MTOR (mechanistic target of rapamycin kinase) - Rat Genome Database
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Gene: MTOR (mechanistic target of rapamycin kinase) Sus scrofa
Analyze
Symbol: MTOR
Name: mechanistic target of rapamycin kinase
RGD ID: 14143837
Description: ENCODES a protein that exhibits kinase activity (ortholog); protein domain specific binding (ortholog); protein kinase activity (ortholog); INVOLVED IN brain development (ortholog); cardiac cell development (ortholog); cardiac muscle tissue development (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-4 signaling pathway; mTOR signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); AIDS-Associated Nephropathy (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); endomembrane system (ortholog); INTERACTS WITH 2-deoxy-D-glucose; antimycin A; deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Also known as: FK506 binding protein 12-rapamycin associated protein 1; FRAP1; serine/threonine-protein kinase mTOR
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,286,989 - 71,412,888 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,286,989 - 71,412,913 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,191,742 - 65,317,489 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adenocarcinoma  (ISO)
AIDS-Associated Nephropathy  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
Cardiomegaly  (ISO)
CEBALID Syndrome  (ISO)
Cerebral Hemorrhage  (ISO)
chondrosarcoma  (ISO)
Chronic Allograft Dysfunction  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
complex cortical dysplasia with other brain malformations  (ISO)
congestive heart failure  (ISO)
crescentic glomerulonephritis  (ISO)
Diabetes Mellitus, New-Onset after Transplantation  (ISO)
Diabetic Nephropathies  (ISO)
Drug-Induced Dyskinesia  (ISO)
end stage renal disease  (ISO)
endocrine system disease  (ISO)
epilepsy  (ISO)
exocrine pancreatic insufficiency  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Familial Atrial Fibrillation 6  (ISO)
Focal Cortical Dysplasia of Taylor  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Hemimegalencephaly  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
idiopathic interstitial pneumonia  (ISO)
Inflammation  (ISO)
intellectual disability  (ISO)
interstitial cystitis  (ISO)
kidney angiomyolipoma  (ISO)
kidney cancer  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
Macrocephaly  (ISO)
malignant glioma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
mantle cell lymphoma  (ISO)
melanoma  (ISO)
Mesothelioma  (ISO)
middle cerebral artery infarction  (ISO)
muscular atrophy  (ISO)
Muscular Dystrophy, Animal  (ISO)
myocardial infarction  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
Parkinsonian Disorders  (ISO)
polycystic kidney disease  (ISO)
portal hypertension  (ISO)
prostate cancer  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal carcinoma  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
Retinal Neovascularization  (ISO)
Right Ventricular Hypertrophy  (ISO)
schizophrenia  (ISO)
Schnyder corneal dystrophy  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
skin melanoma  (ISO)
small cell carcinoma  (ISO)
Smith-Kingsmore Syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
status epilepticus  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
temporal lobe epilepsy  (ISO)
Temporomandibular Joint Disorders  (ISO)
toxic encephalopathy  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
uterine cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
'de novo' pyrimidine nucleobase biosynthetic process  (IEA)
brain development  (ISO)
cardiac cell development  (ISO)
cardiac muscle cell development  (IEA)
cardiac muscle contraction  (IEA)
cardiac muscle tissue development  (ISO)
cell aging  (ISO)
cell projection organization  (ISO)
cellular response to amino acid starvation  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to hypoxia  (IEA)
cellular response to leucine  (IEA)
cellular response to leucine starvation  (IEA)
cellular response to nutrient levels  (ISO)
cellular response to starvation  (ISO)
energy reserve metabolic process  (IEA)
germ cell development  (IEA)
heart morphogenesis  (IEA)
heart valve morphogenesis  (IEA)
long-term memory  (ISO)
lysosome organization  (IEA)
maternal process involved in female pregnancy  (ISO)
mRNA stabilization  (ISO)
multicellular organism growth  (IEA)
negative regulation of autophagy  (ISO)
negative regulation of calcineurin-NFAT signaling cascade  (IEA)
negative regulation of cell size  (IEA)
negative regulation of cholangiocyte apoptotic process  (ISO)
negative regulation of iodide transmembrane transport  (ISO)
negative regulation of macroautophagy  (IEA)
