Myd88 (myeloid differentiation primary response gene 88) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Myd88 (myeloid differentiation primary response gene 88) Mus musculus
Analyze
Symbol: Myd88
Name: myeloid differentiation primary response gene 88
RGD ID: 1551097
MGI Page MGI
Description: Enables ATP-dependent histone chaperone activity; signaling adaptor activity; and signaling receptor binding activity. Involved in several processes, including cellular response to oxidised low-density lipoprotein particle stimulus; positive regulation of macromolecule biosynthetic process; and response to bacterium. Acts upstream of or within several processes, including establishment of endothelial intestinal barrier; regulation of cytokine production; and response to bacterium. Located in cytosol and plasma membrane. Is expressed in several structures, including brain; intestine; and spleen. Used to study Alzheimer's disease; Coronavirus infectious disease; Sjogren's syndrome; and monoclonal gammopathy of uncertain significance. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); hepatocellular carcinoma; lung cancer (multiple); lymphoma (multiple); and primary immunodeficiency disease. Orthologous to human MYD88 (MYD88 innate immune signal transduction adaptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: myeloid differentiation primary response protein 88; myeloid differentiation primary response protein MyD88
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,165,000 - 119,169,084 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,165,000 - 119,170,477 (-)EnsemblGRCm39 Ensembl
GRCm389119,335,934 - 119,340,018 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,335,934 - 119,341,411 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,245,106 - 119,249,158 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,184,686 - 119,188,738 (-)NCBIMGSCv36mm8
Celera9119,805,118 - 119,809,170 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
anemia  (IMP)
anogenital venereal wart  (ISO)
asthma  (IMP)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Bacterial Keratitis  (IMP)
breast cancer  (ISO)
breast carcinoma  (IMP)
Brugada syndrome  (ISO)
Cachexia  (IMP)
Carcinoma, Lewis Lung  (IMP)
central nervous system lymphoma  (ISO)
Chemical and Drug Induced Liver Injury  (IMP)
chronic lymphocytic leukemia  (ISO)
Colitis-Associated Neoplasms  (IMP)
colon adenocarcinoma  (ISO)
colon cancer  (IMP)
colon carcinoma  (IMP)
Colonic Polyps  (IMP)
colorectal adenocarcinoma  (ISO)
colorectal adenoma  (IMP)
colorectal cancer  (IMP,ISO)
Colorectal Cancer 10  (IMP)
colorectal carcinoma  (ISO)
Coronavirus infectious disease  (IAGP)
diarrhea  (IMP)
diffuse large B-cell lymphoma  (ISO)
Eosinophilia  (ISO)
esophageal cancer  (ISO)
Experimental Arthritis  (IMP)
Experimental Colitis  (IMP)
extrahepatic cholestasis  (ISO)
follicular lymphoma  (ISO)
gastroenteritis  (IEP)
genetic disease  (ISO)
Helicobacter Infections  (IMP)
hepatitis B  (ISO)
hepatocellular carcinoma  (IMP,ISO)
hypertension  (ISO)
Immunodeficiency 68  (ISO)
Inflammation  (ISO)
Intestinal Polyps  (IMP)
Liver Injury  (IGI)
lung adenocarcinoma  (IMP)
lung cancer  (ISO)
lung non-small cell carcinoma  (ISO)
lymphoma  (ISO)
lymphoplasmacytic lymphoma  (ISO)
melanoma  (IMP)
metabolic dysfunction-associated steatohepatitis  (IEP)
monoclonal gammopathy of uncertain significance  (IAGP)
multiple myeloma  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
non-Hodgkin lymphoma  (ISO)
Paraproteinemias  (ISO)
plasma cell neoplasm  (ISO)
pneumonia  (ISO)
pulmonary eosinophilia  (ISO)
Reperfusion Injury  (ISO)
severe acute respiratory syndrome  (ISO)
stomach cancer  (IMP)
Stomach Neoplasms  (IMP)
testicular lymphoma  (ISO)
Visceral Heterotaxy 4, Autosomal  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
2,2,2-trichloroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (EXP)
3-mercaptopropanoic acid  (EXP)
3-phenylprop-2-enal  (EXP)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (EXP)
5-fluorouracil  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (ISO)
agomelatine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP,ISO)
Alternaramide  (EXP)
Ammothamnine  (ISO)
ampicillin  (EXP)
anethole  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
artesunate  (ISO)
atorvastatin calcium  (ISO)
ATP  (EXP)
baicalin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP)
benzo[e]pyrene  (ISO)
Bergenin  (EXP)
beta-D-glucan  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
boldenone  (ISO)
bortezomib  (ISO)
bosentan  (ISO)
buspirone  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium selenide  (ISO)
cannabidiol  (EXP,ISO)
carbamazepine  (ISO)
carbon atom  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
casticin  (ISO)
cefoxitin  (EXP)
chaetoglobosin A  (EXP)
chlorogenic acid  (EXP,ISO)
chloroquine  (EXP)
chlorpyrifos  (EXP)
chrysin  (ISO)
cirsilineol  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP)
corn oil  (EXP)
crocin-1  (ISO)
cudratricusxanthone A  (EXP)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
DAPT  (EXP,ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diclofenac  (EXP)
dioxygen  (EXP,ISO)
dorsomorphin  (EXP)
doxorubicin  (ISO)
elemental carbon  (ISO)
epoxiconazole  (EXP)
erlotinib hydrochloride  (ISO)
esculetin  (EXP)
ethanol  (EXP,ISO)
euxanthone  (ISO)
fenthion  (EXP)
ferric oxide  (EXP)
ferroheme b  (EXP)
fisetin  (EXP)
flutamide  (ISO)
folic acid  (EXP)
FR900359  (ISO)
fructose  (EXP)
galactose  (EXP,ISO)
Gastrodin  (ISO)
Genipin  (EXP)
genistein  (ISO)
genkwanin  (ISO)
gentamycin  (EXP,ISO)
Ginkgolide A  (EXP)
glucose  (ISO)
graphene oxide  (EXP)
Harpagide  (EXP)
heme b  (EXP)
high-density lipoprotein cholesterol  (ISO)
hydrogen peroxide  (ISO)
icosanoid  (EXP)
immunological adjuvant  (EXP)
irinotecan  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
Kukoamine B  (EXP)
lactulose  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
melatonin  (ISO)
metam  (EXP)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
metronidazole  (EXP)
monocrotaline  (EXP)
Morroniside  (EXP)
motexafin gadolinium  (ISO)
muramyl dipeptide  (EXP)
myrtenol  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
neomycin  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
Nonylphenol  (ISO)
o-anisidine  (ISO)
obeticholic acid  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (EXP)
pentobarbital  (ISO)
peptidoglycan  (EXP)
perfluorooctanoic acid  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pipoxolan  (EXP)
pirinixic acid  (EXP)
platycodin D  (ISO)
poly(I:C)  (EXP)
polymyxin B2  (EXP)
progesterone  (EXP)
quercetin  (EXP,ISO)
resiquimod  (EXP)
resveratrol  (EXP,ISO)
rosmarinic acid  (ISO)
rotenone  (ISO)
Salvianolic acid A  (EXP)
saxagliptin  (ISO)
scoparone  (EXP)
scopoletin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium acetate trihydrate  (EXP)
sodium arsenite  (EXP,ISO)
sodium propionate  (EXP)
Soman  (ISO)
streptozocin  (EXP,ISO)
sulfasalazine  (ISO)
sulforaphane  (EXP)
sulfur dioxide  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (EXP)
thymoquinone  (ISO)
Timosaponin b ii  (EXP)
titanium atom  (ISO)
titanium dioxide  (ISO)
trans-anethole  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimethyltin  (EXP)
trovafloxacin  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc oxide  (EXP)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-UTR-mediated mRNA stabilization  (ISO)
apoptotic process  (ISO)
cell surface receptor protein serine/threonine kinase signaling pathway  (TAS)
cell surface receptor signaling pathway  (IMP)
cellular response to lipopolysaccharide  (IMP)
cellular response to mechanical stimulus  (ISO)
cellular response to organic substance  (IMP)
cellular response to oxidised low-density lipoprotein particle stimulus  (IMP)
chromatin organization  (IMP)
cytokine-mediated signaling pathway  (ISO)
defense response to bacterium  (ISO)
defense response to Gram-positive bacterium  (IBA,IMP)
defense response to protozoan  (IMP)
defense response to virus  (ISO)
establishment of endothelial intestinal barrier  (IMP)
gene expression  (IMP)
immune response  (TAS)
immune system process  (IEA)
immunoglobulin mediated immune response  (IMP)
induced systemic resistance  (IMP)
inflammatory response  (IMP)
innate immune response  (IBA)
interleukin-1-mediated signaling pathway  (IDA,ISO)
interleukin-33-mediated signaling pathway  (ISO)
JNK cascade  (IMP,ISO)
leukocyte activation involved in inflammatory response  (IGI)
lipopolysaccharide-mediated signaling pathway  (IMP)
microglia differentiation  (IMP)
MyD88-dependent toll-like receptor signaling pathway  (IGI,IMP)
neurogenesis  (IMP)
neutrophil activation involved in immune response  (IGI)
neutrophil-mediated killing of bacterium  (IGI)
phagocytosis  (IMP,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IGI,IMP)
positive regulation of chemokine production  (IGI)
positive regulation of cytokine production involved in inflammatory response  (IMP,ISO)
positive regulation of gene expression  (IGI,IMP)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-17 production  (IMP)
positive regulation of interleukin-23 production  (IMP)
positive regulation of interleukin-6 production  (IMP)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JNK cascade  (IMP)
positive regulation of lymphocyte proliferation  (IMP)
positive regulation of macrophage cytokine production  (IGI,IMP)
positive regulation of NLRP3 inflammasome complex assembly  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP)
positive regulation of tumor necrosis factor production  (IGI,IMP)
positive regulation of type I interferon production  (ISO)
regulation of cell population proliferation  (IGI)
regulation of chemokine (C-X-C motif) ligand 1 production  (IMP)
regulation of chemokine (C-X-C motif) ligand 2 production  (IMP)
regulation of gene expression  (IMP)
regulation of inflammatory response  (IMP)
regulation of interleukin-6 production  (IMP)
regulation of neutrophil migration  (IMP)
regulation of tumor necrosis factor production  (IMP)
response to amine  (ISO)
response to amino acid  (ISO)
response to ethanol  (ISO)
response to interleukin-1  (ISO)
response to lipopolysaccharide  (IGI,IMP)
response to molecule of fungal origin  (IMP)
response to organic cyclic compound  (ISO)
response to organonitrogen compound  (ISO)
