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Gene: Plcb4 (phospholipase C, beta 4) Mus musculus
Symbol: Plcb4
Name: phospholipase C, beta 4
Description: Predicted to have mitogen-activated protein kinase binding activity and phosphatidylinositol phospholipase C activity. Involved in modulation of chemical synaptic transmission. Localizes to several cellular components, including glutamatergic synapse; parallel fiber to Purkinje cell synapse; and smooth endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PLCB4 (phospholipase C beta 4); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; protein kinase C (PKC) signaling pathway; Alzheimer's disease pathway; INTERACTS WITH (+)-pilocarpine; 1,2-dichloroethane; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4; A930039J07Rik; AI854601; C230058B11Rik
Homo sapiens (human) : PLCB4 (phospholipase C beta 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Plcb4 (phospholipase C, beta 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plcb4 (phospholipase C beta 4)
Pan paniscus (bonobo/pygmy chimpanzee) : PLCB4 (phospholipase C beta 4)
Canis lupus familiaris (dog) : PLCB4 (phospholipase C beta 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plcb4 (phospholipase C beta 4)
Sus scrofa (pig) : PLCB4 (phospholipase C beta 4)
Chlorocebus sabaeus (African green monkey) : PLCB4 (phospholipase C beta 4)
Heterocephalus glaber (naked mole-rat) : Plcb4 (phospholipase C beta 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl2135,659,011 - 136,014,593 (+)EnsemblGRCm38mm10GRCm38
GRCm382135,658,603 - 136,014,602 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372135,567,566 - 135,838,804 (+)NCBIGRCm37mm9NCBIm37
MGSCv362135,433,271 - 135,704,509 (+)NCBImm8
Celera2136,939,191 - 137,211,347 (+)NCBICelera
Cytogenetic Map2F3NCBI
cM Map266.64NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Plcb4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11120
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.