Mtor (mechanistic target of rapamycin kinase) - Rat Genome Database

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Gene: Mtor (mechanistic target of rapamycin kinase) Mus musculus
Symbol: Mtor
Name: mechanistic target of rapamycin kinase
RGD ID: 68534
Description: Enables protein serine/threonine kinase activity and ribosome binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; T-helper 1 cell lineage commitment; and neuronal action potential. Acts upstream of or within several processes, including heart development; positive regulation of cellular component biogenesis; and regulation of protein phosphorylation. Located in cytosol; dendrite; and nucleus. Part of TORC1 complex. Colocalizes with PML body. Is expressed in central nervous system; early conceptus; oocyte; respiratory system; and retina. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2610315D21Rik; AI327068; angiopoietin-like factor CDT6; FK506 binding protein 12-rapamycin associated protein 1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein (FRAP); FKBP-rapamycin-associated protein FRAP; FKBP12-rapamycin complex-associated protein; fl; flat; Fr; FRAP; Frap1; FRAP2; mammalian target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); MGC118056; RA; RAF; RAFT1; rapamycin target protein 1; RAPT1; serine/threonine-protein kinase mTOR
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm394148,533,039 - 148,642,142 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,533,068 - 148,642,140 (+)EnsemblGRCm39 Ensembl
GRCm384148,448,582 - 148,557,685 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,448,611 - 148,557,683 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,822,691 - 147,931,794 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364147,292,407 - 147,401,483 (+)NCBIMGSCv36mm8
Celera4150,709,332 - 150,819,308 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adenocarcinoma  (ISO)
AIDS-Associated Nephropathy  (IMP,ISO)
autism spectrum disorder  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
Cardiomegaly  (ISO)
CEBALID Syndrome  (ISO)
Cerebral Hemorrhage  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
chondrosarcoma  (ISO)
Chronic Allograft Dysfunction  (ISO)
colon cancer  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
complex cortical dysplasia with other brain malformations  (ISO)
congestive heart failure  (ISO)
crescentic glomerulonephritis  (ISO)
Diabetes Mellitus, New-Onset after Transplantation  (ISO)
Diabetic Cardiomyopathies  (IEP)
Diabetic Nephropathies  (IMP,ISO)
Drug-Induced Dyskinesia  (ISO)
end stage renal disease  (ISO)
endocrine system disease  (ISO)
epilepsy  (ISO)
exocrine pancreatic insufficiency  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Familial Atrial Fibrillation 6  (ISO)
Focal Cortical Dysplasia of Taylor  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Hemimegalencephaly  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
high grade glioma  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
idiopathic interstitial pneumonia  (ISO)
immunodeficiency 14  (ISO)
Inflammation  (ISO)
intellectual disability  (ISO)
interstitial cystitis  (ISO)
kidney angiomyolipoma  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (IMP)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lupus nephritis  (IMP)
Lymphatic Metastasis  (ISO)
Macrocephaly  (ISO)
mantle cell lymphoma  (ISO)
melanoma  (ISO)
Mesothelioma  (ISO)
middle cerebral artery infarction  (ISO)
muscular atrophy  (ISO)
Muscular Dystrophy, Animal  (IMP)
myocardial infarction  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (IMP)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
osteoarthritis  (IMP)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (IMP)
papillary renal cell carcinoma  (ISO)
Parkinsonism  (IMP)
Peroxisome Biogenesis Disorder, Complementation Group K  (ISO)
polycystic kidney disease  (ISO)
portal hypertension  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal carcinoma  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
Retinal Neovascularization  (IMP)
Right Ventricular Hypertrophy  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
skin melanoma  (ISO)
small cell carcinoma  (ISO)
Smith-Kingsmore Syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
status epilepticus  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
temporal lobe epilepsy  (ISO)
Temporomandibular Joint Disorders  (ISO)
toxic encephalopathy  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (IMP)
uterine cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-taxifolin  (ISO)
(+)-Tetrandrine  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-Arctigenin  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-chloroethanol  (EXP)
2-deoxy-D-glucose  (ISO)
20-hydroxyecdysone  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-bromopyruvic acid  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-methyladenine  (EXP,ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (ISO)
5-fluorouracil  (ISO)
5-methoxypsoralen  (EXP)
7,12-dimethyltetraphene  (EXP)
7-ketocholesterol  (ISO)
9-cis-retinoic acid  (EXP)
acadesine  (EXP,ISO)
acetaldehyde  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
