Mtor (mechanistic target of rapamycin kinase) - Rat Genome Database

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Gene: Mtor (mechanistic target of rapamycin kinase) Mus musculus
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Symbol: Mtor
Name: mechanistic target of rapamycin kinase
RGD ID: 68534
MGI Page MGI
Description: Enables protein serine/threonine kinase activity and ribosome binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; T-helper 1 cell lineage commitment; and neuronal action potential. Acts upstream of or within several processes, including heart development; positive regulation of cellular component biogenesis; and regulation of nervous system development. Located in cytosol; dendrite; and nucleus. Part of TORC1 complex. Colocalizes with PML body. Is expressed in several structures, including central nervous system; early conceptus; oocyte; respiratory system; and retina. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2610315D21Rik; AI327068; angiopoietin-like factor CDT6; FK506 binding protein 12-rapamycin associated protein 1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein (FRAP); FKBP-rapamycin-associated protein FRAP; FKBP12-rapamycin complex-associated protein; fl; flat; Fr; FRAP; Frap1; FRAP2; mammalian target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); MGC118056; RA; RAF; RAFT1; rapamycin target protein 1; RAPT1; serine/threonine-protein kinase mTOR
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,533,039 - 148,642,142 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,533,068 - 148,642,140 (+)EnsemblGRCm39 Ensembl
GRCm384148,448,582 - 148,557,685 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,448,611 - 148,557,683 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,822,691 - 147,931,794 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364147,292,407 - 147,401,483 (+)NCBIMGSCv36mm8
Celera4150,709,332 - 150,819,308 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adenocarcinoma  (ISO)
AIDS-Associated Nephropathy  (IMP,ISO)
atherosclerosis  (IEP)
autism spectrum disorder  (ISO)
autosomal dominant nocturnal frontal lobe epilepsy  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
Cardiomegaly  (ISO)
CEBALID Syndrome  (ISO)
Cerebral Hemorrhage  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
chondrosarcoma  (ISO)
chromosome 1p36 deletion syndrome  (ISO)
Chronic Allograft Dysfunction  (ISO)
colon cancer  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
complex cortical dysplasia with other brain malformations  (ISO)
congestive heart failure  (ISO)
crescentic glomerulonephritis  (ISO)
Diabetes Mellitus, New-Onset after Transplantation  (ISO)
Diabetic Cardiomyopathies  (IEP)
Diabetic Nephropathies  (IMP,ISO)
Drug-Induced Dyskinesia  (ISO)
end stage renal disease  (ISO)
endocrine system disease  (ISO)
epilepsy  (ISO)
exocrine pancreatic insufficiency  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Familial Atrial Fibrillation 6  (ISO)
Focal Cortical Dysplasia of Taylor  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Hemimegalencephaly  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
high grade glioma  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
idiopathic interstitial pneumonia  (ISO)
immunodeficiency 14  (ISO)
Inflammation  (ISO)
intellectual disability  (ISO)
interstitial cystitis  (ISO)
kidney angiomyolipoma  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (IMP)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lupus nephritis  (IMP)
Lymphatic Metastasis  (ISO)
Macrocephaly  (ISO)
mantle cell lymphoma  (ISO)
melanoma  (ISO)
Mesothelioma  (ISO)
middle cerebral artery infarction  (ISO)
muscular atrophy  (ISO)
Muscular Dystrophy, Animal  (IMP)
myocardial infarction  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (IMP)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
osteoarthritis  (IMP)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (IMP)
papillary renal cell carcinoma  (ISO)
Parkinsonism  (IMP)
polycystic kidney disease  (ISO)
portal hypertension  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal carcinoma  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
Retinal Neovascularization  (IMP)
Right Ventricular Hypertrophy  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
skin melanoma  (ISO)
small cell carcinoma  (ISO)
Smith-Kingsmore Syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
status epilepticus  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
temporal lobe epilepsy  (ISO)
Temporomandibular Joint Disorders  (ISO)
toxic encephalopathy  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (IMP,ISO)
uterine cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-taxifolin  (ISO)
(+)-Tetrandrine  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(20S)-ginsenoside Rh2  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-chloroethanol  (EXP)
2-deoxy-D-glucose  (ISO)
20-hydroxyecdysone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-bromopyruvic acid  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-methyladenine  (EXP,ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (ISO)
5-fluorouracil  (ISO)
5-methoxypsoralen  (EXP)
7,12-dimethyltetraphene  (EXP)
7-ketocholesterol  (ISO)
9-cis-retinoic acid  (EXP)
acadesine  (EXP,ISO)
acetaldehyde  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
acrylonitrile  (EXP)
adenosine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP,ISO)
