Irs1 (insulin receptor substrate 1) - Rat Genome Database

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Gene: Irs1 (insulin receptor substrate 1) Mus musculus
Symbol: Irs1
Name: insulin receptor substrate 1
RGD ID: 10816
Description: Enables phosphatidylinositol 3-kinase binding activity and protein kinase binding activity. Involved in cellular response to fatty acid. Acts upstream of or within several processes, including cellular response to insulin stimulus; positive regulation of phosphatidylinositol 3-kinase activity; and protein kinase B signaling. Located in several cellular components, including ciliary basal body; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human IRS1 (insulin receptor substrate 1); PARTICIPATES IN leptin system pathway; insulin signaling pathway; insulin-like growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ENSMUSG00000022591; G972; G972R; IR; IRS-1; predicted gene, ENSMUSG00000022591
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39182,210,826 - 82,269,160 (-)NCBIGRCm39mm39
GRCm39 Ensembl182,210,833 - 82,213,654 (+)Ensembl
GRCm39 Ensembl182,210,822 - 82,269,137 (-)Ensembl
GRCm38182,233,105 - 82,291,439 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl182,233,112 - 82,235,933 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl182,233,101 - 82,291,416 (-)EnsemblGRCm38mm10GRCm38
MGSCv37182,229,680 - 82,288,014 (-)NCBIGRCm37mm9NCBIm37
MGSCv36182,115,634 - 82,170,440 (-)NCBImm8
Celera182,301,640 - 82,360,019 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map142.0NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(S)-nicotine  (ISO)
(Z)-ligustilide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
4-phenylbutyric acid  (EXP)
8-Br-cAMP  (ISO)
9-cis,11-trans-octadecadienoic acid  (EXP,ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alloxan  (EXP,ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
biotin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
buta-1,3-diene  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (EXP)
chromium atom  (EXP,ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
coenzyme Q10  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
Didymin  (ISO)
dioxygen  (EXP)
disodium selenite  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
flavonol  (ISO)
folic acid  (EXP)
folpet  (EXP)
formaldehyde  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (ISO)
Ganoderic acid A  (EXP)
genistein  (ISO)
gingerol  (EXP)
ginsenoside Re  (EXP)
Ginsenoside Rh4  (EXP)
glucose  (ISO)
glyburide  (ISO)
glyphosate  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
hydroquinone  (ISO)
isoprenaline  (EXP)
ketanserin  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
leflunomide  (EXP,ISO)
linsidomine  (EXP)
lipopolysaccharide  (EXP)
lovastatin  (EXP)
melatonin  (EXP)
mercury atom  (EXP)
mercury dibromide  (ISO)
mercury(0)  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methoxychlor  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (EXP,ISO)
miquelianin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
myricetin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
naringin  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
oleanolic acid  (ISO)
orientin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
paroxetine  (ISO)
perfluorododecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (ISO)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
phosgene  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
progesterone  (EXP,ISO)
propiconazole  (EXP)
propionic acid  (EXP)
quercetin  (EXP,ISO)
rebaudioside A  (EXP)
resveratrol  (EXP,ISO)
rivastigmine  (ISO)
rutin  (ISO)
sarpogrelate  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
serotonin  (EXP)
sertraline  (ISO)
silicon dioxide  (EXP)
simvastatin  (EXP)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
Sodium salicylate  (ISO)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (EXP,ISO)
sucrose  (ISO)
sulpiride  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
temozolomide  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
Tiron  (ISO)
titanium dioxide  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
tris(picolinato)chromium  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vitamin E  (ISO)
wortmannin  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
biological_process  (ND)
cellular response to angiotensin  (ISO)
cellular response to brain-derived neurotrophic factor stimulus  (ISO)
cellular response to fatty acid  (IMP)
cellular response to insulin stimulus  (IDA,ISO)
cellular response to radiation  (ISO)
insulin receptor signaling pathway  (IBA,ISO)
insulin secretion  (IMP)
insulin-like growth factor receptor signaling pathway  (ISO)
lipid catabolic process  (IMP)
mammary gland development  (IGI)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of insulin secretion  (ISO)
