MTOR (mechanistic target of rapamycin kinase) - Rat Genome Database
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Gene: MTOR (mechanistic target of rapamycin kinase) Pan paniscus
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Symbol: MTOR
Name: mechanistic target of rapamycin kinase
RGD ID: 12049426
Description: ENCODES a protein that exhibits identical protein binding (ortholog); kinase activity (ortholog); phosphoprotein binding (ortholog); INVOLVED IN 'de novo' pyrimidine nucleobase biosynthetic process (ortholog); brain development (ortholog); cardiac cell development (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-4 signaling pathway; mTOR signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); AIDS-Associated Nephropathy (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: mechanistic target of rapamycin; serine/threonine-protein kinase mTOR
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1111,093,765 - 11,249,841 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,093,765 - 11,249,841 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v019,871,700 - 10,028,704 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adenocarcinoma  (ISO)
AIDS-Associated Nephropathy  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
Cardiomegaly  (ISO)
CEBALID Syndrome  (ISO)
Cerebral Hemorrhage  (ISO)
chondrosarcoma  (ISO)
Chronic Allograft Dysfunction  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
complex cortical dysplasia with other brain malformations  (ISO)
congestive heart failure  (ISO)
crescentic glomerulonephritis  (ISO)
Diabetes Mellitus, New-Onset after Transplantation  (ISO)
Diabetic Nephropathies  (ISO)
Drug-Induced Dyskinesia  (ISO)
end stage renal disease  (ISO)
endocrine system disease  (ISO)
epilepsy  (ISO)
exocrine pancreatic insufficiency  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Familial Atrial Fibrillation 6  (ISO)
Focal Cortical Dysplasia of Taylor  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Hemimegalencephaly  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
idiopathic interstitial pneumonia  (ISO)
Inflammation  (ISO)
intellectual disability  (ISO)
interstitial cystitis  (ISO)
kidney angiomyolipoma  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
Macrocephaly  (ISO)
Mammary Neoplasms, Experimental  (ISO)
mantle cell lymphoma  (ISO)
melanoma  (ISO)
Mesothelioma  (ISO)
middle cerebral artery infarction  (ISO)
muscular atrophy  (ISO)
Muscular Dystrophy, Animal  (ISO)
myocardial infarction  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
Parkinsonism  (ISO)
polycystic kidney disease  (ISO)
portal hypertension  (ISO)
prostate cancer  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal carcinoma  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
Retinal Neovascularization  (ISO)
Right Ventricular Hypertrophy  (ISO)
schizophrenia  (ISO)
Schnyder corneal dystrophy  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
skin melanoma  (ISO)
small cell carcinoma  (ISO)
Smith-Kingsmore Syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
status epilepticus  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
temporal lobe epilepsy  (ISO)
Temporomandibular Joint Disorders  (ISO)
toxic encephalopathy  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
uterine cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (ISO)
visual epilepsy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
'de novo' pyrimidine nucleobase biosynthetic process  (ISO)
brain development  (ISO)
cardiac cell development  (ISO)
cardiac muscle cell development  (ISO)
cardiac muscle contraction  (ISO)
cardiac muscle tissue development  (ISO)
cell aging  (ISO)
cell projection organization  (ISO)
cellular response to amino acid starvation  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to leucine  (ISO)
cellular response to leucine starvation  (ISO)
cellular response to nutrient levels  (ISO)
cellular response to starvation  (ISO)
energy reserve metabolic process  (ISO)
germ cell development  (ISO)
heart morphogenesis  (ISO)
heart valve morphogenesis  (ISO)
long-term memory  (ISO)
lysosome organization  (ISO)
maternal process involved in female pregnancy  (ISO)
mRNA stabilization  (ISO)
multicellular organism growth  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of calcineurin-NFAT signaling cascade  (ISO)
negative regulation of cell size  (ISO)
negative regulation of cholangiocyte apoptotic process  (ISO)
negative regulation of iodide transmembrane transport  (ISO)
negative regulation of macroautophagy  (ISO)
negative regulation of muscle atrophy  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein ubiquitination  (ISO)
nucleus localization  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
phosphorylation  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of cell death  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cholangiocyte proliferation  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of eating behavior  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of granulosa cell proliferation  (ISO)
positive regulation of keratinocyte migration  (ISO)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of lipid biosynthetic process  (ISO)
positive regulation of myotube differentiation  (ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of neuron maturation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of oligodendrocyte differentiation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of sensory perception of pain  (ISO)
positive regulation of skeletal muscle hypertrophy  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of transcription by RNA polymerase III  (ISO)
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I  (ISO)
positive regulation of translation  (ISO)
positive regulation of wound healing, spreading of epidermal cells  (ISO)
post-embryonic development  (ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of autophagy  (ISO)
regulation of brown fat cell differentiation  (ISO)
regulation of carbohydrate metabolic process  (ISO)
regulation of carbohydrate utilization  (ISO)
regulation of cell growth  (ISO)
regulation of cell size  (ISO)
regulation of circadian rhythm  (ISO)
regulation of fatty acid beta-oxidation  (ISO)
regulation of glycogen biosynthetic process  (ISO)
regulation of GTPase activity  (ISO)
regulation of locomotor rhythm  (ISO)
regulation of membrane permeability  (ISO)
regulation of myelination  (ISO)
regulation of osteoclast differentiation  (ISO)
regulation of protein kinase activity  (ISO)
regulation of protein kinase B signaling  (ISO)
