Cyp19a1 (cytochrome P450, family 19, subfamily a, polypeptide 1) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Cyp19a1 (cytochrome P450, family 19, subfamily a, polypeptide 1) Mus musculus
Symbol: Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
RGD ID: 737520
Description: Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within several processes, including negative regulation of macrophage chemotaxis; reproductive structure development; and testosterone biosynthetic process. Predicted to be located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Is expressed in central nervous system; early conceptus; gonad; retina; and stomach. Used to study Sjogren's syndrome and aromatase excess syndrome. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; endometriosis (multiple); ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A; Ar; ArKO; aro; aromatase; Cyp1; Cyp19; CYPXIX; cytochrome P-450AROM; cytochrome P450 19A1; cytochrome P450, 19, aromatase; estrogen synthase; In; Int; Int-5; Int5; MGC124251; MGC124252; p450; p450arom
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39954,073,221 - 54,175,448 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,073,221 - 54,175,394 (-)EnsemblGRCm39 Ensembl
GRCm38954,165,937 - 54,268,164 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl954,165,937 - 54,268,110 (-)EnsemblGRCm38mm10GRCm38
MGSCv37954,013,744 - 54,041,249 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36953,964,074 - 53,991,581 (-)NCBIMGSCv36mm8
Celera951,408,025 - 51,435,376 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(E)-thiamethoxam  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-benzofuran  (ISO)
1-naphthylamine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-Bis(3-hydroxybenzyl)butane-1,4-diol  (ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trichlorophenol  (ISO)
2,4-dibromophenol  (ISO)
2-bromophenol  (ISO)
2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4-dichloroaniline  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
7-hydroxyflavanone  (ISO)
7-hydroxyflavone  (ISO)
8-Br-cAMP  (EXP,ISO)
9-cis-retinoic acid  (ISO)
acetaldehyde  (EXP)
afimoxifene  (ISO)
Aflatoxicol  (ISO)
aflatoxin B1  (ISO)
AH23848  (ISO)
albuterol  (ISO)
aldrin  (ISO)
alginic acid  (EXP)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
alpha-naphthoflavone  (ISO)
alternariol  (ISO)
aminoglutethimide  (ISO)
amitraz  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
amoxicillin  (ISO)
amphetamine  (EXP)
anastrozole  (ISO)
androgen antagonist  (ISO)
androst-4-ene-3,17-dione  (ISO)
androstane-3,17-diol  (ISO)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracene  (ISO)
apigenin  (ISO)
Aroclor 1254  (ISO)
arotinoid acid  (ISO)
arsenite(3-)  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP,ISO)
benomyl  (ISO)
benzo[a]pyrene  (ISO)
benzofurans  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (EXP,ISO)
bicalutamide  (ISO)
bifenthrin  (ISO)
bifonazole  (ISO)
biochanin A  (ISO)
biphenyl-4-ol  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bitertanol  (ISO)
bucladesine  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbendazim  (ISO)
carmustine  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP,ISO)
chlorogenic acid  (ISO)
chlorpyrifos  (ISO)
Chorionic gonadotropin  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
citalopram  (ISO)
clotrimazole  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyanamide  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cyhexatin  (ISO)
cypermethrin  (EXP,ISO)
cyproconazole  (ISO)
cyproterone  (ISO)
D-aspartic acid  (EXP,ISO)
daidzein  (ISO)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
dibutylstannane  (ISO)
dichlorine  (ISO)
dicofol  (ISO)
dicrotophos  (ISO)
dienogest  (ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethoate  (EXP)
dipentyl phthalate  (ISO)
disulfiram  (EXP)
doxorubicin  (ISO)
E-4031  (EXP)
endosulfan  (ISO)
enilconazole  (EXP,ISO)
enniatin  (ISO)
Enterolactone  (ISO)
enzacamene  (ISO)
epoxiconazole  (ISO)
equol  (EXP)
erlotinib hydrochloride  (ISO)
erythrosin B  (ISO)
estriol  (ISO)
estrone  (ISO)
ethanol  (ISO)
ethosuximide  (ISO)
exemestane  (ISO)
farnesol  (ISO)
fenarimol  (EXP,ISO)
fenbuconazole  (ISO)
fentin chloride  (ISO)
fentin hydroxide  (ISO)
fenvalerate  (ISO)
