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Gene: Gucy2e (guanylate cyclase 2e) Mus musculus
Symbol: Gucy2e
Name: guanylate cyclase 2e
Description: Exhibits guanylate cyclase activity. Involved in cGMP biosynthetic process. Localizes to photoreceptor outer segment membrane. Is expressed in dorsal root ganglion and retina outer nuclear layer. Used to study Leber congenital amaurosis 1 and cone-rod dystrophy 6. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 1; choroidal sclerosis; cone-rod dystrophy 6; congenital stationary night blindness; and retinitis pigmentosa. Orthologous to human GUCY2D (guanylate cyclase 2D, retinal); PARTICIPATES IN visual phototransduction pathway; purine metabolic pathway; INTERACTS WITH 4,4'-diaminodiphenylmethane; 4,4'-sulfonyldiphenol; bisphenol F.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BC020186; cDNA sequence BC020186; GC-E; GC1; guanylyl cyclase 2e; guanylyl cyclase GC-E; retinal guanylyl cyclase 1; ROS-GC1
Homo sapiens (human) : GUCY2D (guanylate cyclase 2D, retinal)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gucy2d (guanylate cyclase 2D, retinal)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gucy2d (guanylate cyclase 2D, retinal)
Pan paniscus (bonobo/pygmy chimpanzee) : GUCY2D (guanylate cyclase 2D, retinal)
Canis lupus familiaris (dog) : GUCY2D (guanylate cyclase 2D, retinal)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gucy2d (guanylate cyclase 2D, retinal)
Sus scrofa (pig) : GUCY2D (guanylate cyclase 2D, retinal)
Chlorocebus sabaeus (African green monkey) : GUCY2D (guanylate cyclase 2D, retinal)
Heterocephalus glaber (naked mole-rat) : Gucy2d (guanylate cyclase 2D, retinal)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1169,218,117 - 69,237,036 (-)EnsemblGRCm38mm10GRCm38
GRCm381169,218,117 - 69,237,279 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371169,031,619 - 69,050,524 (-)NCBIGRCm37mm9NCBIm37
MGSCv361169,039,230 - 69,052,840 (-)NCBImm8
Celera1176,171,185 - 76,190,106 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Gucy2e
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733871
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.