negative regulation of muscle atrophy  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein ubiquitination  (ISO)
nucleus localization  (IEA)
peptidyl-serine phosphorylation  (IEA)
peptidyl-threonine phosphorylation  (IEA)
phosphorylation  (ISO)
positive regulation of actin filament polymerization  (IEA)
positive regulation of cell death  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cholangiocyte proliferation  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of eating behavior  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of granulosa cell proliferation  (ISO)
positive regulation of keratinocyte migration  (IEA)
positive regulation of lamellipodium assembly  (IEA)
positive regulation of lipid biosynthetic process  (IEA)
positive regulation of myotube differentiation  (IEA)
positive regulation of neurogenesis  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of neuron maturation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of oligodendrocyte differentiation  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of sensory perception of pain  (ISO)
positive regulation of skeletal muscle hypertrophy  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of stress fiber assembly  (IEA)
positive regulation of transcription by RNA polymerase III  (IEA)
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I  (IEA)
positive regulation of translation  (IEA)
positive regulation of wound healing, spreading of epidermal cells  (IEA)
post-embryonic development  (IEA)
protein autophosphorylation  (IEA)
protein phosphorylation  (IEA)
regulation of actin cytoskeleton organization  (ISO)
regulation of autophagy  (ISO)
regulation of brown fat cell differentiation  (ISO)
regulation of carbohydrate metabolic process  (ISO)
regulation of carbohydrate utilization  (ISO)
regulation of cell growth  (IEA)
regulation of cell size  (ISO)
regulation of circadian rhythm  (ISO)
regulation of fatty acid beta-oxidation  (ISO)
regulation of glycogen biosynthetic process  (ISO)
regulation of GTPase activity  (IEA)
regulation of locomotor rhythm  (IEA)
regulation of membrane permeability  (IEA)
regulation of myelination  (IEA)
regulation of osteoclast differentiation  (IEA)
regulation of protein kinase activity  (IEA)
regulation of protein kinase B signaling  (IEA)
regulation of protein phosphorylation  (ISO)
regulation of response to food  (ISO)
regulation of translation at synapse, modulating synaptic transmission  (ISO)
response to activity  (ISO)
response to amino acid  (ISO)
response to cocaine  (ISO)
response to insulin  (IEA)
response to morphine  (ISO)
response to nutrient  (IEA)
response to nutrient levels  (ISO)
ruffle organization  (IEA)
social behavior  (ISO)
spinal cord development  (ISO)
T-helper 1 cell lineage commitment  (IEA)
TOR signaling  (ISO)
TORC1 signaling  (IEA)
visual learning  (ISO)
voluntary musculoskeletal movement  (IEA)
wound healing  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:20375271   PMID:21654549   PMID:22137265   PMID:22391631   PMID:22915817   PMID:23056260   PMID:23486913   PMID:25280462   PMID:25739982   PMID:26967195   PMID:27040764   PMID:27102282  
PMID:27225947   PMID:27459644   PMID:28257428   PMID:28983783   PMID:31720834  


Genomics

Comparative Map Data
MTOR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,286,989 - 71,412,888 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,286,989 - 71,412,913 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,191,742 - 65,317,489 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTOR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl111,106,535 - 11,262,551 (-)EnsemblGRCh38hg38GRCh38
GRCh38111,106,535 - 11,273,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37111,166,588 - 11,322,614 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,089,179 - 11,245,153 (-)NCBINCBI36hg18NCBI36
Build 34111,100,857 - 11,256,830NCBI
Celera110,278,903 - 10,434,848 (-)NCBI
Cytogenetic Map1p36.22NCBI
HuRef110,317,883 - 10,473,910 (-)NCBIHuRef
CHM1_1111,154,542 - 11,310,885 (-)NCBICHM1_1
Mtor
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,533,039 - 148,642,142 (+)NCBIGRCm39mm39
GRCm384148,448,582 - 148,557,685 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,448,611 - 148,557,683 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,822,691 - 147,931,794 (+)NCBIGRCm37mm9NCBIm37
MGSCv364147,292,407 - 147,401,483 (+)NCBImm8
Celera4150,709,332 - 150,819,308 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.76NCBI
Mtor
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05165,263,813 - 165,373,967 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5165,263,800 - 165,373,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,920,414 - 169,030,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,531,402 - 165,640,899 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,541,594 - 165,651,087 (+)NCBI