finasteride  (ISO)
fingolimod hydrochloride  (ISO)
flavanones  (ISO)
flavone  (ISO)
flavones  (ISO)
flavonoids  (ISO)
fluconazole  (ISO)
flufenoxuron  (EXP)
fluoxetine  (ISO)
flusilazole  (ISO)
flutamide  (ISO)
fluvoxamine  (ISO)
formestane  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
Geniposidic acid  (ISO)
genistein  (ISO)
glyphosate  (EXP,ISO)
heptachlor  (ISO)
herbicide  (ISO)
hesperetin  (ISO)
hexachlorobenzene  (ISO)
hexaconazole  (ISO)
HT-2 toxin  (ISO)
ibuprofen  (ISO)
imidacloprid  (ISO)
indirubin  (ISO)
indometacin  (ISO)
iodoacetic acid  (EXP)
iprodione  (ISO)
isoliquiritigenin  (EXP)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
lamotrigine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
letrozole  (EXP,ISO)
leuprolide  (EXP)
levetiracetam  (ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
malathion  (ISO)
medroxyprogesterone acetate  (ISO)
melamine  (ISO)
melatonin  (ISO)
metformin  (ISO)
methadone  (ISO)
methomyl  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (EXP,ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methyltestosterone  (ISO)
metolachlor  (ISO)
miconazole  (ISO)
microcystin-LR  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (EXP,ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (EXP,ISO)
mycotoxin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-Nitrosopyrrolidine  (ISO)
nandrolone  (ISO)
naphthalene  (EXP,ISO)
nicotine  (ISO)
Niflumic acid  (ISO)
nimesulide  (ISO)
Nonylphenol  (ISO)
NS-398  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oleuropein  (ISO)
Oxadiazon  (ISO)
oxcarbazepine  (ISO)
oxiconazole  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
paclitaxel  (ISO)
paracetamol  (ISO)
parathion-methyl  (ISO)
paroxetine  (ISO)
pasireotide  (ISO)
pentachlorophenol  (ISO)
perflubron  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenanthrene  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirimicarb  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
plumbagin  (ISO)
potassium dichromate  (EXP,ISO)
prochloraz  (ISO)
procymidone  (ISO)
profenofos  (ISO)
progesterone  (ISO)
propamocarb  (ISO)
propazine  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (EXP,ISO)
pyrene  (ISO)
quercetin  (ISO)
quinalphos  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
rolipram  (ISO)
rose bengal  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
rutin  (ISO)
SB-239063  (ISO)
SC-58125  (ISO)
semicarbazide  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simazine  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
terbutylazine  (ISO)
testolactone  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
thiacloprid  (ISO)
thiamethoxam  (ISO)
tiagabine  (ISO)
titanium dioxide  (EXP,ISO)
toxaphene  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
triclosan  (ISO)
triflusulfuron-methyl  (ISO)
triphenylstannane  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
U-73122  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vecuronium bromide  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorozole  (ISO)
zearalenone  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
androgen catabolic process  (ISO)
androgen metabolic process  (IMP,ISO)
bile acid metabolic process  (ISO)
biphenyl metabolic process  (ISO)
bone development  (ISO)
C21-steroid hormone metabolic process  (ISO)
calcineurin-mediated signaling  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to gonadotropin stimulus  (ISO)
cellular response to hydrostatic pressure  (ISO)
dibenzo-p-dioxin metabolic process  (ISO)
estrogen biosynthetic process  (ISO)
female genitalia development  (IMP)
female gonad development  (IMP)
granulocyte differentiation  (ISO)
hippocampus development  (ISO)
hypothalamus development  (ISO)
lipid metabolic process  (IEA)
luteinization  (ISO)
male gonad development  (ISO)
mammary gland development  (IMP)
melatonin metabolic process  (ISO)
negative regulation of bone resorption  (ISO)
negative regulation of chronic inflammatory response  (IMP)
negative regulation of macrophage chemotaxis  (IMP)
phthalate metabolic process  (ISO)
positive regulation of estradiol secretion  (ISO)
prostate gland growth  (IMP)
regulation of synapse structure or activity  (ISO)
response to cesium ion  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to herbicide  (ISO)
