MTOR (mechanistic target of rapamycin kinase) - Rat Genome Database

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Gene: MTOR (mechanistic target of rapamycin kinase) Canis lupus familiaris
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Symbol: MTOR
Name: mechanistic target of rapamycin kinase
RGD ID: 12225589
Description: ENCODES a protein that exhibits kinase activity (ortholog); protein domain specific binding (ortholog); protein kinase activity (ortholog); INVOLVED IN brain development (ortholog); cardiac cell development (ortholog); cardiac muscle cell development (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-4 signaling pathway; mTOR signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); AIDS-Associated Nephropathy (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: FK506 binding protein 12-rapamycin associated protein 1; FRAP1; mechanistic target of rapamycin; serine/threonine-protein kinase mTOR
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,818,893 - 84,939,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,787,708 - 84,939,114 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,349,286 - 81,469,352 (+)NCBI
ROS_Cfam_1.0285,486,181 - 85,601,386 (+)NCBI
UMICH_Zoey_3.1282,229,433 - 82,349,483 (+)NCBI
UNSW_CanFamBas_1.0283,231,190 - 83,351,242 (+)NCBI
UU_Cfam_GSD_1.0284,293,674 - 84,413,764 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adenocarcinoma  (ISO)
AIDS-Associated Nephropathy  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
Cardiomegaly  (ISO)
CEBALID Syndrome  (ISO)
Cerebral Hemorrhage  (ISO)
chondrosarcoma  (ISO)
Chronic Allograft Dysfunction  (ISO)
colon cancer  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
complex cortical dysplasia with other brain malformations  (ISO)
congestive heart failure  (ISO)
crescentic glomerulonephritis  (ISO)
Diabetes Mellitus, New-Onset after Transplantation  (ISO)
Diabetic Nephropathies  (ISO)
Drug-Induced Dyskinesia  (ISO)
end stage renal disease  (ISO)
endocrine system disease  (ISO)
epilepsy  (ISO)
exocrine pancreatic insufficiency  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Familial Atrial Fibrillation 6  (ISO)
Focal Cortical Dysplasia of Taylor  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Hemimegalencephaly  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
high grade glioma  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
idiopathic interstitial pneumonia  (ISO)
Inflammation  (ISO)
intellectual disability  (ISO)
interstitial cystitis  (ISO)
kidney angiomyolipoma  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
Macrocephaly  (ISO)
Mammary Neoplasms, Experimental  (ISO)
mantle cell lymphoma  (ISO)
melanoma  (ISO)
Mesothelioma  (ISO)
middle cerebral artery infarction  (ISO)
muscular atrophy  (ISO)
Muscular Dystrophy, Animal  (ISO)
myocardial infarction  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
Parkinsonism  (ISO)
polycystic kidney disease  (ISO)
portal hypertension  (ISO)
prostate cancer  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal carcinoma  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
Retinal Neovascularization  (ISO)
Right Ventricular Hypertrophy  (ISO)
schizophrenia  (ISO)
Schnyder corneal dystrophy  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
skin melanoma  (ISO)
small cell carcinoma  (ISO)
Smith-Kingsmore Syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
status epilepticus  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
temporal lobe epilepsy  (ISO)
Temporomandibular Joint Disorders  (ISO)
toxic encephalopathy  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
uterine cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (ISO)
visual epilepsy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
'de novo' pyrimidine nucleobase biosynthetic process  (IEA)
brain development  (ISO)
cardiac cell development  (ISO)
cardiac muscle cell development  (IEA,ISO)
cardiac muscle contraction  (IEA,ISO)
cardiac muscle tissue development  (ISO)
cell aging  (ISO)
cell projection organization  (ISO)
cellular response to amino acid starvation  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to hypoxia  (IEA)
cellular response to leucine  (IEA)
cellular response to leucine starvation  (IEA)
cellular response to nutrient levels  (ISO)
cellular response to starvation  (ISO)
energy reserve metabolic process  (IEA,ISO)
germ cell development  (IEA,ISO)
heart morphogenesis  (IEA,ISO)
heart valve morphogenesis  (IEA,ISO)
long-term memory  (ISO)
lysosome organization  (IEA)
maternal process involved in female pregnancy  (ISO)
mRNA stabilization  (ISO)
multicellular organism growth  (IEA,ISO)
negative regulation of autophagy  (ISO)
negative regulation of calcineurin-NFAT signaling cascade  (IEA,ISO)
negative regulation of cell size  (IEA,ISO)
negative regulation of cholangiocyte apoptotic process  (ISO)
negative regulation of iodide transmembrane transport  (ISO)
negative regulation of macroautophagy  (IBA,ISO)
