Ltf (lactotransferrin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ltf (lactotransferrin) Mus musculus
Analyze
Symbol: Ltf
Name: lactotransferrin
RGD ID: 1313478
MGI Page MGI
Description: Enables peptidase activity. Predicted to be involved in several processes, including defense response to other organism; regulation of signal transduction; and regulation of tumor necrosis factor superfamily cytokine production. Located in cytoplasm. Is expressed in several structures, including early conceptus; epithelium; genitourinary system; gut; and liver. Human ortholog(s) of this gene implicated in candidiasis; lung non-small cell carcinoma; and renal cell carcinoma. Orthologous to human LTF (lactotransferrin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Csp82; L; lact; lactoferrin; Lf; minisatellite 10r detected by probe MMS10; MMS10R; Ms10r; N lobe
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,848,360 - 110,871,834 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,848,339 - 110,871,835 (+)EnsemblGRCm39 Ensembl
GRCm389111,019,292 - 111,042,766 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9111,019,271 - 111,042,767 (+)EnsemblGRCm38mm10GRCm38
MGSCv379110,921,796 - 110,945,270 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369110,864,108 - 110,887,582 (+)NCBIMGSCv36mm8
Celera9110,742,738 - 110,766,162 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4-hydroxy-17beta-estradiol  (EXP)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aluminium oxide  (EXP)
apigenin  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
atropine  (ISO)
azathioprine  (EXP)
beclomethasone  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
budesonide  (ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP)
carnosic acid  (EXP)
chlordecone  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
copper(II) chloride  (ISO)
corosolic acid  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
DDT  (EXP)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diamminedichloroplatinum  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (EXP,ISO)
disodium selenite  (ISO)
doxorubicin  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
fenarimol  (ISO)
fonofos  (ISO)
fulvestrant  (EXP,ISO)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (EXP)
irinotecan  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
MeIQx  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP)
myricetin  (ISO)
N,N-dimethylformamide  (ISO)
naloxone  (ISO)
nickel atom  (EXP,ISO)
nicotine  (ISO)
nitric oxide  (ISO)
Nonylphenol  (EXP)
ozone  (EXP)
paracetamol  (EXP)
parathion  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phloretin  (ISO)
phosphatidylcholine  (EXP)
phytosterols  (EXP)
prednisolone  (EXP)
progesterone  (EXP)
pyridaben  (EXP)
reactive oxygen species  (ISO)
senecionine  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (EXP)
sulforaphane  (EXP)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP,ISO)
terbufos  (ISO)
thalidomide  (ISO)
theophylline  (ISO)
titanium dioxide  (EXP)
transplatin  (ISO)
tremolite asbestos  (EXP)
tributylstannane  (EXP)
triphenyl phosphate  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tungsten  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibacterial humoral response  (IBA,ISO,ISS)
antifungal humoral response  (ISO,ISS)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IEA,ISO)
bone morphogenesis  (ISO,ISS)
cytolysis by host of symbiont cells  (ISO)
defense response to Gram-negative bacterium  (IEA,ISO)
defense response to Gram-positive bacterium  (ISO)
innate immune response  (ISO)
innate immune response in mucosa  (ISO,ISS)
iron ion transport  (IBA,IEA)
killing of cells of another organism  (IEA,ISO)
negative regulation by host of viral process  (IEA,ISO)
negative regulation of apoptotic process  (ISS)
negative regulation of ATP-dependent activity  (ISO)
negative regulation of cysteine-type endopeptidase activity  (ISO)
negative regulation of lipopolysaccharide-mediated signaling pathway  (ISO,ISS)
negative regulation of membrane potential  (ISO)
negative regulation of osteoclast development  (ISS)
negative regulation of single-species biofilm formation in or on host organism  (ISO,ISS)
negative regulation of tumor necrosis factor (ligand) superfamily member 11 production  (ISS)
negative regulation of viral genome replication  (IEA,ISO)
negative regulation of viral process  (ISO)
ossification  (IEA)
positive regulation of bone mineralization involved in bone maturation  (ISS)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of chondrocyte proliferation  (ISO,ISS)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of osteoblast differentiation  (ISO,ISS)
positive regulation of osteoblast proliferation  (ISO,ISS)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of toll-like receptor 4 signaling pathway  (IEA,ISO)
proteolysis  (IEA)
regulation of cytokine production  (ISO,ISS)
regulation of tumor necrosis factor production  (ISO,ISS)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Influence of lactoferrin feeding and injection against systemic staphylococcal infections in mice. Bhimani RS, etal., J Appl Microbiol. 1999 Jan;86(1):135-44.