response to ionizing radiation  (ISO)
response to metal ion  (ISO)
response to morphine  (ISO)
response to organic cyclic compound  (ISO)
response to testosterone  (ISO)
response to xenobiotic stimulus  (ISO)
testosterone biosynthetic process  (IMP)
uterus development  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal acrosome assembly  (IAGP)
abnormal aorta bulb morphology  (IAGP)
abnormal auditory brainstem response  (IAGP)
abnormal barbering behavior  (IAGP)
abnormal baroreceptor physiology  (IAGP)
abnormal bone trabecula morphology  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal copulation  (IAGP)
abnormal emotion/affect behavior  (IAGP)
abnormal enzyme/coenzyme level  (IAGP)
abnormal epididymis morphology  (IAGP)
abnormal gait  (IEA)
abnormal glucose homeostasis  (IAGP)
abnormal gonadal fat pad morphology  (IAGP)
abnormal labium morphology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal liver lobule morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal male germ cell morphology  (IAGP)
abnormal male reproductive system morphology  (IAGP)
abnormal mating frequency  (IAGP)
abnormal mature ovarian follicle morphology  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal parental behavior  (IAGP)
abnormal primary sex determination  (IAGP)
abnormal prostate gland physiology  (IAGP)
abnormal reproductive system physiology  (IAGP)
abnormal salivary gland morphology  (IAGP)
abnormal seminiferous tubule epithelium morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal sexual interaction  (IAGP)
abnormal short term spatial reference memory  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal spermiogenesis  (IAGP)
abnormal spleen germinal center morphology  (IAGP)
abnormal systemic arterial blood pressure  (IAGP)
abnormal tertiary ovarian follicle morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal uterus development  (IAGP)
abnormal white adipose tissue morphology  (IAGP)
absent corpus luteum  (IAGP)
absent ovarian follicles  (IAGP)
anovulation  (IAGP)
arrest of spermiogenesis  (IAGP)
asthenozoospermia  (IAGP)
atherosclerotic lesions  (IAGP)
bradykinesia  (IAGP)
decreased aggression  (IAGP)
decreased aggression towards male mice  (IAGP)
decreased bone mass  (IAGP)
decreased bone mineral density of femur  (IAGP)
decreased circulating alkaline phosphatase level  (IEA)
decreased circulating estradiol level  (IAGP)
decreased circulating HDL cholesterol level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased exploration in new environment  (IEA)
decreased heart rate variability  (IAGP)
decreased lean body mass  (IAGP)
decreased leukocyte cell number  (IEA)
decreased locomotor activity  (IEA)
decreased lymphocyte cell number  (IEA)
decreased male germ cell number  (IAGP)
decreased mean corpuscular hemoglobin concentration  (IEA)
decreased mean systemic arterial blood pressure  (IAGP)
decreased systemic arterial diastolic blood pressure  (IAGP)
decreased testis weight  (IAGP)
decreased uterus weight  (IAGP)
enlarged clitoris  (IAGP)
enlarged liver  (IAGP)
enlarged mesenteric lymph nodes  (IAGP)
enlarged prostate gland  (IAGP)
enlarged salivary gland  (IAGP)
enlarged spleen  (IAGP)
failure of ejaculation  (IAGP)
failure of superovulation  (IAGP)
female infertility  (IAGP)
hepatic steatosis  (IAGP)
hypertension  (IAGP)
impaired glucose tolerance  (IAGP)
impaired luteinization  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
increased abdominal adipose tissue amount  (IAGP)
increased abdominal fat pad weight  (IAGP)
increased aggression towards female mice  (IAGP)
increased anti-single stranded DNA antibody level  (IAGP)
increased anxiety-related response  (IEA)
increased autoantibody level  (IAGP)
increased B cell number  (IAGP)
increased blood urea nitrogen level  (IEA)
increased body weight  (IAGP)
increased bone marrow cell number  (IAGP)
increased bone resorption  (IAGP)
increased cardiac muscle contractility  (IAGP)
increased circulating C-reactive protein level  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating dihydrotestosterone level  (IAGP)
increased circulating follicle stimulating hormone level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating HDL cholesterol level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating LDL cholesterol level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased circulating prolactin level  (IAGP)