acrylonitrile  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP,ISO)
Ajugasterone C  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alpha-naphthoflavone  (ISO)
alpha-phellandrene  (ISO)
alternariol  (EXP)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP,ISO)
androst-4-ene-3,17-dione  (ISO)
antimycin A  (ISO)
antroquinonol  (ISO)
arachidonic acid  (ISO)
arecoline  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
Asiaticoside  (ISO)
astragaloside IV  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP)
aucubin  (ISO)
Auriculasin  (ISO)
azathioprine  (ISO)
bafilomycin A1  (EXP)
baicalein  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-thujaplicin  (EXP)
betalain  (ISO)
betulin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (EXP)
butein  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
calix[6]arene  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon disulfide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carnosic acid  (ISO)
celastrol  (ISO)
cepharanthine  (ISO)
chicoric acid  (ISO)
chloroethene  (EXP)
chloroquine  (EXP,ISO)
chlorpyrifos  (EXP)
cholesterol  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (EXP)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
colistin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP)
corosolic acid  (EXP)
corticosterone  (EXP)
Corynoxine B  (ISO)
coumarin  (ISO)
creatine  (EXP)
cucurbitacin E  (EXP,ISO)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
dapagliflozin  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (EXP,ISO)
deguelin  (ISO)
deoxynivalenol  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
dieckol  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
Dihydrotanshinone I  (ISO)
dimercaprol  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
dodecanoic acid  (EXP)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
epoxiconazole  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
etoposide  (ISO)
everolimus  (ISO)
fenvalerate  (ISO)
fingolimod hydrochloride  (ISO)
flavanones  (ISO)
flavokawain B  (ISO)
fluoxetine  (ISO)
fluvastatin  (ISO)
fructose  (ISO)
fucoxanthin  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
Fusaric acid  (EXP)
gabapentin  (ISO)
galangin  (ISO)
gefitinib  (ISO)
geraniol  (ISO)
gingerol  (ISO)
ginsenoside Rg1  (EXP,ISO)
glucose  (EXP,ISO)
glycerol 2-phosphate  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypetin  (ISO)
graphene oxide  (EXP,ISO)
hesperetin  (ISO)
hesperidin  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (EXP,ISO)
HU-308  (EXP,ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
icariin  (ISO)
icariside II  (ISO)
idelalisib  (EXP,ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kahweol  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lapatinib  (ISO)
lead diacetate  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
letrozole  (ISO)
linagliptin  (ISO)
linsidomine  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium chloride  (EXP,ISO)
lithium hydride  (EXP)
loperamide  (ISO)
Lupiwighteone  (ISO)
LY294002  (EXP,ISO)
magnesium atom  (ISO)
maneb  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP,ISO)
mesalamine  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methyl caffeate  (ISO)
methylisothiazolinone  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (EXP,ISO)
methylphenidate  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
mirtazapine  (ISO)
MK-2206  (EXP,ISO)
morin  (ISO)
Morroniside  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-methylnicotinate  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (ISO)
navitoclax  (ISO)
Neferine  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
niclosamide  (ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nitric oxide  (EXP)
nobiletin  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
oleanolic acid  (ISO)
oligopeptide  (ISO)
omacetaxine mepesuccinate  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-cresol  (ISO)
paclitaxel  (ISO)
paeoniflorin  (EXP,ISO)
Paeonol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
PD 0325901  (EXP)
Pentoxifylline  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
perhexiline  (ISO)
perifosine  (EXP)
phenylarsine oxide  (ISO)
phenylephrine  (ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (EXP,ISO)
piclamilast  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP)
platycodin D  (ISO)
pravastatin  (ISO)
progesterone  (ISO)
promethazine  (ISO)
propofol  (ISO)
prostaglandin E2  (EXP)
prothioconazole  (ISO)
psoralen  (ISO)
puerarin  (ISO)
quercetin  (EXP,ISO)
radon atom  (EXP,ISO)
radon(0)  (EXP,ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
rebaudioside A  (EXP)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
ridaforolimus  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
ruthenium atom  (ISO)
Salidroside  (ISO)
sarpogrelate  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serotonin  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
sonidegib  (ISO)
sorafenib  (ISO)
steviol  (EXP)
stevioside  (EXP)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
sulfadiazine  (ISO)
T-2 toxin  (ISO)
tadalafil  (EXP)
tamoxifen  (EXP,ISO)
taurine  (ISO)