negative regulation of somatostatin secretion  (ISO)
phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of cell migration  (IGI)
positive regulation of fatty acid beta-oxidation  (ISO)
positive regulation of glucagon secretion  (ISO)
positive regulation of glucose import  (ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of mesenchymal cell proliferation  (IGI)
positive regulation of phosphatidylinositol 3-kinase activity  (IMP,ISO)
positive regulation of phosphorylation  (ISO)
protein kinase B signaling  (IGI)
protein localization to nucleus  (IDA,IMP)
regulation of gene expression  (IMP)
response to activity  (ISO)
response to caffeine  (ISO)
response to insulin  (ISO)
response to peptide hormone  (ISO)
signal transduction  (IEA)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone healing  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone structure  (IAGP)
abnormal cell differentiation  (IAGP)
abnormal femur morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal gonadal fat pad morphology  (IAGP)
abnormal lipid level  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal postnatal growth/weight/body size  (IAGP)
abnormal tail morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal triglyceride level  (IAGP)
abnormal vascular wound healing  (IAGP)
decreased birth body size  (IAGP)
decreased birth weight  (IAGP)
decreased body height  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone mineral density  (IAGP)
decreased cell proliferation  (IAGP)
decreased chondrocyte number  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating HDL cholesterol level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased compact bone thickness  (IAGP)
decreased fetal weight  (IAGP)
decreased insulin secretion  (IAGP)
decreased liver glycogen level  (IAGP)
decreased long bone epiphyseal plate size  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased osteoblast proliferation  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased total body fat amount  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased triglyceride level  (IAGP)
decreased vasodilation  (IAGP)
decreased white adipose tissue amount  (IAGP)
fetal growth retardation  (IAGP)
hyperglycemia  (IAGP)
hypertension  (IAGP)
impaired glucose tolerance  (IAGP)
impaired lipolysis  (IAGP)
impaired osteoblast differentiation  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased osteoblast cell number  (IAGP)
increased osteoclast cell number  (IAGP)
increased pancreatic beta cell mass  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased systemic arterial diastolic blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
insulin resistance  (IAGP)
muscular atrophy  (IAGP)
pancreatic islet hyperplasia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
proportional dwarf  (IAGP)
short femur  (IAGP)
short tail  (IAGP)
short tibia  (IAGP)
thin tail  (IAGP)

References - curated
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27. Pipeline to import KEGG annotations from KEGG into RGD
28. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
29. Pipeline to import SMPDB annotations from SMPDB into RGD
30. RGD automated import pipeline
31. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. RGD automated import pipeline for gene-chemical interactions
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Additional References at PubMed
PMID:1375946   PMID:7488102   PMID:7526222   PMID:7534300   PMID:7544789   PMID:7629118   PMID:7675087   PMID:7969452   PMID:8048169   PMID:8167159   PMID:8240352   PMID:8448209  
PMID:8505282   PMID:8544845   PMID:8557661   PMID:8626723   PMID:8631859   PMID:8649419   PMID:8876252   PMID:8889548   PMID:8921891   PMID:9032089   PMID:9038347   PMID:9062343  
PMID:9229117   PMID:9348224   PMID:9399964   PMID:9492017   PMID:9495343   PMID:9508089   PMID:9541510   PMID:9565625   PMID:9624169   PMID:9729467   PMID:9813005   PMID:9844629  
PMID:9892694   PMID:10078198   PMID:10349636   PMID:10417963   PMID:10471495   PMID:10512356   PMID:10579310   PMID:10606633   PMID:10615953   PMID:10642598   PMID:10749573   PMID:10801879  
PMID:10811851   PMID:10922068   PMID:11018022   PMID:11042159   PMID:11076861   PMID:11078455   PMID:11147812   PMID:11217851   PMID:11259600   PMID:11375348   PMID:11517161   PMID:11546755  
PMID:11753753   PMID:11875115   PMID:11877394   PMID:11897712   PMID:12055235   PMID:12063262   PMID:12101028   PMID:12153400   PMID:12176670   PMID:12202493   PMID:12213348   PMID:12417588  
PMID:12458213   PMID:12477932   PMID:12502742   PMID:12524443   PMID:12525499   PMID:12554758   PMID:12665856   PMID:12704655   PMID:12730242   PMID:12746333   PMID:12750770   PMID:12765966  
PMID:12783867   PMID:12810606   PMID:12832401   PMID:12878164   PMID:12904469   PMID:12933351   PMID:12944402   PMID:14502571   PMID:14559999   PMID:14579029   PMID:14623341   PMID:14623899  
