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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68534
Species: Mus musculus
RGD Object: Gene
Symbol: Mtor
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:78510
Term: dorsomorphin
Definition: A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.
Chemical ID: MESH:C516138
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mtormultiple interactionsEXP 6480464CTDAlpha-Amanitin inhibits the reaction [dorsomorphin results in increased expression of and results in increased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Cadmium results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [graphene oxide results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Zearalenone results in decreased phosphorylation of MTOR protein]; dorsomorphin results in increased expression of and results in increased phosphorylation of MTOR proteinPMID:21767558 PMID:31982503 PMID:32430275 PMID:37329965
Mtorincreases phosphorylationISOMTOR (Homo sapiens)6480464CTDdorsomorphin results in increased phosphorylation of MTOR proteinPMID:31900833
Mtormultiple interactionsISOMtor (Rattus norvegicus)6480464CTDdorsomorphin inhibits the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [ADIPOQ protein promotes the reaction [Rotenone results in decreased phosphorylation of MTOR protein]]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of MTOR protein]]; dorsomorphin inhibits the reaction [Rotenone results in decreased phosphorylation of MTOR protein]PMID:23211629 PMID:28041982 PMID:33137417
Mtormultiple interactionsISOMTOR (Homo sapiens)6480464CTDdorsomorphin inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] affects the phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Capsaicin results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [graphene oxide results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]]; dorsomorphin inhibits the reaction [Resveratrol results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased phosphorylation of MTOR protein]PMID:19928762 PMID:23111315 PMID:28025121 PMID:31926917 PMID:32430275 PMID:33002460 PMID:36044967
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