Ajugasterone C  (ISO)
albuterol  (EXP)
aldehydo-D-glucose  (EXP,ISO)
allethrin  (ISO)
alpha-amanitin  (EXP,ISO)
alpha-naphthoflavone  (ISO)
alpha-phellandrene  (ISO)
alternariol  (EXP)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP,ISO)
androst-4-ene-3,17-dione  (ISO)
angelicin  (EXP)
antimycin A  (ISO)
Antrocin  (ISO)
antroquinonol  (ISO)
arachidonic acid  (ISO)
arecoline  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
Asiaticoside  (ISO)
astragaloside IV  (EXP,ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP)
aucubin  (ISO)
Auriculasin  (ISO)
azathioprine  (ISO)
bafilomycin A1  (EXP,ISO)
baicalein  (EXP)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
berberine  (ISO)
beta-thujaplicin  (EXP)
betalain  (ISO)
Betanin  (ISO)
betulin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butachlor  (EXP)
butan-1-ol  (EXP)
butein  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
calix[6]arene  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon disulfide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carnosic acid  (ISO)
carteolol  (ISO)
celastrol  (ISO)
cepharanthine  (ISO)
chicoric acid  (ISO)
chloroethene  (EXP)
chloroquine  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (EXP)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
colistin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP)
cordycepin  (EXP,ISO)
corosolic acid  (EXP)
corticosterone  (EXP)
Corynoxine B  (ISO)
coumarin  (ISO)
creatine  (EXP)
cucurbitacin E  (EXP,ISO)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (EXP,ISO)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
dapagliflozin  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (EXP,ISO)
deguelin  (ISO)
deoxynivalenol  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
dieckol  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
Dihydrotanshinone I  (ISO)
dimercaprol  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
dodecanoic acid  (EXP)
dopamine  (ISO)
Doramectin  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
epoxiconazole  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
etoposide  (ISO)
eugenol  (ISO)
everolimus  (ISO)
fenvalerate  (ISO)
fingolimod hydrochloride  (ISO)
flavanones  (ISO)
flavokawain B  (ISO)
fluoxetine  (ISO)
fluvastatin  (ISO)
formoterol fumarate  (EXP)
FR900359  (ISO)
fructose  (ISO)
fucoxanthin  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
Fusaric acid  (EXP)
gabapentin  (ISO)
galangin  (ISO)
gefitinib  (ISO)
geraniol  (ISO)
gingerol  (ISO)
ginsenoside Rg1  (EXP,ISO)
glucose  (EXP,ISO)
glycerol 2-phosphate  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypetin  (ISO)
graphene oxide  (EXP,ISO)
hesperetin  (ISO)
hesperidin  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (EXP,ISO)
HU-308  (EXP,ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
icariin  (ISO)
icariside II  (ISO)
idelalisib  (EXP,ISO)
isoprenaline  (ISO)
isorhamnetin  (ISO)
ivermectin  (ISO)
kahweol  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lapatinib  (ISO)
lead diacetate  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
letrozole  (ISO)
levetiracetam  (ISO)
lidocaine  (ISO)
linagliptin  (ISO)
linsidomine  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium chloride  (EXP,ISO)
lithium hydride  (EXP)
loperamide  (ISO)
Lupiwighteone  (ISO)
LY294002  (EXP,ISO)
magnesium atom  (ISO)
maneb  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP,ISO)
mesalamine  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl caffeate  (ISO)
methylisothiazolinone  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (EXP,ISO)
methylphenidate  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
mirtazapine  (ISO)
MK-2206  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP)
morin  (ISO)
Morroniside  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-methylnicotinate  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-succinylsulfathiazole  (EXP)
naringin  (ISO)
navitoclax  (ISO)
Neferine  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nitric oxide  (EXP)
nobiletin  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
oleanolic acid  (ISO)
oligopeptide  (ISO)
omacetaxine mepesuccinate  (ISO)
omipalisib  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-cresol  (ISO)
paclitaxel  (ISO)
paeoniflorin  (EXP,ISO)
Paeonol  (ISO)
palmatine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
PD 0325901  (EXP)
Pentoxifylline  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
perhexiline  (ISO)
perifosine  (EXP)
phenylarsine oxide  (ISO)
phenylephrine  (ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (EXP,ISO)
piclamilast  (ISO)
pifithrin-?  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP)
platycodin D  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
progesterone  (ISO)
promethazine  (ISO)
propofol  (ISO)
prostaglandin E2  (EXP)
prothioconazole  (ISO)
psoralen  (ISO)
puerarin  (ISO)
quercetin  (EXP,ISO)
radon atom  (EXP,ISO)
radon(0)  (EXP,ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
rebaudioside A  (EXP)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
ridaforolimus  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
roxarsone  (ISO)
ruthenium atom  (ISO)
Salidroside  (ISO)
Sanggenon C  (ISO)
sarpogrelate  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serotonin  (ISO)
serpentine asbestos  (ISO)
sertraline  (EXP,ISO)
sevoflurane  (ISO)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