response to peptidoglycan  (IMP)
response to virus  (IMP)
signal transduction  (IEA)
skin development  (IMP)
Toll signaling pathway  (IBA,ISO)
toll-like receptor 4 signaling pathway  (IBA,ISO)
toll-like receptor 8 signaling pathway  (ISO)
type I interferon-mediated signaling pathway  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adaptive immunity  (IAGP)
abnormal airway responsiveness  (IAGP)
abnormal CD4-positive, alpha-beta T cell physiology  (IAGP)
abnormal cell-mediated immunity  (IAGP)
abnormal chemokine level  (IAGP)
abnormal chemokine secretion  (IAGP)
abnormal circulating chemokine level  (IAGP)
abnormal cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell antigen presentation  (IAGP)
abnormal dendritic cell differentiation  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal enterocyte morphology  (IAGP)
abnormal enterocyte physiology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal gut flora balance  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal innate immunity  (IAGP)
abnormal interferon level  (IAGP)
abnormal leukocyte migration  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal memory T cell physiology  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal NK T cell physiology  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal pancreatic beta cell physiology  (IAGP)
abnormal parametrial fat pad morphology  (IAGP)
abnormal plasmacytoid dendritic cell morphology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal response to infection  (IAGP)
abnormal retina progenitor cell morphology  (IAGP)
abnormal somatic hypermutation frequency  (IAGP)
abnormal splenic cell ratio  (IAGP)
abnormal survival  (IAGP)
abnormal susceptibility to bacterial infection  (IAGP)
abnormal susceptibility to hearing loss  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T-helper 1 cell differentiation  (IAGP)
abnormal T-helper 1 physiology  (IAGP)
abnormal T-helper 17 cell physiology  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
bronchiolitis  (IAGP)
cecum inflammation  (IAGP)
decreased B cell proliferation  (IAGP)
decreased body length  (IAGP)
decreased circulating alanine transaminase level  (IAGP)
decreased circulating aspartate transaminase level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating interleukin-10 level  (IAGP)
decreased circulating interleukin-12b level  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased circulating tumor necrosis factor level  (IAGP)
decreased CXCL10 level  (IAGP)
decreased effector memory CD4-positive, alpha-beta T cell number  (IAGP)
decreased epididymal fat pad weight  (IAGP)
decreased fat cell size  (IAGP)
decreased food intake  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG2c level  (IAGP)
decreased IgG3 level  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased inflammatory response  (IAGP)
decreased interferon-alpha secretion  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-1 beta secretion  (IAGP)
decreased interleukin-10 secretion  (IAGP)
decreased interleukin-12 secretion  (IAGP)
decreased interleukin-12b secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased liver tumor incidence  (IAGP)
decreased locomotor activity  (IAGP)
decreased macrophage cell number  (IAGP)
decreased macrophage cytokine production  (IAGP)
decreased macrophage nitric oxide production  (IAGP)
decreased mature B cell number  (IAGP)
decreased mean corpuscular volume  (IEA)
decreased monocyte cell number  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased Paneth cell number  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased susceptibility to kidney reperfusion injury  (IAGP)
decreased susceptibility to parasitic infection  (IAGP)
decreased total body fat amount  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
demyelination  (IAGP)
enlarged spleen  (IAGP)
hyperglycemia  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased apoptosis  (IAGP)
increased B cell proliferation  (IAGP)
increased B-1 B cell number  (IAGP)
increased body weight  (IEA)
increased circulating alanine transaminase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased dendritic cell number  (IAGP)
increased energy expenditure  (IAGP)
increased enterocyte apoptosis  (IAGP)
increased germinal center B cell number  (IAGP)
increased IgA level  (IAGP)
increased IgE level  (IAGP)
increased IgG1 level  (IAGP)
increased IgM level  (IAGP)
increased insulin sensitivity  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased plasma cell number  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to Coronaviridae infection  (IAGP)
increased susceptibility to Coronaviridae infection induced morbidity/mortality  (IAGP)
increased susceptibility to Herpesvirales infection  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to injury  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased susceptibility to parasitic infection induced morbidity/mortality  (IAGP)
increased susceptibility to Picornaviridae infection  (IAGP)
paralysis  (IAGP)
rectal hemorrhage  (IAGP)
small pancreatic islets  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study. Anderson BJ, etal., Crit Care. 2019 Dec 9;23(1):400. doi: 10.1186/s13054-019-2684-2.
2. Deficiency of the myeloid differentiation primary response molecule MyD88 leads to an early and rapid development of Helicobacter-induced gastric malignancy. Banerjee A, etal., Infect Immun. 2014 Jan;82(1):356-63. doi: 10.1128/IAI.01344-13. Epub 2013 Oct 28.
3. The Toll-Like Receptor/MyD88/XBP1 Signaling Axis Mediates Skeletal Muscle Wasting during Cancer Cachexia. Bohnert KR, etal., Mol Cell Biol. 2019 Jul 16;39(15). pii: MCB.00184-19. doi: 10.1128/MCB.00184-19. Print 2019 Aug 1.
4. Patients with primary breast and primary female genital tract diffuse large B cell lymphoma have a high frequency of MYD88 and CD79B mutations. Cao XX, etal., Ann Hematol. 2017 Nov;96(11):1867-1871. doi: 10.1007/s00277-017-3094-7. Epub 2017 Aug 12.
5. Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer. Chang CW, etal., Int J Mol Sci. 2020 Jan 8;21(2). pii: ijms21020386. doi: 10.3390/ijms21020386.
6. Morphologic Patterns and the Correlation With MYD88 L265P, CD79B Mutations in Primary Adrenal Diffuse Large B-Cell Lymphoma. Chen Z, etal., Am J Surg Pathol. 2020 Apr;44(4):444-455. doi: 10.1097/PAS.0000000000001386.
7. Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis. Coleman OI, etal., Gastroenterology. 2018 Nov;155(5):1539-1552.e12. doi: 10.1053/j.gastro.2018.07.028. Epub 2018 Jul 29.
8. Effect of ST2825 on the proliferation and apoptosis of human hepatocellular carcinoma cells. Deng Y, etal., Genet Mol Res. 2016 Mar 4;15(1):15016826. doi: 10.4238/gmr.15016826.
9. Baishouwu Extract Suppresses the Development of Hepatocellular Carcinoma via TLR4/MyD88/NF-κB Pathway. Ding YF, etal., Front Pharmacol. 2019 Apr 24;10:389. doi: 10.3389/fphar.2019.00389. eCollection 2019.
10. Growth, metastasis, and expression of CCL2 and CCL5 by murine mammary carcinomas are dependent upon Myd88. Egunsola AT, etal., Cell Immunol. 2012;272(2):220-9. doi: 10.1016/j.cellimm.2011.10.008. Epub 2011 Oct 25.
11. Mutational frequencies of CD79B and MYD88 vary greatly between primary testicular DLBCL and gastrointestinal DLBCL. Frick M, etal., Leuk Lymphoma. 2018 May;59(5):1260-1263. doi: 10.1080/10428194.2017.1370546. Epub 2017 Sep 3.
12. Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma. Grommes C, etal., Cancer Discov. 2017 Sep;7(9):1018-1029. doi: 10.1158/2159-8290.CD-17-0613. Epub 2017 Jun 15.
13. Glycosaminoglycans are important mediators of neutrophilic inflammation in vivo. Gschwandtner M, etal., Cytokine. 2017 Mar;91:65-73. doi: 10.1016/j.cyto.2016.12.008. Epub 2016 Dec 21.
14. Ligand-independent toll-like receptor signals generated by ectopic overexpression of MyD88 generate local and systemic antitumor immunity. Hartman ZC, etal., Cancer Res. 2010 Sep 15;70(18):7209-20. doi: 10.1158/0008-5472.CAN-10-0905. Epub 2010 Sep 7.
15. Adamantane-linked isothiourea derivatives suppress the growth of experimental hepatocellular carcinoma via inhibition of TLR4-MyD88-NF-κB signaling. Hassan HM, etal., Am J Cancer Res. 2021 Feb 1;11(2):350-369. eCollection 2021.
16. Desert dust induces TLR signaling to trigger Th2-dominant lung allergic inflammation via a MyD88-dependent signaling pathway. He M, etal., Toxicol Appl Pharmacol. 2016 Apr 1;296:61-72. doi: 10.1016/j.taap.2016.02.011. Epub 2016 Feb 13.
17. Cell-type specific MyD88 signaling is required for intestinal tumor initiation and progression to malignancy. Holtorf A, etal., Oncoimmunology. 2018 Jun 11;7(8):e1466770. doi: 10.1080/2162402X.2018.1466770. eCollection 2018.
18. Blockade of Myd88 signaling induces antitumor effects by skewing the immunosuppressive function of myeloid-derived suppressor cells. Hong EH, etal., Int J Cancer. 2013 Jun 15;132(12):2839-48. doi: 10.1002/ijc.27974. Epub 2012 Dec 19.
19. Association between interleukin-8 -251A/T polymorphism and the risk of tuberculosis: A meta-analysis. Hu Q, etal., J Int Med Res. 2020 May;48(5):300060520917877. doi: 10.1177/0300060520917877.
20. Enhanced myeloid differentiation factor 88 promotes tumor metastasis via induction of epithelial-mesenchymal transition in human hepatocellular carcinoma. Jia RJ, etal., Cell Death Dis. 2014 Mar 6;5:e1103. doi: 10.1038/cddis.2014.71.
21. Commensal Microbiota Promote Lung Cancer Development via γδ T Cells. Jin C, etal., Cell. 2019 Feb 21;176(5):998-1013.e16. doi: 10.1016/j.cell.2018.12.040. Epub 2019 Jan 31.
22. Synthetic lethality between MyD88 loss and mutations in Wnt/β-catenin pathway in intestinal tumor epithelial cells. Kajino-Sakamoto R, etal., Oncogene. 2021 Jan;40(2):408-420. doi: 10.1038/s41388-020-01541-3. Epub 2020 Nov 12.
23. Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis. Kennedy CL, etal., Oncogene. 2014 May 8;33(19):2540-6. doi: 10.1038/onc.2013.205. Epub 2013 Jun 3.
24. Clinical and pathological significance of myeloid differentiation factor 88 expression in human hepatocellular carcinoma tissues. Kinowaki K, etal., Pathol Int. 2017 May;67(5):256-263. doi: 10.1111/pin.12529. Epub 2017 Apr 3.
25. Functional TLR5 genetic variants affect human colorectal cancer survival. Klimosch SN, etal., Cancer Res. 2013 Dec 15;73(24):7232-42. doi: 10.1158/0008-5472.CAN-13-1746. Epub 2013 Oct 23.
26. Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis. Koliaraki V, etal., Cell Rep. 2019 Jan 15;26(3):536-545.e4. doi: 10.1016/j.celrep.2018.12.072.
27. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
28. Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection. Li C, etal., Cardiovasc Res 2004 Feb 15;61(3):538-47.
29. Genetic polymorphism of CCL2-2518, CXCL10-201, IL8+781 and susceptibility to severity of Enterovirus-71 infection in a Chinese population. Li JA, etal., Inflamm Res. 2014 Jul;63(7):549-56. doi: 10.1007/s00011-014-0724-6. Epub 2014 Mar 9.
30. Mutation and expression analysis of the IDH1, IDH2, DNMT3A, and MYD88 genes in colorectal cancer. Li WL, etal., Gene. 2014 Aug 10;546(2):263-70. doi: 10.1016/j.gene.2014.05.070. Epub 2014 Jun 2.
31. Implication of myeloid differentiation factor 88 inhibitor TJ-M2010-5 for therapeutic intervention of hepatocellular carcinoma. Liu J, etal., Hepatol Res. 2019 Oct;49(10):1182-1194. doi: 10.1111/hepr.13359. Epub 2019 May 9.
32. Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer. Lozano-Pope I, etal., BMC Cancer. 2017 Feb 15;17(1):133. doi: 10.1186/s12885-017-3114-y.
33. Myeloid Differentiation Factor 88 Signaling in Bone Marrow-Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment. Maeda Y, etal., Cancer Prev Res (Phila). 2016 Mar;9(3):253-63. doi: 10.1158/1940-6207.CAPR-15-0315. Epub 2016 Feb 17.
34. MGDs mouse GO annotations MGD data from the GO Consortium
35. MGD IEA MGD IEA
36. MyD88-dependent signaling in non-parenchymal cells promotes liver carcinogenesis. Mohs A, etal., Carcinogenesis. 2020 Apr 22;41(2):171-181. doi: 10.1093/carcin/bgy173.
37. Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians. Natividad A, etal., BMC Med Genet. 2009 Dec 16;10:138. doi: 10.1186/1471-2350-10-138.
38. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Naugler WE, etal., Science. 2007 Jul 6;317(5834):121-4. doi: 10.1126/science.1140485.
39. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
40. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
41. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
42. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
43. Hepatitis B virus (HBV) induces the expression of interleukin-8 that in turn reduces HBV sensitivity to interferon-alpha. Pollicino T, etal., Virology. 2013 Sep;444(1-2):317-28. doi: 10.1016/j.virol.2013.06.028. Epub 2013 Jul 23.
44. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Rakoff-Nahoum S and Medzhitov R, Science. 2007 Jul 6;317(5834):124-7. doi: 10.1126/science.1140488.
45. Comparative analysis of apoptosis and inflammation genes of mice and humans. Reed JC, etal., Genome Res 2003 Jun;13(6B):1376-88.
46. Mouse MP Annotation Import Pipeline RGD automated import pipeline
47. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
48. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
49. Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer. Rhee SH, etal., Gastroenterology. 2008 Aug;135(2):518-28. doi: 10.1053/j.gastro.2008.04.022. Epub 2008 Apr 23.
50. Nucleotide-binding oligomerization domain 2 and Toll-like receptor 2 function independently in a murine model of arthritis triggered by intraarticular peptidoglycan. Rosenzweig HL, etal., Arthritis Rheum. 2010 Apr;62(4):1051-9. doi: 10.1002/art.27335.
51. Expression of pattern recognition receptor genes and mortality in patients with colorectal adenocarcinoma. Royse KE, etal., Int J Mol Epidemiol Genet. 2017 Apr 15;8(2):8-18. eCollection 2017.
52. MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. Salcedo R, etal., J Exp Med. 2010 Aug 2;207(8):1625-36. doi: 10.1084/jem.20100199. Epub 2010 Jul 12.
53. A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis. Scheeren FA, etal., Nat Cell Biol. 2014 Dec;16(12):1238-48. doi: 10.1038/ncb3058. Epub 2014 Nov 2.
54. Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages. Schiechl G, etal., J Clin Invest. 2011 May;121(5):1692-708. doi: 10.1172/JCI42540. Epub 2011 Apr 25.
55. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
56. Overexpression of FOXO3, MYD88, and GAPDH Identified by Suppression Subtractive Hybridization in Esophageal Cancer Is Associated with Autophagy. Soltany-Rezaee-Rad M, etal., Gastroenterol Res Pract. 2014;2014:185035. doi: 10.1155/2014/185035. Epub 2014 Jan 8.
57. Deleting MyD88 signaling in myeloid cells promotes development of adenocarcinomas of the colon. Song J, etal., Cancer Lett. 2018 Oct 1;433:65-75. doi: 10.1016/j.canlet.2018.06.036. Epub 2018 Jun 28.
58. Staphylococcus aureus-induced corneal inflammation is dependent on Toll-like receptor 2 and myeloid differentiation factor 88. Sun Y, etal., Infect Immun. 2006 Sep;74(9):5325-32.
59. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Verstrepen L, etal., Cell Mol Life Sci. 2008 Oct;65(19):2964-78.
60. High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer. Wang EL, etal., Br J Cancer. 2010 Mar 2;102(5):908-15. doi: 10.1038/sj.bjc.6605558. Epub 2010 Feb 9.
61. Interleukin-1 (IL-1) pathway. Weber A, etal., Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1.
62. Increased expression of MyD88 and association with paclitaxel resistance in breast cancer. Xiang F, etal., Tumour Biol. 2016 May;37(5):6017-25. doi: 10.1007/s13277-015-4436-5. Epub 2015 Nov 23.
63. Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated Colorectal Cancer. Xie L, etal., J Natl Cancer Inst. 2015 Dec 28;108(4). pii: djv364. doi: 10.1093/jnci/djv364. Print 2016 Apr.
64. Sex hormone affects the severity of non-alcoholic steatohepatitis through the MyD88-dependent IL-6 signaling pathway. Xin G, etal., Exp Biol Med (Maywood). 2015 Oct;240(10):1279-86. doi: 10.1177/1535370215570189. Epub 2015 Mar 18.
65. IL33 activates CD8+T and NK cells through MyD88 pathway to suppress the lung cancer cell growth in mice. Xu L, etal., Biotechnol Lett. 2020 Jul;42(7):1113-1121. doi: 10.1007/s10529-020-02815-2. Epub 2020 Mar 5.
66. Long non-coding RNA Myd88 promotes growth and metastasis in hepatocellular carcinoma via regulating Myd88 expression through H3K27 modification. Xu X, etal., Cell Death Dis. 2017 Oct 12;8(10):e3124. doi: 10.1038/cddis.2017.519.
67. Primary diffuse large B-cell lymphomas of central nervous system exhibit remarkably high prevalence of oncogenic MYD88 and CD79B mutations. Yamada S, etal., Leuk Lymphoma. 2015 Jul;56(7):2141-5. doi: 10.3109/10428194.2014.979413. Epub 2015 Jan 14.
68. Thymosin α1 promotes the activation of myeloid-derived suppressor cells in a Lewis lung cancer model by upregulating Arginase 1. Yuan C, etal., Biochem Biophys Res Commun. 2015 Aug 14;464(1):249-55. doi: 10.1016/j.bbrc.2015.06.132. Epub 2015 Jun 23.
69. Direct inhibition of the TLR4/MyD88 pathway by geniposide suppresses HIF-1α-independent VEGF expression and angiogenesis in hepatocellular carcinoma. Zhang C, etal., Br J Pharmacol. 2020 Jul;177(14):3240-3257. doi: 10.1111/bph.15046. Epub 2020 Apr 12.
70. Curcumin inhibits cell proliferation and migration in NSCLC through a synergistic effect on the TLR4/MyD88 and EGFR pathways. Zhang L, etal., Oncol Rep. 2019 Nov;42(5):1843-1855. doi: 10.3892/or.2019.7278. Epub 2019 Aug 14.
71. Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Zhou R, etal., Invest Ophthalmol Vis Sci. 2012 Oct 25;53(11):7382-8. doi: 10.1167/iovs.12-10238.
72. Toll-like receptor 5 agonist inhibition of growth of A549 lung cancer cells in vivo in a Myd88 dependent manner. Zhou SX, etal., Asian Pac J Cancer Prev. 2012;13(6):2807-12. doi: 10.7314/apjcp.2012.13.6.2807.
73. MyD88 mediates colorectal cancer cell proliferation, migration and invasion via NF‑κB/AP‑1 signaling pathway. Zhu G, etal., Int J Mol Med. 2020 Jan;45(1):131-140. doi: 10.3892/ijmm.2019.4390. Epub 2019 Oct 31.
74. Promoter methylation status of ASC/TMS1/PYCARD is associated with decreased overall survival and TNM status in patients with early stage non-small cell lung cancer (NSCLC). Šutić M, etal., Transl Lung Cancer Res. 2019 Dec;8(6):1000-1015. doi: 10.21037/tlcr.2019.12.08.
