Mtor (mechanistic target of rapamycin kinase) - Rat Genome Database

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Gene: Mtor (mechanistic target of rapamycin kinase) Mus musculus
Symbol: Mtor
Name: mechanistic target of rapamycin kinase
RGD ID: 68534
Description: Exhibits protein serine/threonine kinase activity and ribosome binding activity. Involved in several processes, including heart development; positive regulation of cellular component biogenesis; and protein phosphorylation. Localizes to several cellular components, including TORC1 complex; cytosol; and dendrite. Colocalizes with PML body. Is expressed in central nervous system; early conceptus; respiratory system; and retina. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-4 signaling pathway; mTOR signaling pathway; INTERACTS WITH (S)-nicotine; 1,1-dichloroethene; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2610315D21Rik; AI327068; angiopoietin-like factor CDT6; FK506 binding protein 12-rapamycin associated protein 1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein (FRAP); FKBP-rapamycin-associated protein FRAP; FKBP12-rapamycin complex-associated protein; fl; flat; Fr; FRAP; Frap1; FRAP2; mammalian target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); MGC118056; RA; RAF; RAFT1; rapamycin target protein 1; RAPT1; serine/threonine-protein kinase mTOR
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm394148,533,039 - 148,642,142 (+)NCBIGRCm39mm39
GRCm39 Ensembl4148,533,068 - 148,642,140 (+)Ensembl
GRCm384148,448,582 - 148,557,685 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,448,611 - 148,557,683 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,822,691 - 147,931,794 (+)NCBIGRCm37mm9NCBIm37
MGSCv364147,292,407 - 147,401,483 (+)NCBImm8
Celera4150,709,332 - 150,819,308 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adenocarcinoma  (ISO)
AIDS-Associated Nephropathy  (IMP,ISO)
autosomal dominant polycystic kidney disease  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
Cardiomegaly  (ISO)
CEBALID Syndrome  (ISO)
Cerebral Hemorrhage  (ISO)
chondrosarcoma  (ISO)
Chronic Allograft Dysfunction  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
complex cortical dysplasia with other brain malformations  (ISO)
congestive heart failure  (ISO)
crescentic glomerulonephritis  (ISO)
Diabetes Mellitus, New-Onset after Transplantation  (ISO)
Diabetic Nephropathies  (IMP,ISO)
Drug-Induced Dyskinesia  (ISO)
end stage renal disease  (ISO)
endocrine system disease  (ISO)
epilepsy  (ISO)
exocrine pancreatic insufficiency  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Familial Atrial Fibrillation 6  (ISO)
Focal Cortical Dysplasia of Taylor  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Hemimegalencephaly  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
high grade glioma  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
idiopathic interstitial pneumonia  (ISO)
Inflammation  (ISO)
intellectual disability  (ISO)
interstitial cystitis  (ISO)
kidney angiomyolipoma  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (IMP)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lupus nephritis  (IMP)
Lymphatic Metastasis  (ISO)
Macrocephaly  (ISO)
Mammary Neoplasms, Experimental  (ISO)
mantle cell lymphoma  (ISO)
melanoma  (ISO)
Mesothelioma  (ISO)
middle cerebral artery infarction  (ISO)
muscular atrophy  (ISO)
Muscular Dystrophy, Animal  (IMP)
myocardial infarction  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (IMP)
obesity  (ISO)
osteoarthritis  (IMP)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (IMP)
papillary renal cell carcinoma  (ISO)
Parkinsonism  (IMP)
polycystic kidney disease  (ISO)
portal hypertension  (ISO)
prostate cancer  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal carcinoma  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
Retinal Neovascularization  (IMP)
Right Ventricular Hypertrophy  (ISO)
schizophrenia  (ISO)
Schnyder corneal dystrophy  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
skin melanoma  (ISO)
small cell carcinoma  (ISO)
Smith-Kingsmore Syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
status epilepticus  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
temporal lobe epilepsy  (ISO)
Temporomandibular Joint Disorders  (ISO)
toxic encephalopathy  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (IMP)
uterine cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-Tetrandrine  (ISO)
