Pten (phosphatase and tensin homolog) - Rat Genome Database

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Gene: Pten (phosphatase and tensin homolog) Mus musculus
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Symbol: Pten
Name: phosphatase and tensin homolog
RGD ID: 62287
MGI Page MGI
Description: Enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity and protein kinase binding activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of neuron projection development; and nervous system development. Acts upstream of or within several processes, including circulatory system development; negative regulation of cell population proliferation; and regulation of apoptotic process. Located in several cellular components, including Schmidt-Lanterman incisure; myelin sheath adaxonal region; and neuron projection. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; genitourinary system; and integumental system. Used to study several diseases, including Cowden syndrome (multiple); carcinoma (multiple); macrocephaly-autism syndrome; persistent fetal circulation syndrome; and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast cancer (multiple); macrocephaly-autism syndrome; nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 2310035O07Rik; A130070J02Rik; AI463227; B430203M17Rik; MGC183880; mitochondrial PTENalpha; MMAC; MMAC1; mutated in multiple advanced cancers 1; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; PTENbeta; PTENepsilon; RIKEN cDNA B430203M17 gene; TEP; TEP1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391932,734,977 - 32,803,560 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1932,734,897 - 32,803,560 (+)EnsemblGRCm39 Ensembl
GRCm381932,757,577 - 32,826,160 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1932,757,497 - 32,826,160 (+)EnsemblGRCm38mm10GRCm38
MGSCv371932,832,067 - 32,900,650 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361932,823,574 - 32,892,157 (+)NCBIMGSCv36mm8
Celera1933,541,182 - 33,610,051 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1928.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model