(+)-pilocarpine multiple interactions ISO RGD:61995 6480464 PTEN protein mutant form inhibits the reaction [Pilocarpine results in increased activity of NGFR protein] CTD PMID:21084616 (-)-epigallocatechin 3-gallate decreases expression ISO RGD:69119 6480464 epigallocatechin gallate results in decreased expression of PTEN mRNA CTD PMID:32512070 (R)-noradrenaline multiple interactions ISO RGD:61995 6480464 [Estradiol co-treated with Norepinephrine] results in decreased expression of PTEN mRNA more ... CTD PMID:16954335 (S)-nicotine increases expression ISO RGD:61995 6480464 Nicotine results in increased expression of PTEN mRNA CTD PMID:11478936 1,2-dimethylhydrazine decreases expression EXP 6480464 1, 2-Dimethylhydrazine results in decreased expression of PTEN mRNA CTD PMID:22206623 1,2-dimethylhydrazine multiple interactions EXP 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PTEN mRNA CTD PMID:22206623 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expression EXP 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:31907031 15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactions EXP 6480464 [15-deoxy-delta(12, 14)-prostaglandin J2 co-treated with alitretinoin] results in increased expression of PTEN protein CTD PMID:16611854 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTEN mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression ISO RGD:61995 6480464 Ethinyl Estradiol results in increased expression of PTEN mRNA CTD PMID:29097150 17alpha-ethynylestradiol affects expression ISO RGD:69119 6480464 Ethinyl Estradiol affects the expression of PTEN mRNA CTD PMID:20170705 , PMID:26865667 17beta-estradiol decreases expression ISO RGD:69119 6480464 Estradiol results in decreased expression of PTEN mRNA CTD PMID:21890461 17beta-estradiol decreases expression ISO RGD:61995 6480464 Estradiol results in decreased expression of PTEN mRNA CTD PMID:16954335 17beta-estradiol multiple interactions ISO RGD:61995 6480464 [Estradiol co-treated with Norepinephrine] results in decreased expression of PTEN mRNA CTD PMID:16954335 17beta-estradiol increases expression ISO RGD:69119 6480464 Estradiol results in increased expression of PTEN mRNA, Estradiol results in increased expression of PTEN protein CTD PMID:19264808 more ... 17beta-estradiol multiple interactions ISO RGD:69119 6480464 [ESR2 protein results in increased susceptibility to Estradiol] which results in increased expression of PTEN protein more ... CTD PMID:19264808 more ... 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one decreases response to substance ISO RGD:69119 6480464 PTEN protein results in decreased susceptibility to Metribolone CTD PMID:16637073 1H-pyrazole decreases expression EXP 6480464 pyrazole results in decreased expression of PTEN mRNA CTD PMID:17945193 2,2',4,4',5,5'-hexachlorobiphenyl decreases expression ISO RGD:61995 6480464 2 more ... CTD PMID:24726520 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:69119 6480464 Tetrachlorodibenzodioxin results in decreased expression of PTEN mRNA CTD PMID:17101203 2,3,7,8-tetrachlorodibenzodioxine decreases phosphorylation ISO RGD:69119 6480464 Tetrachlorodibenzodioxin results in decreased phosphorylation of PTEN protein CTD PMID:27312872 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of PTEN mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:61995 6480464 Tetrachlorodibenzodioxin results in decreased expression of PTEN mRNA CTD PMID:18796159 , PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:17942748 more ... 2,3-bis(4-hydroxyphenyl)propionitrile increases expression ISO RGD:69119 6480464 2, 3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of PTEN protein CTD PMID:19264808 2,3-bis(4-hydroxyphenyl)propionitrile multiple interactions ISO RGD:69119 6480464 ESR1 protein affects the reaction [2, 3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of PTEN protein] CTD PMID:19264808 2-acetamidofluorene decreases expression ISO RGD:61995 6480464 2-Acetylaminofluorene results in decreased expression of PTEN protein CTD PMID:19167416 2-butoxyethanol decreases expression EXP 6480464 n-butoxyethanol results in decreased expression of PTEN mRNA CTD PMID:19812364 2-methylcholine affects expression ISO RGD:69119 6480464 beta-methylcholine affects the expression of PTEN mRNA CTD PMID:21179406 2-tert-butylhydroquinone multiple interactions ISO RGD:69119 6480464 PTEN protein affects the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA] CTD PMID:23829535 2-trans,6-trans,10-trans-geranylgeranyl diphosphate multiple interactions ISO RGD:61995 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PTEN mRNA] CTD PMID:20578043 3,3',5,5'-tetrabromobisphenol A decreases expression ISO RGD:61995 6480464 tetrabromobisphenol A results in decreased expression of PTEN mRNA CTD PMID:28970181 3,4-methylenedioxymethamphetamine increases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of PTEN mRNA CTD PMID:20188158 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:69119 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PTEN mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PTEN mRNA CTD PMID:28628672 3H-1,2-dithiole-3-thione decreases expression ISO RGD:61995 6480464 1, 2-dithiol-3-thione results in decreased expression of PTEN mRNA CTD PMID:19162173 4-hydroxyphenyl retinamide decreases expression EXP 6480464 Fenretinide results in decreased expression of PTEN mRNA CTD PMID:28973697 4-nitrophenol decreases expression EXP 6480464 4-nitrophenol results in decreased expression of PTEN mRNA CTD PMID:34673133 4-nonylphenol decreases phosphorylation ISO RGD:61995 6480464 4-nonylphenol results in decreased phosphorylation of PTEN protein CTD PMID:30228064 4-nonylphenol increases expression ISO RGD:61995 6480464 4-nonylphenol results in increased expression of PTEN mRNA CTD PMID:30228064 4-nonylphenol multiple interactions ISO RGD:61995 6480464 4-nonylphenol promotes the reaction [bisphenol A results in decreased phosphorylation of PTEN protein], bisphenol A inhibits the reaction [4-nonylphenol results in decreased phosphorylation of PTEN protein] CTD PMID:30228064 5-aza-2'-deoxycytidine increases expression ISO RGD:69119 6480464 Decitabine results in increased expression of PTEN mRNA CTD PMID:21170675 , PMID:21801466 5-aza-2'-deoxycytidine multiple interactions ISO RGD:69119 6480464 [Decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of PTEN mRNA more ... CTD PMID:18622747 more ... 5-aza-2'-deoxycytidine decreases methylation ISO RGD:69119 6480464 Decitabine results in decreased methylation of PTEN gene, Decitabine results in decreased methylation of PTEN promoter CTD PMID:21170675 , PMID:21801466 5-azacytidine multiple interactions ISO RGD:69119 6480464 Azacitidine inhibits the reaction [TGFB1 protein results in decreased expression of PTEN mRNA] more ... CTD PMID:22841775 5-fluorouracil decreases expression ISO RGD:69119 6480464 Fluorouracil results in decreased expression of PTEN mRNA CTD PMID:17039268 5-fluorouracil increases expression ISO RGD:69119 6480464 Fluorouracil results in increased expression of PTEN mRNA CTD PMID:24737281 5-methoxypsoralen multiple interactions ISO RGD:69119 6480464 pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of PTEN protein] CTD PMID:30576070 5-methoxypsoralen increases expression ISO RGD:69119 6480464 5-Methoxypsoralen results in increased expression of PTEN protein CTD PMID:30576070 9-cis-retinoic acid multiple interactions EXP 6480464 [15-deoxy-delta(12, 14)-prostaglandin J2 co-treated with Alitretinoin] results in increased expression of PTEN protein CTD PMID:16611854 acrylamide decreases expression ISO RGD:61995 6480464 Acrylamide results in decreased expression of PTEN mRNA CTD PMID:28959563 aflatoxin B1 decreases methylation ISO RGD:69119 6480464 Aflatoxin B1 results in decreased methylation of PTEN gene CTD PMID:27153756 AICA ribonucleotide increases response to substance ISO RGD:69119 6480464 PTEN protein results in increased susceptibility to AICA ribonucleotide CTD PMID:19625624 all-trans-retinoic acid multiple interactions ISO RGD:69119 6480464 [Tretinoin co-treated with IFNG protein] results in increased expression of PTEN protein more ... CTD PMID:17960384 , PMID:21801466 all-trans-retinoic acid decreases methylation ISO RGD:69119 6480464 Tretinoin results in decreased methylation of PTEN promoter CTD PMID:21801466 all-trans-retinoic acid increases expression ISO RGD:69119 6480464 Tretinoin results in increased expression of PTEN mRNA CTD PMID:23724009 , PMID:33167477 ammonium chloride affects