negative regulation of muscle atrophy  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein ubiquitination  (ISO)
nucleus localization  (IEA)
peptidyl-serine phosphorylation  (IEA,ISO)
peptidyl-threonine phosphorylation  (IEA,ISO)
phosphorylation  (ISO)
positive regulation of actin filament polymerization  (IEA,ISO)
positive regulation of cell death  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cholangiocyte proliferation  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of eating behavior  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of granulosa cell proliferation  (ISO)
positive regulation of keratinocyte migration  (IEA)
positive regulation of lamellipodium assembly  (IEA,ISO)
positive regulation of lipid biosynthetic process  (IEA)
positive regulation of myotube differentiation  (IEA,ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of neuron maturation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of oligodendrocyte differentiation  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of sensory perception of pain  (ISO)
positive regulation of skeletal muscle hypertrophy  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of stress fiber assembly  (IEA,ISO)
positive regulation of transcription by RNA polymerase III  (IEA)
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I  (IEA)
positive regulation of translation  (IEA,ISO)
positive regulation of wound healing, spreading of epidermal cells  (IEA)
post-embryonic development  (IEA,ISO)
protein autophosphorylation  (IEA,ISO)
protein phosphorylation  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of autophagy  (ISO)
regulation of brown fat cell differentiation  (ISO)
regulation of carbohydrate metabolic process  (ISO)
regulation of carbohydrate utilization  (ISO)
regulation of cell growth  (IEA)
regulation of cell size  (ISO)
regulation of circadian rhythm  (ISO)
regulation of fatty acid beta-oxidation  (ISO)
regulation of glycogen biosynthetic process  (ISO)
regulation of GTPase activity  (IEA,ISO)
regulation of locomotor rhythm  (IEA)
regulation of membrane permeability  (IEA,ISO)
regulation of myelination  (IEA,ISO)
regulation of osteoclast differentiation  (IEA)
regulation of protein kinase activity  (IEA,ISO)
regulation of protein kinase B signaling  (IEA,ISO)
regulation of protein phosphorylation  (ISO)
regulation of response to food  (ISO)
regulation of translation at synapse, modulating synaptic transmission  (ISO)
response to activity  (ISO)
response to amino acid  (ISO)
response to cocaine  (ISO)
response to insulin  (IEA,ISO)
response to morphine  (ISO)
response to nutrient  (IEA)
response to nutrient levels  (ISO)
ruffle organization  (IEA,ISO)
social behavior  (ISO)
spinal cord development  (ISO)
T-helper 1 cell lineage commitment  (IEA)
TOR signaling  (ISO)
TORC1 signaling  (IBA)
visual learning  (ISO)
voluntary musculoskeletal movement  (IEA,ISO)
wound healing  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:21321942   PMID:22177999   PMID:22789858   PMID:24651621   PMID:30011343   PMID:30476726  


Genomics

Comparative Map Data
MTOR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,818,893 - 84,939,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,787,708 - 84,939,114 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,349,286 - 81,469,352 (+)NCBI
ROS_Cfam_1.0285,486,181 - 85,601,386 (+)NCBI
UMICH_Zoey_3.1282,229,433 - 82,349,483 (+)NCBI
UNSW_CanFamBas_1.0283,231,190 - 83,351,242 (+)NCBI
UU_Cfam_GSD_1.0284,293,674 - 84,413,764 (+)NCBI
MTOR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl111,106,535 - 11,262,551 (-)EnsemblGRCh38hg38GRCh38
GRCh38111,106,535 - 11,273,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37111,166,592 - 11,322,608 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,089,179 - 11,245,153 (-)NCBINCBI36hg18NCBI36
Build 34111,100,857 - 11,256,830NCBI
Celera110,278,903 - 10,434,848 (-)NCBI
Cytogenetic Map1p36.22NCBI
HuRef110,317,883 - 10,473,910 (-)NCBIHuRef
CHM1_1111,154,542 - 11,310,885 (-)NCBICHM1_1
Mtor
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,533,039 - 148,642,142 (+)NCBIGRCm39mm39
GRCm39 Ensembl4148,533,068 - 148,642,140 (+)Ensembl
GRCm384148,448,582 - 148,557,685 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,448,611 - 148,557,683 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,822,691 - 147,931,794 (+)NCBIGRCm37mm9NCBIm37
MGSCv364147,292,407 - 147,401,483 (+)NCBImm8
Celera4150,709,332 - 150,819,308 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.76NCBI
Mtor
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25158,884,856 - 158,994,311 (+)NCBI
Rnor_6.0 Ensembl5165,263,800 - 165,373,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05165,263,813 - 165,373,967 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05168,920,414 - 169,030,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,531,402 - 165,640,899 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,541,594 - 165,651,087 (+)NCBI
Celera5157,161,454 - 157,270,899 (+)NCBICelera