PMID:14668342   PMID:14673165   PMID:14684612   PMID:14710352   PMID:14733908   PMID:14736890   PMID:14966267   PMID:14966273   PMID:14969391   PMID:15020250   PMID:15069074   PMID:15102881  
PMID:15135063   PMID:15161756   PMID:15161794   PMID:15169905   PMID:15183122   PMID:15197263   PMID:15199052   PMID:15249583   PMID:15256535   PMID:15344880   PMID:15364919   PMID:15372107  
PMID:15380067   PMID:15467829   PMID:15485932   PMID:15522123   PMID:15537637   PMID:15581362   PMID:15587270   PMID:15611085   PMID:15689562   PMID:15692808   PMID:15718274   PMID:15721320  
PMID:15760467   PMID:15764603   PMID:15805118   PMID:15827066   PMID:15849359   PMID:15965906   PMID:15967802   PMID:15975995   PMID:16055440   PMID:16099428   PMID:16105663   PMID:16123266  
PMID:16127460   PMID:16128672   PMID:16141072   PMID:16141073   PMID:16170362   PMID:16374520   PMID:16406665   PMID:16418171   PMID:16455755   PMID:16556765   PMID:16616006   PMID:16625210  
PMID:16702017   PMID:16880210   PMID:16944949   PMID:17021050   PMID:17030605   PMID:17038556   PMID:17068339   PMID:17200721   PMID:17325037   PMID:17379643   PMID:17443674   PMID:17508357  
PMID:17545163   PMID:17620314   PMID:17641282   PMID:17662267   PMID:17823215   PMID:17916629   PMID:17928362   PMID:17950694   PMID:17965023   PMID:18059474   PMID:18064649   PMID:18202124  
PMID:18256806   PMID:18285345   PMID:18296638   PMID:18506777   PMID:18584041   PMID:18590687   PMID:18590692   PMID:18590693   PMID:18633112   PMID:18653708   PMID:18755774   PMID:18786922  
PMID:18834857   PMID:18927238   PMID:18952604   PMID:18955497   PMID:19001411   PMID:19057532   PMID:19066218   PMID:19079291   PMID:19117011   PMID:19164446   PMID:19228596   PMID:19273608  
PMID:19357198   PMID:19475691   PMID:19542202   PMID:19546233   PMID:19560437   PMID:19561084   PMID:19587264   PMID:19596788   PMID:19596798   PMID:19607904   PMID:19952108   PMID:20009030  
PMID:20018868   PMID:20028942   PMID:20032200   PMID:20058231   PMID:20074531   PMID:20097161   PMID:20103709   PMID:20144759   PMID:20203102   PMID:20207740   PMID:20351777   PMID:20525764  
PMID:20578241   PMID:20798132   PMID:20804756   PMID:20837540   PMID:20843941   PMID:20947509   PMID:21081708   PMID:21135130   PMID:21238928   PMID:21267068   PMID:21283571   PMID:21321084  
PMID:21356519   PMID:21454638   PMID:21628386   PMID:21666240   PMID:21756814   PMID:21804605   PMID:21852229   PMID:21873635   PMID:21986524   PMID:22033112   PMID:22188104   PMID:22199371  
PMID:22210743   PMID:22288475   PMID:22652453   PMID:22688336   PMID:22761437   PMID:22788551   PMID:22820890   PMID:22859932   PMID:22955994   PMID:22975078   PMID:23142081   PMID:23160735  
PMID:23257267   PMID:23349480   PMID:23354051   PMID:23401856   PMID:23557604   PMID:23607966   PMID:23720771   PMID:23741292   PMID:23863152   PMID:23907538   PMID:23940800   PMID:23965929  
PMID:24053798   PMID:24159000   PMID:24177427   PMID:24186867   PMID:24333417   PMID:24438070   PMID:24470116   PMID:24624118   PMID:24677713   PMID:24686304   PMID:24844433   PMID:24846082  
PMID:25002528   PMID:25059507   PMID:25569103   PMID:25586176   PMID:25887310   PMID:26047734   PMID:26433160   PMID:26474286   PMID:26773517   PMID:26846849   PMID:26887316   PMID:26888756  
PMID:26997483   PMID:27378176   PMID:27439864   PMID:27452396   PMID:27452800   PMID:27534441   PMID:27568561   PMID:27623927   PMID:27708159   PMID:27708333   PMID:27739494   PMID:28003360  
PMID:28190325   PMID:28322786   PMID:28456145   PMID:28591635   PMID:28630133   PMID:28710407   PMID:28739640   PMID:28987000   PMID:29045833   PMID:29188534   PMID:29259227   PMID:29269414  
PMID:29364977   PMID:29433422   PMID:29610318   PMID:29728617   PMID:29786968   PMID:29867232   PMID:29884820   PMID:30116740   PMID:30240435   PMID:30483735   PMID:30532187   PMID:30550785  
PMID:30578299   PMID:30679431   PMID:30770439   PMID:31042800   PMID:31515271   PMID:32051546   PMID:32213702   PMID:32721050   PMID:33270683   PMID:33761350   PMID:33839150   PMID:33980693  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39182,210,826 - 82,269,160 (-)NCBIGRCm39mm39
GRCm39 Ensembl182,210,833 - 82,213,654 (+)Ensembl
GRCm39 Ensembl182,210,822 - 82,269,137 (-)Ensembl
GRCm38182,233,105 - 82,291,439 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl182,233,112 - 82,235,933 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl182,233,101 - 82,291,416 (-)EnsemblGRCm38mm10GRCm38
MGSCv37182,229,680 - 82,288,014 (-)NCBIGRCm37mm9NCBIm37
MGSCv36182,115,634 - 82,170,440 (-)NCBImm8
Celera182,301,640 - 82,360,019 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map142.0NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2226,731,312 - 226,799,820 (-)EnsemblGRCh38hg38GRCh38
GRCh382226,731,312 - 226,799,820 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372227,596,028 - 227,664,536 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,308,182 - 227,372,719 (-)NCBINCBI36hg18NCBI36