sonidegib  (ISO)
Sophoricoside  (EXP)
sorafenib  (ISO)
steviol  (EXP)
stevioside  (EXP)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
sulfadiazine  (ISO)
sulfamethizole  (EXP)
swainsonine  (EXP)
T-2 toxin  (ISO)
tadalafil  (EXP)
tamoxifen  (EXP,ISO)
taurine  (ISO)
tauroursodeoxycholic acid  (ISO)
temozolomide  (EXP,ISO)
Temsirolimus  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrahydropalmatine  (ISO)
tetramethylpyrazine  (EXP)
tetrathiomolybdate(2-)  (ISO)
Theaflavin 3,3'-digallate  (ISO)
theobromine  (ISO)
thioacetamide  (EXP)
Thiorphan  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
torin 1  (ISO)
trabectedin  (ISO)
trans-piceid  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
trifluoperazine  (EXP,ISO)
trimellitic anhydride  (EXP)
Triptolide  (EXP)
triptonide  (EXP)
tris(2-chloroethyl) phosphate  (ISO)
tungsten  (EXP)
tunicamycin  (EXP,ISO)
tyrphostin AG 1478  (ISO)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
verapamil  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
wortmannin  (EXP,ISO)
XL765  (EXP)
Y-27632  (ISO)
Yessotoxin  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (ISO)
zinc oxide  (EXP,ISO)
zinc pyrithione  (ISO)
zingerone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
'de novo' pyrimidine nucleobase biosynthetic process  (IDA)
behavioral response to pain  (IGI)
calcineurin-NFAT signaling cascade  (IMP)
cardiac cell development  (IMP)
cardiac muscle cell development  (IMP)
cardiac muscle contraction  (IMP)
cardiac muscle tissue development  (IMP)
cell projection organization  (IMP,ISO)
cellular response to amino acid starvation  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to hypoxia  (IDA,NAS)
cellular response to insulin stimulus  (ISO)
cellular response to L-leucine  (ISO)
cellular response to leucine starvation  (ISO)
cellular response to methionine  (ISO)
cellular response to nutrient  (ISO)
cellular response to nutrient levels  (IDA,ISO,NAS)
cellular response to osmotic stress  (NAS)
cellular response to starvation  (ISO)
cytoskeleton organization  (NAS)
DNA damage response  (NAS)
energy reserve metabolic process  (IMP)
germ cell development  (IDA)
heart morphogenesis  (IMP)
heart valve morphogenesis  (IMP)
inflammatory response  (IGI)
long-term memory  (ISO)
lysosome organization  (ISO)
macroautophagy  (IMP)
maternal process involved in female pregnancy  (ISO)
mRNA stabilization  (ISO)
multicellular organism growth  (IMP)
negative regulation of apoptotic process  (NAS)
negative regulation of autophagy  (IMP,ISO,NAS)
negative regulation of calcineurin-NFAT signaling cascade  (IMP)
negative regulation of cell size  (IGI,ISO)
negative regulation of cholangiocyte apoptotic process  (ISO)
negative regulation of iodide transmembrane transport  (ISO)
negative regulation of lysosome organization  (ISO)
negative regulation of macroautophagy  (IBA,IMP,ISO)
negative regulation of muscle atrophy  (ISO)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein ubiquitination  (ISO)
neuronal action potential  (IGI)
nucleus localization  (ISO)
oligodendrocyte differentiation  (IMP)
positive regulation of actin filament polymerization  (IDA,IMP)
positive regulation of cell growth  (NAS)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cellular senescence  (ISO)
positive regulation of cholangiocyte proliferation  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of eating behavior  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell apoptotic process  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of glycolytic process  (NAS)
positive regulation of granulosa cell proliferation  (ISO)
positive regulation of keratinocyte migration  (ISO)
positive regulation of lamellipodium assembly  (IDA)
positive regulation of lipid biosynthetic process  (ISO,NAS)
positive regulation of myotube differentiation  (IGI)
positive regulation of neurogenesis  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron maturation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of oligodendrocyte differentiation  (IMP,ISO)
positive regulation of pentose-phosphate shunt  (NAS)
positive regulation of peptidyl-tyrosine phosphorylation  (IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein phosphorylation  (IMP)
positive regulation of skeletal muscle hypertrophy  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of stress fiber assembly  (IDA)
positive regulation of transcription by RNA polymerase III  (ISO)
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I  (ISO)
positive regulation of translation  (ISO)
positive regulation of translational initiation  (ISO)
positive regulation of wound healing, spreading of epidermal cells  (ISO)
post-embryonic development  (IMP)
protein autophosphorylation  (ISO)
protein destabilization  (ISO)
protein phosphorylation  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of autophagosome assembly  (ISO)
regulation of autophagy  (IDA)
regulation of brown fat cell differentiation  (ISO)
regulation of carbohydrate metabolic process  (ISO)
regulation of carbohydrate utilization  (ISO)
regulation of cell growth  (ISO)
regulation of cell size  (ISO)
regulation of circadian rhythm  (IMP)
regulation of fatty acid beta-oxidation  (ISO)
regulation of glycogen biosynthetic process  (ISO)
regulation of locomotor rhythm  (IMP)
regulation of membrane permeability  (IMP)
regulation of myelination  (IMP)