expression ISO RGD:61995 6480464 Ammonium Chloride affects the expression of PTEN mRNA CTD PMID:16483693 ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of PTEN mRNA CTD PMID:31310755 ammonium chloride decreases expression ISO RGD:61995 6480464 Ammonium Chloride results in decreased expression of PTEN protein CTD PMID:16483693 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:69119 6480464 pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased expression of PTEN protein] CTD PMID:20534739 antimycin A increases expression ISO RGD:69119 6480464 Antimycin A results in increased expression of PTEN mRNA CTD PMID:35430258 antimycin A multiple interactions ISO RGD:69119 6480464 Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of PTEN mRNA] CTD PMID:35430258 antirheumatic drug increases expression ISO RGD:69119 6480464 Antirheumatic Agents results in increased expression of PTEN mRNA CTD PMID:24449571 aristolochic acid A decreases expression ISO RGD:69119 6480464 aristolochic acid I results in decreased expression of PTEN mRNA CTD PMID:33212167 arsane decreases expression ISO RGD:69119 6480464 Arsenic results in decreased expression of PTEN protein CTD PMID:25586904 arsenic atom decreases expression ISO RGD:69119 6480464 Arsenic results in decreased expression of PTEN protein CTD PMID:25586904 arsenite(3-) decreases expression ISO RGD:69119 6480464 arsenite results in decreased expression of PTEN protein CTD PMID:22387281 arsenite(3-) multiple interactions ISO RGD:69119 6480464 RELA mutant form inhibits the reaction [arsenite results in decreased expression of PTEN protein] CTD PMID:22387281 arsenous acid increases expression ISO RGD:69119 6480464 Arsenic Trioxide results in increased expression of PTEN mRNA, Arsenic Trioxide results in increased expression of PTEN protein CTD PMID:20534739 more ... arsenous acid multiple interactions ISO RGD:69119 6480464 MAPK8 protein affects the reaction [Arsenic Trioxide results in increased expression of PTEN protein] more ... CTD PMID:20534739 more ... arsenous acid decreases expression ISO RGD:69119 6480464 Arsenic Trioxide results in decreased expression of PTEN mRNA CTD PMID:23497375 arsenous acid increases response to substance ISO RGD:69119 6480464 PTEN protein results in increased susceptibility to Arsenic Trioxide CTD PMID:22185283 astaxanthin multiple interactions ISO RGD:69119 6480464 astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of PTEN mRNA] CTD PMID:33212048 atorvastatin calcium increases expression ISO RGD:61995 6480464 Atorvastatin results in increased expression of PTEN protein CTD PMID:15837263 benomyl increases expression ISO RGD:61995 6480464 Benomyl results in increased expression of PTEN mRNA CTD PMID:33930522 benzene multiple interactions ISO RGD:61995 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PTEN mRNA CTD PMID:17905399 Benzenesulfonamide decreases expression ISO RGD:69119 6480464 benzenesulfonamide analog results in decreased expression of PTEN CTD PMID:22713211 benzo[a]pyrene multiple interactions EXP 6480464 Benzo(a)pyrene inhibits the reaction [AHR protein binds to PTEN promoter] CTD PMID:19654925 benzo[a]pyrene increases expression ISO RGD:69119 6480464 Benzo(a)pyrene metabolite results in increased expression of PTEN mRNA CTD PMID:26314263 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of PTEN mRNA CTD PMID:20504355 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:69119 6480464 7 more ... CTD PMID:19150397 , PMID:20018196 Benzo[ghi]perylene decreases expression EXP 6480464 1, 12-benzoperylene results in decreased expression of PTEN mRNA CTD PMID:26377693 berberine increases expression EXP 6480464 Berberine results in increased expression of PTEN protein CTD PMID:29408570 berberine multiple interactions EXP 6480464 ((3Z)-N-(3-chlorophenyl)-3-((3 more ... CTD PMID:29408570 bicalutamide multiple interactions ISO RGD:69119 6480464 bicalutamide promotes the reaction [PTEN protein results in decreased expression of KLK3 mRNA] CTD PMID:16637073 bicalutamide increases activity ISO RGD:69119 6480464 bicalutamide results in increased activity of PTEN protein CTD PMID:16637073 bilirubin IXalpha multiple interactions ISO RGD:69119 6480464 Bilirubin inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 biliverdin multiple interactions ISO RGD:69119 6480464 Biliverdine inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of PTEN mRNA, Diethylhexyl Phthalate results in decreased expression of PTEN protein CTD PMID:24804967 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:61995 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate] results in decreased expression of PTEN protein, [Plant Extracts co-treated with Diethylhexyl Phthalate] results in decreased expression of PTEN mRNA CTD PMID:29777495 , PMID:34910997 bis(2-ethylhexyl) phthalate affects expression ISO RGD:61995 6480464 Diethylhexyl Phthalate affects the expression of PTEN mRNA CTD PMID:29777495 bis(2-ethylhexyl) phthalate affects expression EXP 6480464 Diethylhexyl Phthalate affects the expression of PTEN mRNA CTD PMID:31211961 bis(2-ethylhexyl) phthalate increases expression ISO RGD:69119 6480464 Diethylhexyl Phthalate results in increased expression of PTEN protein CTD PMID:31163220 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:69119 6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PTEN protein] CTD PMID:31163220 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A increases phosphorylation ISO RGD:69119 6480464 bisphenol A results in increased phosphorylation of PTEN protein CTD PMID:21890461 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PTEN mRNA CTD PMID:33221593 bisphenol A multiple interactions ISO RGD:61995 6480464 4-nonylphenol promotes the reaction [bisphenol A results in decreased phosphorylation of PTEN protein] more ... CTD PMID:29777495 more ... bisphenol A decreases phosphorylation ISO RGD:61995 6480464 bisphenol A results in decreased phosphorylation of PTEN protein CTD PMID:30228064 bisphenol A multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A affects expression ISO RGD:61995 6480464 bisphenol A affects the expression of PTEN protein CTD PMID:27296223 bisphenol A decreases expression ISO RGD:61995 6480464 bisphenol A results in decreased expression of PTEN mRNA, bisphenol A results in decreased expression of PTEN protein CTD PMID:24884420 more ... bisphenol A multiple interactions ISO RGD:69119 6480464 [bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of PTEN mRNA more ... CTD PMID:24831732 more ... bisphenol A increases expression ISO RGD:69119 6480464 bisphenol A results in increased expression of PTEN protein CTD PMID:24831732 bisphenol A increases expression ISO RGD:61995 6480464 bisphenol A results in increased expression of PTEN mRNA, bisphenol A results in increased expression of PTEN protein CTD PMID:24464975 more ... bisphenol A affects expression ISO RGD:69119 6480464 bisphenol A affects the expression of PTEN mRNA CTD PMID:20170705 bisphenol A decreases expression ISO RGD:69119 6480464 bisphenol A results in decreased expression of PTEN mRNA, bisphenol A results in decreased expression of PTEN protein CTD PMID:21890461 , PMID:32387340 Bisphenol A diglycidyl ether multiple interactions ISO RGD:69119 6480464 2 more ... CTD PMID:16806087 , PMID:21769449 Bisphenol B decreases expression ISO RGD:69119 6480464 bisphenol B results in decreased expression of PTEN mRNA CTD PMID:32387340 bisphenol F multiple interactions ISO RGD:69119 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PTEN mRNA CTD PMID:28628672 bleomycin A2 multiple interactions EXP 6480464 ((3Z)-N-(3-chlorophenyl)-3-((3 more ... CTD PMID:29408570 bleomycin A2 decreases expression EXP 6480464 Bleomycin results in decreased expression of PTEN mRNA, Bleomycin results in decreased expression of PTEN protein CTD PMID:29408570 Butylbenzyl phthalate decreases expression ISO RGD:69119 6480464 butylbenzyl phthalate results in decreased expression of PTEN mRNA, butylbenzyl phthalate results in decreased expression of PTEN protein CTD PMID:29864457 Butylbenzyl phthalate multiple interactions ISO RGD:69119 6480464 MIR19A mRNA affects the reaction [butylbenzyl phthalate results in decreased expression of PTEN protein], MIR19B1 mRNA affects the reaction [butylbenzyl phthalate results in decreased expression of PTEN protein] CTD PMID:29864457 cadmium atom multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Cadmium results in increased degradation of and results in decreased expression of PTEN protein] more ... CTD