Additional References at PubMed
PMID:2374694   PMID:2788176   PMID:7567467   PMID:8957090   PMID:9013863   PMID:9344657   PMID:9575168   PMID:9697844   PMID:9734363   PMID:10047546   PMID:10349636   PMID:10435584  
PMID:10465784   PMID:10607756   PMID:10854325   PMID:10922068   PMID:11025209   PMID:11042159   PMID:11067888   PMID:11076861   PMID:11160328   PMID:11217851   PMID:11286707   PMID:11313410  
PMID:11500829   PMID:11521059   PMID:11526399   PMID:11544529   PMID:11547333   PMID:11698470   PMID:11739528   PMID:11812998   PMID:11823477   PMID:11909531   PMID:11911827   PMID:11923871  
PMID:12055206   PMID:12218091   PMID:12244183   PMID:12244184   PMID:12244198   PMID:12270723   PMID:12447442   PMID:12477932   PMID:12538665   PMID:12559494   PMID:12626561   PMID:12665855  
PMID:12682240   PMID:12682257   PMID:12695520   PMID:12714520   PMID:12719478   PMID:12750407   PMID:12847214   PMID:12855817   PMID:12865424   PMID:12872135   PMID:12874236   PMID:12902324  
PMID:12917260   PMID:12928382   PMID:12933875   PMID:12935356   PMID:12960345   PMID:14517275   PMID:14517278   PMID:14530329   PMID:14563635   PMID:14568952   PMID:14579265   PMID:14610273  
PMID:14625548   PMID:14630816   PMID:14634130   PMID:14636418   PMID:14638820   PMID:14638995   PMID:14668429   PMID:14670305   PMID:14698224   PMID:14716310   PMID:14734753   PMID:14742526  
PMID:14742577   PMID:14744795   PMID:14764662   PMID:14768061   PMID:14971048   PMID:14976261   PMID:14976262   PMID:14978111   PMID:14993594   PMID:15004134   PMID:15004140   PMID:15029200  
PMID:15034058   PMID:15034062   PMID:15034070   PMID:15034168   PMID:15034566   PMID:15039335   PMID:15039368   PMID:15067049   PMID:15128790   PMID:15128822   PMID:15128825   PMID:15137944  
PMID:15153511   PMID:15155621   PMID:15190057   PMID:15197227   PMID:15214027   PMID:15240744   PMID:15249654   PMID:15258598   PMID:15260992   PMID:15265925   PMID:15265935   PMID:15302901  
PMID:15307830   PMID:15322035   PMID:15322195   PMID:15331330   PMID:15345224   PMID:15353553   PMID:15361868   PMID:15368304   PMID:15375173   PMID:15452235   PMID:15489334   PMID:15492225  
PMID:15507117   PMID:15517610   PMID:15534227   PMID:15539158   PMID:15542452   PMID:15593126   PMID:15599404   PMID:15606799   PMID:15611251   PMID:15615857   PMID:15618166   PMID:15630134  
PMID:15634894   PMID:15650773   PMID:15650774   PMID:15654326   PMID:15654341   PMID:15661931   PMID:15665823   PMID:15671286   PMID:15694359   PMID:15709004   PMID:15709016   PMID:15711573  
PMID:15714580   PMID:15723296   PMID:15724245   PMID:15731053   PMID:15731095   PMID:15765149   PMID:15778492   PMID:15781585   PMID:15782199   PMID:15800576   PMID:15814710   PMID:15814731  
PMID:15815647   PMID:15826931   PMID:15845454   PMID:15855642   PMID:15860593   PMID:15890912   PMID:15895089   PMID:15905587   PMID:15922717   PMID:15944297   PMID:15952741   PMID:15956283  
PMID:15964841   PMID:15972526   PMID:15972679   PMID:16002681   PMID:16002682   PMID:16002720   PMID:16025156   PMID:16039576   PMID:16040976   PMID:16041030   PMID:16041408   PMID:16047338  
PMID:16052598   PMID:16081822   PMID:16116197   PMID:16116224   PMID:16118350   PMID:16141072   PMID:16141073   PMID:16142239   PMID:16148103   PMID:16148139   PMID:16148144   PMID:16186163  
PMID:16204620   PMID:16207247   PMID:16210631   PMID:16216974   PMID:16226506   PMID:16236128   PMID:16236719   PMID:16237045   PMID:16237098   PMID:16237099   PMID:16239556   PMID:16244651  
PMID:16254214   PMID:16260486   PMID:16272281   PMID:16272328   PMID:16272344   PMID:16275884   PMID:16276483   PMID:16286919   PMID:16292312   PMID:16300676   PMID:16301743   PMID:16306937  
PMID:16323245   PMID:16339557   PMID:16358337   PMID:16365150   PMID:16369011   PMID:16401773   PMID:16407889   PMID:16413925   PMID:16413926   PMID:16413927   PMID:16424940   PMID:16428431  
PMID:16428731   PMID:16440059   PMID:16456008   PMID:16456012   PMID:16456013   PMID:16461338   PMID:16461893   PMID:16473828   PMID:16473830   PMID:16477040   PMID:16491077   PMID:16492804  
PMID:16495516   PMID:16513388   PMID:16517734   PMID:16517740   PMID:16518342   PMID:16552045   PMID:16552075   PMID:16554296   PMID:16574902   PMID:16585574   PMID:16585586   PMID:16586493  
PMID:16609927   PMID:16625202   PMID:16648192   PMID:16670325   PMID:16670327   PMID:16703513   PMID:16703567   PMID:16709840   PMID:16709871   PMID:16710369   PMID:16714560   PMID:16714586  
PMID:16714594   PMID:16732281   PMID:16751103   PMID:16777969   PMID:16782034   PMID:16782035   PMID:16785494   PMID:16785551   PMID:16785556   PMID:16789835   PMID:16818783   PMID:16818787  
PMID:16825490   PMID:16829620   PMID:16832055   PMID:16849485   PMID:16874736   PMID:16878177   PMID:16879997   PMID:16886064   PMID:16887997   PMID:16888020   PMID:16889948   PMID:16892068  
PMID:16893899   PMID:16920916   PMID:16920942   PMID:16921381   PMID:16935388   PMID:16936244   PMID:16951309   PMID:16951362   PMID:16951367   PMID:16954198   PMID:16955143   PMID:16980981  
PMID:16982918   PMID:16983331   PMID:16985170   PMID:16990136   PMID:17000122   PMID:17015716   PMID:17018642   PMID:17027299   PMID:17030581   PMID:17034585   PMID:17038530   PMID:17038589  
PMID:17049055   PMID:17053835   PMID:17055754   PMID:17056519   PMID:17056539   PMID:17057095   PMID:17060475   PMID:17074859   PMID:17082622   PMID:17085599   PMID:17114485   PMID:17118979  
PMID:17135446   PMID:17145958   PMID:17158234   PMID:17159982   PMID:17167049   PMID:17178920   PMID:17178921   PMID:17185603   PMID:17190817   PMID:17194808   PMID:17200722   PMID:17202370  
PMID:17202381   PMID:17227910   PMID:17229689   PMID:17242162   PMID:17267571   PMID:17275788   PMID:17277123   PMID:17277144   PMID:17283089   PMID:17289654   PMID:17292937   PMID:17312158  
PMID:17312163   PMID:17329566   PMID:17339355   PMID:17339471   PMID:17339472   PMID:17353199   PMID:17353291   PMID:17353783   PMID:17357057   PMID:17360653   PMID:17361131   PMID:17363730  
PMID:17369491   PMID:17371981   PMID:17372011   PMID:17374847   PMID:17389237   PMID:17389381   PMID:17398124   PMID:17404295   PMID:17404300   PMID:17404301   PMID:17404302   PMID:17408640  
PMID:17417641   PMID:17433728   PMID:17442966   PMID:17450126   PMID:17450144   PMID:17452470   PMID:17452523   PMID:17456769   PMID:17458858   PMID:17469144   PMID:17475835   PMID:17475853  
PMID:17475882   PMID:17485511   PMID:17486093   PMID:17490432   PMID:17495130   PMID:17496895   PMID:17502662   PMID:17506816   PMID:17507369   PMID:17507480   PMID:17513714   PMID:17525287  
PMID:17537666   PMID:17540841   PMID:17548519   PMID:17548579   PMID:17548587   PMID:17548596   PMID:17548806   PMID:17567694   PMID:17572156   PMID:17572686   PMID:17573354   PMID:17576775  
PMID:17576821   PMID:17579019   PMID:17579042   PMID:17579078   PMID:17591966   PMID:17601656   PMID:17617606   PMID:17617611   PMID:17617634   PMID:17618294   PMID:17626835   PMID:17631139  
PMID:17635956   PMID:17638914   PMID:17652449   PMID:17658280   PMID:17660297   PMID:17664289   PMID:17666571   PMID:17668900   PMID:17673516   PMID:17686871   PMID:17704767   PMID:17705131  
PMID:17707128   PMID:17713535   PMID:17717323   PMID:17722035   PMID:17723216   PMID:17724133   PMID:17785432   PMID:17785804   PMID:17785847   PMID:17804687   PMID:17853409   PMID:17853945  
PMID:17878370   PMID:17881510   PMID:17911638   PMID:17925397   PMID:17925880   PMID:17942529   PMID:17945349   PMID:17947236   PMID:17947655   PMID:17947673   PMID:17947688   PMID:17947692  
PMID:17947693   PMID:17954569   PMID:17974599   PMID:17979981   PMID:17982041   PMID:17982056   PMID:17991771   PMID:17992263   PMID:18003835   PMID:18008007   PMID:18025183   PMID:18025202  
PMID:18025224   PMID:18025234   PMID:18026101   PMID:18032677   PMID:18039832   PMID:18039950   PMID:18057004   PMID:18071261   PMID:18085664   PMID:18086870   PMID:18086890   PMID:18086918  
PMID:18097414   PMID:18156186   PMID:18178624   PMID:18178848   PMID:18178857   PMID:18180310   PMID:18180766   PMID:18195069   PMID:18200498   PMID:18200499   PMID:18203139   PMID:18209086  
PMID:18211965   PMID:18227170   PMID:18250441   PMID:18250459   PMID:18252871   PMID:18256040   PMID:18256152   PMID:18256672   PMID:18266299   PMID:18268035   PMID:18268142   PMID:18285403  
PMID:18287559   PMID:18295350   PMID:18297073   PMID:18299340   PMID:18308927   PMID:18319258   PMID:18322196   PMID:18322216   PMID:18322222   PMID:18322244   PMID:18337753   PMID:18342009  
PMID:18347044   PMID:18354186   PMID:18354200   PMID:18354209   PMID:18354210   PMID:18354215   PMID:18362170   PMID:18363877   PMID:18375954   PMID:18376402   PMID:18378636   PMID:18378686  
PMID:18390710   PMID:18391010   PMID:18398934   PMID:18423196   PMID:18424698   PMID:18424719   PMID:18441280   PMID:18448455   PMID:18458086   PMID:18480050   PMID:18480244   PMID:18490717  
PMID:18492657   PMID:18493980   PMID:18509511   PMID:18510678   PMID:18516037   PMID:18523294   PMID:18523439   PMID:18548002   PMID:18552351   PMID:18559428   PMID:18566426   PMID:18567586  
PMID:18587008   PMID:18624355   PMID:18641322   PMID:18641352   PMID:18641654   PMID:18644971   PMID:18656388   PMID:18660455   PMID:18669894   PMID:18691914   PMID:18692153   PMID:18701460  
PMID:18708593   PMID:18714019   PMID:18716618   PMID:18768827   PMID:18768833   PMID:18768886   PMID:18772134   PMID:18776126   PMID:18776906   PMID:18780793   PMID:18782351   PMID:18782768  