Build 342227,425,442 - 227,489,980NCBI
Celera2221,365,560 - 221,433,036 (-)NCBI
Cytogenetic Map2q36.3NCBI
HuRef2219,439,592 - 219,507,082 (-)NCBIHuRef
CHM1_12227,601,926 - 227,669,382 (-)NCBICHM1_1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2983,552,964 - 83,605,797 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl983,548,944 - 83,606,122 (-)Ensembl
Rnor_6.0988,033,668 - 88,086,488 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl988,033,668 - 88,086,488 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0987,782,499 - 87,835,248 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4981,585,251 - 81,638,071 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1981,768,669 - 81,821,490 (-)NCBI
Celera980,997,490 - 81,050,250 (-)NCBICelera
Cytogenetic Map9q34NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554537,685,715 - 7,742,262 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554537,685,715 - 7,742,262 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.12B232,785,822 - 232,853,997 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B232,849,239 - 232,852,967 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B113,973,191 - 114,041,127 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12539,624,554 - 39,687,991 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2540,246,368 - 40,306,296 (-)NCBI
ROS_Cfam_1.02539,876,307 - 39,936,286 (-)NCBI
UMICH_Zoey_3.12539,811,057 - 39,873,068 (-)NCBI
UNSW_CanFamBas_1.02539,647,771 - 39,707,665 (-)NCBI
UU_Cfam_GSD_1.02539,826,700 - 39,886,691 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405303181,813,749 - 181,875,259 (-)NCBI
SpeTri2.0NW_0049365259,064,442 - 9,125,972 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl15128,245,846 - 128,308,335 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115128,245,846 - 128,307,321 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215142,086,134 - 142,147,797 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.110112,748,283 - 112,812,368 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604086,628,478 - 86,694,818 (+)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046248431,113,075 - 1,178,859 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38182,233,334 - 82,233,414UniSTSGRCm38
MGSCv37182,284,090 - 82,284,461UniSTSGRCm37
MGSCv37182,233,217 - 82,233,392UniSTSGRCm37
Celera182,301,869 - 82,301,949UniSTS
Cytogenetic Map1C5UniSTS
cM Map1 UniSTS
cM Map157.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38182,241,583 - 82,241,703UniSTSGRCm38
MGSCv37182,238,158 - 82,238,278UniSTSGRCm37
Celera182,310,117 - 82,310,237UniSTS
Cytogenetic Map1C5UniSTS
cM Map157.0UniSTS
Whitehead_YAC1 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38182,287,724 - 82,287,915UniSTSGRCm38
MGSCv37182,284,299 - 82,284,490UniSTSGRCm37
Celera182,356,201 - 82,356,392UniSTS
Cytogenetic Map1C5UniSTS
cM Map157.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38182,287,515 - 82,287,886UniSTSGRCm38
MGSCv37182,284,090 - 82,284,461UniSTSGRCm37
Celera182,355,992 - 82,356,363UniSTS
Cytogenetic Map1C5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38182,236,642 - 82,236,817UniSTSGRCm38
MGSCv37182,233,217 - 82,233,392UniSTSGRCm37
Celera182,305,177 - 82,305,352UniSTS
Cytogenetic Map1C5UniSTS
cM Map1 UniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134721057150318120Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134721057150318120Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134721057150318120Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139093727126517573Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145744740189571420Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14884984782850051Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14884984782850051Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14885318682853326Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15085105784851057Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5138244685382446Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52418578182423027Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15593578989935898Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15622705590227201Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15622705590227201Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15668776390687918Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15668776390687918Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15790219291902192Mouse
14747009Manh49_mmandible shape 49 (mouse)15790219291902192Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15795281891952921Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15795281891952921Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15795281891952921Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15857254792572799Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15857254792572799Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162907596120601949Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163815531189571420Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163880843153681816Mouse