(-)-Arctigenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,1-dichloroethene  (EXP)
1,4-phenylenediamine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-chloroethanol  (EXP)
2-deoxy-D-glucose  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-bromopyruvic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyladenine  (ISO)
4'-epidoxorubicin  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
7-ketocholesterol  (ISO)
9-cis-retinoic acid  (EXP)
acadesine  (EXP,ISO)
acetaldehyde  (ISO)
acetylsalicylic acid  (ISO)
afimoxifene  (ISO)
AICA ribonucleotide  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
alpha-naphthoflavone  (ISO)
alternariol  (EXP)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP,ISO)
androst-4-ene-3,17-dione  (ISO)
antroquinonol  (ISO)
arachidonic acid  (ISO)
arecoline  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
Asiaticoside  (ISO)
aucubin  (ISO)
azathioprine  (ISO)
bafilomycin A1  (EXP)
baicalein  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-thujaplicin  (EXP)
betulin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
calix[6]arene  (ISO)
camptothecin  (ISO)
capsaicin  (ISO)
carbon disulfide  (EXP,ISO)
carbon nanotube  (EXP)
carnosic acid  (ISO)
celastrol  (ISO)
cepharanthine  (ISO)
Chicoric acid  (ISO)
chloroethene  (EXP)
chloroquine  (EXP,ISO)
chlorpyrifos  (EXP)
cholesterol  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (EXP)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP)
corticosterone  (EXP)
Corynoxine B  (ISO)
creatine  (EXP)
cucurbitacin E  (EXP,ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (EXP)
Deguelin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
dieckol  (ISO)
dieldrin  (ISO)
Dihydrotanshinone I  (ISO)
dimercaprol  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
etoposide  (ISO)
everolimus  (ISO)
fenvalerate  (ISO)
fingolimod hydrochloride  (ISO)
flavanones  (ISO)
flavokawain B  (ISO)
fluoxetine  (ISO)
fulvestrant  (ISO)
Fusaric acid  (EXP)
galangin  (ISO)
gefitinib  (ISO)
geraniol  (ISO)
gingerol  (ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
glycerol 2-phosphate  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypetin  (ISO)
graphene oxide  (EXP,ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (EXP,ISO)
HU-308  (EXP,ISO)
hydrogen peroxide  (ISO)
icariside II  (ISO)
isoprenaline  (ISO)
kahweol  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lapatinib  (ISO)
lead diacetate  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
letrozole  (ISO)
linsidomine  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium chloride  (EXP)
lithium hydride  (EXP)
LY294002  (ISO)
magnesium atom  (ISO)
maneb  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methyl caffeate  (ISO)
methylisothiazolinone  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (EXP,ISO)
methylphenidate  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
MK-2206  (EXP)
morin  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-methylnicotinate  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (ISO)
navitoclax  (ISO)
niclosamide  (ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nitric oxide  (EXP)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
oleanolic acid  (ISO)
oligopeptide  (ISO)
omacetaxine mepesuccinate  (ISO)
oxaliplatin  (ISO)
p-cresol  (ISO)
paclitaxel  (ISO)
paeoniflorin  (EXP,ISO)
Paeonol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
PD 0325901  (EXP)
perfluorooctanoic acid  (EXP)
perhexiline  (ISO)
perifosine  (EXP)
phenylarsine oxide  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (EXP,ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP)
platycodin D  (ISO)
pravastatin  (ISO)
progesterone  (ISO)
promethazine  (ISO)
prostaglandin E2  (EXP)
puerarin  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
rebaudioside A  (EXP)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
Salidroside  (ISO)
sarpogrelate  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
serotonin  (ISO)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
sonidegib  (ISO)
sorafenib  (ISO)
steviol  (EXP)
stevioside  (EXP)
stilbenoid  (ISO)
streptozocin  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
taurine  (ISO)
tauroursodeoxycholic acid  (ISO)
temozolomide  (EXP,ISO)
Temsirolimus  (EXP,ISO)
testosterone  (ISO)
tetrahydropalmatine  (ISO)
tetramethylpyrazine  (EXP)
thioacetamide  (EXP)
Thiorphan  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
torin 1  (ISO)
trabectedin  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
trifluoperazine  (EXP,ISO)
trimellitic anhydride  (EXP)
Triptolide  (EXP)
triptonide  (EXP)
tris(2-chloroethyl) phosphate  (ISO)
tungsten  (EXP)
tunicamycin  (EXP)
tyrphostin AG 1478  (ISO)
ursolic acid  (ISO)
usnic acid  (ISO)
vancomycin  (EXP)
vorinostat  (ISO)
wortmannin  (ISO)
XL765  (EXP)
Y-27632  (ISO)
Yessotoxin  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (ISO)
zinc oxide  (EXP)
zinc pyrithione  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
'de novo' pyrimidine nucleobase biosynthetic process  (IDA)
brain development  (ISO)
cardiac cell development  (IMP)
cardiac muscle cell development  (IMP)
cardiac muscle contraction  (IMP)
cardiac muscle tissue development  (IMP)
cell aging  (ISO)
cell projection organization  (IMP,ISO)
cellular response to amino acid starvation  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to hypoxia  (IDA)
cellular response to leucine  (ISO)
cellular response to leucine starvation  (ISO)
cellular response to nutrient levels  (IDA)
cellular response to starvation  (ISO)
energy reserve metabolic process  (IMP)
germ cell development  (IDA)
heart morphogenesis  (IMP)
heart valve morphogenesis  (IMP)
long-term memory  (ISO)
lysosome organization  (ISO)
maternal process involved in female pregnancy  (ISO)
mRNA stabilization  (ISO)
multicellular organism growth  (IMP)
negative regulation of autophagy  (IMP,ISO)
negative regulation of calcineurin-NFAT signaling cascade  (IMP)
negative regulation of cell size  (IGI,ISO)
negative regulation of cholangiocyte apoptotic process  (ISO)
negative regulation of iodide transmembrane transport  (ISO)
negative regulation of macroautophagy  (IBA,IMP,ISO)
negative regulation of muscle atrophy  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein ubiquitination  (ISO)
nucleus localization  (ISO)
peptidyl-serine phosphorylation  (IDA,IMP,ISO)
peptidyl-threonine phosphorylation  (IDA)
phosphorylation  (ISO)
positive regulation of actin filament polymerization  (IDA,IMP)
positive regulation of cell death  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cholangiocyte proliferation  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of eating behavior  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of granulosa cell proliferation  (ISO)
positive regulation of keratinocyte migration  (ISO)
positive regulation of lamellipodium assembly  (IDA)
positive regulation of lipid biosynthetic process  (ISO)
positive regulation of myotube differentiation  (IGI)
positive regulation of neurogenesis  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of neuron maturation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of oligodendrocyte differentiation  (IMP,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IMP)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein phosphorylation  (IMP)
positive regulation of sensory perception of pain  (ISO)
positive regulation of skeletal muscle hypertrophy  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of stress fiber assembly  (IDA)
positive regulation of transcription by RNA polymerase III  (ISO)
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I  (ISO)
positive regulation of translation  (ISO)
positive regulation of wound healing, spreading of epidermal cells  (ISO)
post-embryonic development  (IMP)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of autophagy  (IDA)
regulation of brown fat cell differentiation  (ISO)
regulation of carbohydrate metabolic process  (ISO)
regulation of carbohydrate utilization  (ISO)
regulation of cell growth  (ISO)
regulation of cell size  (ISO)
regulation of circadian rhythm  (IMP)
regulation of fatty acid beta-oxidation  (ISO)
regulation of glycogen biosynthetic process  (ISO)
regulation of GTPase activity  (IMP)
regulation of locomotor rhythm  (IMP)
regulation of membrane permeability  (IMP)
regulation of myelination  (IMP)
regulation of osteoclast differentiation  (IDA)
regulation of protein kinase activity  (IGI)
regulation of protein kinase B signaling  (IMP)
regulation of protein phosphorylation  (IDA)
regulation of response to food  (ISO)
regulation of translation at synapse, modulating synaptic transmission  (ISO)
response to activity  (ISO)
response to amino acid  (IDA,ISO)
response to cocaine  (ISO)
response to insulin  (IDA)
response to morphine  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
rhythmic process  (IEA)
ruffle organization  (IDA)
social behavior  (ISO)
spinal cord development  (ISO)