PMID:18792393   PMID:18798338   PMID:18799693   PMID:18799752   PMID:18804339   PMID:18806225   PMID:18806780   PMID:18818389   PMID:18820644   PMID:18820679   PMID:18824534   PMID:18824541  
PMID:18824599   PMID:18832584   PMID:18844999   PMID:18924132   PMID:18931363   PMID:18941235   PMID:18941239   PMID:18941240   PMID:18946505   PMID:18948575   PMID:18974879   PMID:18981086  
PMID:18981097   PMID:18981139   PMID:18981140   PMID:18981153   PMID:18981228   PMID:18986247   PMID:18987631   PMID:19004989   PMID:19006696   PMID:19009526   PMID:19009528   PMID:19017981  
PMID:19017982   PMID:19019963   PMID:19049649   PMID:19050243   PMID:19050265   PMID:19050267   PMID:19052080   PMID:19064699   PMID:19075245   PMID:19079579   PMID:19096031   PMID:19109436  
PMID:19112093   PMID:19120489   PMID:19120490   PMID:19121660   PMID:19122641   PMID:19124755   PMID:19129756   PMID:19130473   PMID:19130558   PMID:19139077   PMID:19139169   PMID:19139171  
PMID:19141452   PMID:19144984   PMID:19144988   PMID:19152336   PMID:19155485   PMID:19157556   PMID:19158348   PMID:19167362   PMID:19181857   PMID:19200759   PMID:19201871   PMID:19201879  
PMID:19201885   PMID:19201901   PMID:19204112   PMID:19214214   PMID:19218085   PMID:19218193   PMID:19224641   PMID:19234201   PMID:19234608   PMID:19246719   PMID:19262671   PMID:19265123  
PMID:19266498   PMID:19270748   PMID:19272387   PMID:19273561   PMID:19278729   PMID:19285437   PMID:19288856   PMID:19289601   PMID:19291703   PMID:19297619   PMID:19299691   PMID:19299716  
PMID:19299719   PMID:19332531   PMID:19332535   PMID:19339971   PMID:19341611   PMID:19342644   PMID:19342674   PMID:19342691   PMID:19357791   PMID:19362020   PMID:19364834   PMID:19376887  
PMID:19378012   PMID:19382893   PMID:19398543   PMID:19406832   PMID:19406986   PMID:19412180   PMID:19414781   PMID:19414785   PMID:19424969   PMID:19430477   PMID:19433551   PMID:19451398  
PMID:19454663   PMID:19454708   PMID:19454718   PMID:19461045   PMID:19474102   PMID:19483718   PMID:19492426   PMID:19494269   PMID:19494277   PMID:19494325   PMID:19521510   PMID:19535624  
PMID:19540914   PMID:19542370   PMID:19542372   PMID:19542374   PMID:19542460   PMID:19548630   PMID:19551144   PMID:19553532   PMID:19553541   PMID:19561082   PMID:19561102   PMID:19561617  
PMID:19570822   PMID:19574958   PMID:19576795   PMID:19585512   PMID:19586942   PMID:19587376   PMID:19587448   PMID:19592489   PMID:19596768   PMID:19596990   PMID:19596996   PMID:19602669  
PMID:19609356   PMID:19617536   PMID:19620295   PMID:19620296   PMID:19635859   PMID:19635909   PMID:19635922   PMID:19638630   PMID:19644121   PMID:19652017   PMID:19652202   PMID:19652710  
PMID:19657352   PMID:19658093   PMID:19666528   PMID:19666548   PMID:19667044   PMID:19668221   PMID:19675137   PMID:19679552   PMID:19710454   PMID:19717510   PMID:19720838   PMID:19740375  
PMID:19740707   PMID:19747212   PMID:19753301   PMID:19762681   PMID:19781786   PMID:19783673   PMID:19786535   PMID:19786565   PMID:19797072   PMID:19805227   PMID:19806220   PMID:19808018  
PMID:19808647   PMID:19812205   PMID:19812209   PMID:19815506   PMID:19822644   PMID:19839009   PMID:19843690   PMID:19843934   PMID:19843957   PMID:19846873   PMID:19850892   PMID:19865078  
PMID:19875664   PMID:19877013   PMID:19879164   PMID:19880493   PMID:19889726   PMID:19890051   PMID:19898473   PMID:19904768   PMID:19913447   PMID:19917690   PMID:19919859   PMID:19923465  
PMID:19930040   PMID:19932745   PMID:19933833   PMID:19933851   PMID:19936231   PMID:19940113   PMID:19943952   PMID:19949074   PMID:19950169   PMID:19950174   PMID:19952354   PMID:19955209  
PMID:19955495   PMID:19965653   PMID:19995952   PMID:20007575   PMID:20007584   PMID:20008526   PMID:20019195   PMID:20034887   PMID:20037584   PMID:20038642   PMID:20038715   PMID:20042569  
PMID:20051628   PMID:20059544   PMID:20067532   PMID:20067542   PMID:20068222   PMID:20089701   PMID:20093176   PMID:20107166   PMID:20107183   PMID:20123960   PMID:20124098   PMID:20124105  
PMID:20124491   PMID:20130216   PMID:20142359   PMID:20162551   PMID:20164423   PMID:20167866   PMID:20181884   PMID:20190759   PMID:20194588   PMID:20200270   PMID:20200276   PMID:20207969  
PMID:20224597   PMID:20228254   PMID:20231693   PMID:20308556   PMID:20333623   PMID:20348242   PMID:20348425   PMID:20351139   PMID:20351694   PMID:20357263   PMID:20360404   PMID:20362473  
PMID:20364087   PMID:20368346   PMID:20375303   PMID:20375605   PMID:20381591   PMID:20383124   PMID:20383149   PMID:20393111   PMID:20393135   PMID:20404081   PMID:20419140   PMID:20422028  
PMID:20431058   PMID:20431620   PMID:20432233   PMID:20435892   PMID:20436484   PMID:20442858   PMID:20452828   PMID:20456021   PMID:20457788   PMID:20465563   PMID:20473304   PMID:20473309  
PMID:20479237   PMID:20483752   PMID:20488784   PMID:20488794   PMID:20493731   PMID:20495560   PMID:20498021   PMID:20500691   PMID:20504885   PMID:20508155   PMID:20519121   PMID:20526283  
PMID:20530205   PMID:20534434   PMID:20538615   PMID:20566828   PMID:20581153   PMID:20585036   PMID:20610649   PMID:20610651   PMID:20617171   PMID:20628601   PMID:20631245   PMID:20631258  
PMID:20639251   PMID:20639876   PMID:20643338   PMID:20644172   PMID:20650880   PMID:20650929   PMID:20660347   PMID:20660707   PMID:20661430   PMID:20668218   PMID:20668698   PMID:20675594  
PMID:20676093   PMID:20683250   PMID:20686126   PMID:20696131   PMID:20696947   PMID:20699281   PMID:20699362   PMID:20702415   PMID:20802178   PMID:20817868   PMID:20819925   PMID:20826748  
PMID:20837714   PMID:20855887   PMID:20865117   PMID:20869044   PMID:20870935   PMID:20876350   PMID:20881045   PMID:20886104   PMID:20890285   PMID:20921145   PMID:20927103   PMID:20937844  
PMID:20941850   PMID:20944006   PMID:20947763   PMID:20956347   PMID:20957750   PMID:20962508   PMID:20966396   PMID:20971730   PMID:20974827   PMID:20975040   PMID:21029863   PMID:21035758  
PMID:21036155   PMID:21041647   PMID:21041656   PMID:21045126   PMID:21051439   PMID:21056969   PMID:21059770   PMID:21078858   PMID:21088116   PMID:21093317   PMID:21094136   PMID:21098092  
PMID:21098219   PMID:21098220   PMID:21098227   PMID:21109237   PMID:21115688   PMID:21115693   PMID:21125645   PMID:21131352   PMID:21131367   PMID:21131426   PMID:21145762   PMID:21149607  
PMID:21149611   PMID:21160041   PMID:21164516   PMID:21169550   PMID:21173242   PMID:21182074   PMID:21182089   PMID:21191074   PMID:21203444   PMID:21204785   PMID:21204848   PMID:21205640  
PMID:21206087   PMID:21206089   PMID:21220692   PMID:21233312   PMID:21239713   PMID:21242294   PMID:21246055   PMID:21248035   PMID:21248248   PMID:21257927   PMID:21257963   PMID:21257968  
PMID:21264236   PMID:21270399   PMID:21273385   PMID:21282509   PMID:21282652   PMID:21283748   PMID:21296813   PMID:21300776   PMID:21308681   PMID:21325272   PMID:21333555   PMID:21339365  
PMID:21353603   PMID:21376021   PMID:21376231   PMID:21376805   PMID:21383239   PMID:21383499   PMID:21398616   PMID:21402950   PMID:21421554   PMID:21422180   PMID:21430222   PMID:21441453  
PMID:21441935   PMID:21458307   PMID:21460206   PMID:21467996   PMID:21474346   PMID:21480215   PMID:21482681   PMID:21482736   PMID:21482737   PMID:21487011   PMID:21496301   PMID:21496466  
PMID:21498664   PMID:21512004   PMID:21515787   PMID:21518783   PMID:21533069   PMID:21540455   PMID:21544241   PMID:21551061   PMID:21551232   PMID:21555485   PMID:21555560   PMID:21557220  
PMID:21559293   PMID:21572023   PMID:21576324   PMID:21596042   PMID:21596591   PMID:21602824   PMID:21606507   PMID:21610198   PMID:21622562   PMID:21622863   PMID:21622869   PMID:21623379  
PMID:21625574   PMID:21627651   PMID:21666244   PMID:21677750   PMID:21683627   PMID:21685248   PMID:21685327   PMID:21687712   PMID:21690093   PMID:21690321   PMID:21690334   PMID:21690387  
PMID:21698299   PMID:21708993   PMID:21723157   PMID:21724589   PMID:21731762   PMID:21738466   PMID:21743479   PMID:21746857   PMID:21760953   PMID:21763676   PMID:21775438   PMID:21804016  
PMID:21804564   PMID:21808234   PMID:21810608   PMID:21813778   PMID:21820332   PMID:21829592   PMID:21829705   PMID:21832166   PMID:21835795   PMID:21844234   PMID:21844383   PMID:21858193  
PMID:21859896   PMID:21859955   PMID:21865389   PMID:21873635   PMID:21881005   PMID:21890657   PMID:21892173   PMID:21899704   PMID:21901151   PMID:21930764   PMID:21930915   PMID:21935459  
PMID:21949249   PMID:21955045   PMID:21960441   PMID:21960563   PMID:21966468   PMID:21967771   PMID:21980379   PMID:21987815   PMID:21989292   PMID:21993848   PMID:21998396   PMID:21998457  
PMID:21998580   PMID:21998589   PMID:22000287   PMID:22011580   PMID:22019834   PMID:22025508   PMID:22028692   PMID:22031762   PMID:22031950   PMID:22034510   PMID:22036947   PMID:22037600  
PMID:22039448   PMID:22041900   PMID:22051943   PMID:22068236   PMID:22072781   PMID:22073274   PMID:22075646   PMID:22075928   PMID:22075930   PMID:22078797   PMID:22084408   PMID:22105301  
PMID:22110092   PMID:22114338   PMID:22114673   PMID:22115825   PMID:22123964   PMID:22124111   PMID:22137454   PMID:22144628   PMID:22147588   PMID:22155109   PMID:22156342   PMID:22156493  
PMID:22158417   PMID:22174456   PMID:22184724   PMID:22187460   PMID:22194975   PMID:22198947   PMID:22206014   PMID:22207622   PMID:22219191   PMID:22219328   PMID:22227568   PMID:22231517  
PMID:22248128   PMID:22250085   PMID:22250086   PMID:22251703   PMID:22253596   PMID:22258450   PMID:22262768   PMID:22275801   PMID:22291094   PMID:22297845   PMID:22306056   PMID:22307620  