tauroursodeoxycholic acid  (ISO)
temozolomide  (EXP,ISO)
Temsirolimus  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrahydropalmatine  (ISO)
tetramethylpyrazine  (EXP)
theobromine  (ISO)
thioacetamide  (EXP)
Thiorphan  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
torin 1  (ISO)
trabectedin  (ISO)
trans-piceid  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
trifluoperazine  (EXP,ISO)
trimellitic anhydride  (EXP)
Triptolide  (EXP)
triptonide  (EXP)
tris(2-chloroethyl) phosphate  (ISO)
tungsten  (EXP)
tunicamycin  (EXP)
tyrphostin AG 1478  (ISO)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
verapamil  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
XL765  (EXP)
Y-27632  (ISO)
Yessotoxin  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (ISO)
zinc oxide  (EXP,ISO)
zinc pyrithione  (ISO)
zingerone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
'de novo' pyrimidine nucleobase biosynthetic process  (IDA)
behavioral response to pain  (IGI)
brain development  (ISO)
calcineurin-NFAT signaling cascade  (IMP)
cardiac cell development  (IMP)
cardiac muscle cell development  (IMP)
cardiac muscle contraction  (IMP)
cardiac muscle tissue development  (IMP)
cell projection organization  (IMP,ISO)
cellular response to amino acid starvation  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to hypoxia  (IDA,NAS)
cellular response to leucine  (ISO)
cellular response to leucine starvation  (ISO)
cellular response to nutrient levels  (IDA,NAS)
cellular response to osmotic stress  (NAS)
cellular response to starvation  (ISO)
cytoskeleton organization  (NAS)
DNA damage response  (NAS)
energy reserve metabolic process  (IMP)
germ cell development  (IDA)
heart morphogenesis  (IMP)
heart valve morphogenesis  (IMP)
inflammatory response  (IGI)
long-term memory  (ISO)
lysosome organization  (ISO)
macroautophagy  (IMP)
maternal process involved in female pregnancy  (ISO)
mRNA stabilization  (ISO)
multicellular organism growth  (IMP)
negative regulation of apoptotic process  (NAS)
negative regulation of autophagy  (IMP,ISO,NAS)
negative regulation of calcineurin-NFAT signaling cascade  (IMP)
negative regulation of cell size  (IGI,ISO)
negative regulation of cholangiocyte apoptotic process  (ISO)
negative regulation of iodide transmembrane transport  (ISO)
negative regulation of macroautophagy  (IBA,IMP,ISO)
negative regulation of muscle atrophy  (ISO)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein ubiquitination  (ISO)
neuronal action potential  (IGI)
nucleus localization  (ISO)
oligodendrocyte differentiation  (IMP)
peptidyl-serine phosphorylation  (IDA,IMP,ISO)
peptidyl-threonine phosphorylation  (IDA)
phosphorylation  (ISO)
positive regulation of actin filament polymerization  (IDA,IMP)
positive regulation of cell growth  (NAS)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cellular senescence  (ISO)
positive regulation of cholangiocyte proliferation  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of eating behavior  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell apoptotic process  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of glycolytic process  (NAS)
positive regulation of granulosa cell proliferation  (ISO)
positive regulation of keratinocyte migration  (ISO)
positive regulation of lamellipodium assembly  (IDA)
positive regulation of lipid biosynthetic process  (ISO,NAS)
positive regulation of myotube differentiation  (IGI)
positive regulation of neurogenesis  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of neuron maturation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of oligodendrocyte differentiation  (IMP,ISO)
positive regulation of pentose-phosphate shunt  (NAS)
positive regulation of peptidyl-tyrosine phosphorylation  (IMP)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein phosphorylation  (IMP)
positive regulation of sensory perception of pain  (ISO)
positive regulation of sensory perception of pain  (ISO)
positive regulation of skeletal muscle hypertrophy  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of stress fiber assembly  (IDA)
positive regulation of transcription by RNA polymerase III  (ISO)
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I  (ISO)
positive regulation of translation  (ISO)
positive regulation of translational initiation  (ISO)
positive regulation of wound healing, spreading of epidermal cells  (ISO)
post-embryonic development  (IMP)
protein autophosphorylation  (ISO)
protein phosphorylation  (IBA,ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of autophagy  (IDA)
regulation of brown fat cell differentiation  (ISO)
regulation of carbohydrate metabolic process  (ISO)
regulation of carbohydrate utilization  (ISO)
regulation of cell growth  (ISO)
regulation of cell size  (ISO)
regulation of circadian rhythm  (IMP)
regulation of fatty acid beta-oxidation  (ISO)
regulation of glycogen biosynthetic process  (ISO)
regulation of GTPase activity  (IMP)
regulation of locomotor rhythm  (IMP)
regulation of membrane permeability  (IMP)
regulation of myelination  (IMP)
regulation of osteoclast differentiation  (IDA)
regulation of protein kinase activity  (IGI)
regulation of protein kinase B signaling  (IMP)