regulation of osteoclast differentiation  (IDA)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
regulation of protein phosphorylation  (IDA)
regulation of response to food  (ISO)
regulation of translation at synapse, modulating synaptic transmission  (ISO)
response to activity  (ISO)
response to amino acid  (IDA,ISO)
response to cocaine  (ISO)
response to heat  (IGI)
response to insulin  (IDA)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
rhythmic process  (IEA)
ruffle organization  (IDA)
social behavior  (ISO)
spinal cord development  (ISO)
T-helper 1 cell lineage commitment  (IMP)
TOR signaling  (IGI,IMP,ISO)
TORC1 signaling  (IBA,ISO)
TORC2 signaling  (ISO)
visual learning  (ISO)
voluntary musculoskeletal movement  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal autophagy  (IAGP)
abnormal axolemma morphology  (IAGP)
abnormal axon morphology  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal cell morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal diaphragm morphology  (IAGP)
abnormal diencephalon morphology  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal gastrocnemius morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal internode morphology  (IAGP)
abnormal limb muscle morphology  (IAGP)
abnormal limb posture  (IAGP)
abnormal midbrain morphology  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal muscle contractility  (IAGP)
abnormal muscle morphology  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal muscle relaxation  (IAGP)
abnormal myelin sheath morphology  (IAGP)
abnormal myelination  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal oxygen consumption  (IAGP)
abnormal podocyte morphology  (IAGP)
abnormal renal glomerular capsule morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal sarcomere morphology  (IAGP)
abnormal Schwann cell morphology  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal soleus morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T cell subpopulation ratio  (IAGP)
abnormal thymus cell ratio  (IAGP)
abnormal tibialis anterior morphology  (IAGP)
abnormal translation  (IAGP)
abnormal trophoblast giant cell morphology  (IAGP)
abnormal trophoblast layer morphology  (IAGP)
abnormal urine homeostasis  (IAGP)
absent embryonic telencephalon  (IAGP)
absent inner cell mass proliferation  (IAGP)
ascites  (IAGP)
cardiac interstitial fibrosis  (IAGP)
centrally nucleated skeletal muscle fibers  (IAGP)
congestive heart failure  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased blood urea nitrogen level  (IEA)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cardiomyocyte apoptosis  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased circulating LDL cholesterol level  (IEA)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased follicular B cell number  (IAGP)
decreased heart left ventricle wall thickness  (IAGP)
decreased IgG level  (IAGP)
decreased IgM level  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-17 secretion  (IAGP)
decreased interleukin-2 secretion  (IAGP)
decreased lean body mass  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased mitochondrial number  (IAGP)
decreased monocyte cell number  (IAGP)
decreased myocardial fiber size  (IAGP)
decreased nerve conduction velocity  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased oxygen consumption  (IAGP)
decreased plasma cell number  (IAGP)
decreased respiration  (IAGP)
decreased Schwann cell number  (IAGP)
decreased skeletal muscle weight  (IAGP)
decreased splenocyte apoptosis  (IAGP)
decreased splenocyte number  (IAGP)
decreased splenocyte proliferation  (IAGP)
decreased T cell proliferation  (IAGP)
decreased thymocyte number  (IAGP)
decreased transitional stage T1 B cell number  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
decreased ventricle muscle contractility  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated mitochondrion  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged heart  (IAGP)
extended life span  (IAGP)
forebrain hypoplasia  (IAGP)
incomplete embryo turning  (IAGP)
increased cardiomyocyte apoptosis  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased circulating LDL cholesterol level  (IEA)
increased glomerular capsule space  (IAGP)
increased heart atrium size  (IAGP)
increased heart ventricle size  (IAGP)
increased mean corpuscular hemoglobin  (IEA)
increased muscle fatigability  (IAGP)
increased regulatory T cell number  (IAGP)
increased response of heart to induced stress  (IAGP)
increased skeletal muscle glycogen level  (IAGP)
increased total body fat amount  (IAGP)
inner cell mass degeneration  (IAGP)
kyphosis  (IAGP)
no abnormal phenotype detected  (IAGP)
pleural effusion  (IAGP)
podocyte foot process effacement  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
preweaning lethality, incomplete penetrance  (IAGP)
skeletal muscle degeneration  (IAGP)
skeletal muscle fiber degeneration  (IAGP)
small ectoplacental cone  (IAGP)
small spleen  (IAGP)
thin interventricular septum  (IAGP)
References

References - curated
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56. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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72. Essential amino acid enriched high-protein enteral nutrition modulates insulin-like growth factor-1 system function in a rat model of trauma-hemorrhagic shock. Xia X, etal., PLoS One. 2013 Oct 28;8(10):e77823. doi: 10.1371/journal.pone.0077823. eCollection 2013.
