Car9 (carbonic anhydrase 9) - Rat Genome Database

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Gene: Car9 (carbonic anhydrase 9) Mus musculus
Analyze
Symbol: Car9
Name: carbonic anhydrase 9
RGD ID: 1315035
MGI Page MGI
Description: Predicted to have carbonate dehydratase activity. Involved in morphogenesis of an epithelium and secretion. Predicted to localize to basolateral plasma membrane. Is expressed in several structures, including central nervous system; early embryo; genitourinary system; gut; and heart. Human ortholog(s) of this gene implicated in hepatitis B and renal cell carcinoma. Orthologous to human CA9 (carbonic anhydrase 9); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CA; CA-IX; Ca9; CAIX; carbonate dehydratase IX; carbonic anhydrase IX; membrane antigen MN homolog; MN/C; MN/CA9
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,507,026 - 43,513,729 (+)NCBIGRCm39mm39
GRCm39 Ensembl443,506,966 - 43,513,729 (+)Ensembl
GRCm38443,507,026 - 43,513,729 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,506,966 - 43,513,729 (+)EnsemblGRCm38mm10GRCm38
MGSCv37443,519,898 - 43,526,597 (+)NCBIGRCm37mm9NCBIm37
MGSCv36443,528,107 - 43,534,829 (+)NCBImm8
Celera443,540,895 - 43,547,584 (+)NCBICelera
Cytogenetic Map4A5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-methylumbelliferyl beta-D-galactoside  (ISO)
acetamide  (ISO)
acetazolamide  (ISO)
acrylamide  (ISO)
ampicillin  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A5  (ISO)
bortezomib  (ISO)
butanal  (ISO)
butyric acid  (ISO)
calcitriol  (ISO)
captan  (EXP)
carbonates  (ISO)
chloric acid  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
Deguelin  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (ISO)
ethanol  (ISO)
folpet  (EXP)
Genipin  (ISO)
heptanal  (ISO)
hexanal  (ISO)
hydroquinone  (ISO)
iron(III) citrate  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
LY294002  (ISO)
molybdate  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitric acid  (ISO)
Nonidet P-40  (ISO)
O-methyleugenol  (ISO)
octanal  (ISO)
oryzalin  (ISO)
oxaliplatin  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perchlorate  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
rac-lactic acid  (ISO)
serpentine asbestos  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulfamic acid  (ISO)
sulfates  (ISO)
sulindac  (ISO)
tributylstannane  (ISO)
Triptolide  (ISO)
tungstate  (ISO)
Tungsten carbide  (ISO)
urethane  (ISO)
vorinostat  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12454846   PMID:12466851   PMID:12477932   PMID:14604546   PMID:14681479   PMID:15385577   PMID:16141072   PMID:16141073  
PMID:16217040   PMID:16245156   PMID:16396925   PMID:16602821   PMID:16719910   PMID:16924128   PMID:17362527   PMID:17418408   PMID:18003750   PMID:19074859   PMID:19564335   PMID:20399150  
PMID:20562862   PMID:20573196   PMID:21179203   PMID:21306648   PMID:21547424   PMID:21677750   PMID:21873635   PMID:23233153   PMID:23441228   PMID:23945394   PMID:24789143   PMID:25623234  
PMID:26152355   PMID:28262664   PMID:28692057   PMID:28748627   PMID:31078621   PMID:31202927   PMID:31777931   PMID:31905844  