regulation of protein phosphorylation  (ISO)
regulation of response to food  (ISO)
regulation of translation at synapse, modulating synaptic transmission  (ISO)
response to activity  (ISO)
response to amino acid  (ISO)
response to cocaine  (ISO)
response to insulin  (ISO)
response to morphine  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
ruffle organization  (ISO)
social behavior  (ISO)
spinal cord development  (ISO)
T-helper 1 cell lineage commitment  (ISO)
TOR signaling  (ISO)
TORC1 signaling  (ISO)
visual learning  (ISO)
voluntary musculoskeletal movement  (ISO)
wound healing  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
MTOR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1111,093,765 - 11,249,841 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,093,765 - 11,249,841 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v019,871,700 - 10,028,704 (-)NCBIMhudiblu_PPA_v0panPan3
MTOR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl111,106,535 - 11,262,551 (-)EnsemblGRCh38hg38GRCh38
GRCh38111,106,535 - 11,273,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37111,166,592 - 11,322,608 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,089,179 - 11,245,153 (-)NCBINCBI36hg18NCBI36
Build 34111,100,857 - 11,256,830NCBI
Celera110,278,903 - 10,434,848 (-)NCBI
Cytogenetic Map1p36.22NCBI
HuRef110,317,883 - 10,473,910 (-)NCBIHuRef
CHM1_1111,154,542 - 11,310,885 (-)NCBICHM1_1
Mtor
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,533,039 - 148,642,142 (+)NCBIGRCm39mm39
GRCm39 Ensembl4148,533,068 - 148,642,140 (+)Ensembl
GRCm384148,448,582 - 148,557,685 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,448,611 - 148,557,683 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,822,691 - 147,931,794 (+)NCBIGRCm37mm9NCBIm37
MGSCv364147,292,407 - 147,401,483 (+)NCBImm8
Celera4150,709,332 - 150,819,308 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.76NCBI
Mtor
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25158,884,856 - 158,994,311 (+)NCBI
Rnor_6.0 Ensembl5165,263,800 - 165,373,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05165,263,813 - 165,373,967 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05168,920,414 - 169,030,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,531,402 - 165,640,899 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,541,594 - 165,651,087 (+)NCBI
Celera5157,161,454 - 157,270,899 (+)NCBICelera
Cytogenetic Map5q36NCBI
Mtor
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,487,642 - 2,599,694 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,487,642 - 2,599,694 (+)NCBIChiLan1.0ChiLan1.0
MTOR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl284,787,708 - 84,939,114 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1284,818,893 - 84,939,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Mtor
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936474158,376 - 282,310 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTOR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,286,989 - 71,412,888 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,286,989 - 71,412,913 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,191,742 - 65,317,489 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTOR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120120,522,667 - 120,678,988 (+)NCBI
ChlSab1.1 Ensembl20120,525,737 - 120,679,020 (+)Ensembl
Mtor
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248181,570,155 - 1,698,264 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000049434   ⟹   ENSPPAP00000026600
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl111,093,765 - 11,249,841 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000049450   ⟹   ENSPPAP00000026616
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl111,214,610 - 11,246,670 (-)Ensembl
RefSeq Acc Id: XM_003822083   ⟹   XP_003822131
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1111,093,765 - 11,249,830 (-)NCBI
Mhudiblu_PPA_v019,871,700 - 10,028,700 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008975614   ⟹   XP_008973862
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1111,093,772 - 11,249,841 (-)NCBI
Mhudiblu_PPA_v019,872,163 - 10,028,668 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034955325   ⟹   XP_034811216
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v019,871,700 - 10,014,292 (-)NCBI
RefSeq Acc Id: XR_004670344
RefSeq Status:
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v019,879,939 - 10,028,704 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003822131 (Get FASTA)   NCBI Sequence Viewer  
  XP_008973862 (Get FASTA)   NCBI Sequence Viewer  
  XP_034811216 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003822131   ⟸   XM_003822083
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008973862   ⟸   XM_008975614
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_034811216   ⟸   XM_034955325
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000026600   ⟸   ENSPPAT00000049434
RefSeq Acc Id: ENSPPAP00000026616   ⟸   ENSPPAT00000049450
Protein Domains
DUF3385   FAT   FATC   PI3K/PI4K


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036364 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000026600 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000026616 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000049434 UniProtKB/TrEMBL
  ENSPPAT00000049450 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/TrEMBL
  1.20.120.150 UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
  1.25.40.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  DUF3385_TOR UniProtKB/TrEMBL
  FATC_dom UniProtKB/TrEMBL
  FRB_dom UniProtKB/TrEMBL
  FRB_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/TrEMBL
  PIK-rel_kinase_FAT UniProtKB/TrEMBL
  PIK_FAT UniProtKB/TrEMBL
  TOR UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100980204 UniProtKB/TrEMBL
NCBI Gene MTOR ENTREZGENE
PANTHER PTHR11139:SF9 UniProtKB/TrEMBL
Pfam DUF3385 UniProtKB/TrEMBL
  FAT UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  FRB_dom UniProtKB/TrEMBL
  PI3_PI4_kinase UniProtKB/TrEMBL
PROSITE FAT UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  PI3_4_KINASE_1 UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/TrEMBL
SMART DUF3385 UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  PI3Kc UniProtKB/TrEMBL
Superfamily-SCOP SSF47212 UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9BE99_PANPA UniProtKB/TrEMBL
  A0A2R9BI87_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-08 MTOR  mechanistic target of rapamycin kinase    mechanistic target of rapamycin  Symbol and/or name change 5135510 APPROVED