PMID:24449419 cadmium dichloride affects expression EXP 6480464 Cadmium Chloride affects the expression of PTEN mRNA CTD PMID:18974090 cadmium dichloride increases phosphorylation ISO RGD:69119 6480464 Cadmium Chloride results in increased phosphorylation of PTEN protein CTD PMID:34905088 cadmium dichloride decreases expression ISO RGD:69119 6480464 Cadmium Chloride results in decreased expression of PTEN mRNA, Cadmium Chloride results in decreased expression of PTEN protein CTD PMID:21195169 more ... cadmium dichloride decreases expression ISO RGD:61995 6480464 Cadmium Chloride results in decreased expression of PTEN protein CTD PMID:21195169 , PMID:24111524 cadmium dichloride multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of PTEN protein] more ... CTD PMID:24449419 cadmium dichloride multiple interactions ISO RGD:61995 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein] more ... CTD PMID:21195169 , PMID:24111524 cadmium dichloride decreases response to substance ISO RGD:69119 6480464 PTEN results in decreased susceptibility to Cadmium Chloride CTD PMID:21883094 cadmium dichloride multiple interactions ISO RGD:69119 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein] more ... CTD PMID:21195169 calciol increases expression EXP 6480464 Cholecalciferol results in increased expression of PTEN mRNA CTD PMID:16508948 calciol increases expression ISO RGD:69119 6480464 Cholecalciferol results in increased expression of PTEN mRNA CTD PMID:21801466 calciol decreases methylation ISO RGD:69119 6480464 Cholecalciferol results in decreased methylation of PTEN promoter CTD PMID:21801466 calciol multiple interactions ISO RGD:69119 6480464 Cholecalciferol promotes the reaction [Cladribine results in increased expression of PTEN mRNA] more ... CTD PMID:21801466 camptothecin multiple interactions ISO RGD:69119 6480464 Camptothecin results in decreased expression of and results in decreased phosphorylation of PTEN protein CTD PMID:30885713 cannabidiol increases expression ISO RGD:69119 6480464 Cannabidiol results in increased expression of PTEN mRNA, Cannabidiol results in increased expression of PTEN protein CTD PMID:30713602 cannabidiol multiple interactions ISO RGD:69119 6480464 [Cannabidiol co-treated with moringin] results in decreased expression of PTEN mRNA CTD PMID:30096889 cantharidin increases expression ISO RGD:69119 6480464 Cantharidin results in increased expression of PTEN mRNA, Cantharidin results in increased expression of PTEN protein CTD PMID:31945315 carbamazepine affects expression ISO RGD:69119 6480464 Carbamazepine affects the expression of PTEN mRNA CTD PMID:24752500 carbon monoxide multiple interactions ISO RGD:69119 6480464 Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 carbon nanotube decreases expression EXP 6480464 Nanotubes more ... CTD PMID:25554681 , PMID:25620056 carnosic acid multiple interactions ISO RGD:69119 6480464 salvin promotes the reaction [arsenic trioxide results in increased expression of PTEN mRNA] CTD PMID:23239002 carnosic acid increases expression ISO RGD:69119 6480464 salvin results in increased expression of PTEN mRNA CTD PMID:23239002 celastrol multiple interactions ISO RGD:61995 6480464 celastrol inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein] more ... CTD PMID:24111524 chloroquine increases expression EXP 6480464 Chloroquine results in increased expression of PTEN mRNA CTD PMID:31310755 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of PTEN mRNA CTD PMID:29156651 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PTEN gene CTD PMID:20938992 ciglitazone increases expression ISO RGD:61995 6480464 ciglitazone results in increased expression of PTEN protein CTD PMID:20578043 ciguatoxin CTX1B affects expression EXP 6480464 Ciguatoxins affects the expression of PTEN mRNA CTD PMID:18353800 cilostazol multiple interactions ISO RGD:69119 6480464 cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein] more ... CTD PMID:12807996 cilostazol decreases phosphorylation ISO RGD:61995 6480464 cilostazol results in decreased phosphorylation of PTEN protein CTD PMID:15978173 cisplatin increases activity ISO RGD:69119 6480464 Cisplatin results in increased activity of PTEN protein CTD PMID:11707646 cisplatin increases phosphorylation EXP 6480464 Cisplatin results in increased phosphorylation of PTEN protein CTD PMID:33031932 cisplatin multiple interactions EXP 6480464 Rutin inhibits the reaction [Cisplatin results in increased phosphorylation of PTEN protein] CTD PMID:33031932 cisplatin multiple interactions ISO RGD:69119 6480464 [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of PTEN mRNA more ... CTD PMID:23466500 , PMID:30871063 cisplatin increases response to substance ISO RGD:69119 6480464 PTEN results in increased susceptibility to Cisplatin CTD PMID:21116717 cladribine increases expression ISO RGD:69119 6480464 Cladribine results in increased expression of PTEN mRNA CTD PMID:21801466 cladribine multiple interactions ISO RGD:69119 6480464 Cholecalciferol promotes the reaction [Cladribine results in increased expression of PTEN mRNA] more ... CTD PMID:21801466 cladribine decreases methylation ISO RGD:69119 6480464 Cladribine results in decreased methylation of PTEN promoter CTD PMID:21801466 clodronic acid multiple interactions EXP 6480464 Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of CD68 mRNA] more ... CTD PMID:27022031 cobalt dichloride multiple interactions ISO RGD:69119 6480464 PTEN protein inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein] more ... CTD PMID:19808899 cobalt dichloride increases expression ISO RGD:69119 6480464 cobaltous chloride results in increased expression of PTEN mRNA CTD PMID:19376846 , PMID:26314263 cobalt dichloride increases expression ISO RGD:61995 6480464 cobaltous chloride results in increased expression of PTEN mRNA CTD PMID:24386269 cocaine affects expression EXP 6480464 Cocaine affects the expression of PTEN mRNA CTD PMID:15681117 copper atom multiple interactions ISO RGD:69119 6480464 [Chelating Agents binds to Copper] which results in increased expression of PTEN mRNA, [Copper co-treated with Disulfiram] results in decreased expression of PTEN protein CTD PMID:20424113 , PMID:30911355 copper(0) multiple interactions ISO RGD:69119 6480464 [Chelating Agents binds to Copper] which results in increased expression of PTEN mRNA, [Copper co-treated with Disulfiram] results in decreased expression of PTEN protein CTD PMID:20424113 , PMID:30911355 copper(II) sulfate decreases expression ISO RGD:69119 6480464 Copper Sulfate results in decreased expression of PTEN mRNA CTD PMID:19549813 corticosterone increases phosphorylation EXP 6480464 Corticosterone results in increased phosphorylation of PTEN protein CTD PMID:21647420 coumestrol decreases expression ISO RGD:69119 6480464 Coumestrol results in decreased expression of PTEN mRNA CTD PMID:19167446 crocidolite asbestos decreases expression ISO RGD:69119 6480464 Asbestos, Crocidolite results in decreased expression of PTEN protein CTD PMID:21570478 cucurbitacin E multiple interactions ISO RGD:69119 6480464 cucurbitacin E results in increased expression of and results in increased phosphorylation of PTEN protein CTD PMID:27106530 curcumin multiple interactions ISO RGD:69119 6480464 Curcumin inhibits the reaction [bisphenol A results in increased expression of PTEN protein] CTD PMID:24831732 cycloheximide multiple interactions ISO RGD:69119 6480464 Cycloheximide affects the reaction [sodium arsenite affects the expression of PTEN protein] more ... CTD PMID:16425225 , PMID:33256086 cytarabine increases response to substance ISO RGD:69119 6480464 PTEN protein results in increased susceptibility to Cytarabine CTD PMID:22185283 D-glucitol affects localization EXP 6480464 Sorbitol affects the localization of PTEN protein CTD PMID:16807353 D-glucitol affects localization ISO RGD:61995 6480464 Sorbitol affects the localization of PTEN protein CTD PMID:16807353 D-glucitol affects localization ISO RGD:69119 6480464 Sorbitol affects the localization of PTEN protein CTD PMID:16807353 dactolisib increases response to substance ISO RGD:69119 6480464 PTEN gene mutant form results in increased susceptibility to dactolisib CTD PMID:21372221 daunorubicin increases response to substance ISO RGD:69119 6480464 PTEN results in increased susceptibility to Daunorubicin CTD PMID:21187093 deoxynivalenol increases expression ISO RGD:69119 6480464 deoxynivalenol results in increased expression of PTEN mRNA CTD PMID:22846391 dexamethasone multiple interactions EXP 