regulation of protein phosphorylation  (IDA)
regulation of response to food  (ISO)
regulation of translation at synapse, modulating synaptic transmission  (ISO)
response to activity  (ISO)
response to amino acid  (IDA,ISO)
response to cocaine  (ISO)
response to heat  (IGI)
response to insulin  (IDA)
response to morphine  (ISO)
response to morphine  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
rhythmic process  (IEA)
ruffle organization  (IDA)
social behavior  (ISO)
spinal cord development  (ISO)
T-helper 1 cell lineage commitment  (IMP)
TOR signaling  (IBA,IGI,ISO)
TORC1 signaling  (ISO)
TORC2 signaling  (ISO)
visual learning  (ISO)
voluntary musculoskeletal movement  (IMP)
wound healing  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal autophagy  (IAGP)
abnormal axolemma morphology  (IAGP)
abnormal axon morphology  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal cell morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal diaphragm morphology  (IAGP)
abnormal diencephalon morphology  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal gastrocnemius morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal internode morphology  (IAGP)
abnormal limb muscle morphology  (IAGP)
abnormal limb posture  (IAGP)
abnormal midbrain morphology  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal muscle contractility  (IAGP)
abnormal muscle morphology  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal muscle relaxation  (IAGP)
abnormal myelin sheath morphology  (IAGP)
abnormal myelination  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal oxygen consumption  (IAGP)
abnormal podocyte morphology  (IAGP)
abnormal renal glomerular capsule morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal respiration  (IAGP)
abnormal sarcomere morphology  (IAGP)
abnormal Schwann cell morphology  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal soleus morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T cell subpopulation ratio  (IAGP)
abnormal thymus cell ratio  (IAGP)
abnormal tibialis anterior morphology  (IAGP)
abnormal translation  (IAGP)
abnormal trophoblast giant cell morphology  (IAGP)
abnormal trophoblast layer morphology  (IAGP)
abnormal urine homeostasis  (IAGP)
absent embryonic telencephalon  (IAGP)
absent inner cell mass proliferation  (IAGP)
ascites  (IAGP)
cardiac interstitial fibrosis  (IAGP)
centrally nucleated skeletal muscle fibers  (IAGP)
congestive heart failure  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased blood urea nitrogen level  (IEA)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cardiomyocyte apoptosis  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased circulating LDL cholesterol level  (IEA)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased follicular B cell number  (IAGP)
decreased IgG level  (IAGP)
decreased IgM level  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-17 secretion  (IAGP)
decreased interleukin-2 secretion  (IAGP)
decreased lean body mass  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased mitochondrial number  (IAGP)
decreased monocyte cell number  (IAGP)
decreased nerve conduction velocity  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased oxygen consumption  (IAGP)
decreased plasma cell number  (IAGP)
decreased Schwann cell number  (IAGP)
decreased skeletal muscle weight  (IAGP)
decreased splenocyte apoptosis  (IAGP)
decreased splenocyte number  (IAGP)
decreased splenocyte proliferation  (IAGP)
decreased T cell proliferation  (IAGP)
decreased thymocyte number  (IAGP)
decreased transitional stage T1 B cell number  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
decreased ventricle muscle contractility  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated mitochondrion  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged heart  (IAGP)
enlarged heart atrium  (IAGP)
extended life span  (IAGP)
forebrain hypoplasia  (IAGP)
incomplete embryo turning  (IAGP)
increased cardiomyocyte apoptosis  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased circulating LDL cholesterol level  (IEA)
increased glomerular capsule space  (IAGP)
increased heart ventricle size  (IAGP)
increased mean corpuscular hemoglobin  (IEA)
increased muscle fatigability  (IAGP)
increased regulatory T cell number  (IAGP)
increased response of heart to induced stress  (IAGP)
increased skeletal muscle glycogen level  (IAGP)
increased total body fat amount  (IAGP)
inner cell mass degeneration  (IAGP)
kyphosis  (IAGP)
no abnormal phenotype detected  (IAGP)
pleural effusion  (IAGP)
podocyte foot process effacement  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
preweaning lethality, incomplete penetrance  (IAGP)
skeletal muscle degeneration  (IAGP)
skeletal muscle fiber degeneration  (IAGP)
small ectoplacental cone  (IAGP)
small myocardial fiber  (IAGP)
small spleen  (IAGP)
thin interventricular septum  (IAGP)
thin ventricular wall  (IAGP)

References - curated
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24. BAFF/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin. Li PP, etal., J Ethnopharmacol. 2012 May 7;141(1):290-300. doi: 10.1016/j.jep.2012.02.034. Epub 2012 Feb 27.