Celera5157,161,454 - 157,270,899 (+)NCBICelera
Cytogenetic Map5q36NCBI
Mtor
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,487,642 - 2,599,694 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,487,642 - 2,599,694 (+)NCBIChiLan1.0ChiLan1.0
MTOR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1111,093,765 - 11,249,841 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,093,765 - 11,249,841 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v019,871,700 - 10,028,704 (-)NCBIMhudiblu_PPA_v0panPan3
MTOR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl284,787,708 - 84,939,114 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1284,818,893 - 84,939,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Mtor
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936474158,376 - 282,310 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTOR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120120,522,667 - 120,678,988 (+)NCBI
ChlSab1.1 Ensembl20120,525,737 - 120,679,020 (+)Ensembl
Mtor
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248181,570,155 - 1,698,264 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 1 7 2
Low 10 4 3 3 1 16 2 1 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000003786   ⟹   ENSSSCP00000003699
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl671,286,989 - 71,412,888 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000052098   ⟹   ENSSSCP00000057123
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl671,286,989 - 71,412,888 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000055666   ⟹   ENSSSCP00000057643
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl671,295,602 - 71,412,885 (-)Ensembl
RefSeq Acc Id: XM_003127584   ⟹   XP_003127632
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1671,286,989 - 71,412,913 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003127632 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABX79676 (Get FASTA)   NCBI Sequence Viewer  
  ACX85490 (Get FASTA)   NCBI Sequence Viewer  
  JAG69359 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003127632   ⟸   XM_003127584
- UniProtKB: A0A287AWH2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000057643   ⟸   ENSSSCT00000055666
RefSeq Acc Id: ENSSSCP00000057123   ⟸   ENSSSCT00000052098
RefSeq Acc Id: ENSSSCP00000003699   ⟸   ENSSSCT00000003786
Protein Domains
FAT   FATC   PI3K/PI4K


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003413 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070029477 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000003699 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000057123 UniProtKB/TrEMBL
  ENSSSCP00000057643 UniProtKB/TrEMBL
  ENSSSCP00070050428 UniProtKB/TrEMBL
  ENSSSCP00070050430 UniProtKB/TrEMBL
  ENSSSCP00070050431 UniProtKB/TrEMBL
  ENSSSCP00070050432 UniProtKB/TrEMBL
  ENSSSCP00070050433 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003786 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000052098 UniProtKB/TrEMBL
  ENSSSCT00000055666 UniProtKB/TrEMBL
  ENSSSCT00070059230 UniProtKB/TrEMBL
  ENSSSCT00070059232 UniProtKB/TrEMBL
  ENSSSCT00070059233 UniProtKB/TrEMBL
  ENSSSCT00070059234 UniProtKB/TrEMBL
  ENSSSCT00070059235 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/TrEMBL
  1.20.120.150 UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
  1.25.40.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  DUF3385_TOR UniProtKB/TrEMBL
  FATC_dom UniProtKB/TrEMBL
  FRB_dom UniProtKB/TrEMBL
  FRB_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/TrEMBL
  PIK-rel_kinase_FAT UniProtKB/TrEMBL
  PIK_FAT UniProtKB/TrEMBL
  TOR UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:100127359 UniProtKB/TrEMBL
NCBI Gene MTOR ENTREZGENE
PANTHER PTHR11139:SF9 UniProtKB/TrEMBL
Pfam DUF3385 UniProtKB/TrEMBL
  FAT UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  FRB_dom UniProtKB/TrEMBL
  PI3_PI4_kinase UniProtKB/TrEMBL
PROSITE FAT UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  PI3_4_KINASE_1 UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/TrEMBL
SMART DUF3385 UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  PI3Kc UniProtKB/TrEMBL
Superfamily-SCOP SSF47212 UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A287AWH2 ENTREZGENE
  A0A287BKJ8_PIG UniProtKB/TrEMBL
  A0A287BMJ2_PIG UniProtKB/TrEMBL
  A0A4X1W2G5_PIG UniProtKB/TrEMBL
  A0A4X1W7H7_PIG UniProtKB/TrEMBL
  A0A4X1W882_PIG UniProtKB/TrEMBL
  A0A4X1W9I1_PIG UniProtKB/TrEMBL
  F1RHR8_PIG UniProtKB/TrEMBL
UniProt Secondary A0A287AWH2 UniProtKB/TrEMBL
VGNC ID VGNC:90466 ENTREZGENE