1302119Cia15_mcollagen induced arthritis 15 (mouse)Not determined16584984788568379Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167300000129800000Mouse
4141625Emo4_memotionality 4 (mouse)Not determined6803218686307305Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170205811104211835Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173227055108910684Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73687970107688108Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173687970107688108Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173716016147249632Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74477076148839837Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174952818133363199Mouse
1300821Lore1_mloss of righting induced by ethanol 1 (mouse)Not determined17557254793013355Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)176000000128600000Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)176000000148900000Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)176000000181500000Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177146478110608345Mouse
14697706Stsl3a_mSalmonella typhimurium susceptibility locus 3a (mouse)17750000095900000Mouse
14696691Malq1_mmean attack latency QTL 1 (mouse)17800000088000000Mouse
14696693Avd2q1_mattack value day 2 QTL 1 (mouse)17900000091000000Mouse
4141725Wbcq4_mwhite blood cell quantitative locus 4 (mouse)Not determined179930958113931066Mouse
12050069Nabq1_mnasal bone morphology QTL 1 (mouse)179930958113931066Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180267876126458780Mouse
1302029Sst1_msusceptibility to tuberculosis 1 (mouse)Not determined18167439987203100Mouse
14696692Tavq1_mtotal attack value QTL 1 (mouse)18200000088500000Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir145ammu-miR-145a-5pMirtarbaseexternal_infoWestern blotFunctional MTI18064649

Predicted Target Of
Summary Value
Count of predictions:2421
Count of miRNA genes:858
Interacting mature miRNAs:1178
Transcripts:ENSMUST00000023262, ENSMUST00000069799
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSMUST00000023262   ⟹   ENSMUSP00000023262
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl182,210,833 - 82,213,654 (+)Ensembl
GRCm38.p6 Ensembl182,233,112 - 82,235,933 (+)Ensembl
RefSeq Acc Id: ENSMUST00000069799   ⟹   ENSMUSP00000063795
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl182,210,822 - 82,269,137 (-)Ensembl
GRCm38.p6 Ensembl182,233,101 - 82,291,416 (-)Ensembl
RefSeq Acc Id: NM_010570   ⟹   NP_034700
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39182,210,826 - 82,269,160 (-)NCBI
GRCm38182,233,105 - 82,291,439 (-)NCBI
MGSCv37182,229,680 - 82,288,014 (-)RGD
Celera182,301,640 - 82,360,019 (-)RGD
Reference Sequences
RefSeq Acc Id: NP_034700   ⟸   NM_010570
- UniProtKB: P35569 (UniProtKB/Swiss-Prot),   Q543V3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000063795   ⟸   ENSMUST00000069799
RefSeq Acc Id: ENSMUSP00000023262   ⟸   ENSMUST00000023262
Protein Domains
IRS-type PTB   PH

RGD ID:6817958
Promoter ID:MM_KWN:1325
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Mouse AssemblyChrPosition (strand)Source
MGSCv36182,283,416 - 82,288,157 (-)MPROMDB
RGD ID:6874222
Promoter ID:EPDNEW_M562
Type:single initiation site
Description:Mus musculus insulin receptor substrate 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M563  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38182,290,906 - 82,290,966EPDNEW
RGD ID:6874224
Promoter ID:EPDNEW_M563
Type:initiation region
Description:Mus musculus insulin receptor substrate 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M562  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38182,291,380 - 82,291,440EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99454 AgrOrtholog
Ensembl Genes ENSMUSG00000022591 Ensembl, UniProtKB/TrEMBL
  ENSMUSG00000055980 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000023262 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023262 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IRS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRS_PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16367 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR10614 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IRS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Irs1 PhenoGen
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PTBI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-08 Irs1  insulin receptor substrate 1  ENSMUSG00000022591  predicted gene, ENSMUSG00000022591  Data Merged 737654 PROVISIONAL