PMID:22308317   PMID:22312125   PMID:22323544   PMID:22323740   PMID:22323829   PMID:22326531   PMID:22326848   PMID:22327071   PMID:22341560   PMID:22341910   PMID:22357629   PMID:22370717  
PMID:22371391   PMID:22371392   PMID:22374079   PMID:22385341   PMID:22386951   PMID:22387558   PMID:22394636   PMID:22401992   PMID:22407920   PMID:22412192   PMID:22419116   PMID:22419664  
PMID:22421433   PMID:22422888   PMID:22442158   PMID:22442445   PMID:22447976   PMID:22455839   PMID:22465073   PMID:22466646   PMID:22474023   PMID:22474354   PMID:22479178   PMID:22491177  
PMID:22493489   PMID:22496642   PMID:22496659   PMID:22497726   PMID:22511319   PMID:22536449   PMID:22537289   PMID:22541070   PMID:22542147   PMID:22544439   PMID:22545147   PMID:22547696  
PMID:22565313   PMID:22577359   PMID:22586041   PMID:22610069   PMID:22610280   PMID:22619481   PMID:22628037   PMID:22634614   PMID:22655058   PMID:22661085   PMID:22662179   PMID:22666391  
PMID:22673523   PMID:22677551   PMID:22679002   PMID:22689818   PMID:22693446   PMID:22706912   PMID:22713870   PMID:22723524   PMID:22728937   PMID:22745379   PMID:22745710   PMID:22749354  
PMID:22760779   PMID:22761313   PMID:22761364   PMID:22772444   PMID:22777483   PMID:22777843   PMID:22806454   PMID:22811544   PMID:22826298   PMID:22837197   PMID:22837203   PMID:22837383  
PMID:22840842   PMID:22848400   PMID:22851711   PMID:22851749   PMID:22875802   PMID:22878960   PMID:22879997   PMID:22884360   PMID:22895517   PMID:22895704   PMID:22896628   PMID:22896636  
PMID:22904300   PMID:22904341   PMID:22908323   PMID:22908325   PMID:22927048   PMID:22943202   PMID:22968996   PMID:22980983   PMID:23006848   PMID:23018455   PMID:23018456   PMID:23018458  
PMID:23019612   PMID:23022387   PMID:23023391   PMID:23031643   PMID:23034650   PMID:23047678   PMID:23064150   PMID:23071157   PMID:23075849   PMID:23084425   PMID:23103862   PMID:23110254  
PMID:23123061   PMID:23135279   PMID:23139754   PMID:23142781   PMID:23144170   PMID:23148704   PMID:23166161   PMID:23166489   PMID:23169590   PMID:23179078   PMID:23194377   PMID:23209800  
PMID:23219390   PMID:23221343   PMID:23223360   PMID:23235530   PMID:23238076   PMID:23247210   PMID:23248261   PMID:23251783   PMID:23255009   PMID:23257360   PMID:23257921   PMID:23263554  
PMID:23264657   PMID:23275600   PMID:23275606   PMID:23284054   PMID:23296706   PMID:23297132   PMID:23297238   PMID:23307811   PMID:23308247   PMID:23314004   PMID:23319328   PMID:23325805  
PMID:23326458   PMID:23334413   PMID:23334414   PMID:23341605   PMID:23348507   PMID:23349877   PMID:23365077   PMID:23365081   PMID:23374751   PMID:23382563   PMID:23386616   PMID:23395676  
PMID:23395911   PMID:23408632   PMID:23426369   PMID:23457630   PMID:23460520   PMID:23460746   PMID:23478323   PMID:23483951   PMID:23487424   PMID:23487794   PMID:23492189   PMID:23499488  
PMID:23499490   PMID:23521885   PMID:23522925   PMID:23526822   PMID:23545301   PMID:23585683   PMID:23589622   PMID:23608706   PMID:23630357   PMID:23636052   PMID:23645836   PMID:23650378  
PMID:23658628   PMID:23663738   PMID:23667106   PMID:23671208   PMID:23683462   PMID:23698118   PMID:23708969   PMID:23716075   PMID:23716300   PMID:23716674   PMID:23722163   PMID:23727238  
PMID:23731896   PMID:23733748   PMID:23747950   PMID:23754400   PMID:23762028   PMID:23768919   PMID:23770722   PMID:23774593   PMID:23785118   PMID:23791643   PMID:23811849   PMID:23817427  
PMID:23831471   PMID:23842751   PMID:23843519   PMID:23843525   PMID:23844229   PMID:23845303   PMID:23845800   PMID:23853595   PMID:23853597   PMID:23857504   PMID:23858030   PMID:23869087  
PMID:23874797   PMID:23896513   PMID:23900586   PMID:23906379   PMID:23909393   PMID:23913971   PMID:23920326   PMID:23935195   PMID:23935505   PMID:23940344   PMID:23940714   PMID:23940747  
PMID:23941302   PMID:23942123   PMID:23950714   PMID:23950842   PMID:23956419   PMID:23956420   PMID:23959899   PMID:23964013   PMID:23965627   PMID:23966299   PMID:23966300   PMID:23968977  
PMID:23973223   PMID:23973224   PMID:23980098   PMID:23986602   PMID:23995283   PMID:23997213   PMID:23997219   PMID:23997221   PMID:24023674   PMID:24030499   PMID:24037091   PMID:24038087  
PMID:24042114   PMID:24043892   PMID:24055061   PMID:24062413   PMID:24067878   PMID:24078691   PMID:24078692   PMID:24086273   PMID:24091132   PMID:24120862   PMID:24127866   PMID:24133169  
PMID:24141713   PMID:24143212   PMID:24146959   PMID:24154627   PMID:24154870   PMID:24165160   PMID:24166710   PMID:24167293   PMID:24185615   PMID:24216477   PMID:24248350   PMID:24278020  
PMID:24293628   PMID:24321498   PMID:24335288   PMID:24353176   PMID:24361484   PMID:24361939   PMID:24362933   PMID:24363429   PMID:24367096   PMID:24368419   PMID:24374193   PMID:24374967  
PMID:24375488   PMID:24376264   PMID:24376269   PMID:24379120   PMID:24391492   PMID:24391503   PMID:24391507   PMID:24403581   PMID:24412615   PMID:24424084   PMID:24431229   PMID:24435955  
PMID:24439266   PMID:24442437   PMID:24448240   PMID:24453255   PMID:24453940   PMID:24453977   PMID:24470066   PMID:24477912   PMID:24477914   PMID:24478090   PMID:24478096   PMID:24480625  
PMID:24486456   PMID:24488984   PMID:24489087   PMID:24489101   PMID:24491580   PMID:24500834   PMID:24508233   PMID:24516564   PMID:24518205   PMID:24519940   PMID:24528866   PMID:24529375  
PMID:24529704   PMID:24532577   PMID:24532579   PMID:24534189   PMID:24554667   PMID:24555985   PMID:24557880   PMID:24566622   PMID:24572365   PMID:24595131   PMID:24595141   PMID:24599590  
PMID:24604832   PMID:24614655   PMID:24614801   PMID:24625929   PMID:24646742   PMID:24650018   PMID:24659689   PMID:24663215   PMID:24670424   PMID:24675804   PMID:24683544   PMID:24688025  
PMID:24698267   PMID:24705038   PMID:24713702   PMID:24717539   PMID:24718259   PMID:24722226   PMID:24726878   PMID:24727091   PMID:24743339   PMID:24745334   PMID:24745336   PMID:24747744  
PMID:24752295   PMID:24752299   PMID:24752302   PMID:24754835   PMID:24760892   PMID:24783958   PMID:24799678   PMID:24801628   PMID:24805106   PMID:24807222   PMID:24808358   PMID:24813849  
PMID:24821799   PMID:24878639   PMID:24879442   PMID:24958710   PMID:24973449   PMID:24973819   PMID:24983319   PMID:24990882   PMID:24990886   PMID:25008929   PMID:25010669   PMID:25024136  
PMID:25026888   PMID:25033445   PMID:25049377   PMID:25050810   PMID:25053813   PMID:25054155   PMID:25058342   PMID:25068658   PMID:25070848   PMID:25083866   PMID:25084278   PMID:25088769  
PMID:25089642   PMID:25104770   PMID:25112711   PMID:25114104   PMID:25116321   PMID:25124962   PMID:25125146   PMID:25132550   PMID:25134989   PMID:25149452   PMID:25152077   PMID:25174876  
PMID:25177709   PMID:25186904   PMID:25213347   PMID:25220465   PMID:25229618   PMID:25232836   PMID:25252960   PMID:25253340   PMID:25254554   PMID:25273132   PMID:25274297   PMID:25274725  
PMID:25305320   PMID:25313083   PMID:25329699   PMID:25344724   PMID:25348624   PMID:25365203   PMID:25367117   PMID:25369374   PMID:25389373   PMID:25403892   PMID:25406276   PMID:25415419  
PMID:25421226   PMID:25437548   PMID:25447519   PMID:25448706   PMID:25456137   PMID:25461391   PMID:25466902   PMID:25476696   PMID:25548220   PMID:25567679   PMID:25572843   PMID:25578733  
PMID:25583527   PMID:25593326   PMID:25599561   PMID:25603464   PMID:25607842   PMID:25612611   PMID:25621893   PMID:25628461   PMID:25629406   PMID:25657250   PMID:25659093   PMID:25667266  
PMID:25675510   PMID:25678692   PMID:25681338   PMID:25681348   PMID:25691701   PMID:25692415   PMID:25692705   PMID:25693118   PMID:25700108   PMID:25705883   PMID:25711908   PMID:25715168  
PMID:25723469   PMID:25725353   PMID:25729924   PMID:25733102   PMID:25753415   PMID:25756897   PMID:25760938   PMID:25761602   PMID:25774716   PMID:25776754   PMID:25788530   PMID:25801896  
PMID:25823227   PMID:25848020   PMID:25848864   PMID:25862090   PMID:25874713   PMID:25887709   PMID:25908663   PMID:25923988   PMID:25926397   PMID:25937283   PMID:25954804   PMID:25964372  
PMID:25968578   PMID:25969543   PMID:26011644   PMID:26034136   PMID:26092469   PMID:26095366   PMID:26104484   PMID:26106158   PMID:26136579   PMID:26140582   PMID:26147228   PMID:26151355  
PMID:26160380   PMID:26165843   PMID:26169940   PMID:26173697   PMID:26175492   PMID:26178922   PMID:26187411   PMID:26195481   PMID:26195555   PMID:26195802   PMID:26200012   PMID:26200013  
PMID:26212365   PMID:26217083   PMID:26223660   PMID:26231118   PMID:26237551   PMID:26256668   PMID:26259586   PMID:26272622   PMID:26283478   PMID:26321659   PMID:26361887   PMID:26363072  
PMID:26365184   PMID:26367276   PMID:26374999   PMID:26376975   PMID:26386401   PMID:26416964   PMID:26423149   PMID:26440518   PMID:26440613   PMID:26442657   PMID:26453377   PMID:26466961  
PMID:26479925   PMID:26483549   PMID:26487367   PMID:26515416   PMID:26518437   PMID:26565030   PMID:26578650   PMID:26610689   PMID:26612263   PMID:26627460   PMID:26641462   PMID:26649979  
PMID:26651944   PMID:26655640   PMID:26656686   PMID:26669856   PMID:26678340   PMID:26682986   PMID:26690700   PMID:26694221   PMID:26712805   PMID:26719415   PMID:26720279   PMID:26730403  
PMID:26752353   PMID:26755162   PMID:26779811   PMID:26787722   PMID:26790027   PMID:26808628   PMID:26831104   PMID:26885858   PMID:26926994   PMID:26936962   PMID:26951334   PMID:26971223  