2. A randomized, double-blind, placebo-controlled, phase II study of oral talactoferrin in combination with carboplatin and paclitaxel in previously untreated locally advanced or metastatic non-small cell lung cancer. Digumarti R, etal., J Thorac Oncol. 2011 Jun;6(6):1098-103. doi: 10.1097/JTO.0b013e3182156250.
3. Lung injury after ozone exposure is iron dependent. Ghio AJ, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L134-43. Epub 2006 Aug 11.
4. A phase 2 randomized, double-blind, placebo-controlled study of the safety and efficacy of talactoferrin in patients with severe sepsis. Guntupalli K, etal., Crit Care Med. 2013 Mar;41(3):706-16. doi: 10.1097/CCM.0b013e3182741551.
5. Involvement of protein kinase C in C5a-primed neutrophils for ANCA-mediated activation. Hao J, etal., Mol Immunol. 2013 May;54(1):68-73. doi: 10.1016/j.molimm.2012.10.041. Epub 2012 Nov 28.
6. Human lactoferrin-derived peptide's antifungal activities against disseminated Candida albicans infection. Lupetti A, etal., J Infect Dis. 2007 Nov 1;196(9):1416-24. Epub 2007 Oct 2.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. Biliary lactoferrin concentrations are increased in active inflammatory bowel disease: a factor in the pathogenesis of primary sclerosing cholangitis? Pereira SP, etal., Clin Sci (Lond). 1998 Nov;95(5):637-44.
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Acute inflammatory proteins constitute the organic matrix of prostatic corpora amylacea and calculi in men with prostate cancer. Sfanos KS, etal., Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3443-8. doi: 10.1073/pnas.0810473106. Epub 2009 Feb 6.
15. ANCA with specificity for lactoferrin in systemic lupus erythematosus (SLE). Sinico RA, etal., Adv Exp Med Biol. 1993;336:385-7.
Additional References at PubMed
PMID:1311279   PMID:1482377   PMID:1939212   PMID:2181376   PMID:3036827   PMID:3478818   PMID:3611056   PMID:7550308   PMID:7819129   PMID:8093048   PMID:8441416   PMID:8592515  
PMID:9611252   PMID:10098524   PMID:10349636   PMID:10447107   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11210178   PMID:11217851   PMID:11786226   PMID:11908639  
PMID:11937551   PMID:12140191   PMID:12390874   PMID:12461651   PMID:12477932   PMID:12482971   PMID:14727813   PMID:15222482   PMID:15489334   PMID:15572693   PMID:15809042   PMID:15919778  
PMID:16141072   PMID:16141073   PMID:16176985   PMID:16602821   PMID:16765951   PMID:16866365   PMID:16989572   PMID:17023661   PMID:18321995   PMID:18717818   PMID:19524877   PMID:20599473  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:22100262   PMID:23295235   PMID:23333090   PMID:23879888   PMID:24561791   PMID:24816278   PMID:24823394   PMID:24877241   PMID:24893171  
PMID:24909139   PMID:24971735   PMID:25057912   PMID:25062410   PMID:25415419   PMID:26057579   PMID:26148296   PMID:26184908   PMID:26393907   PMID:26672975   PMID:27358915   PMID:28049832  
PMID:28368537   PMID:28424251   PMID:28576768   PMID:29036275   PMID:29202468   PMID:29426931   PMID:29546371   PMID:29636422   PMID:29911998   PMID:29934619   PMID:29975946   PMID:30021163  
PMID:30142194   PMID:30356064   PMID:30782821   PMID:31221639   PMID:31462711   PMID:31780662   PMID:32213656   PMID:32218351   PMID:32325033   PMID:32900950   PMID:32968170   PMID:33176148  
PMID:33222288   PMID:33399260   PMID:33496365   PMID:34402888   PMID:34659251   PMID:35383354   PMID:35650365   PMID:35806481   PMID:35835555   PMID:35946355   PMID:36646738   PMID:37198149  
PMID:37528140   PMID:37907907   PMID:38063014  


Genomics

Comparative Map Data
Ltf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,848,360 - 110,871,834 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,848,339 - 110,871,835 (+)EnsemblGRCm39 Ensembl
GRCm389111,019,292 - 111,042,766 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9111,019,271 - 111,042,767 (+)EnsemblGRCm38mm10GRCm38
MGSCv379110,921,796 - 110,945,270 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369110,864,108 - 110,887,582 (+)NCBIMGSCv36mm8
Celera9110,742,738 - 110,766,162 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