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75. PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways. Xiong X, etal., Neurobiol Dis. 2014 Jun;66:43-52. doi: 10.1016/j.nbd.2014.02.006. Epub 2014 Feb 27.
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77. Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia. Xu JT, etal., J Clin Invest. 2014 Feb;124(2):592-603. doi: 10.1172/JCI70236. Epub 2014 Jan 2.
78. Anti-angiogenic effects of mammalian target of rapamycin inhibitors in a mouse model of oxygen-induced retinopathy. Yagasaki R, etal., Biol Pharm Bull. 2014;37(11):1838-42.
79. Leucine stimulates insulin secretion via down-regulation of surface expression of adrenergic alpha2A receptor through the mTOR (mammalian target of rapamycin) pathway: implication in new-onset diabetes in renal transplantation. Yang J, etal., J Biol Chem. 2012 Jul 13;287(29):24795-806. doi: 10.1074/jbc.M112.344259. Epub 2012 May 29.
80. Integration analysis of quantitative proteomics and transcriptomics data identifies potential targets of frizzled-8 protein-related antiproliferative factor in vivo. Yang W, etal., BJU Int. 2012 Dec;110(11 Pt C):E1138-46. doi: 10.1111/j.1464-410X.2012.11299.x. Epub 2012 Jun 28.
81. The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy. Zeng LH, etal., J Neurosci. 2009 May 27;29(21):6964-72. doi: 10.1523/JNEUROSCI.0066-09.2009.
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PMID:29150432   PMID:29163060   PMID:29170130   PMID:29175333   PMID:29191093   PMID:29215029   PMID:29238073   PMID:29246441   PMID:29275959   PMID:29315990   PMID:29351469   PMID:29364507  
PMID:29384525   PMID:29392777   PMID:29393976   PMID:29399633   PMID:29403037   PMID:29415880   PMID:29428724   PMID:29445126   PMID:29461205   PMID:29463562   PMID:29476105   PMID:29484383  
PMID:29515594   PMID:29524020   PMID:29532456   PMID:29551674   PMID:29551680   PMID:29554648   PMID:29555746   PMID:29563176   PMID:29567716   PMID:29567961   PMID:29625033   PMID:29636366  
PMID:29712777   PMID:29720621   PMID:29722913   PMID:29725084   PMID:29734780   PMID:29749519   PMID:29750810   PMID:29763880   PMID:29784807   PMID:29784808   PMID:29786082   PMID:29844370  
PMID:29849151   PMID:29854093   PMID:29867114   PMID:29937275   PMID:29950673   PMID:29965873   PMID:29968502   PMID:29975682   PMID:30020076   PMID:30049881   PMID:30060081   PMID:30093533  
PMID:30125581   PMID:30141265   PMID:30144045   PMID:30145794   PMID:30154246   PMID:30171261   PMID:30185770   PMID:30202948   PMID:30231482   PMID:30236984   PMID:30242894   PMID:30257881  
PMID:30297433   PMID:30318987   PMID:30372902   PMID:30442943   PMID:30461220   PMID:30466882   PMID:30523512   PMID:30586442   PMID:30621510   PMID:30623816   PMID:30626971   PMID:30704899  
PMID:30724690   PMID:30735697   PMID:30761608   PMID:30767021   PMID:30794695   PMID:30843872   PMID:30867239   PMID:30913328   PMID:30926666   PMID:30941147   PMID:30973865   PMID:30984011  
PMID:30985297   PMID:31013253   PMID:31078612   PMID:31095752   PMID:31120172   PMID:31124382   PMID:31125447   PMID:31134915   PMID:31228582   PMID:31262977   PMID:31278268   PMID:31278836  
PMID:31281888   PMID:31289211   PMID:31296735   PMID:31383303   PMID:31432191   PMID:31433805   PMID:31441226   PMID:31467416   PMID:31483294   PMID:31487224   PMID:31494242   PMID:31527800  
PMID:31534053   PMID:31548308   PMID:31615574   PMID:31625631   PMID:31636454   PMID:31638187   PMID:31668132   PMID:31698999   PMID:31704290   PMID:31836471   PMID:31874168   PMID:31915252  
PMID:31961824   PMID:31971854   PMID:32001717   PMID:32039915   PMID:32043969   PMID:32066462   PMID:32084429   PMID:32093570   PMID:32127537   PMID:32139584   PMID:32154791   PMID:32236601  
PMID:32281743   PMID:32282093   PMID:32289154   PMID:32294406   PMID:32304342   PMID:32325033   PMID:32348753   PMID:32348869   PMID:32404105   PMID:32421985   PMID:32457486   PMID:32479529  
PMID:32510855   PMID:32538722   PMID:32557691   PMID:32567735   PMID:32576681   PMID:32687428   PMID:32722876   PMID:32730856   PMID:32744119   PMID:32747503   PMID:32764535   PMID:32795289  
PMID:32807950   PMID:32839235   PMID:32866472   PMID:32868461   PMID:32909150   PMID:32917361   PMID:33009372   PMID:33052068   PMID:33054526   PMID:33059001   PMID:33065005   PMID:33077617  
PMID:33108356   PMID:33150381   PMID:33212147   PMID:33285244   PMID:33303641   PMID:33323119   PMID:33352197   PMID:33402432   PMID:33443202   PMID:33462112   PMID:33520086   PMID:33542495  
PMID:33597177   PMID:33617094   PMID:33637094   PMID:33676386   PMID:33725483   PMID:33766857   PMID:33769701   PMID:33795689   PMID:33806698   PMID:33823141   PMID:33840455   PMID:33860440  