PMID:26976823   PMID:27001940   PMID:27005451   PMID:27015965   PMID:27027293   PMID:27043414   PMID:27043494   PMID:27048211   PMID:27064448   PMID:27100622   PMID:27100888   PMID:27102485  
PMID:27112509   PMID:27125280   PMID:27125343   PMID:27146354   PMID:27151946   PMID:27159323   PMID:27172902   PMID:27178223   PMID:27189410   PMID:27196572   PMID:27218225   PMID:27253707  
PMID:27264973   PMID:27287257   PMID:27288407   PMID:27288486   PMID:27292635   PMID:27293190   PMID:27309732   PMID:27312666   PMID:27317262   PMID:27328989   PMID:27332875   PMID:27339979  
PMID:27354411   PMID:27384869   PMID:27391428   PMID:27396388   PMID:27396959   PMID:27409807   PMID:27418552   PMID:27435819   PMID:27452656   PMID:27459510   PMID:27506999   PMID:27509078  
PMID:27528076   PMID:27542117   PMID:27551155   PMID:27560112   PMID:27569535   PMID:27574188   PMID:27576776   PMID:27606421   PMID:27607191   PMID:27607533   PMID:27614844   PMID:27621416  
PMID:27621420   PMID:27623388   PMID:27647833   PMID:27653694   PMID:27676214   PMID:27716507   PMID:27716849   PMID:27717824   PMID:27731325   PMID:27760315   PMID:27768832   PMID:27775020  
PMID:27783947   PMID:27792766   PMID:27793594   PMID:27798617   PMID:27842213   PMID:27861728   PMID:27869651   PMID:27879260   PMID:27912060   PMID:27917412   PMID:27923071   PMID:27930350  
PMID:27977701   PMID:27979975   PMID:27997610   PMID:28002730   PMID:28011934   PMID:28069819   PMID:28074039   PMID:28076786   PMID:28089363   PMID:28099860   PMID:28111880   PMID:28130494  
PMID:28131803   PMID:28137851   PMID:28161820   PMID:28165624   PMID:28187270   PMID:28198368   PMID:28199836   PMID:28202619   PMID:28223334   PMID:28232117   PMID:28235196   PMID:28238930  
PMID:28273457   PMID:28283665   PMID:28327409   PMID:28327619   PMID:28329706   PMID:28346408   PMID:28356391   PMID:28363496   PMID:28380665   PMID:28383283   PMID:28383552   PMID:28400473  
PMID:28410990   PMID:28416579   PMID:28416600   PMID:28419838   PMID:28432355   PMID:28442574   PMID:28446897   PMID:28461572   PMID:28468798   PMID:28469251   PMID:28479366   PMID:28502093  
PMID:28520792   PMID:28539427   PMID:28564605   PMID:28576260   PMID:28580440   PMID:28607116   PMID:28607148   PMID:28614714   PMID:28615357   PMID:28615695   PMID:28630094   PMID:28634194  
PMID:28642279   PMID:28645296   PMID:28652396   PMID:28652397   PMID:28658630   PMID:28659358   PMID:28662055   PMID:28662171   PMID:28674182   PMID:28698597   PMID:28704551   PMID:28704651  
PMID:28716804   PMID:28723569   PMID:28724768   PMID:28729291   PMID:28733486   PMID:28736216   PMID:28751470   PMID:28758900   PMID:28768728   PMID:28775078   PMID:28796783   PMID:28813659  
PMID:28813662   PMID:28830942   PMID:28848717   PMID:28867282   PMID:28869974   PMID:28874687   PMID:28875549   PMID:28887522   PMID:28895840   PMID:28912382   PMID:28942917   PMID:28951422  
PMID:28951424   PMID:28954231   PMID:28954888   PMID:28970238   PMID:28971472   PMID:28978634   PMID:29036304   PMID:29038503   PMID:29041928   PMID:29049365   PMID:29056340   PMID:29067999  
PMID:29115392   PMID:29118245   PMID:29120743   PMID:29120744   PMID:29128406   PMID:29147584   PMID:29157665   PMID:29158520   PMID:29212904   PMID:29212908   PMID:29232557   PMID:29234000  
PMID:29242168   PMID:29247242   PMID:29249358   PMID:29253517   PMID:29267523   PMID:29269727   PMID:29281834   PMID:29282308   PMID:29288203   PMID:29292386   PMID:29321275   PMID:29358175  
PMID:29358180   PMID:29363545   PMID:29400698   PMID:29440372   PMID:29450586   PMID:29459437   PMID:29476183   PMID:29500225   PMID:29512786   PMID:29521626   PMID:29522531   PMID:29556203  
PMID:29568058   PMID:29576482   PMID:29618478   PMID:29636416   PMID:29651005   PMID:29664021   PMID:29717063   PMID:29728508   PMID:29754819   PMID:29760082   PMID:29777026   PMID:29786074  
PMID:29791904   PMID:29867931   PMID:29898958   PMID:29930103   PMID:29943459   PMID:29948634   PMID:29959173   PMID:29972776   PMID:29987162   PMID:29990310   PMID:30008389   PMID:30010933  
PMID:30021146   PMID:30025110   PMID:30038386   PMID:30046112   PMID:30076215   PMID:30089902   PMID:30097537   PMID:30099194   PMID:30104364   PMID:30108181   PMID:30131424   PMID:30146391  
PMID:30170812   PMID:30185516   PMID:30209176   PMID:30224457   PMID:30240621   PMID:30240702   PMID:30250175   PMID:30250184   PMID:30277599   PMID:30286201   PMID:30317551   PMID:30337494  
PMID:30358438   PMID:30442645   PMID:30447281   PMID:30455267   PMID:30455400   PMID:30470758   PMID:30479367   PMID:30510167   PMID:30582448   PMID:30590048   PMID:30639056   PMID:30642901  
PMID:30666625   PMID:30674337   PMID:30675063   PMID:30675064   PMID:30683700   PMID:30696945   PMID:30720218   PMID:30729183   PMID:30735126   PMID:30755476   PMID:30761150   PMID:30770250  
PMID:30772517   PMID:30781796   PMID:30783017   PMID:30794604   PMID:30799265   PMID:30800124   PMID:30802297   PMID:30816327   PMID:30853218   PMID:30873168   PMID:30883606   PMID:30930901  
PMID:30940817   PMID:30944411   PMID:30952815   PMID:30973865   PMID:30979817   PMID:30988118   PMID:31039009   PMID:31048358   PMID:31053533   PMID:31053626   PMID:31065023   PMID:31086261  
PMID:31087643   PMID:31094704   PMID:31112525   PMID:31134057   PMID:31142830   PMID:31164412   PMID:31167146   PMID:31169521   PMID:31197259   PMID:31201384   PMID:31210415   PMID:31231033  
PMID:31235962   PMID:31243359   PMID:31249303   PMID:31264967   PMID:31268348   PMID:31292433   PMID:31293597   PMID:31302461   PMID:31340983   PMID:31346040   PMID:31350179   PMID:31387916  
PMID:31447838   PMID:31506384   PMID:31507610   PMID:31511628   PMID:31533918   PMID:31542340   PMID:31590685   PMID:31591571   PMID:31626642   PMID:31628426   PMID:31666509   PMID:31676329  
PMID:31719183   PMID:31729371   PMID:31844326   PMID:31852751   PMID:31900344   PMID:31930677   PMID:31964819   PMID:31980634   PMID:31989925   PMID:31993047   PMID:31999809   PMID:32020030  
PMID:32024700   PMID:32073735   PMID:32075762   PMID:32078678   PMID:32094226   PMID:32125695   PMID:32130954   PMID:32144270   PMID:32150572   PMID:32173863   PMID:32179652   PMID:32183481  
PMID:32187540   PMID:32205880   PMID:32209688   PMID:32213589   PMID:32234476   PMID:32269339   PMID:32269573   PMID:32272082   PMID:32295905   PMID:32321514   PMID:32373120   PMID:32385332  
PMID:32398640   PMID:32413093   PMID:32424099   PMID:32424229   PMID:32429710   PMID:32434410   PMID:32445619   PMID:32515732   PMID:32516576   PMID:32540868   PMID:32560726   PMID:32561755  
PMID:32576672   PMID:32610078   PMID:32610084   PMID:32611241   PMID:32611726   PMID:32632165   PMID:32644192   PMID:32652081   PMID:32661363   PMID:32723479   PMID:32723480   PMID:32731255  
PMID:32745117   PMID:32758418   PMID:32763970   PMID:32889432   PMID:32892753   PMID:32941658   PMID:32970964   PMID:32989095   PMID:32991669   PMID:33002631   PMID:33042124   PMID:33049560  
PMID:33087566   PMID:33095261   PMID:33123130   PMID:33123170   PMID:33174138   PMID:33212011   PMID:33220232   PMID:33229758   PMID:33239787   PMID:33240286   PMID:33338425   PMID:33343574  
PMID:33397971   PMID:33412104   PMID:33535045   PMID:33556431   PMID:33596533   PMID:33619117   PMID:33622246   PMID:33666647   PMID:33723368   PMID:33747981   PMID:33790474   PMID:33795743  
PMID:33798492   PMID:33802409   PMID:33824339   PMID:33826887   PMID:33834387   PMID:33933610   PMID:33934399   PMID:33956941   PMID:33958388   PMID:33963333   PMID:33979578   PMID:34010642  
PMID:34017329   PMID:34023381   PMID:34077724   PMID:34093543   PMID:34115982   PMID:34125603   PMID:34172587   PMID:34183650   PMID:34206078   PMID:34211474   PMID:34242922   PMID:34253576  
PMID:34262176   PMID:34287077   PMID:34291735   PMID:34320366   PMID:34324837   PMID:34325487   PMID:34360700   PMID:34375313   PMID:34381449   PMID:34397115   PMID:34399617   PMID:34461100  
PMID:34462225   PMID:34504008   PMID:34512626   PMID:34528666   PMID:34529751   PMID:34529935   PMID:34551296   PMID:34585114   PMID:34597344   PMID:34605740   PMID:34625556   PMID:34625557  
PMID:34644537   PMID:34650551   PMID:34662211   PMID:34678150   PMID:34685673   PMID:34735226   PMID:34755600   PMID:34811946   PMID:34822994   PMID:34830293   PMID:34852217   PMID:34867973  
PMID:34877502   PMID:34927243   PMID:34971898   PMID:35003083   PMID:35021075   PMID:35023810   PMID:35039331   PMID:35041723   PMID:35043940   PMID:35046933   PMID:35065706   PMID:35069570  
PMID:35077396   PMID:35081371   PMID:35089465   PMID:35112724   PMID:35131445   PMID:35137688   PMID:35245345   PMID:35303419   PMID:35316647   PMID:35364006   PMID:35381888   PMID:35395059  
PMID:35417681   PMID:35464475   PMID:35484116   PMID:35493520   PMID:35545033   PMID:35574480   PMID:35581352   PMID:35584674   PMID:35588739   PMID:35670567   PMID:35692080   PMID:35708745  
PMID:35709757   PMID:35759728   PMID:35793767   PMID:35811033   PMID:35838047   PMID:35878016   PMID:36032091   PMID:36037380   PMID:36078075   PMID:36096673   PMID:36116148   PMID:36271704  
PMID:36278484   PMID:36333322   PMID:36341527   PMID:36342063   PMID:36374941   PMID:36377658   PMID:36405694   PMID:36461592   PMID:36481697   PMID:36482445   PMID:36539616   PMID:36591307  
PMID:36598999   PMID:36603588   PMID:36650150   PMID:36685040   PMID:36738733   PMID:36740514   PMID:36779805   PMID:36883865   PMID:37116499   PMID:37130522   PMID:37175545   PMID:37244938  