6480464 Dexamethasone inhibits the reaction [OVAL protein results in decreased expression of PTEN mRNA], Dexamethasone inhibits the reaction [OVAL protein results in decreased expression of PTEN protein] CTD PMID:25739523 dexamethasone multiple interactions ISO RGD:69119 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PTEN mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PTEN mRNA CTD PMID:28628672 dextran sulfate multiple interactions EXP 6480464 [APC protein affects the susceptibility to Dextran Sulfate] which results in increased chemical synthesis of PTEN protein modified form, resorcinol inhibits the reaction [[APC protein affects the susceptibility to Dextran Sulfate] which results in increased chemical synthesis of PTEN protein modified form] CTD PMID:26262998 diarsenic trioxide decreases expression ISO RGD:69119 6480464 Arsenic Trioxide results in decreased expression of PTEN mRNA CTD PMID:23497375 diarsenic trioxide multiple interactions ISO RGD:69119 6480464 MAPK8 protein affects the reaction [Arsenic Trioxide results in increased expression of PTEN protein] more ... CTD PMID:20534739 more ... diarsenic trioxide increases response to substance ISO RGD:69119 6480464 PTEN protein results in increased susceptibility to Arsenic Trioxide CTD PMID:22185283 diarsenic trioxide increases expression ISO RGD:69119 6480464 Arsenic Trioxide results in increased expression of PTEN mRNA, Arsenic Trioxide results in increased expression of PTEN protein CTD PMID:20534739 more ... diazinon increases methylation ISO RGD:69119 6480464 Diazinon results in increased methylation of PTEN gene CTD PMID:22964155 diazinon decreases expression ISO RGD:61995 6480464 Diazinon results in decreased expression of PTEN mRNA CTD PMID:35403302 diazinon multiple interactions ISO RGD:61995 6480464 Dietary Fats promotes the reaction [Diazinon results in increased expression of PTEN mRNA] CTD PMID:30359674 diazinon increases expression ISO RGD:61995 6480464 Diazinon results in increased expression of PTEN mRNA CTD PMID:30359674 diazinon affects expression ISO RGD:61995 6480464 Diazinon affects the expression of PTEN mRNA CTD PMID:22546817 dibenzo[a,l]pyrene increases methylation EXP 6480464 dibenzo(a, l)pyrene results in increased methylation of PTEN promoter CTD PMID:28476633 dibutyl phthalate increases expression ISO RGD:61995 6480464 Dibutyl Phthalate results in increased expression of PTEN mRNA CTD PMID:21266533 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of PTEN protein CTD PMID:33331133 dibutyl phthalate multiple interactions EXP 6480464 ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in increased expression of PTEN protein] CTD PMID:33331133 diclofenac affects expression ISO RGD:69119 6480464 Diclofenac affects the expression of PTEN mRNA CTD PMID:24752500 diclofenac increases expression EXP 6480464 Diclofenac results in increased expression of PTEN mRNA CTD PMID:26934552 dicrotophos decreases expression ISO RGD:69119 6480464 dicrotophos results in decreased expression of PTEN mRNA CTD PMID:28302478 dieldrin increases response to substance ISO RGD:69119 6480464 PTEN gene mutant form results in increased susceptibility to Dieldrin CTD PMID:32421776 diethylstilbestrol decreases expression EXP 6480464 Diethylstilbestrol results in decreased expression of PTEN mRNA CTD PMID:16804899 digitoxin increases expression ISO RGD:69119 6480464 Digitoxin results in increased expression of PTEN protein CTD PMID:34717917 dioxygen decreases response to substance ISO RGD:69119 6480464 PTEN protein results in decreased susceptibility to Oxygen deficiency CTD PMID:21994956 dioxygen multiple interactions ISO RGD:69119 6480464 PTEN protein inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 protein]] more ... CTD PMID:19808899 dioxygen multiple interactions EXP 6480464 rosiglitazone inhibits the reaction [Oxygen deficiency results in decreased expression of PTEN protein] CTD PMID:19520921 dioxygen decreases expression EXP 6480464 Oxygen deficiency results in decreased expression of PTEN protein CTD PMID:19520921 disulfiram multiple interactions ISO RGD:69119 6480464 [Copper co-treated with Disulfiram] results in decreased expression of PTEN protein CTD PMID:20424113 dorsomorphin multiple interactions ISO RGD:69119 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:20673057 , PMID:27188386 doxorubicin multiple interactions ISO RGD:69119 6480464 [Doxorubicin co-treated with resveratrol] results in increased expression of PTEN mRNA more ... CTD PMID:16438844 more ... doxorubicin multiple interactions ISO RGD:61995 6480464 plumbagin inhibits the reaction [Doxorubicin results in decreased phosphorylation of PTEN protein] CTD PMID:32691977 doxorubicin decreases phosphorylation ISO RGD:61995 6480464 Doxorubicin results in decreased phosphorylation of PTEN protein CTD PMID:32691977 doxorubicin affects expression ISO RGD:69119 6480464 Doxorubicin affects the expression of PTEN mRNA CTD PMID:26969377 doxorubicin increases response to substance ISO RGD:69119 6480464 PTEN protein results in increased susceptibility to Doxorubicin, PTEN results in increased susceptibility to Doxorubicin CTD PMID:15548710 more ... doxorubicin increases activity ISO RGD:69119 6480464 Doxorubicin results in increased activity of PTEN protein CTD PMID:11707646 endosulfan decreases expression ISO RGD:61995 6480464 Endosulfan results in decreased expression of PTEN mRNA CTD PMID:31464424 enzyme inhibitor multiple interactions ISO RGD:69119 6480464 Enzyme Inhibitors inhibits the reaction [gossypetin results in increased expression of PTEN protein] CTD PMID:25622137 ethanol multiple interactions ISO RGD:61995 6480464 [Ethanol results in decreased susceptibility to INS1 protein] which results in increased activity of PTEN protein more ... CTD PMID:12700235 ethanol affects splicing EXP 6480464 Ethanol affects the splicing of PTEN mRNA CTD PMID:30319688 ethyl methanesulfonate increases expression ISO RGD:69119 6480464 Ethyl Methanesulfonate results in increased expression of PTEN mRNA CTD PMID:23649840 etoposide multiple interactions ISO RGD:69119 6480464 PTEN protein inhibits the reaction [Etoposide results in increased phosphorylation of and results in increased activity of AKT1 protein] more ... CTD PMID:16807353 , PMID:17935137 etoposide increases response to substance ISO RGD:69119 6480464 PTEN protein results in increased susceptibility to Etoposide CTD PMID:17935137 fenhexamid decreases expression ISO RGD:69119 6480464 N-(2, 3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of PTEN mRNA CTD PMID:23052036 ferulic acid multiple interactions ISO RGD:61995 6480464 ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTEN protein] more ... CTD PMID:35110471 flavanone increases expression ISO RGD:69119 6480464 flavanone results in increased expression of PTEN protein CTD PMID:22056764 fludioxonil decreases expression ISO RGD:69119 6480464 fludioxonil results in decreased expression of PTEN mRNA CTD PMID:23052036 flutamide increases expression ISO RGD:61995 6480464 Flutamide results in increased expression of PTEN mRNA CTD PMID:24136188 folic acid multiple interactions EXP 6480464 [1 more ... CTD PMID:20938992 , PMID:22206623 folic acid increases methylation ISO RGD:69119 6480464 Folic Acid results in increased methylation of PTEN promoter CTD PMID:23219837 folic acid decreases expression ISO RGD:69119 6480464 Folic Acid results in decreased expression of PTEN mRNA CTD PMID:23219837 folic acid multiple interactions ISO RGD:69119 6480464 Folic Acid inhibits the reaction [aluminum maltolate results in increased expression of PTEN protein] more ... CTD PMID:27113042 formaldehyde increases expression ISO RGD:69119 6480464 Formaldehyde results in increased expression of PTEN mRNA CTD PMID:23649840 fructose multiple interactions ISO RGD:61995 6480464 tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of PTEN protein] CTD PMID:26358169 fructose increases expression ISO RGD:61995 6480464 Fructose results in increased expression of PTEN protein CTD PMID:26358169 fulvestrant increases response to substance ISO RGD:69119 6480464 PTEN protein results in increased susceptibility to fulvestrant CTD PMID:19435893 fulvestrant increases methylation ISO RGD:69119 6480464 Fulvestrant results in increased methylation of PTEN gene CTD PMID:31601247 fulvestrant multiple interactions ISO RGD:69119 6480464 fulvestrant inhibits the reaction [Quercetin results in increased expression of PTEN protein] CTD PMID:21732360 gallic acid increases secretion ISO RGD:69119 6480464 