increased circulating serum albumin level  (IEA)
increased circulating testosterone level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased circulating VLDL cholesterol level  (IAGP)
increased dendritic cell number  (IAGP)
increased fat cell size  (IAGP)
increased gonadal fat pad weight  (IAGP)
increased granulocyte number  (IAGP)
increased granulosa cell apoptosis  (IAGP)
increased grooming behavior  (IAGP)
increased heart rate  (IAGP)
increased IgG level  (IAGP)
increased leukocyte cell number  (IAGP)
increased Leydig cell number  (IAGP)
increased liver weight  (IAGP)
increased lymphocyte cell number  (IAGP)
increased macrophage cell number  (IAGP)
increased male germ cell apoptosis  (IAGP)
increased mammary fat pad weight  (IAGP)
increased mature B cell number  (IAGP)
increased neutrophil cell number  (IEA)
increased osteoclast cell number  (IAGP)
increased ovary apoptosis  (IAGP)
increased prostate gland anterior lobe weight  (IAGP)
increased prostate gland dorsolateral lobe weight  (IAGP)
increased prostate gland ventral lobe weight  (IAGP)
increased prostate gland weight  (IAGP)
increased renal fat pad weight  (IAGP)
increased seminal vesicle weight  (IAGP)
increased susceptibility to age-related hepatic steatosis  (IAGP)
increased susceptibility to autoimmune disorder  (IAGP)
increased susceptibility to weight gain  (IAGP)
increased systemic arterial blood pressure  (IAGP)
increased total body fat amount  (IAGP)
increased urine protein level  (IAGP)
insulin resistance  (IAGP)
kidney inflammation  (IAGP)
lacrimal gland inflammation  (IAGP)
male infertility  (IAGP)
multinucleated giant male germ cells  (IAGP)
no abnormal phenotype detected  (IAGP)
obese  (IAGP)
oligozoospermia  (IAGP)
ovarian follicular cyst  (IAGP)
ovary cyst  (IAGP)
ovary hemorrhage  (IAGP)
pale liver  (IAGP)
prostate gland anterior lobe hyperplasia  (IAGP)
prostate gland dorsolateral lobe hyperplasia  (IAGP)
prostate gland hyperplasia  (IAGP)
prostate gland ventral lobe hyperplasia  (IAGP)
reduced male fertility  (IAGP)
reduced male mating frequency  (IAGP)
renal glomerular immunoglobulin deposits  (IAGP)
salivary gland inflammation  (IAGP)
small uterus  (IAGP)
spleen hyperplasia  (IAGP)
thin endometrium  (IAGP)
thin myometrium  (IAGP)
thrombocytosis  (IEA)
tremors  (IEA)
uterus hypoplasia  (IAGP)

References - curated
# Reference Title Reference Citation
1. Diabetes alters aromatase enzyme levels in gonadal tissues of rats. Burul-Bozkurt N, etal., Naunyn Schmiedebergs Arch Pharmacol. 2010 Jul;382(1):33-41. Epub 2010 Apr 29.
2. Maternal malnutrition during lactation affects folliculogenesis, gonadotropins, and leptin receptors in adult rats. da Silva Faria T, etal., Nutrition. 2010 Oct;26(10):1000-7. Epub 2009 Dec 16.
3. Increased endogenous estrogen synthesis leads to the sequential induction of prostatic inflammation (prostatitis) and prostatic pre-malignancy. Ellem SJ, etal., Am J Pathol. 2009 Sep;175(3):1187-99. doi: 10.2353/ajpath.2009.081107. Epub 2009 Aug 21.
4. Comparative analysis of SNP in estrogen-metabolizing enzymes for ovarian, endometrial, and breast cancers in Novosibirsk, Russia. Gulyaeva LF, etal., Adv Exp Med Biol. 2008;617:359-66.
5. Short term hypothyroidism affects ovarian function in the cycling rat. Hapon MB, etal., Reprod Biol Endocrinol. 2010 Feb 11;8:14.
6. [Study on the relationship between polymorphisms of genes (CYP17, CYP19 and SULT1A1) and susceptibility to breast cancer in Chinese women] Hu MB, etal., Zhonghua Liu Xing Bing Xue Za Zhi. 2006 Apr;27(4):351-5.
7. CYP19 haplotypes increase risk for Alzheimer's disease. Huang R and Poduslo SE, J Med Genet. 2006 Aug;43(8):e42.
8. Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries. Ito Y, etal., Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11673-7.
9. The aromatase inhibitor letrozole reduces adhesion formation after intraperitoneal surgery in a rat uterine horn model. Keskin HL, etal., Eur J Obstet Gynecol Reprod Biol. 2013 Apr;167(2):199-204. doi: 10.1016/j.ejogrb.2012.12.002. Epub 2013 Feb 8.
10. Impact of androgen/estrogen ratio: lessons learned from the aromatase over-expression mice. Li X and Rahman N, Gen Comp Endocrinol. 2008 Oct;159(1):1-9. Epub 2008 Aug 14.
