RGD Reference Report - Inhibition of the mammalian target of rapamycin pathway by rapamycin blocks cocaine-induced locomotor sensitization. - Rat Genome Database

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Inhibition of the mammalian target of rapamycin pathway by rapamycin blocks cocaine-induced locomotor sensitization.

Authors: Wu, J  McCallum, SE  Glick, SD  Huang, Y 
Citation: Wu J, etal., Neuroscience. 2011 Jan 13;172:104-9. doi: 10.1016/j.neuroscience.2010.10.041. Epub 2010 Oct 25.
RGD ID: 10040960
Pubmed: PMID:20977929   (View Abstract at PubMed)
PMCID: PMC3204354   (View Article at PubMed Central)
DOI: DOI:10.1016/j.neuroscience.2010.10.041   (Journal Full-text)

Repeated cocaine exposure induces locomotor sensitization, which is mediated by adaptive changes in synaptic transmission in the mesolimbic dopamine pathway. The molecular mechanisms underlying this adaptation remain poorly understood. One pathway that may play a role is the mammalian target of rapamycin (mTOR) which is implicated in synaptic plasticity. In the present study, we found that cocaine exposure stimulates mTOR activity in rat brain. Furthermore, inhibition of mTOR by rapamycin blocked the induction as well as the expression of cocaine-induced locomotor sensitization in rats. These data elucidate a novel mechanism by which the mTOR pathway mediates cocaine-induced behavioral changes and could suggest a new interventional strategy for drug abuse.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MtorRatresponse to cocaine  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mtor  (mechanistic target of rapamycin kinase)


Additional Information