Gallic Acid results in increased secretion of PTEN protein CTD PMID:26530725 gefitinib multiple interactions ISO RGD:61995 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Gefitinib results in increased expression of PTEN mRNA] CTD PMID:32370496 gefitinib increases expression ISO RGD:61995 6480464 Gefitinib results in increased expression of PTEN mRNA more ... CTD PMID:32370496 genistein multiple interactions ISO RGD:69119 6480464 dorsomorphin inhibits the reaction [Genistein results in increased expression of PTEN protein] CTD PMID:20673057 genistein affects expression ISO RGD:69119 6480464 Genistein affects the expression of PTEN mRNA CTD PMID:26865667 genistein increases response to substance ISO RGD:69119 6480464 PTEN protein results in increased susceptibility to Genistein CTD PMID:20673057 genistein increases expression ISO RGD:69119 6480464 Genistein results in increased expression of PTEN mRNA, Genistein results in increased expression of PTEN protein CTD PMID:15829497 , PMID:20673057 genistein decreases expression EXP 6480464 Genistein results in decreased expression of PTEN mRNA CTD PMID:21048042 geraniol multiple interactions ISO RGD:61995 6480464 geraniol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of PTEN protein] CTD PMID:28428697 ginsenoside Rg1 multiple interactions EXP 6480464 ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in increased expression of PTEN protein] CTD PMID:33331133 glufosinate affects expression EXP 6480464 phosphinothricin affects the expression of PTEN mRNA CTD PMID:25477793 gossypetin increases expression ISO RGD:69119 6480464 gossypetin results in increased expression of PTEN protein CTD PMID:25622137 gossypetin multiple interactions ISO RGD:69119 6480464 Enzyme Inhibitors inhibits the reaction [gossypetin results in increased expression of PTEN protein] CTD PMID:25622137 graphene oxide decreases expression ISO RGD:69119 6480464 graphene oxide results in decreased expression of PTEN mRNA CTD PMID:32070776 graphene oxide increases expression ISO RGD:69119 6480464 graphene oxide results in increased expression of PTEN protein CTD PMID:32070776 hemin multiple interactions ISO RGD:69119 6480464 Hemin inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 hesperetin multiple interactions ISO RGD:61995 6480464 hesperetin analog inhibits the reaction [bisperoxovanadium analog promotes the reaction [TGFB1 protein results in decreased expression of PTEN protein]] more ... CTD PMID:27818223 hexadecanoic acid multiple interactions ISO RGD:61995 6480464 MIR141 mRNA promotes the reaction [Palmitic Acid results in increased expression of PTEN protein] CTD PMID:34897970 hexadecanoic acid increases expression ISO RGD:61995 6480464 Palmitic Acid results in increased expression of PTEN protein CTD PMID:34897970 hydrogen peroxide increases abundance EXP 6480464 PTEN gene mutant form results in increased abundance of Hydrogen Peroxide CTD PMID:27022031 hydrogen peroxide increases expression ISO RGD:69119 6480464 Hydrogen Peroxide results in increased expression of PTEN mRNA CTD PMID:33212048 hydrogen peroxide multiple interactions ISO RGD:69119 6480464 astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of PTEN mRNA], Hydrogen Peroxide results in increased oxidation of and results in decreased activity of PTEN protein CTD PMID:11916965 , PMID:33212048 hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of PTEN protein CTD PMID:27494022 hydrogen peroxide multiple interactions EXP 6480464 PI103 inhibits the reaction [Hydrogen Peroxide results in decreased expression of PTEN protein], Quercetin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PTEN protein] CTD PMID:27494022 hydroxyflutamide increases phosphorylation ISO RGD:61995 6480464 hydroxyflutamide results in increased phosphorylation of PTEN protein CTD PMID:26437446 hydroxyflutamide multiple interactions ISO RGD:61995 6480464 hydroxyflutamide promotes the reaction [Testosterone results in increased phosphorylation of PTEN protein] CTD PMID:26437446 indometacin multiple interactions ISO RGD:69119 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PTEN mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PTEN mRNA CTD PMID:28628672 isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of PTEN mRNA CTD PMID:20003209 isoprenaline increases expression ISO RGD:61995 6480464 Isoproterenol results in increased expression of PTEN mRNA, Isoproterenol results in increased expression of PTEN protein CTD PMID:16188065 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PTEN gene CTD PMID:20938992 lead(0) affects expression ISO RGD:69119 6480464 Lead affects the expression of PTEN mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:69119 6480464 Lead affects the expression of PTEN mRNA CTD PMID:28903495 leflunomide increases expression ISO RGD:69119 6480464 leflunomide results in increased expression of PTEN mRNA CTD PMID:28988120 linsidomine increases oxidation ISO RGD:61995 6480464 linsidomine results in increased oxidation of PTEN protein CTD PMID:17302912 lipopolysaccharide multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [PTEN gene mutant form results in increased secretion of GPT protein]] more ... CTD PMID:27022031 lipopolysaccharide increases expression ISO RGD:61995 6480464 Lipopolysaccharides results in increased expression of PTEN protein CTD PMID:35110471 lipopolysaccharide multiple interactions ISO RGD:61995 6480464 ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTEN protein] more ... CTD PMID:35110471 lipopolysaccharide increases abundance EXP 6480464 PTEN gene mutant form results in increased abundance of Lipopolysaccharides CTD PMID:27022031 lovastatin multiple interactions ISO RGD:69119 6480464 Cycloheximide inhibits the reaction [Lovastatin results in increased expression of PTEN protein], PPARG protein affects the reaction [Lovastatin results in increased expression of PTEN protein] CTD PMID:16425225 lovastatin multiple interactions ISO RGD:61995 6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [Lovastatin results in increased expression of PTEN mRNA] more ... CTD PMID:20578043 lovastatin increases expression ISO RGD:61995 6480464 Lovastatin results in increased expression of PTEN mRNA CTD PMID:20578043 lovastatin increases expression EXP 6480464 Lovastatin results in increased expression of PTEN protein CTD PMID:16425225 lovastatin multiple interactions EXP 6480464 PPARG affects the reaction [Lovastatin results in increased expression of PTEN protein] CTD PMID:16425225 lovastatin increases expression ISO RGD:69119 6480464 Lovastatin results in increased expression of PTEN protein CTD PMID:16425225 lupeol increases expression ISO RGD:69119 6480464 lupeol results in increased expression of PTEN protein CTD PMID:20979057 lupeol increases response to substance ISO RGD:69119 6480464 PTEN protein results in increased susceptibility to lupeol CTD PMID:20979057 luteolin multiple interactions ISO RGD:61995 6480464 Luteolin inhibits the reaction [Methamphetamine results in increased expression of PTEN protein] CTD PMID:32035215 LY294002 multiple interactions ISO RGD:69119 6480464 [decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of PTEN mRNA more ... CTD PMID:18622747 , PMID:19808899 LY294002 multiple interactions ISO RGD:61995 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Gefitinib results in increased expression of PTEN mRNA] CTD PMID:32370496 LY294002 affects response to substance ISO RGD:69119 6480464 PTEN protein affects the susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one CTD PMID:33256086 LY294002 increases expression ISO RGD:61995 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PTEN mRNA CTD PMID:32370496 maculosin multiple interactions EXP 6480464 maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of PTEN protein] CTD PMID:34726822 malonaldehyde increases abundance ISO RGD:69119 6480464 PTEN mutant form results in increased abundance of Malondialdehyde CTD PMID:26548909 mercury dichloride decreases expression ISO RGD:69119 6480464 Mercuric Chloride results in decreased expression of PTEN mRNA CTD PMID:27188386 metformin multiple interactions ISO RGD:61995 6480464 Metformin inhibits the reaction [Testosterone results in decreased expression of PTEN mRNA] CTD PMID:26492952 methamphetamine increases expression ISO RGD:61995 6480464 Methamphetamine results in increased expression of PTEN mRNA, Methamphetamine results in increased expression of PTEN protein CTD PMID:19564919 , PMID:32035215 methamphetamine multiple interactions ISO RGD:61995 