11. Molecular mechanisms of bladder outlet obstruction in transgenic male mice overexpressing aromatase (Cyp19a1). Lin W, etal., Am J Pathol. 2011 Mar;178(3):1233-44. doi: 10.1016/j.ajpath.2010.11.056.
12. [Expression of steroidogenic enzymes in the rat model of polycystic ovary syndrome]. Lin W, etal., Sheng Li Xue Bao. 2013 Apr 25;65(2):171-7.
13. The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue. MacKenzie SM, etal., J Endocrinol. 2008 Jan;196(1):123-30.
14. Continuous administration of a P450 aromatase inhibitor induces polycystic ovary syndrome with a metabolic and endocrine phenotype in female rats at adult age. Maliqueo M, etal., Endocrinology. 2013 Jan;154(1):434-45. doi: 10.1210/en.2012-1693. Epub 2012 Nov 26.
15. Combined inhibition of aromatase activity and dihydrotestosterone supplementation attenuates renal injury in male streptozotocin (STZ)-induced diabetic rats. Manigrasso MB, etal., Am J Physiol Renal Physiol. 2012 May 1;302(9):F1203-9. doi: 10.1152/ajprenal.00569.2011. Epub 2012 Feb 1.
16. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
17. MGDs mouse GO annotations MGD data from the GO Consortium
19. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
20. Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter? Miller WR, etal., Oncologist. 2008 Aug;13(8):829-37. Epub 2008 Aug 11.
21. Promotion of bladder cancer development and progression by androgen receptor signals. Miyamoto H, etal., J Natl Cancer Inst. 2007 Apr 4;99(7):558-68.
22. Genetic polymorphism at Val80 (rs700518) of the CYP19A1 gene is associated with aromatase inhibitor associated bone loss in women with ER + breast cancer. Napoli N, etal., Bone. 2013 Aug;55(2):309-14. doi: 10.1016/j.bone.2013.04.021. Epub 2013 May 1.
23. Aromatase expression in endometriosis. Noble LS, etal., J Clin Endocrinol Metab. 1996 Jan;81(1):174-9.
24. Intrauterine growth restriction alters hippocampal expression and chromatin structure of Cyp19a1 variants. O'Grady SP, etal., Syst Biol Reprod Med. 2010 Aug;56(4):292-302.
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Payne AH and Hales DB, Endocr Rev. 2004 Dec;25(6):947-70.
27. Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the hypothalamic KiSS-1/GPR54/GnRH system. Pinilla L, etal., Endocrinology. 2009 Jun;150(6):2889-97. Epub 2009 Feb 19.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. Mouse MP Annotation Import Pipeline RGD automated import pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Identification of an aromatase haplotype that is associated with gene expression and postmenopausal osteoporosis. Riancho JA, etal., J Clin Endocrinol Metab. 2007 Feb;92(2):660-5. Epub 2006 Nov 21.
33. Common variations in estrogen-related genes are associated with severe large-joint osteoarthritis: a multicenter genetic and functional study. Riancho JA, etal., Osteoarthritis Cartilage. 2010 Jul;18(7):927-33. doi: 10.1016/j.joca.2010.04.002. Epub 2010 Apr 22.
34. Impairment of spermatogenesis in mice lacking a functional aromatase (cyp 19) gene. Robertson KM, etal., Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7986-91.
35. Aminoglutethimide as treatment of postmenopausal women with advanced breast carcinoma. Santen RJ, etal., Ann Intern Med. 1982 Jan;96(1):94-101.
36. Protective Role of Testosterone in Ischemia-Reperfusion-induced Acute Kidney Injury. Soljancic A, etal., Am J Physiol Regul Integr Comp Physiol. 2013 Apr 3.
37. Infravesical obstruction in aromatase over expressing transgenic male mice with increased ratio of serum estrogen-to-androgen concentration. Streng T, etal., J Urol. 2002 Jul;168(1):298-302.
38. Megestrol acetate inhibits the expression of cytoplasmic aromatase through nuclear C/EBPbeta in reperfusion injury-induced ischemic rat hippocampus. Ugur PK, etal., Eur J Pharmacol. 2010 Nov 27.
39. A common polymorphism in the human aromatase gene alters the risk for polycystic ovary syndrome and modifies aromatase activity in vitro. Wang H, etal., Mol Hum Reprod. 2011 Jun;17(6):386-91. doi: 10.1093/molehr/gar007. Epub 2011 Jan 31.
40. Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. Wu IC, etal., Neoplasia. 2011 Apr;13(4):386-92. doi: 10.1593/neo.101722.
41. [Effect of letrozole on endometrosis and apoptosis of ectopic endometrial cells in rats]. Xia X, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Jan;38(1):54-9. doi: 10.3969/j.issn.1672-7347.2013.01.010.
42. Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. Xiong DH, etal., J Bone Miner Res. 2006 Nov;21(11):1678-95.
Additional References at PubMed
PMID:812160   PMID:1425429   PMID:1491788   PMID:1705320   PMID:1897929   PMID:2792009   PMID:3002039   PMID:6327073   PMID:7632740   PMID:7669221   PMID:7958412   PMID:8013361  
PMID:8043507   PMID:8199860   PMID:8248223   PMID:8440194   PMID:8597600   PMID:8742817   PMID:8764102   PMID:8809197   PMID:8949389   PMID:9052933   PMID:9365205   PMID:9365217  
PMID:9618522   PMID:9630396   PMID:9826549   PMID:9838103   PMID:9852162   PMID:9879712   PMID:10095084   PMID:10349636   PMID:10385621   PMID:10491617   PMID:10732324   PMID:10854693  
PMID:10862797   PMID:10867819   PMID:10875266   PMID:11042159   PMID:11070087   PMID:11076861   PMID:11162635   PMID:11182758   PMID:11217851   PMID:11226072   PMID:11241177   PMID:11280746  
PMID:11351342   PMID:11356692   PMID:11356695   PMID:11369132   PMID:11415992   PMID:11424220   PMID:11427156   PMID:11431142   PMID:11545296   PMID:11557891   PMID:11738552   PMID:11850201  
PMID:11850202   PMID:11850204   PMID:11850207   PMID:11850223   PMID:11850232   PMID:11922772   PMID:11985600   PMID:12107266   PMID:12130556   PMID:12160996   PMID:12205030   PMID:12239119  
PMID:12350373   PMID:12388618   PMID:12466851   PMID:12472878   PMID:12477932   PMID:12553872   PMID:12568797   PMID:12604651   PMID:12639931   PMID:12648528   PMID:12725902   PMID:12745259  
PMID:12754080   PMID:12845227   PMID:12880107   PMID:12884966   PMID:12933663   PMID:14507969   PMID:14561933   PMID:14563698   PMID:14576203   PMID:14623546   PMID:14681479   PMID:14684602  
PMID:14684609   PMID:14695903   PMID:14982857   PMID:14993062   PMID:14999024   PMID:15117342   PMID:15142992   PMID:15178650   PMID:15245494   PMID:15269096   PMID:15271885   PMID:15314222  
PMID:15555924   PMID:15607536   PMID:15733652   PMID:15823796   PMID:15955696   PMID:15961088   PMID:16003771   PMID:16029903   PMID:16054355   PMID:16083992   PMID:16141072   PMID:16141073  
PMID:16213803   PMID:16298349   PMID:16306085   PMID:16326017   PMID:16423895   PMID:16448653   PMID:16566897   PMID:16602821   PMID:16723702   PMID:16754860   PMID:16867177   PMID:16942806  
PMID:16964442   PMID:17077188   PMID:17079138   PMID:17103052   PMID:17567817   PMID:17604617   PMID:17708714   PMID:17716913   PMID:17951050   PMID:18000311   PMID:18055862   PMID:18215238  
PMID:18317592   PMID:18346740   PMID:18448329   PMID:18653624   PMID:18822378   PMID:19176355   PMID:19393092   PMID:19500729   PMID:19538736   PMID:19640321   PMID:19686804   PMID:19804754  
PMID:19945459   PMID:20026603   PMID:20093417   PMID:20133657   PMID:20181795   PMID:20194728   PMID:20226875   PMID:20383121   PMID:20435002   PMID:20580788   PMID:21093158   PMID:21148416  
PMID:21248289   PMID:21267068   PMID:21621614   PMID:21816154   PMID:21873635   PMID:22019577   PMID:22028441   PMID:22028442   PMID:22147013   PMID:22185842   PMID:22366072   PMID:22426781  
PMID:22508516   PMID:22654807   PMID:22705581   PMID:22713853   PMID:22734700   PMID:22759381   PMID:23233261   PMID:23239821   PMID:23744640   PMID:24076016   PMID:24194600   PMID:24272335  
PMID:24508640   PMID:24520329   PMID:24582702   PMID:24646567   PMID:24880616   PMID:24952961   PMID:25084452   PMID:25398007   PMID:25447050   PMID:25620703   PMID:25625588   PMID:25725066  
PMID:25837259   PMID:25957088   PMID:26067405   PMID:26169831   PMID:26231585   PMID:26919384   PMID:27067638   PMID:27160809   PMID:27216894   PMID:28341248   PMID:28649695   PMID:28655716  
PMID:28706210   PMID:28822806   PMID:29163055   PMID:29459742   PMID:29880879   PMID:30211334   PMID:30712868   PMID:30778289   PMID:31520742   PMID:31712577   PMID:31971970   PMID:32081742  
PMID:32325033   PMID:32620696   PMID:32623449   PMID:32910181   PMID:32945847   PMID:33110090   PMID:33559105   PMID:34561233   PMID:35906245   PMID:36464512   PMID:36464513  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39954,073,221 - 54,175,448 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,073,221 - 54,175,394 (-)EnsemblGRCm39 Ensembl
GRCm38954,165,937 - 54,268,164 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl954,165,937 - 54,268,110 (-)EnsemblGRCm38mm10GRCm38
