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Gene: Ngef (neuronal guanine nucleotide exchange factor) Mus musculus
Symbol: Ngef
Name: neuronal guanine nucleotide exchange factor
Description: Exhibits ephrin receptor binding activity. Involved in several processes, including ephrin receptor signaling pathway; negative regulation of dendritic spine morphogenesis; and synapse pruning. Localizes to the glutamatergic synapse. Is expressed in several structures, including brain; eye; female reproductive system; forelimb; and liver. Orthologous to human NGEF (neuronal guanine nucleotide exchange factor); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: eph-interacting exchange protein; ephexin; ephexin-1; Tims2; transforming immortalised mammary epithelial sequence 2
Homo sapiens (human) : NGEF (neuronal guanine nucleotide exchange factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ngef (neuronal guanine nucleotide exchange factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ngef (neuronal guanine nucleotide exchange factor)
Pan paniscus (bonobo/pygmy chimpanzee) : NGEF (neuronal guanine nucleotide exchange factor)
Canis lupus familiaris (dog) : NGEF (neuronal guanine nucleotide exchange factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ngef (neuronal guanine nucleotide exchange factor)
Sus scrofa (pig) : NGEF (neuronal guanine nucleotide exchange factor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl187,476,834 - 87,573,870 (-)Ensembl
GRCm38187,476,829 - 87,573,870 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37189,373,404 - 89,470,445 (-)NCBIGRCm37mm9NCBIm37
MGSCv36189,308,005 - 89,341,517 (-)NCBImm8
Celera190,442,498 - 90,539,911 (-)NCBICelera
Cytogenetic Map1 DNCBI
cM Map144.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ngef
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319182
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.