RGD Reference Report - Hypothalamic mTOR signaling regulates food intake. - Rat Genome Database

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Hypothalamic mTOR signaling regulates food intake.

Authors: Cota, D  Proulx, K  Smith, KA  Kozma, SC  Thomas, G  Woods, SC  Seeley, RJ 
Citation: Cota D, etal., Science. 2006 May 12;312(5775):927-30.
RGD ID: 1625614
Pubmed: (View Article at PubMed) PMID:16690869
DOI: Full-text: DOI:10.1126/science.1124147

The mammalian Target of Rapamycin (mTOR) protein is a serine-threonine kinase that regulates cell-cycle progression and growth by sensing changes in energy status. We demonstrated that mTOR signaling plays a role in the brain mechanisms that respond to nutrient availability, regulating energy balance. In the rat, mTOR signaling is controlled by energy status in specific regions of the hypothalamus and colocalizes with neuropeptide Y and proopiomelanocortin neurons in the arcuate nucleus. Central administration of leucine increases hypothalamic mTOR signaling and decreases food intake and body weight. The hormone leptin increases hypothalamic mTOR activity, and the inhibition of mTOR signaling blunts leptin's anorectic effect. Thus, mTOR is a cellular fuel sensor whose hypothalamic activity is directly tied to the regulation of energy intake.



Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Mtor  (mechanistic target of rapamycin kinase)


Additional Information