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28. Antiproliferation of cardamonin is involved in mTOR on aortic smooth muscle cells in high fructose-induced insulin resistance rats. Liao Q, etal., Eur J Pharmacol. 2010 Sep 1;641(2-3):179-86. doi: 10.1016/j.ejphar.2010.05.024. Epub 2010 Jun 4.
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47. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
48. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
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54. Mouse MP Annotation Import Pipeline RGD automated import pipeline
55. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
56. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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70. Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis. Wen ZH, etal., Oncogene. 2013 Jan 10;32(2):160-70. doi: 10.1038/onc.2012.47. Epub 2012 Feb 20.
71. Essential amino acid enriched high-protein enteral nutrition modulates insulin-like growth factor-1 system function in a rat model of trauma-hemorrhagic shock. Xia X, etal., PLoS One. 2013 Oct 28;8(10):e77823. doi: 10.1371/journal.pone.0077823. eCollection 2013.
72. Ischemic post-conditioning facilitates brain recovery after stroke by promoting Akt/mTOR activity in nude rats. Xie R, etal., J Neurochem. 2013 Dec;127(5):723-32. doi: 10.1111/jnc.12342. Epub 2013 Jul 8.
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75. Proteomic Analysis of Hydroxysafflor Yellow A Against Cerebral Ischemia/Reperfusion Injury in Rats. Xu H, etal., Rejuvenation Res. 2019 Dec;22(6):503-512. doi: 10.1089/rej.2018.2145. Epub 2019 Mar 19.
76. Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia. Xu JT, etal., J Clin Invest. 2014 Feb;124(2):592-603. doi: 10.1172/JCI70236. Epub 2014 Jan 2.
77. Anti-angiogenic effects of mammalian target of rapamycin inhibitors in a mouse model of oxygen-induced retinopathy. Yagasaki R, etal., Biol Pharm Bull. 2014;37(11):1838-42.
78. Leucine stimulates insulin secretion via down-regulation of surface expression of adrenergic alpha2A receptor through the mTOR (mammalian target of rapamycin) pathway: implication in new-onset diabetes in renal transplantation. Yang J, etal., J Biol Chem. 2012 Jul 13;287(29):24795-806. doi: 10.1074/jbc.M112.344259. Epub 2012 May 29.
79. Integration analysis of quantitative proteomics and transcriptomics data identifies potential targets of frizzled-8 protein-related antiproliferative factor in vivo. Yang W, etal., BJU Int. 2012 Dec;110(11 Pt C):E1138-46. doi: 10.1111/j.1464-410X.2012.11299.x. Epub 2012 Jun 28.
80. The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy. Zeng LH, etal., J Neurosci. 2009 May 27;29(21):6964-72. doi: 10.1523/JNEUROSCI.0066-09.2009.
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82. Abrogation of chronic rejection in rat model system involves modulation of the mTORC1 and mTORC2 pathways. Zhang L, etal., Transplantation. 2013 Nov 15;96(9):782-90. doi: 10.1097/TP.0b013e3182a2034f.
83. Enhancement of chondrocyte autophagy is an early response in the degenerative cartilage of the temporomandibular joint to biomechanical dental stimulation. Zhang M, etal., Apoptosis. 2013 Apr;18(4):423-34. doi: 10.1007/s10495-013-0811-0.
84. Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis. Zhang Y, etal., Ann Rheum Dis. 2014 Mar 20. doi: 10.1136/annrheumdis-2013-204599.
85. Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1alpha through mTOR-dependent pathway. Zhao Y, etal., Fitoterapia. 2014 Dec;99:318-27. doi: 10.1016/j.fitote.2014.10.009. Epub 2014 Oct 16.
86. Effect of electroacupuncture on the expression of mTOR and eIF4E in hippocampus of rats with vascular dementia. Zhu Y, etal., Neurol Sci. 2013 Jul;34(7):1093-7. doi: 10.1007/s10072-012-1209-4. Epub 2012 Oct 9.
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