MGSCv37954,013,744 - 54,041,249 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36953,964,074 - 53,991,581 (-)NCBIMGSCv36mm8
Celera951,408,025 - 51,435,376 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.49NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381551,208,057 - 51,338,596 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1551,208,057 - 51,338,601 (-)EnsemblGRCh38hg38GRCh38
GRCh371551,500,254 - 51,630,793 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361549,288,961 - 49,418,086 (-)NCBINCBI36Build 36hg18NCBI36
Celera1528,393,650 - 28,524,194 (-)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1528,330,314 - 28,460,872 (-)NCBIHuRef
CHM1_11551,618,344 - 51,748,904 (-)NCBICHM1_1
T2T-CHM13v2.01549,015,801 - 49,146,366 (-)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2854,553,165 - 54,580,758 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl854,553,165 - 54,580,758 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx860,087,103 - 60,114,553 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0858,366,113 - 58,393,560 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0856,230,358 - 56,257,810 (-)NCBIRnor_WKY
Rnor_6.0858,744,849 - 58,772,408 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl858,744,849 - 58,772,408 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0857,321,085 - 57,348,481 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1857,671,013 - 57,691,109 (-)NCBI
Celera854,044,272 - 54,071,684 (-)NCBICelera
Cytogenetic Map8q24NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554093,266,233 - 3,313,142 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554093,198,622 - 3,313,072 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11548,486,688 - 48,616,347 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1548,486,688 - 48,521,554 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01530,152,924 - 30,282,854 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13016,954,020 - 17,056,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3016,957,215 - 16,988,353 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3016,883,348 - 16,914,898 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03017,098,681 - 17,221,672 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3017,101,433 - 17,133,428 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13017,024,100 - 17,055,822 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03017,141,587 - 17,173,348 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03017,248,285 - 17,280,035 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440864095,258,165 - 95,328,751 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647113,107,603 - 13,136,910 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647113,107,603 - 13,136,910 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1120,367,667 - 120,695,899 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11120,652,172 - 120,695,899 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21133,903,926 - 133,936,093 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12632,074,260 - 32,164,926 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2632,132,425 - 32,164,277 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048109,028,218 - 109,061,355 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247319,053,803 - 9,100,212 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247319,053,644 - 9,100,212 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID

Predicted Target Of
Summary Value
Count of predictions:405
Count of miRNA genes:289
Interacting mature miRNAs:320
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
4141572Ntta3_mneurotensin transcript abundance 3 (mouse)Not determined4659767165831177Mouse
4141754Fecq4_mfecundity QTL 4 (mouse)Not determined94754302457805204Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94883105682831177Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94883105682831177Mouse
1301051Eae9_msusceptibility to experimental allergic encephalomyelitis 9 (mouse)Not determined94942029863239852Mouse
1301049El4_mepilepsy 4 (mouse)Not determined94942029867151448Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
14746993Manh66_mmandible shape 66 (mouse)94981404883814048Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95015132084151448Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95203447899792481Mouse
13525008Hrtiq1_mheart rate time index, QTL 1 (mouse)95242609868556008Mouse
13515056Adip20c_madiposity 20c (mouse)95414986354194054Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37954,014,607 - 54,014,809UniSTSGRCm37
Celera951,408,896 - 51,409,098UniSTS