PMID:33863779   PMID:33897705   PMID:33898168   PMID:33951440   PMID:33959973   PMID:33965410   PMID:33972181   PMID:33976157   PMID:34013332   PMID:34023907   PMID:34032632   PMID:34038402  
PMID:34052210   PMID:34052832   PMID:34077553   PMID:34153521   PMID:34180075   PMID:34186168   PMID:34193412   PMID:34201030   PMID:34204880   PMID:34220329   PMID:34242625   PMID:34245780  
PMID:34251297   PMID:34309874   PMID:34343821   PMID:34348992   PMID:34358226   PMID:34395439   PMID:34417330   PMID:34445375   PMID:34446757   PMID:34453483   PMID:34463540   PMID:34473651  
PMID:34541875   PMID:34619135   PMID:34633285   PMID:34639052   PMID:34695452   PMID:34732708   PMID:34748756   PMID:34902357   PMID:34952420   PMID:34964999   PMID:35058797   PMID:35132962  
PMID:35163395   PMID:35216141   PMID:35235160   PMID:35235799   PMID:35238644   PMID:35248829   PMID:35276460   PMID:35298048   PMID:35357751   PMID:35428325   PMID:35435531   PMID:35443177  
PMID:35552649   PMID:35595017   PMID:35645731   PMID:35733999   PMID:35781329   PMID:35858542   PMID:35869262   PMID:35968506   PMID:36002021   PMID:36044864   PMID:36154620   PMID:36334595  
PMID:36370710   PMID:36385234   PMID:36433959   PMID:36438486   PMID:36440598   PMID:36509146   PMID:36571761   PMID:36587526   PMID:36621327   PMID:36710409   PMID:36722312   PMID:36796753  
PMID:36843585   PMID:36870538   PMID:36899882   PMID:36927703   PMID:36961448   PMID:36976763   PMID:37029318   PMID:37037996   PMID:37104068   PMID:37121553   PMID:37169038   PMID:37198150  
PMID:37218597   PMID:37245531   PMID:37261543   PMID:37409967   PMID:37463107   PMID:37477632   PMID:37494420   PMID:37511199   PMID:37511253   PMID:37532788   PMID:37536502   PMID:37578594  
PMID:37587260   PMID:37814881   PMID:37855320   PMID:37872660   PMID:37956909   PMID:37964636   PMID:37976569   PMID:37979583   PMID:38013049   PMID:38103552   PMID:38139347   PMID:38185904  
PMID:38252153   PMID:38325289   PMID:38355793   PMID:38377133   PMID:38411015   PMID:38411613   PMID:38474134   PMID:38519468  


Genomics

Comparative Map Data
Mtor
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,533,039 - 148,642,142 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,533,068 - 148,642,140 (+)EnsemblGRCm39 Ensembl
GRCm384148,448,582 - 148,557,685 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,448,611 - 148,557,683 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,822,691 - 147,931,794 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364147,292,407 - 147,401,483 (+)NCBIMGSCv36mm8
Celera4150,709,332 - 150,819,308 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.76NCBI
MTOR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,106,535 - 11,262,551 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,106,535 - 11,262,556 (-)EnsemblGRCh38hg38GRCh38
GRCh37111,166,592 - 11,322,608 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,089,179 - 11,245,153 (-)NCBINCBI36Build 36hg18NCBI36
Build 34111,100,857 - 11,256,830NCBI
Celera110,278,903 - 10,434,848 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef110,317,883 - 10,473,910 (-)NCBIHuRef
CHM1_1111,154,542 - 11,310,885 (-)NCBICHM1_1
T2T-CHM13v2.0110,648,106 - 10,804,142 (-)NCBIT2T-CHM13v2.0
Mtor
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85164,167,985 - 164,277,438 (+)NCBIGRCr8
mRatBN7.25158,884,856 - 158,994,311 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,884,804 - 158,994,311 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,601,607 - 161,711,017 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05163,423,732 - 163,533,437 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05163,380,079 - 163,489,786 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05165,263,813 - 165,373,967 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5165,263,800 - 165,373,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,920,414 - 169,030,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,531,402 - 165,640,899 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15165,541,594 - 165,651,087 (+)NCBI
Celera5157,161,454 - 157,270,899 (+)NCBICelera
Cytogenetic Map5q36NCBI
Mtor
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,487,642 - 2,599,694 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,487,642 - 2,599,694 (+)NCBIChiLan1.0ChiLan1.0
MTOR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,957,987 - 217,115,402 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,604,358 - 215,761,670 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019,871,700 - 10,028,704 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,093,765 - 11,249,841 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,093,765 - 11,249,841 (-)Ensemblpanpan1.1panPan2