LTF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,435,645 - 46,485,234 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,435,645 - 46,485,234 (-)EnsemblGRCh38hg38GRCh38
GRCh37346,477,136 - 46,526,724 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,452,500 - 46,481,399 (-)NCBINCBI36Build 36hg18NCBI36
Build 34346,452,500 - 46,481,399NCBI
Celera346,414,868 - 46,443,775 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,519,882 - 46,548,964 (-)NCBIHuRef
CHM1_1346,427,517 - 46,456,606 (-)NCBICHM1_1
T2T-CHM13v2.0346,451,475 - 46,501,054 (-)NCBIT2T-CHM13v2.0
Ltf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,878,344 - 119,901,189 (+)NCBIGRCr8
mRatBN7.28110,999,948 - 111,022,795 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,999,948 - 111,022,795 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8116,614,671 - 116,637,494 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,813,884 - 114,836,711 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,656,706 - 112,679,539 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08119,290,416 - 119,313,261 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,290,416 - 119,313,261 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,632,730 - 118,655,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,417,764 - 115,440,609 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18115,437,256 - 115,458,062 (+)NCBI
Celera8110,282,264 - 110,305,105 (+)NCBICelera
Cytogenetic Map8q32NCBI
Ltf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542025,580,359 - 25,604,331 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542025,580,449 - 25,604,277 (+)NCBIChiLan1.0ChiLan1.0
LTF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,394,851 - 46,423,796 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,399,619 - 46,428,572 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,337,738 - 46,367,476 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,442,440 - 47,471,532 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,442,440 - 47,471,532 (-)Ensemblpanpan1.1panPan2
LTF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,231,994 - 42,263,202 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,231,994 - 42,263,202 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,147,994 - 42,179,342 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,714,382 - 42,745,648 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,698,084 - 42,745,648 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12041,955,622 - 41,986,941 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,357,046 - 42,388,364 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,637,942 - 42,669,274 (+)NCBIUU_Cfam_GSD_1.0
Ltf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118200,795,136 - 200,824,718 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936596344,274 - 373,952 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936596344,287 - 373,788 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LTF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,413,886 - 29,445,739 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,413,886 - 29,445,751 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,577,743 - 32,609,425 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LTF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,867,332 - 7,896,403 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,867,286 - 7,894,521 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041159,254,403 - 159,283,476 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ltf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473074,636,522 - 74,656,886 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473074,636,554 - 74,656,817 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ltf
778 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:267
Count of miRNA genes:216
Interacting mature miRNAs:236
Transcripts:ENSMUST00000035077