6480464 Luteolin inhibits the reaction [Methamphetamine results in increased expression of PTEN protein] CTD PMID:32035215 methidathion decreases expression EXP 6480464 methidathion results in decreased expression of PTEN mRNA CTD PMID:34813904 methotrexate increases expression ISO RGD:69119 6480464 Methotrexate results in increased expression of PTEN mRNA CTD PMID:17400583 methyl methanesulfonate increases expression ISO RGD:69119 6480464 Methyl Methanesulfonate results in increased expression of PTEN mRNA CTD PMID:23649840 methylarsonic acid decreases expression ISO RGD:61995 6480464 monomethylarsonic acid results in decreased expression of PTEN mRNA CTD PMID:24091636 methylarsonic acid decreases expression ISO RGD:69119 6480464 monomethylarsonic acid results in decreased expression of PTEN mRNA CTD PMID:24091636 methylmercury chloride decreases expression ISO RGD:69119 6480464 methylmercuric chloride results in decreased expression of PTEN mRNA CTD PMID:26272509 , PMID:28001369 methylmercury chloride increases expression ISO RGD:69119 6480464 methylmercuric chloride results in increased expression of PTEN mRNA CTD PMID:28001369 methylmercury chloride decreases expression ISO RGD:61995 6480464 methylmercuric chloride results in decreased expression of PTEN protein modified form CTD PMID:28821999 methylmercury(1+) multiple interactions ISO RGD:61995 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PTEN mRNA CTD PMID:17905399 methylmercury(1+) increases expression ISO RGD:69119 6480464 methylmercury II results in increased expression of PTEN mRNA CTD PMID:26314263 methylseleninic acid increases expression ISO RGD:69119 6480464 methylselenic acid results in increased expression of PTEN mRNA CTD PMID:12517777 mevinphos multiple interactions ISO RGD:61995 6480464 Mevinphos results in increased activity of and results in decreased oxidation of PTEN protein more ... CTD PMID:28601397 microcystin-LR decreases expression ISO RGD:69119 6480464 cyanoginosin LR results in decreased expression of PTEN mRNA, cyanoginosin LR results in decreased expression of PTEN protein CTD PMID:28062358 mono(2-ethylhexyl) phthalate multiple interactions ISO RGD:69119 6480464 [bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of PTEN mRNA more ... CTD PMID:34910997 morin multiple interactions ISO RGD:61995 6480464 morin inhibits the reaction [Diethylnitrosamine results in decreased expression of PTEN protein modified form] CTD PMID:19931519 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of PTEN protein] more ... CTD PMID:24449419 , PMID:27022031 N-acetyl-L-cysteine multiple interactions ISO RGD:61995 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein] CTD PMID:21195169 N-acetyl-L-cysteine multiple interactions ISO RGD:69119 6480464 Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of PTEN mRNA], Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein] CTD PMID:21195169 , PMID:35430258 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:61995 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Zinc Sulfate results in decreased stability of PTEN protein] CTD PMID:20100827 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases expression ISO RGD:69119 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PTEN protein CTD PMID:33256086 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of PTEN protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium results in increased degradation of and results in decreased expression of PTEN protein] CTD PMID:24449419 N-ethyl-N-nitrosourea increases mutagenesis EXP 6480464 Ethylnitrosourea results in increased mutagenesis of PTEN gene CTD PMID:15755804 , PMID:16724327 N-ethyl-N-nitrosourea decreases expression EXP 6480464 Ethylnitrosourea results in decreased expression of PTEN protein CTD PMID:32902906 N-methyl-4-phenylpyridinium increases expression ISO RGD:69119 6480464 1-Methyl-4-phenylpyridinium results in increased expression of PTEN protein CTD PMID:31907031 N-methyl-N'-nitro-N-nitrosoguanidine decreases expression ISO RGD:61995 6480464 Methylnitronitrosoguanidine results in decreased expression of PTEN protein CTD PMID:28428697 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO RGD:61995 6480464 geraniol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of PTEN protein] CTD PMID:28428697 N-methyl-N'-nitro-N-nitrosoguanidine decreases response to substance EXP 6480464 PTEN protein results in decreased susceptibility to Methylnitronitrosoguanidine CTD PMID:20530668 N-methyl-N-nitrosourea decreases expression EXP 6480464 Methylnitrosourea results in decreased expression of PTEN mRNA CTD PMID:16616109 N-nitrosodiethylamine multiple interactions ISO RGD:61995 6480464 3 more ... CTD PMID:19931519 , PMID:27048571 N-nitrosodiethylamine multiple interactions EXP 6480464 maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of PTEN protein], Quercetin inhibits the reaction [Diethylnitrosamine results in decreased expression of PTEN protein] CTD PMID:34726822 N-nitrosodiethylamine decreases expression EXP 6480464 Diethylnitrosamine results in decreased expression of PTEN protein CTD PMID:34726822 N-nitrosodiethylamine decreases expression ISO RGD:61995 6480464 Diethylnitrosamine results in decreased expression of PTEN protein modified form CTD PMID:19931519 nefazodone increases expression ISO RGD:61995 6480464 nefazodone results in increased expression of PTEN mRNA CTD PMID:24136188 nickel dichloride increases expression ISO RGD:69119 6480464 nickel chloride results in increased expression of PTEN mRNA CTD PMID:17312168 nickel sulfate increases expression ISO RGD:69119 6480464 nickel sulfate results in increased expression of PTEN mRNA CTD PMID:16780908 niclosamide increases expression ISO RGD:69119 6480464 Niclosamide results in increased expression of PTEN mRNA CTD PMID:29843133 nicotine increases expression ISO RGD:61995 6480464 Nicotine results in increased expression of PTEN mRNA CTD PMID:11478936 Nonylphenol multiple interactions ISO RGD:61995 6480464 wortmannin inhibits the reaction [nonylphenol results in decreased expression of PTEN protein] CTD PMID:27832966 Nonylphenol increases expression ISO RGD:61995 6480464 nonylphenol results in increased expression of PTEN mRNA CTD PMID:27832966 Nonylphenol decreases expression ISO RGD:61995 6480464 nonylphenol results in decreased expression of PTEN protein CTD PMID:27832966 ochratoxin A decreases expression ISO RGD:69119 6480464 ochratoxin A results in decreased expression of PTEN mRNA CTD PMID:19287073 ochratoxin A increases expression ISO RGD:69119 6480464 ochratoxin A metabolite results in increased expression of PTEN mRNA more ... CTD PMID:26314263 , PMID:34101318 ochratoxin A decreases phosphorylation ISO RGD:69119 6480464 ochratoxin A results in decreased phosphorylation of PTEN protein CTD PMID:25002221 oleanolic acid increases expression ISO RGD:69119 6480464 Oleanolic Acid results in increased expression of PTEN protein CTD PMID:20726234 omacetaxine mepesuccinate increases expression ISO RGD:69119 6480464 Homoharringtonine results in increased expression of PTEN protein CTD PMID:31726078 orlistat increases expression ISO RGD:69119 6480464 Orlistat results in increased expression of PTEN protein CTD PMID:32045588 orlistat multiple interactions ISO RGD:69119 6480464 Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in decreased expression of PTEN protein] CTD PMID:32045588 osthole increases expression ISO RGD:69119 6480464 osthol results in increased expression of PTEN protein CTD PMID:31870840 paclitaxel increases response to substance ISO RGD:69119 6480464 PTEN results in increased susceptibility to Paclitaxel CTD PMID:15548710 paclitaxel increases activity ISO RGD:69119 6480464 Paclitaxel results in increased activity of PTEN protein CTD PMID:11707646 paracetamol increases expression ISO RGD:61995 6480464 Acetaminophen results in increased expression of PTEN mRNA CTD PMID:33387578 paraquat multiple interactions ISO RGD:61995 6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [Rosiglitazone inhibits the reaction [Paraquat results in decreased expression of PTEN mRNA]] more ... CTD PMID:30797787 paraquat decreases expression ISO RGD:61995 6480464 Paraquat results in decreased expression of PTEN mRNA, Paraquat results in decreased expression of PTEN protein CTD PMID:30797787 paxilline multiple interactions ISO RGD:69119 6480464 paxilline inhibits the reaction [cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]] CTD PMID:12807996 perfluorooctanoic acid increases expression ISO RGD:69119 