T-helper 1 cell lineage commitment  (IMP)
TOR signaling  (IGI,ISO)
TORC1 signaling  (IBA,ISO)
visual learning  (ISO)
voluntary musculoskeletal movement  (IMP)
wound healing  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal autophagy  (IAGP)
abnormal axolemma morphology  (IAGP)
abnormal axon morphology  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal cell morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal diaphragm morphology  (IAGP)
abnormal diencephalon morphology  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal gastrocnemius morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal hypaxial muscle morphology  (IAGP)
abnormal internode morphology  (IAGP)
abnormal limb posture  (IAGP)
abnormal midbrain morphology  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal muscle contractility  (IAGP)
abnormal muscle morphology  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal muscle relaxation  (IAGP)
abnormal myelin sheath morphology  (IAGP)
abnormal myelination  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal oxygen consumption  (IAGP)
abnormal podocyte morphology  (IAGP)
abnormal renal glomerular capsule morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal respiration  (IAGP)
abnormal sarcomere morphology  (IAGP)
abnormal Schwann cell morphology  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal soleus morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T cell subpopulation ratio  (IAGP)
abnormal thymus cell ratio  (IAGP)
abnormal tibialis anterior morphology  (IAGP)
abnormal translation  (IAGP)
abnormal trophoblast giant cell morphology  (IAGP)
abnormal trophoblast layer morphology  (IAGP)
abnormal urine homeostasis  (IAGP)
absent embryonic telencephalon  (IAGP)
absent inner cell mass proliferation  (IAGP)
ascites  (IAGP)
cardiac interstitial fibrosis  (IAGP)
centrally nucleated skeletal muscle fibers  (IAGP)
congestive heart failure  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased blood urea nitrogen level  (IEA)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cardiomyocyte apoptosis  (IAGP)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased circulating LDL cholesterol level  (IEA)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased follicular B cell number  (IAGP)
decreased IgG level  (IAGP)
decreased IgM level  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-17 secretion  (IAGP)
decreased interleukin-2 secretion  (IAGP)
decreased lean body mass  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased mitochondrial number  (IAGP)
decreased monocyte cell number  (IAGP)
decreased nerve conduction velocity  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased oxygen consumption  (IAGP)
decreased plasma cell number  (IAGP)
decreased Schwann cell number  (IAGP)
decreased skeletal muscle weight  (IAGP)
decreased splenocyte apoptosis  (IAGP)
decreased splenocyte number  (IAGP)
decreased splenocyte proliferation  (IAGP)
decreased T cell proliferation  (IAGP)
decreased thymocyte number  (IAGP)
decreased transitional stage T1 B cell number  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
decreased ventricle muscle contractility  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated mitochondria  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged heart  (IAGP)
enlarged heart atrium  (IAGP)
extended life span  (IAGP)
forebrain hypoplasia  (IAGP)
incomplete embryo turning  (IAGP)
increased cardiomyocyte apoptosis  (IAGP)
increased CD4-positive, alpha beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased circulating LDL cholesterol level  (IEA)
increased glomerular capsule space  (IAGP)
increased heart ventricle size  (IAGP)
increased mean corpuscular hemoglobin  (IEA)
increased regulatory T cell number  (IAGP)
increased response of heart to induced stress  (IAGP)
increased skeletal muscle glycogen level  (IAGP)
increased total body fat amount  (IAGP)
inner cell mass degeneration  (IAGP)
kyphosis  (IAGP)
muscle fatigue  (IAGP)
no abnormal phenotype detected  (IAGP)
pleural effusion  (IAGP)
podocyte foot process effacement  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
preweaning lethality, incomplete penetrance  (IAGP)
skeletal muscle degeneration  (IAGP)
skeletal muscle fiber degeneration  (IAGP)
small ectoplacental cone  (IAGP)
small myocardial fiber  (IAGP)
small spleen  (IAGP)
thin interventricular septum  (IAGP)
thin ventricular wall  (IAGP)

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