Genomics

Comparative Map Data
Car9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,507,026 - 43,513,729 (+)NCBIGRCm39mm39
GRCm39 Ensembl443,506,966 - 43,513,729 (+)Ensembl
GRCm38443,507,026 - 43,513,729 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,506,966 - 43,513,729 (+)EnsemblGRCm38mm10GRCm38
MGSCv37443,519,898 - 43,526,597 (+)NCBIGRCm37mm9NCBIm37
MGSCv36443,528,107 - 43,534,829 (+)NCBImm8
Celera443,540,895 - 43,547,584 (+)NCBICelera
Cytogenetic Map4A5NCBI
CA9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl935,673,918 - 35,681,159 (+)EnsemblGRCh38hg38GRCh38
GRCh38935,673,809 - 35,681,159 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37935,673,925 - 35,681,156 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,663,915 - 35,671,152 (+)NCBINCBI36hg18NCBI36
Build 34935,663,914 - 35,671,152NCBI
Celera935,607,463 - 35,614,702 (+)NCBI
Cytogenetic Map9p13.3NCBI
HuRef935,629,523 - 35,636,764 (+)NCBIHuRef
CHM1_1935,673,743 - 35,680,984 (+)NCBICHM1_1
Ca9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2557,763,234 - 57,769,838 (+)NCBI
Rnor_6.0 Ensembl559,008,933 - 59,015,528 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0559,008,277 - 59,015,535 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0563,533,527 - 63,540,129 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,986,413 - 59,993,015 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1559,986,589 - 59,992,484 (+)NCBI
Celera556,343,808 - 56,350,416 (+)NCBICelera
Cytogenetic Map5q22NCBI
Ca9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955472619,245 - 625,051 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955472619,084 - 625,570 (-)NCBIChiLan1.0ChiLan1.0
CA9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1936,328,205 - 36,335,474 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,328,303 - 36,335,340 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0935,525,877 - 35,533,159 (+)NCBIMhudiblu_PPA_v0panPan3
CA9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,205,619 - 52,211,281 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,205,668 - 52,211,267 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,773,252 - 50,778,851 (+)NCBI
ROS_Cfam_1.01153,270,515 - 53,276,220 (+)NCBI
UMICH_Zoey_3.11151,815,201 - 51,820,803 (+)NCBI
UNSW_CanFamBas_1.01151,798,686 - 51,804,281 (+)NCBI
UU_Cfam_GSD_1.01152,500,820 - 52,506,421 (+)NCBI
Ca9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,124,669 - 167,131,057 (+)NCBI
SpeTri2.0NW_0049365243,672,393 - 3,678,630 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,388,690 - 236,400,822 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,393,727 - 236,400,994 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21264,118,816 - 264,126,024 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CA9
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,921,530 - 44,929,504 (-)NCBI
ChlSab1.1 Ensembl1244,921,665 - 44,928,831 (-)Ensembl
Ca9
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248685,110,602 - 5,131,167 (-)NCBI