PMID:37265402   PMID:37283745   PMID:37467575   PMID:37492941   PMID:37566679   PMID:37606850   PMID:37616368   PMID:37620322   PMID:37691934   PMID:37718683   PMID:37719363   PMID:37741861  
PMID:37783266   PMID:37787782   PMID:37846891   PMID:37871107   PMID:37967662   PMID:38022511   PMID:38102579   PMID:38170734   PMID:38280906   PMID:38291436   PMID:38353638  


Genomics

Comparative Map Data
Myd88
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,165,000 - 119,169,084 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,165,000 - 119,170,477 (-)EnsemblGRCm39 Ensembl
GRCm389119,335,934 - 119,340,018 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,335,934 - 119,341,411 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,245,106 - 119,249,158 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,184,686 - 119,188,738 (-)NCBIMGSCv36mm8
Celera9119,805,118 - 119,809,170 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI
MYD88
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38338,138,661 - 38,143,022 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl338,138,552 - 38,143,024 (+)EnsemblGRCh38hg38GRCh38
GRCh37338,180,152 - 38,184,513 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,155,009 - 38,159,517 (+)NCBINCBI36Build 36hg18NCBI36
Build 34338,155,156 - 38,159,514NCBI
Celera338,115,770 - 38,120,314 (+)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef338,220,931 - 38,225,475 (+)NCBIHuRef
CHM1_1338,131,949 - 38,136,493 (+)NCBICHM1_1
T2T-CHM13v2.0338,144,330 - 38,148,691 (+)NCBIT2T-CHM13v2.0
Myd88
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,952,161 - 127,956,230 (-)NCBIGRCr8
mRatBN7.28119,074,439 - 119,078,508 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,074,437 - 119,079,415 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,656,479 - 124,660,550 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,855,496 - 122,859,567 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,689,025 - 120,693,095 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,022,512 - 128,027,462 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,022,473 - 128,026,841 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,229,273 - 127,234,226 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,299,729 - 124,303,798 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18124,319,465 - 124,323,535 (-)NCBI
Celera8118,225,640 - 118,229,709 (-)NCBICelera
Cytogenetic Map8q32NCBI
Myd88
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542725,553,589 - 25,559,138 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542725,553,589 - 25,557,654 (+)NCBIChiLan1.0ChiLan1.0
MYD88
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2238,091,180 - 38,096,494 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1338,096,783 - 38,101,258 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0338,036,565 - 38,041,014 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1338,319,024 - 38,323,572 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,319,024 - 38,323,572 (+)Ensemblpanpan1.1panPan2
MYD88
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1237,901,578 - 7,905,274 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl237,901,250 - 7,904,534 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha237,943,535 - 7,947,227 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0238,191,155 - 8,194,847 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,191,134 - 8,194,847 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1238,005,061 - 8,008,753 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0238,146,176 - 8,149,868 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0238,138,449 - 8,142,140 (+)NCBIUU_Cfam_GSD_1.0
Myd88
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118194,532,893 - 194,537,794 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647327,671,797 - 27,676,372 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647327,672,237 - 27,676,339 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYD88
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1322,966,137 - 22,983,109 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11322,976,951 - 22,979,568 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,181,100 - 25,183,718 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYD88
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,276,804 - 1,281,811 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl151,276,798 - 1,281,166 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606310,006,548 - 10,011,071 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myd88
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247312,677,290 - 2,681,489 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247312,677,259 - 2,681,408 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myd88
101 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:679
Count of miRNA genes:441
Interacting mature miRNAs:517
Transcripts:ENSMUST00000035092, ENSMUST00000139870, ENSMUST00000150837
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse

Markers in Region
X51397  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389119,336,773 - 119,336,862UniSTSGRCm38
MGSCv379119,245,891 - 119,245,980UniSTSGRCm37
Celera9119,805,903 - 119,805,992UniSTS
Cytogenetic Map9F3UniSTS
cM Map970.0UniSTS
Whitehead/MRC_RH91175.69UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_010851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC128702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ790885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ790886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY130516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY130517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U84409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U89023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X51397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X86457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000035092   ⟹   ENSMUSP00000035092
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9119,165,000 - 119,169,107 (-)Ensembl
GRCm38.p6 Ensembl9119,335,934 - 119,340,041 (-)Ensembl
RefSeq Acc Id: ENSMUST00000139870   ⟹   ENSMUSP00000115746
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9119,168,756 - 119,170,477 (-)Ensembl
GRCm38.p6 Ensembl9119,339,690 - 119,341,411 (-)Ensembl
RefSeq Acc Id: ENSMUST00000150837
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9119,165,012 - 119,169,068 (-)Ensembl
GRCm38.p6 Ensembl9119,335,946 - 119,340,002 (-)Ensembl
RefSeq Acc Id: NM_010851   ⟹   NP_034981
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,165,000 - 119,169,084 (-)NCBI
GRCm389119,335,934 - 119,340,018 (-)NCBI
MGSCv379119,245,106 - 119,249,158 (-)RGD
Celera9119,805,118 - 119,809,170 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034981   ⟸   NM_010851
- UniProtKB: O35916 (UniProtKB/Swiss-Prot),   P22366 (UniProtKB/Swiss-Prot),   Q3U7M4 (UniProtKB/TrEMBL),   Q3TIB3 (UniProtKB/TrEMBL),   Q3U6W5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000115746   ⟸   ENSMUST00000139870
RefSeq Acc Id: ENSMUSP00000035092   ⟸   ENSMUST00000035092
Protein Domains
Death   TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22366-F1-model_v2 AlphaFold P22366 1-296 view protein structure

Promoters
RGD ID:6844839
Promoter ID:MM_KWN:59130
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000040319,   OTTMUST00000040320
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,248,986 - 119,250,157 (-)MPROMDB
RGD ID:6844841
Promoter ID:MM_KWN:59132
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_2Hour,   MEF_B4
Transcripts:OTTMUST00000040321
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,250,521 - 119,251,452 (-)MPROMDB
RGD ID:8671188
Promoter ID:EPDNEW_M13625
Type:initiation region
Name:Myd88_1
Description:Mus musculus myeloid differentiation primary response gene 88, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389119,339,999 - 119,340,059EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108005 AgrOrtholog
Ensembl Genes ENSMUSG00000032508 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035092 ENTREZGENE
  ENSMUST00000035092.7 UniProtKB/Swiss-Prot
  ENSMUST00000139870.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.10140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Death_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MyD88_Death UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myelin_different_resp_MyD88 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:108005 ENTREZGENE
NCBI Gene 17874 ENTREZGENE
PANTHER MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15079 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Death UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
  TIR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Myd88 PhenoGen
PIRSF MyD88 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DEATH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DEATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1S5WLE4_MOUSE UniProtKB/TrEMBL
  A0A1S5WLF0_MOUSE UniProtKB/TrEMBL
  F6SPW1_MOUSE UniProtKB/TrEMBL
  MYD88_MOUSE UniProtKB/Swiss-Prot
  O35916 ENTREZGENE
  P22366 ENTREZGENE
  Q0PM15_MOUSE UniProtKB/TrEMBL
  Q0PM16_MOUSE UniProtKB/TrEMBL
  Q3TIB3 ENTREZGENE, UniProtKB/TrEMBL
  Q3U6W5 ENTREZGENE, UniProtKB/TrEMBL
  Q3U7M4 ENTREZGENE, UniProtKB/TrEMBL
  Q3UDG9_MOUSE UniProtKB/TrEMBL
  Q8C1X0_MOUSE UniProtKB/TrEMBL
UniProt Secondary O35916 UniProtKB/Swiss-Prot