Pten (phosphatase and tensin homolog) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Pten (phosphatase and tensin homolog) Mus musculus
Analyze
Symbol: Pten
Name: phosphatase and tensin homolog
RGD ID: 62287
MGI Page MGI
Description: Enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity and protein kinase binding activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of neuron projection development; and nervous system development. Acts upstream of or within several processes, including circulatory system development; regulation of apoptotic process; and regulation of intracellular signal transduction. Located in several cellular components, including Schmidt-Lanterman incisure; myelin sheath adaxonal region; and neuron projection. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study several diseases, including Bannayan-Riley-Ruvalcaba syndrome; Cowden syndrome; endocrine gland cancer (multiple); macrocephaly-autism syndrome; and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome; PTEN hamartoma tumor syndrome; breast cancer (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2310035O07Rik; A130070J02Rik; AI463227; B430203M17Rik; MGC183880; mitochondrial PTENalpha; MMAC; MMAC1; mutated in multiple advanced cancers 1; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; PTENbeta; PTENepsilon; RIKEN cDNA B430203M17 gene; TEP; TEP1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391932,734,977 - 32,803,560 (+)NCBIGRCm39mm39
GRCm39 Ensembl1932,734,897 - 32,803,560 (+)Ensembl
GRCm381932,757,577 - 32,826,160 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1932,757,497 - 32,826,160 (+)EnsemblGRCm38mm10GRCm38
MGSCv371932,832,067 - 32,900,650 (+)NCBIGRCm37mm9NCBIm37
MGSCv361932,823,574 - 32,892,157 (+)NCBImm8
Celera1933,541,182 - 33,610,051 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1928.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model