Position Markers
Car9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38443,508,734 - 43,509,004UniSTSGRCm38
Celera443,542,613 - 43,542,883UniSTS
Cytogenetic Map4B1UniSTS
cM Map423.05UniSTS
Car9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4B1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse
10401905Sicd3_mseizure-induced cell death 3 (mouse)Not determined4939552543760862Mouse
10401115Pgia35_mproteoglycan induced arthritis 35 (mouse)Not determined41256237746562509Mouse
12880405Jcdq1_mjoint cartilage degeneration QTL 1 (mouse)41256237746562509Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763365441Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117215009Mouse
1301203Alcp8_malcohol preference locus 8 (mouse)Not determined41739516051395290Mouse
1301237Alcp7_malcohol preference locus 7 (mouse)Not determined41739516051395290Mouse
4141555Nbwa2_mNZB and NZW autoimmunity 2 (mouse)Not determined41789251551892635Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261689063979Mouse
1357645Lvrq9_mliver weight QTL 9 (mouse)Not determined41789261689063979Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261689063979Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261689063979Mouse
25440481Moaq1_mmodifier of alien QTL 1 (mouse)41950000046000000Mouse
1300769Pcyts2_mplasmacytoma susceptibility 2 (mouse)Not determined42211194456112145Mouse
1302058Hrtfm3_mheart failure modifier 3 (mouse)Not determined42211194456112145Mouse
1302075Bdln6_mbody length 6 (mouse)Not determined42237344856373612Mouse
1301437Scon1_msucrose consumption 1 (mouse)Not determined42237344856373612Mouse
1301697Sluc18_msusceptibility to lung cancer 18 (mouse)Not determined42237344856373612Mouse
1302184Aaom1_mautoimmune aoritis in MRL mice 1 (mouse)Not determined42432229946332776Mouse
1300574Im2_mimmunoregulatory 2 (mouse)Not determined42807768262077816Mouse
1301586Stheal3_msoft tissue heal 3 (mouse)Not determined42865844262658566Mouse
1357877Synch1_msynechia 1 (mouse)Not determined42870992562710107Mouse
1301990Arvm1_mautoimmune renal vasculitis 1 (mouse)Not determined42933264663332776Mouse
4142290Ssrq9_mstress response QTL 9 (mouse)Not determined3439516046332776Mouse
1301792Hdlq10_mHDL QTL 10 (mouse)Not determined43585970769859853Mouse
1300977Mopkd1_mmodifier of polycystic kidney disease progression 1 (mouse)Not determined43655083970550967Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000129100000Mouse
1302116Bbaa1_mB.burgdorferi-associated arthritis 1 (mouse)Not determined43825093072251078Mouse
10412178Habiir2_mhyperoxic acute lung injury imprinted region 2 (mouse)Not determined43945212663365441Mouse
1301786Bpq3_mblood pressure QTL 3 (mouse)Not determined44240224076402381Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108500000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1015
Count of miRNA genes:571
Interacting mature miRNAs:675
Transcripts:ENSMUST00000030183, ENSMUST00000124114, ENSMUST00000126750, ENSMUST00000128232, ENSMUST00000129996, ENSMUST00000138073, ENSMUST00000154251
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000030183   ⟹   ENSMUSP00000030183
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl443,506,966 - 43,513,729 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124114
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl443,507,024 - 43,513,729 (+)Ensembl
RefSeq Acc Id: ENSMUST00000126750
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl443,508,543 - 43,509,035 (+)Ensembl
RefSeq Acc Id: ENSMUST00000128232
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl443,507,877 - 43,508,974 (+)Ensembl
RefSeq Acc Id: ENSMUST00000129996
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl443,508,937 - 43,512,455 (+)Ensembl
RefSeq Acc Id: ENSMUST00000138073   ⟹   ENSMUSP00000114493
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl443,507,312 - 43,513,058 (+)Ensembl
RefSeq Acc Id: ENSMUST00000154251
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl443,512,132 - 43,512,942 (+)Ensembl
RefSeq Acc Id: NM_139305   ⟹   NP_647466
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39443,507,026 - 43,513,725 (+)NCBI
GRCm38443,507,026 - 43,513,725 (+)NCBI
MGSCv37443,519,898 - 43,526,597 (+)RGD
Celera443,540,895 - 43,547,584 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006537831   ⟹   XP_006537894
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39443,507,956 - 43,513,729 (+)NCBI
GRCm38443,507,956 - 43,513,729 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_647466   ⟸   NM_139305
- Peptide Label: precursor
- UniProtKB: Q8VHB5 (UniProtKB/Swiss-Prot),   Q3UUZ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006537894   ⟸   XM_006537831
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000114493   ⟸   ENSMUST00000138073
RefSeq Acc Id: ENSMUSP00000030183   ⟸   ENSMUST00000030183
Protein Domains
Alpha-carbonic anhydrase

Promoters
RGD ID:6883226
Promoter ID:EPDNEW_M5064
Type:multiple initiation site
Name:Car9_1
Description:Mus musculus carbonic anhydrase 9 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38443,507,026 - 43,507,086EPDNEW
RGD ID:6834998
Promoter ID:MM_KWN:37348
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   ES_Cell,   Kidney,   Lung,   MEF_B4,   Spleen
Transcripts:OTTMUST00000016053,   OTTMUST00000016060
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36443,521,439 - 43,521,939 (+)MPROMDB
RGD ID:6835000
Promoter ID:MM_KWN:37350
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B4,   MEF_B6
Transcripts:OTTMUST00000016061
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36443,524,866 - 43,525,366 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2447188 AgrOrtholog
Ensembl Genes ENSMUSG00000028463 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000030183 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000114493 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000030183 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000138073 UniProtKB/TrEMBL
Gene3D-CATH 3.10.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CA9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:230099 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2447188 ENTREZGENE
NCBI Gene 230099 ENTREZGENE
PANTHER PTHR18952 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18952:SF18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Car9 PhenoGen
PROSITE ALPHA_CA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALPHA_CA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51069 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A1ECK8_MOUSE UniProtKB/TrEMBL
  CAH9_MOUSE UniProtKB/Swiss-Prot
  F6XXU0_MOUSE UniProtKB/TrEMBL
  Q3TLN7_MOUSE UniProtKB/TrEMBL
  Q3UUZ9 ENTREZGENE, UniProtKB/TrEMBL
  Q8VHB5 ENTREZGENE
UniProt Secondary Q8K1G1 UniProtKB/Swiss-Prot
  Q8VDE4 UniProtKB/Swiss-Prot