RGD Reference Report - Repetitive stretch suppresses denervation-induced atrophy of soleus muscle in rats. - Rat Genome Database

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Repetitive stretch suppresses denervation-induced atrophy of soleus muscle in rats.

Authors: Agata, N  Sasai, N  Inoue-Miyazu, M  Kawakami, K  Hayakawa, K  Kobayashi, K  Sokabe, M 
Citation: Agata N, etal., Muscle Nerve. 2009 Apr;39(4):456-62. doi: 10.1002/mus.21103.
RGD ID: 10041027
Pubmed: (View Article at PubMed) PMID:19260063
DOI: Full-text: DOI:10.1002/mus.21103

This study was conducted to examine whether stretch-related mechanical loading on skeletal muscle can suppress denervation-induced muscle atrophy, and if so, to depict the underlying molecular mechanism. Denervated rat soleus muscle was repetitively stretched (every 5 s for 15 min/day) for 2 weeks. Histochemical analysis showed that the cross-sectional area of denervated soleus muscle fibers with repetitive stretching was significantly larger than that of control denervated muscle (P<0.05). We then examined the involvement of the Akt/mammalian target of the rapamycin (mTOR) cascade in the suppressive effects of repetitive stretching on muscle atrophy. Repetitive stretching significantly increased the Akt, p70S6K, and 4E-BP1 phosphorylation in denervated soleus muscle compared to controls (P<0.05). Furthermore, repetitive stretching-induced suppression of muscle atrophy was fully inhibited by rapamycin, a potent inhibitor of mTOR. These results indicate that denervation-induced muscle atrophy is significantly suppressed by stretch-related mechanical loading of the muscle through upregulation of the Akt/mTOR signal pathway.

Disease Annotations    
muscular atrophy  (IMP,ISO)

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Mtor  (mechanistic target of rapamycin kinase)

Genes (Mus musculus)
Mtor  (mechanistic target of rapamycin kinase)

Genes (Homo sapiens)
MTOR  (mechanistic target of rapamycin kinase)

Additional Information