_MOUSE UniProtKB/TrEMBL
  Q64337 ENTREZGENE
  Q99JM8 ENTREZGENE
  SQSTM_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q99JM8 UniProtKB/Swiss-Prot