6480464 perfluorooctanoic acid results in increased expression of PTEN mRNA CTD PMID:23978341 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of PTEN mRNA CTD PMID:32320774 peroxynitrous acid increases oxidation ISO RGD:61995 6480464 Peroxynitrous Acid results in increased oxidation of PTEN protein CTD PMID:17302912 phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of PTEN mRNA CTD PMID:23091169 phenobarbital multiple interactions ISO RGD:61995 6480464 3 more ... CTD PMID:27048571 PhIP decreases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in decreased expression of PTEN protein CTD PMID:22581815 phosphatidylcholine affects binding ISO RGD:69119 6480464 PTEN protein binds to Phosphatidylcholines CTD PMID:15313215 phosphatidylcholine multiple interactions ISO RGD:69119 6480464 [TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to Phosphatidylcholines] CTD PMID:15313215 phosphatidylethanolamine affects binding ISO RGD:69119 6480464 PTEN protein binds to phosphatidylethanolamine CTD PMID:15313215 phosphatidylethanolamine multiple interactions ISO RGD:69119 6480464 [TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to phosphatidylethanolamine] CTD PMID:15313215 pioglitazone increases expression ISO RGD:69119 6480464 Pioglitazone results in increased expression of PTEN mRNA CTD PMID:32589349 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of PTEN mRNA CTD PMID:20813756 plumbagin multiple interactions ISO RGD:61995 6480464 plumbagin inhibits the reaction [Doxorubicin results in decreased phosphorylation of PTEN protein] CTD PMID:32691977 procymidone increases expression ISO RGD:61995 6480464 procymidone results in increased expression of PTEN mRNA CTD PMID:15686871 progesterone multiple interactions ISO RGD:61995 6480464 [Progesterone co-treated with Norepinephrine] results in increased expression of PTEN mRNA CTD PMID:16954335 progesterone affects expression EXP 6480464 Progesterone affects the expression of PTEN mRNA CTD PMID:17251523 propofol multiple interactions ISO RGD:69119 6480464 CASC9 protein inhibits the reaction [Propofol results in increased expression of PTEN protein] CTD PMID:35238236 propofol increases expression ISO RGD:69119 6480464 Propofol results in increased expression of PTEN protein CTD PMID:35238236 quercetin increases expression ISO RGD:61995 6480464 Quercetin results in increased expression of PTEN mRNA CTD PMID:18095365 quercetin multiple interactions ISO RGD:69119 6480464 [ESR2 protein results in increased susceptibility to Quercetin] which results in increased expression of PTEN protein, fulvestrant inhibits the reaction [Quercetin results in increased expression of PTEN protein] CTD PMID:21732360 quercetin increases expression ISO RGD:69119 6480464 Quercetin results in increased expression of PTEN mRNA, Quercetin results in increased expression of PTEN protein CTD PMID:14715546 more ... quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Diethylnitrosamine results in decreased expression of PTEN protein], Quercetin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PTEN protein] CTD PMID:27494022 , PMID:34726822 reactive oxygen species decreases expression ISO RGD:69119 6480464 Reactive Oxygen Species results in decreased expression of PTEN mRNA CTD PMID:25800948 resorcinol multiple interactions EXP 6480464 resorcinol inhibits the reaction [[APC protein affects the susceptibility to Dextran Sulfate] which results in increased chemical synthesis of PTEN protein modified form] CTD PMID:26262998 resveratrol increases activity ISO RGD:69119 6480464 resveratrol results in increased activity of PTEN protein CTD PMID:24812624 resveratrol decreases methylation ISO RGD:69119 6480464 resveratrol results in decreased methylation of PTEN promoter CTD PMID:21801466 resveratrol decreases expression ISO RGD:69119 6480464 resveratrol results in decreased expression of PTEN mRNA CTD PMID:22971900 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [OVAL protein results in decreased expression of PTEN mRNA], resveratrol inhibits the reaction [OVAL protein results in decreased expression of PTEN protein] CTD PMID:25739523 resveratrol increases expression ISO RGD:69119 6480464 resveratrol results in increased expression of PTEN mRNA, resveratrol results in increased expression of PTEN protein CTD PMID:15829497 more ... resveratrol decreases phosphorylation ISO RGD:69119 6480464 resveratrol results in decreased phosphorylation of PTEN protein CTD PMID:26530632 resveratrol increases phosphorylation EXP 6480464 resveratrol results in increased phosphorylation of PTEN protein CTD PMID:22363816 resveratrol multiple interactions ISO RGD:69119 6480464 [Doxorubicin co-treated with resveratrol] results in increased expression of PTEN mRNA more ... CTD PMID:20729295 more ... rimonabant multiple interactions ISO RGD:61995 6480464 [(3R)-((2 more ... CTD PMID:32833042 rimonabant affects expression ISO RGD:61995 6480464 Rimonabant affects the expression of PTEN mRNA CTD PMID:32833042 rivastigmine multiple interactions ISO RGD:61995 6480464 Rivastigmine inhibits the reaction [Streptozocin results in increased expression of PTEN mRNA] CTD PMID:32805344 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of PTEN mRNA CTD PMID:26806867 rutin multiple interactions EXP 6480464 Rutin inhibits the reaction [Cisplatin results in increased phosphorylation of PTEN protein] CTD PMID:33031932 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions EXP 6480464 Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of PTEN protein], Buthionine Sulfoximine promotes the reaction [Cadmium results in increased degradation of and results in decreased expression of PTEN protein] CTD PMID:24449419 SB 203580 multiple interactions ISO RGD:69119 6480464 SB 203580 inhibits the reaction [IL18 protein results in increased expression of PTEN mRNA] CTD PMID:18215737 SB 431542 multiple interactions ISO RGD:69119 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide affects methylation ISO RGD:69119 6480464 Silicon Dioxide affects the methylation of PTEN promoter CTD PMID:27621875 simvastatin increases expression EXP 6480464 Simvastatin results in increased expression of PTEN mRNA, Simvastatin results in increased expression of PTEN protein CTD PMID:20060890 sirolimus multiple interactions ISO RGD:69119 6480464 [Decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of PTEN mRNA, Sirolimus inhibits the reaction [TNF protein results in decreased expression of PTEN protein] CTD PMID:18622747 , PMID:31676321 sirolimus multiple interactions ISO RGD:61995 6480464 Sirolimus inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein] CTD PMID:21195169 sirolimus decreases expression EXP 6480464 Sirolimus results in decreased expression of PTEN protein CTD PMID:18303120 sirolimus decreases response to substance ISO RGD:69119 6480464 PTEN protein results in decreased susceptibility to Sirolimus CTD PMID:19625624 sodium arsenate increases expression EXP 6480464 sodium arsenate results in increased expression of PTEN mRNA CTD PMID:21795629 sodium arsenate decreases expression ISO RGD:61995 6480464 sodium arsenate results in decreased expression of PTEN mRNA, sodium arsenate results in decreased expression of PTEN protein CTD PMID:14713550 sodium arsenite affects methylation ISO RGD:69119 6480464 sodium arsenite affects the methylation of PTEN gene CTD PMID:28589171 sodium arsenite affects expression ISO RGD:69119 6480464 sodium arsenite affects the expression of PTEN protein CTD PMID:33256086 sodium arsenite affects response to substance ISO RGD:69119 6480464 PTEN protein affects the susceptibility to sodium arsenite CTD PMID:33256086 sodium arsenite increases phosphorylation ISO RGD:69119 6480464 sodium arsenite results in increased phosphorylation of PTEN protein CTD PMID:29039521 sodium arsenite multiple interactions ISO RGD:69119 6480464 Cycloheximide affects the reaction [sodium arsenite affects the expression of PTEN protein] more ... CTD PMID:26432159 more ... sodium arsenite decreases expression ISO RGD:61995 6480464 sodium arsenite results in decreased expression of PTEN protein CTD PMID:26432159 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of PTEN mRNA CTD PMID:16014739 sodium arsenite decreases expression ISO RGD:69119 6480464 sodium arsenite results in decreased expression of PTEN mRNA, sodium arsenite results in decreased expression of PTEN protein CTD PMID:20056578 more ... sodium fluoride increases expression EXP 6480464 Sodium Fluoride results in increased expression of PTEN mRNA CTD