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982792386116792481Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979279863113279941Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975682646114303447Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982792386116792481Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989859058118767089Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982792386116792481Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978522698112522808Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975682646114303447Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994863354112701997Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981680321115680445Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984406017118406120Mouse
13515058Adip20d_madiposity 20d (mouse)9108744078118744078Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse

Markers in Region
Ltf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9FUniSTS
cM Map970.2UniSTS
cM Map970.2UniSTS
D9Mit38  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389111,021,446 - 111,021,636UniSTSGRCm38
MGSCv379110,923,950 - 110,924,140UniSTSGRCm37
Celera9110,744,924 - 110,745,116UniSTS
Cytogenetic Map9FUniSTS
cM Map961.0UniSTS
Whitehead Genetic960.1UniSTS
Whitehead_YAC9 UniSTS
PMC140657P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389111,022,440 - 111,022,954UniSTSGRCm38
MGSCv379110,924,944 - 110,925,458UniSTSGRCm37
Celera9110,745,920 - 110,746,434UniSTS
Cytogenetic Map9FUniSTS
cM Map970.2UniSTS
PMC24216P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389111,021,976 - 111,022,867UniSTSGRCm38
MGSCv379110,924,480 - 110,925,371UniSTSGRCm37
Celera9110,745,456 - 110,746,347UniSTS
Cytogenetic Map9FUniSTS
cM Map970.2UniSTS
Ltf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9FUniSTS
cM Map970.2UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC118727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY792500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D88510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ538998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M74778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000035077   ⟹   ENSMUSP00000035077
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,848,360 - 110,871,835 (+)Ensembl
GRCm38.p6 Ensembl9111,019,292 - 111,042,767 (+)Ensembl
Ensembl Acc Id: ENSMUST00000196122   ⟹   ENSMUSP00000143234
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,848,378 - 110,854,076 (+)Ensembl
GRCm38.p6 Ensembl9111,019,310 - 111,025,008 (+)Ensembl
Ensembl Acc Id: ENSMUST00000196209   ⟹   ENSMUSP00000143731
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,848,360 - 110,869,561 (+)Ensembl
GRCm38.p6 Ensembl9111,019,292 - 111,040,493 (+)Ensembl
Ensembl Acc Id: ENSMUST00000196777   ⟹   ENSMUSP00000143629
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,848,360 - 110,851,531 (+)Ensembl
GRCm38.p6 Ensembl9111,019,292 - 111,022,463 (+)Ensembl
Ensembl Acc Id: ENSMUST00000197575   ⟹   ENSMUSP00000142691
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,867,873 - 110,871,394 (+)Ensembl
GRCm38.p6 Ensembl9111,038,805 - 111,042,326 (+)Ensembl
Ensembl Acc Id: ENSMUST00000197893
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,856,190 - 110,857,561 (+)Ensembl
GRCm38.p6 Ensembl9111,027,122 - 111,028,493 (+)Ensembl
Ensembl Acc Id: ENSMUST00000198152   ⟹   ENSMUSP00000143342
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,851,484 - 110,856,488 (+)Ensembl
GRCm38.p6 Ensembl9111,022,416 - 111,027,420 (+)Ensembl
Ensembl Acc Id: ENSMUST00000198233
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,864,707 - 110,869,545 (+)Ensembl
GRCm38.p6 Ensembl9111,035,639 - 111,040,477 (+)Ensembl
Ensembl Acc Id: ENSMUST00000198884   ⟹   ENSMUSP00000142432
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,848,339 - 110,869,561 (+)Ensembl
GRCm38.p6 Ensembl9111,019,271 - 111,040,493 (+)Ensembl
Ensembl Acc Id: ENSMUST00000199313   ⟹   ENSMUSP00000142739
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,856,428 - 110,864,876 (+)Ensembl
GRCm38.p6 Ensembl9111,027,360 - 111,035,808 (+)Ensembl
Ensembl Acc Id: ENSMUST00000199815   ⟹   ENSMUSP00000142403
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,860,189 - 110,869,545 (+)Ensembl