Cytogenetic Map5q36NCBI
Mtor
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,487,642 - 2,599,694 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,487,642 - 2,599,694 (+)NCBIChiLan1.0ChiLan1.0
MTOR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1111,093,765 - 11,249,841 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,093,765 - 11,249,841 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v019,871,700 - 10,028,704 (-)NCBIMhudiblu_PPA_v0panPan3
Mtor
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,333,597 - 34,457,567 (-)NCBI
SpeTri2.0NW_004936474158,376 - 282,310 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTOR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,286,989 - 71,412,888 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,286,989 - 71,412,913 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,191,742 - 65,317,489 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTOR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120120,522,667 - 120,678,988 (+)NCBI
ChlSab1.1 Ensembl20120,525,737 - 120,679,020 (+)Ensembl
Vero_WHO_p1.0NW_02366605424,431,846 - 24,582,610 (+)NCBI
Mtor
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248181,570,155 - 1,698,264 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 5 16 2 6 3 12 8 10 6
Low 1 6 6 4 6 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000026412   ⟹   ENSCAFP00000024527
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl284,787,708 - 84,939,114 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000064130   ⟹   ENSCAFP00000044316
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl284,833,061 - 84,939,114 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000070228   ⟹   ENSCAFP00000065177
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl284,787,708 - 84,939,114 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000074234   ⟹   ENSCAFP00000048878
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl284,787,708 - 84,939,114 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000077589   ⟹   ENSCAFP00000054233
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl284,787,708 - 84,939,114 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000082268   ⟹   ENSCAFP00000063184
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl284,787,708 - 84,939,114 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000084601   ⟹   ENSCAFP00000047415
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl284,787,708 - 84,939,114 (+)Ensembl
RefSeq Acc Id: XM_005618003   ⟹   XP_005618060
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1284,818,893 - 84,939,283 (+)NCBI
Dog10K_Boxer_Tasha281,349,286 - 81,469,352 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005618004   ⟹   XP_005618061
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1284,818,893 - 84,939,283 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038471116   ⟹   XP_038327044
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1282,229,433 - 82,349,483 (+)NCBI
RefSeq Acc Id: XM_038532031   ⟹   XP_038387959
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0284,293,674 - 84,413,764 (+)NCBI
RefSeq Acc Id: XM_038596294   ⟹   XP_038452222
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0283,231,190 - 83,351,242 (+)NCBI
RefSeq Acc Id: XM_038660368   ⟹   XP_038516296
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0285,486,181 - 85,601,386 (+)NCBI
RefSeq Acc Id: XM_535407   ⟹   XP_535407
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1284,820,190 - 84,939,283 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005618060   ⟸   XM_005618003
- Peptide Label: isoform X5
- UniProtKB: E2R2L2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005618061   ⟸   XM_005618004
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_535407   ⟸   XM_535407
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000044316   ⟸   ENSCAFT00000064130
RefSeq Acc Id: ENSCAFP00000048878   ⟸   ENSCAFT00000074234
RefSeq Acc Id: ENSCAFP00000065177   ⟸   ENSCAFT00000070228
RefSeq Acc Id: ENSCAFP00000047415   ⟸   ENSCAFT00000084601
RefSeq Acc Id: ENSCAFP00000054233   ⟸   ENSCAFT00000077589
RefSeq Acc Id: ENSCAFP00000063184   ⟸   ENSCAFT00000082268
RefSeq Acc Id: ENSCAFP00000024527   ⟸   ENSCAFT00000026412
RefSeq Acc Id: XP_038327044   ⟸   XM_038471116
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038452222   ⟸   XM_038596294
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038516296   ⟸   XM_038660368
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038387959   ⟸   XM_038532031
- Peptide Label: isoform X4
Protein Domains
FAT   FATC   PI3K/PI4K


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016648 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000054233 ENTREZGENE
NCBI Gene MTOR ENTREZGENE
UniProt E2R2L2 ENTREZGENE
VGNC ID VGNC:43490 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-08 MTOR  mechanistic target of rapamycin kinase    mechanistic target of rapamycin  Symbol and/or name change 5135510 APPROVED