GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mtor | multiple interactions | EXP | | 6480464 | CTD | [perifosine co-treated with temsirolimus] results in decreased activity of MTOR protein | PMID:21267448 | Mtor | decreases activity | ISO | MTOR (Homo sapiens) | 6480464 | CTD | temsirolimus results in decreased activity of MTOR protein | PMID:16033649 | Mtor | decreases expression | ISO | MTOR (Homo sapiens) | 6480464 | CTD | temsirolimus results in decreased expression of MTOR protein | PMID:24493623 | Mtor | multiple interactions | ISO | MTOR (Homo sapiens) | 6480464 | CTD | Cisplatin promotes the reaction [temsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]]; Cisplatin promotes the reaction [temsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6 protein]]; KRAS protein mutant form inhibits the reaction [temsirolimus inhibits the reaction [CIP2A protein binds to MTOR protein]]; KRAS protein mutant form inhibits the reaction [temsirolimus results in decreased expression of MTOR protein]; temsirolimus inhibits the reaction [CIP2A protein binds to MTOR protein]; temsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]; temsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6 protein] | PMID:21358348 PMID:24493623 | | ||||||||||||||||||||||
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