MTOR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,818,893 - 84,939,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,787,708 - 84,939,114 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,349,286 - 81,469,352 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,486,181 - 85,601,386 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,480,139 - 85,601,386 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1282,229,433 - 82,349,483 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0283,231,190 - 83,351,242 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,293,674 - 84,413,764 (+)NCBIUU_Cfam_GSD_1.0
Mtor
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,333,597 - 34,457,567 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474157,590 - 282,342 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936474158,376 - 282,310 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTOR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,286,989 - 71,412,888 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,286,989 - 71,412,913 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,191,742 - 65,317,489 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTOR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120120,522,667 - 120,678,988 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20120,525,737 - 120,679,020 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605424,431,846 - 24,582,610 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mtor
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,570,276 - 1,698,259 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248181,570,155 - 1,698,264 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mtor
239 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:677
Count of miRNA genes:429
Interacting mature miRNAs:522
Transcripts:ENSMUST00000057580, ENSMUST00000103221, ENSMUST00000123566, ENSMUST00000129715
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137617848151654550Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
12738431Lfibq20_mliver fibrosis QTL 20 (mouse)4144699835148907426Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133154678150789451Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138943725156860686Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137674005150676858Mouse

Markers in Region
AI327068  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,557,354 - 148,557,499UniSTSGRCm38
MGSCv374147,931,463 - 147,931,608UniSTSGRCm37
Celera4150,818,978 - 150,819,123UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic Map4E1UniSTS
cM Map471.0UniSTS
Whitehead/MRC_RH41917.46UniSTS
MARC_7131-7132:996687522:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,549,394 - 148,549,858UniSTSGRCm38
MGSCv374147,923,503 - 147,923,967UniSTSGRCm37
Celera4150,810,860 - 150,811,324UniSTS
Cytogenetic Map4E1UniSTS
cM Map471.0UniSTS
RH134710  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,557,508 - 148,557,670UniSTSGRCm38
MGSCv374147,931,617 - 147,931,779UniSTSGRCm37
Celera4150,819,132 - 150,819,294UniSTS
Cytogenetic Map4E1UniSTS
Cytogenetic Map4E2UniSTS
cM Map471.0UniSTS
MARC_17911-17912:1025019877:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,537,413 - 148,537,928UniSTSGRCm38
MGSCv374147,911,522 - 147,912,037UniSTSGRCm37
Celera4150,798,667 - 150,799,183UniSTS
Cytogenetic Map4E1UniSTS
cM Map471.0UniSTS
Mtor  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4E1UniSTS
cM Map471.0UniSTS
PMC299869P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,465,001 - 148,465,116UniSTSGRCm38
MGSCv374147,839,110 - 147,839,225UniSTSGRCm37
Celera4150,726,371 - 150,726,486UniSTS
Cytogenetic Map4E1UniSTS
cM Map471.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_020009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF152838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF350362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK012031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL713995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL731654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC043920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC112904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ130100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU210865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN076323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN076324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000057580   ⟹   ENSMUSP00000054164