PMID:21340527 sodium fluoride decreases expression ISO RGD:69119 6480464 Sodium Fluoride results in decreased expression of PTEN protein CTD PMID:34942272 sodium fluoride multiple interactions ISO RGD:69119 6480464 MIR21 mRNA affects the reaction [Sodium Fluoride results in decreased expression of PTEN protein] CTD PMID:34942272 streptozocin multiple interactions ISO RGD:61995 6480464 Phycocyanin inhibits the reaction [Streptozocin results in increased expression of PTEN mRNA] more ... CTD PMID:32805344 streptozocin increases expression ISO RGD:61995 6480464 Streptozocin results in increased expression of PTEN mRNA CTD PMID:32805344 sunitinib multiple interactions ISO RGD:69119 6480464 PTEN protein inhibits the reaction [sunitinib results in increased expression of and results in increased secretion of CXCL8 protein], PTEN protein inhibits the reaction [sunitinib results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:22532600 sunitinib increases response to substance ISO RGD:69119 6480464 PTEN protein results in increased susceptibility to sunitinib CTD PMID:22532600 tamoxifen increases response to substance ISO RGD:69119 6480464 PTEN protein results in increased susceptibility to Tamoxifen CTD PMID:19435893 tert-butyl hydroperoxide increases expression ISO RGD:69119 6480464 tert-Butylhydroperoxide results in increased expression of PTEN mRNA CTD PMID:15336504 testosterone multiple interactions ISO RGD:61995 6480464 hydroxyflutamide promotes the reaction [Testosterone results in increased phosphorylation of PTEN protein] more ... CTD PMID:16954335 more ... testosterone decreases expression ISO RGD:69119 6480464 Testosterone results in decreased expression of PTEN mRNA CTD PMID:33359661 testosterone increases phosphorylation ISO RGD:61995 6480464 Testosterone results in increased phosphorylation of PTEN protein CTD PMID:26437446 testosterone decreases expression ISO RGD:61995 6480464 Testosterone results in decreased expression of PTEN mRNA CTD PMID:16954335 , PMID:26492952 tetrachloromethane decreases expression ISO RGD:61995 6480464 Carbon Tetrachloride results in decreased expression of PTEN mRNA, Carbon Tetrachloride results in decreased expression of PTEN protein CTD PMID:22841775 , PMID:27818223 tetrachloromethane multiple interactions ISO RGD:61995 6480464 hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTEN mRNA], hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTEN protein] CTD PMID:27818223 tetrachloromethane increases methylation ISO RGD:61995 6480464 Carbon Tetrachloride results in increased methylation of PTEN promoter CTD PMID:22841775 tetracycline increases expression EXP 6480464 Tetracycline results in increased expression of PTEN mRNA CTD PMID:16917069 thalidomide increases expression ISO RGD:69119 6480464 Thalidomide results in increased expression of PTEN protein CTD PMID:19567134 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of PTEN mRNA CTD PMID:29128614 , PMID:29264374 toluene 2,4-diisocyanate multiple interactions EXP 6480464 PTEN protein inhibits the reaction [Toluene 2 more ... CTD PMID:17982072 tributylstannane increases expression ISO RGD:69119 6480464 tributyltin results in increased expression of PTEN mRNA CTD PMID:26314263 Tributyltin oxide increases expression ISO RGD:69119 6480464 bis(tri-n-butyltin)oxide results in increased expression of PTEN mRNA CTD PMID:24247028 , PMID:26314263 trichloroethene multiple interactions ISO RGD:61995 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PTEN mRNA CTD PMID:17905399 trichloroethene increases expression ISO RGD:61995 6480464 Trichloroethylene results in increased expression of PTEN mRNA CTD PMID:19448997 trichostatin A multiple interactions ISO RGD:69119 6480464 [Doxorubicin co-treated with trichostatin A] results in increased expression of PTEN mRNA more ... CTD PMID:17330857 , PMID:27188386 trichostatin A increases expression ISO RGD:69119 6480464 trichostatin A results in increased expression of PTEN mRNA, trichostatin A results in increased expression of PTEN protein CTD PMID:17330857 more ... triphenyl phosphate increases expression ISO RGD:61995 6480464 triphenyl phosphate results in increased expression of PTEN mRNA CTD PMID:30589522 Triptolide multiple interactions EXP 6480464 NOTCH1 protein modified form inhibits the reaction [triptolide results in increased expression of PTEN protein] CTD PMID:30394310 Triptolide increases expression ISO RGD:69119 6480464 triptolide results in increased expression of PTEN protein CTD PMID:30394310 Triptolide increases expression EXP 6480464 triptolide results in increased expression of PTEN protein CTD PMID:30394310 trovafloxacin multiple interactions EXP 6480464 [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTEN mRNA CTD PMID:18930950 tubastatin A increases expression ISO RGD:69119 6480464 tubastatin A results in increased expression of PTEN mRNA CTD PMID:34910997 tubastatin A multiple interactions ISO RGD:69119 6480464 [bisphenol A co-treated with tubastatin A] results in increased expression of PTEN mRNA more ... CTD PMID:34910997 urethane increases expression ISO RGD:69119 6480464 Urethane results in increased expression of PTEN mRNA CTD PMID:28818685 valproic acid decreases methylation ISO RGD:69119 6480464 Valproic Acid results in decreased methylation of PTEN gene CTD PMID:29154799 valproic acid affects splicing ISO RGD:61995 6480464 Valproic Acid affects the splicing of PTEN mRNA CTD PMID:29427782 valproic acid decreases expression ISO RGD:69119 6480464 Valproic Acid results in decreased expression of PTEN mRNA CTD PMID:28001369 valproic acid multiple interactions ISO RGD:69119 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTEN mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:69119 6480464 Valproic Acid results in increased expression of PTEN mRNA CTD PMID:26272509 veliparib decreases response to substance EXP 6480464 PTEN protein results in decreased susceptibility to veliparib CTD PMID:20530668 vinclozolin increases expression ISO RGD:61995 6480464 vinclozolin results in increased expression of PTEN mRNA CTD PMID:15686871 vinyl carbamate decreases expression EXP 6480464 vinyl carbamate results in decreased expression of PTEN mRNA CTD PMID:17849452 vorinostat decreases expression ISO RGD:69119 6480464 vorinostat results in decreased expression of PTEN mRNA CTD PMID:27188386 WIN 55212-2 multiple interactions ISO RGD:61995 6480464 [(3R)-((2 more ... CTD PMID:32833042 WIN 55212-2 affects expression ISO RGD:61995 6480464 (3R)-((2 more ... CTD PMID:32833042 wortmannin multiple interactions ISO RGD:69119 6480464 wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Doxorubicin], wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Etoposide] CTD PMID:17935137 wortmannin multiple interactions ISO RGD:61995 6480464 Wortmannin inhibits the reaction [nonylphenol results in decreased expression of PTEN protein] more ... CTD PMID:20100827 more ... zearalenone increases expression EXP 6480464 Zearalenone results in increased expression of PTEN mRNA CTD PMID:30717214 zinc atom multiple interactions ISO RGD:69119 6480464 PTEN protein inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA], PTEN protein inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein] CTD PMID:15980035 zinc atom increases degradation ISO RGD:69119 6480464 Zinc results in increased degradation of PTEN protein CTD PMID:15980035 zinc sulfate multiple interactions ISO RGD:69119 6480464 PTEN mutant form inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA], PTEN promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA] CTD PMID:21883094 zinc sulfate increases ubiquitination ISO RGD:61995 6480464 Zinc Sulfate results in increased ubiquitination of PTEN protein CTD PMID:20100827 zinc sulfate multiple interactions ISO RGD:61995 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Zinc Sulfate results in decreased stability of PTEN protein] more ... CTD PMID:20100827 zinc sulfate increases response to substance ISO RGD:61995 6480464 PTEN protein results in increased susceptibility to Zinc Sulfate CTD PMID:20100827 zinc sulfate decreases expression EXP 6480464 Zinc Sulfate results in decreased expression of PTEN protein CTD PMID:20100827 zinc(0) multiple interactions ISO RGD:69119 6480464 PTEN protein inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA], PTEN protein inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein] CTD PMID:15980035 zinc(0) increases degradation ISO RGD:69119 6480464 Zinc results in increased degradation of PTEN protein CTD PMID:15980035