GRCm38.p6 Ensembl9111,031,121 - 111,040,477 (+)Ensembl
Ensembl Acc Id: ENSMUST00000200459
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,853,454 - 110,854,571 (+)Ensembl
GRCm38.p6 Ensembl9111,024,386 - 111,025,503 (+)Ensembl
RefSeq Acc Id: NM_008522   ⟹   NP_032548
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,848,360 - 110,871,834 (+)NCBI
GRCm389111,019,292 - 111,042,766 (+)ENTREZGENE
MGSCv379110,921,796 - 110,945,270 (+)RGD
Celera9110,742,738 - 110,766,162 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032548   ⟸   NM_008522
- Peptide Label: precursor
- UniProtKB: Q8CBA0 (UniProtKB/Swiss-Prot),   Q61799 (UniProtKB/Swiss-Prot),   P70690 (UniProtKB/Swiss-Prot),   Q922P2 (UniProtKB/Swiss-Prot),   P08071 (UniProtKB/Swiss-Prot),   Q3TP24 (UniProtKB/TrEMBL),   Q3UBV2 (UniProtKB/TrEMBL),   Q4FJR3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000142432   ⟸   ENSMUST00000198884
Ensembl Acc Id: ENSMUSP00000143342   ⟸   ENSMUST00000198152
Ensembl Acc Id: ENSMUSP00000142691   ⟸   ENSMUST00000197575
Ensembl Acc Id: ENSMUSP00000035077   ⟸   ENSMUST00000035077
Ensembl Acc Id: ENSMUSP00000142403   ⟸   ENSMUST00000199815
Ensembl Acc Id: ENSMUSP00000142739   ⟸   ENSMUST00000199313
Ensembl Acc Id: ENSMUSP00000143234   ⟸   ENSMUST00000196122
Ensembl Acc Id: ENSMUSP00000143731   ⟸   ENSMUST00000196209
Ensembl Acc Id: ENSMUSP00000143629   ⟸   ENSMUST00000196777
Protein Domains
Transferrin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08071-F1-model_v2 AlphaFold P08071 1-707 view protein structure

Promoters
RGD ID:8671048
Promoter ID:EPDNEW_M13555
Type:multiple initiation site
Name:Ltf_1
Description:Mus musculus lactotransferrin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389111,019,292 - 111,019,352EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96837 AgrOrtholog
Ensembl Genes ENSMUSG00000032496 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035077 ENTREZGENE
  ENSMUST00000035077.8 UniProtKB/Swiss-Prot
  ENSMUST00000196122.3 UniProtKB/TrEMBL
  ENSMUST00000196209.5 UniProtKB/TrEMBL
  ENSMUST00000196777.5 UniProtKB/TrEMBL
  ENSMUST00000197575.2 UniProtKB/TrEMBL
  ENSMUST00000198152.2 UniProtKB/TrEMBL
  ENSMUST00000198884.5 UniProtKB/TrEMBL
  ENSMUST00000199313.2 UniProtKB/TrEMBL
  ENSMUST00000199815.5 UniProtKB/TrEMBL
Gene3D-CATH Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Lactotransferrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferrin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferrin_Fe_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17002 UniProtKB/Swiss-Prot
MGD MGI:96837 ENTREZGENE
NCBI Gene 17002 ENTREZGENE
PANTHER LACTOTRANSFERRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LD22449P UniProtKB/TrEMBL
  TRANSFERRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Transferrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ltf PhenoGen
PIRSF Lactotransferrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TRANSFERRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRANSFERRIN_LIKE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSFERRIN_LIKE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSFERRIN_LIKE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSFERRIN_LIKE_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TR_FER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JDK4_MOUSE UniProtKB/TrEMBL
  A0A0G2JDN0_MOUSE UniProtKB/TrEMBL
  A0A0G2JEA3_MOUSE UniProtKB/TrEMBL
  A0A0G2JEE4_MOUSE UniProtKB/TrEMBL
  A0A0G2JFM6_MOUSE UniProtKB/TrEMBL
  A0A0G2JFX4_MOUSE UniProtKB/TrEMBL
  A0A0G2JGN1_MOUSE UniProtKB/TrEMBL
  A0A0G2JGX1_MOUSE UniProtKB/TrEMBL
  B8YJF9_MOUSE UniProtKB/TrEMBL
  P08071 ENTREZGENE
  P70690 ENTREZGENE
  Q3TP24 ENTREZGENE, UniProtKB/TrEMBL
  Q3UBV2 ENTREZGENE, UniProtKB/TrEMBL
  Q4FJR3 ENTREZGENE, UniProtKB/TrEMBL
  Q5MJE7_MOUSE UniProtKB/TrEMBL
  Q61799 ENTREZGENE
  Q8CBA0 ENTREZGENE
  Q922P2 ENTREZGENE
  TRFL_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary P70690 UniProtKB/Swiss-Prot
  Q61799 UniProtKB/Swiss-Prot
  Q8CBA0 UniProtKB/Swiss-Prot
  Q922P2 UniProtKB/Swiss-Prot