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,533,082 - 148,539,430 (+)Ensembl
GRCm38.p6 Ensembl4148,448,625 - 148,454,973 (+)Ensembl
RefSeq Acc Id: ENSMUST00000103221   ⟹   ENSMUSP00000099510
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,533,068 - 148,642,140 (+)Ensembl
GRCm38.p6 Ensembl4148,448,611 - 148,557,683 (+)Ensembl
RefSeq Acc Id: ENSMUST00000123566
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,533,068 - 148,539,426 (+)Ensembl
GRCm38.p6 Ensembl4148,448,611 - 148,454,969 (+)Ensembl
RefSeq Acc Id: ENSMUST00000129715
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,628,870 - 148,632,245 (+)Ensembl
GRCm38.p6 Ensembl4148,544,413 - 148,547,788 (+)Ensembl
RefSeq Acc Id: NM_020009   ⟹   NP_064393
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,533,039 - 148,642,142 (+)NCBI
GRCm384148,448,582 - 148,557,685 (+)ENTREZGENE
MGSCv374147,822,691 - 147,931,794 (+)RGD
Celera4150,709,332 - 150,819,308 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006539077   ⟹   XP_006539140
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,549,532 - 148,642,140 (+)NCBI
GRCm384148,465,075 - 148,557,683 (+)NCBI
Sequence:
RefSeq Acc Id: NP_064393   ⟸   NM_020009
- UniProtKB: Q811J5 (UniProtKB/Swiss-Prot),   Q2KHT0 (UniProtKB/Swiss-Prot),   Q9CST1 (UniProtKB/Swiss-Prot),   Q9JLN9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006539140   ⟸   XM_006539077
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000099510   ⟸   ENSMUST00000103221
RefSeq Acc Id: ENSMUSP00000054164   ⟸   ENSMUST00000057580
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JLN9-F1-model_v2 AlphaFold Q9JLN9 1-2549 view protein structure

Promoters
RGD ID:6835743
Promoter ID:MM_KWN:40818
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_020009,   OTTMUST00000025686,   UC008VUQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364147,822,301 - 147,822,801 (+)MPROMDB
RGD ID:6835362
Promoter ID:MM_KWN:40820
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000025687
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364147,918,171 - 147,918,671 (+)MPROMDB
RGD ID:6885522
Promoter ID:EPDNEW_M6212
Type:initiation region
Name:Mtor_1
Description:Mus musculus mechanistic target of rapamycin kinase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384148,448,580 - 148,448,640EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1928394 AgrOrtholog
Ensembl Genes ENSMUSG00000028991 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000057580.8 UniProtKB/Swiss-Prot
  ENSMUST00000103221 ENTREZGENE
  ENSMUST00000103221.10 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1070.11 UniProtKB/Swiss-Prot
  1.20.120.150 UniProtKB/Swiss-Prot
  1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.10 UniProtKB/Swiss-Prot
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3385_TOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FATC_dom UniProtKB/Swiss-Prot
  FRB_dom UniProtKB/Swiss-Prot
  FRB_sf UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_dom UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_sf UniProtKB/Swiss-Prot
  PI3/4_kinase_CS UniProtKB/Swiss-Prot
  PIK-rel_kinase_FAT UniProtKB/Swiss-Prot
  PIK_FAT UniProtKB/Swiss-Prot
  TOR UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:56717 UniProtKB/Swiss-Prot
MGD MGI:1928394 ENTREZGENE
NCBI Gene 56717 ENTREZGENE
PANTHER ATAXIA TELANGIECTASIA MUTATED ATM -RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11139:SF9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF3385 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAT UniProtKB/Swiss-Prot
  FATC UniProtKB/Swiss-Prot
  FRB_dom UniProtKB/Swiss-Prot
  PI3_PI4_kinase UniProtKB/Swiss-Prot
PharmGKB FRAP1 RGD
PhenoGen Mtor PhenoGen
PROSITE FAT UniProtKB/Swiss-Prot
  FATC UniProtKB/Swiss-Prot
  PI3_4_KINASE_1 UniProtKB/Swiss-Prot
  PI3_4_KINASE_2 UniProtKB/Swiss-Prot
  PI3_4_KINASE_3 UniProtKB/Swiss-Prot
SMART DUF3385 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FATC UniProtKB/Swiss-Prot
  PI3Kc UniProtKB/Swiss-Prot
  Rapamycin_bind UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47212 UniProtKB/Swiss-Prot
  SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot
UniProt MTOR_MOUSE UniProtKB/Swiss-Prot
  Q2KHT0 ENTREZGENE
  Q3T9E1_MOUSE UniProtKB/TrEMBL
  Q811J5 ENTREZGENE
  Q9CST1 ENTREZGENE
  Q9JLN9 ENTREZGENE
UniProt Secondary Q2KHT0 UniProtKB/Swiss-Prot
  Q811J5 UniProtKB/Swiss-Prot
  Q9CST1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-02-20 Mtor  mechanistic target of rapamycin kinase    mechanistic target of rapamycin (serine/threonine kinase)  Symbol and/or name change 5135510 APPROVED