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Gene: Ucp2 (uncoupling protein 2 (mitochondrial, proton carrier)) Mus musculus
Symbol: Ucp2
Name: uncoupling protein 2 (mitochondrial, proton carrier)
Description: Predicted to have oxidative phosphorylation uncoupler activity. Involved in positive regulation of cold-induced thermogenesis and regulation of mitochondrial membrane potential. Localizes to mitochondrion. Is expressed in several structures, including adipose tissue; hemolymphoid system; integumental system; nose; and skeletal muscle. Used to study polycystic liver disease. Human ortholog(s) of this gene implicated in artery disease (multiple); diabetic neuropathy; end stage renal disease; non-alcoholic fatty liver disease; and obesity. Orthologous to human UCP2 (uncoupling protein 2); PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: mitochondrial uncoupling protein 2; Slc25a8; solute carrier family 25 member 8; UCP 2; UCPH; uncoupling protein 2, mitochondrial
Homo sapiens (human) : UCP2 (uncoupling protein 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ucp2 (uncoupling protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ucp2 (uncoupling protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : UCP2 (uncoupling protein 2)
Canis lupus familiaris (dog) : UCP2 (uncoupling protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ucp2 (uncoupling protein 2)
Sus scrofa (pig) : UCP2 (uncoupling protein 2)
Chlorocebus sabaeus (African green monkey) : UCP2 (uncoupling protein 2)
Heterocephalus glaber (naked mole-rat) : Ucp2 (uncoupling protein 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl7100,493,337 - 100,502,020 (+)EnsemblGRCm38mm10GRCm38
GRCm387100,493,337 - 100,499,629 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377107,641,854 - 107,650,682 (+)NCBIGRCm37mm9NCBIm37
MGSCv367100,367,446 - 100,376,102 (+)NCBImm8
Celera7100,830,936 - 100,839,747 (+)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ucp2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69171
Created: 2001-11-08
Species: Mus musculus
Last Modified: 2020-07-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.