Cytogenetic Map9A5.3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38954,166,553 - 54,166,695UniSTSGRCm38
MGSCv37954,014,360 - 54,014,502UniSTSGRCm37
Celera951,408,649 - 51,408,791UniSTS
Cytogenetic Map9A5.3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38954,193,431 - 54,193,520UniSTSGRCm38
MGSCv37954,041,238 - 54,041,327UniSTSGRCm37
Celera951,435,365 - 51,435,454UniSTS
Cytogenetic Map9A5.3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A5.3UniSTS
cM Map931.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A5.3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A5.3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38954,166,800 - 54,167,002UniSTSGRCm38
MGSCv37954,014,607 - 54,014,809UniSTSGRCm37
Celera951,408,896 - 51,409,098UniSTS
Cytogenetic Map9A5.3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A5.3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A5.3UniSTS



Nucleotide Sequences
RefSeq Transcripts NM_001348171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001348172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001348173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC159816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC162180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ437576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC103670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC104489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU252014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ619058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ619059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ619060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U19724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000034811   ⟹   ENSMUSP00000034811
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,073,221 - 54,100,726 (-)Ensembl
GRCm38.p6 Ensembl954,165,937 - 54,193,442 (-)Ensembl
RefSeq Acc Id: ENSMUST00000214358
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,100,539 - 54,175,394 (-)Ensembl
GRCm38.p6 Ensembl954,193,255 - 54,268,110 (-)Ensembl
RefSeq Acc Id: ENSMUST00000215736   ⟹   ENSMUSP00000150729
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,073,223 - 54,100,806 (-)Ensembl
GRCm38.p6 Ensembl954,165,939 - 54,193,522 (-)Ensembl
RefSeq Acc Id: ENSMUST00000216974
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,100,569 - 54,109,505 (-)Ensembl
GRCm38.p6 Ensembl954,193,285 - 54,202,221 (-)Ensembl
RefSeq Acc Id: ENSMUST00000217040
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,087,417 - 54,089,358 (-)Ensembl
GRCm38.p6 Ensembl954,180,133 - 54,182,074 (-)Ensembl
RefSeq Acc Id: NM_001348171   ⟹   NP_001335100
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39954,073,221 - 54,175,448 (-)NCBI
GRCm38954,165,937 - 54,268,164 (-)NCBI
RefSeq Acc Id: NM_001348172   ⟹   NP_001335101
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39954,073,221 - 54,136,198 (-)NCBI
GRCm38954,165,937 - 54,228,914 (-)NCBI
RefSeq Acc Id: NM_001348173   ⟹   NP_001335102
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39954,073,221 - 54,109,500 (-)NCBI
GRCm38954,165,937 - 54,202,216 (-)NCBI
RefSeq Acc Id: NM_007810   ⟹   NP_031836
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39954,073,221 - 54,101,027 (-)NCBI
GRCm38954,165,937 - 54,193,743 (-)NCBI
MGSCv37954,013,744 - 54,041,249 (-)RGD
Celera951,408,025 - 51,435,376 (-)RGD
Reference Sequences
RefSeq Acc Id: NP_031836   ⟸   NM_007810
- UniProtKB: P28649 (UniProtKB/Swiss-Prot),   Q3ZAT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001335100   ⟸   NM_001348171
- UniProtKB: P28649 (UniProtKB/Swiss-Prot),   Q3ZAT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001335101   ⟸   NM_001348172
- UniProtKB: P28649 (UniProtKB/Swiss-Prot),   Q3ZAT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001335102   ⟸   NM_001348173
- UniProtKB: P28649 (UniProtKB/Swiss-Prot),   Q3ZAT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000034811   ⟸   ENSMUST00000034811
RefSeq Acc Id: ENSMUSP00000150729   ⟸   ENSMUST00000215736

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28649-F1-model_v2 AlphaFold P28649 1-503 view protein structure

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88587 AgrOrtholog
Ensembl Genes ENSMUSG00000032274 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034811 ENTREZGENE
  ENSMUSP00000034811.8 UniProtKB/Swiss-Prot
  ENSMUSP00000150729.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034811 ENTREZGENE
  ENSMUST00000034811.8 UniProtKB/Swiss-Prot
  ENSMUST00000215736.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13075 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp19a1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL