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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68534
Species: Mus musculus
RGD Object: Gene
Symbol: Mtor
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:88249
Term: PD 0325901
Definition: A hydroxamic acid ester that is benzhydroxamic acid (N-hydroxybenzamide) in which the hydroxamic acid group has been converted to the corresponding 2,3-dihydroxypropyl ester and in which the benzene ring has been substituted at position 2 by a (2-fluoro-4-iodophenyl)amino group and at positions 3 and 4 by fluorines (the R enantiomer).
Chemical ID: MESH:C506614
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mtormultiple interactionsEXP 6480464CTDmirdametinib inhibits the reaction [MTOR gene mutant form results in increased phosphorylation of MAPK1 protein]; mirdametinib inhibits the reaction [MTOR gene mutant form results in increased phosphorylation of MAPK3 protein]PMID:29384525
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