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Gene: Mtor (mechanistic target of rapamycin kinase) Mus musculus
Symbol: Mtor
Name: mechanistic target of rapamycin kinase
Description: Exhibits protein serine/threonine kinase activity and ribosome binding activity. Involved in several processes, including heart development; positive regulation of cellular component organization; and protein phosphorylation. Localizes to several cellular components, including the TORC1 complex; cytosol; and dendrite. Colocalizes with the PML body. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Is expressed in central nervous system; early conceptus; respiratory system; and retina. Orthologous to human MTOR (mechanistic target of rapamycin kinase); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-4 signaling pathway; mTOR signaling pathway; INTERACTS WITH 1,1-dichloroethene; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 15-deoxy-Delta(12,14)-prostaglandin J2.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2610315D21Rik; AI327068; angiopoietin-like factor CDT6; FK506 binding protein 12-rapamycin associated protein 1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein (FRAP); FKBP-rapamycin-associated protein FRAP; FKBP12-rapamycin complex-associated protein; flat; FRAP; Frap1; FRAP2; mammalian target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); MGC118056; RAFT1; rapamycin target protein 1; RAPT1; serine/threonine-protein kinase mTOR
Homo sapiens (human) : MTOR (mechanistic target of rapamycin kinase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mtor (mechanistic target of rapamycin kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mtor (mechanistic target of rapamycin kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : MTOR (mechanistic target of rapamycin kinase)
Canis lupus familiaris (dog) : MTOR (mechanistic target of rapamycin kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mtor (mechanistic target of rapamycin kinase)
Sus scrofa (pig) : MTOR (mechanistic target of rapamycin kinase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl4148,448,611 - 148,557,683 (+)Ensembl
GRCm384148,448,582 - 148,557,685 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374147,822,691 - 147,931,794 (+)NCBIGRCm37mm9NCBIm37
MGSCv364147,292,407 - 147,401,483 (+)NCBImm8
Celera4150,709,332 - 150,819,308 (+)NCBICelera
Cytogenetic Map4 E2NCBI
cM Map478.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Mtor
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68534
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2020-01-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.