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Gene: Ngef (neuronal guanine nucleotide exchange factor) Mus musculus
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Symbol: Ngef
Name: neuronal guanine nucleotide exchange factor
Description: Exhibits ephrin receptor binding activity. Involved in several processes, including ephrin receptor signaling pathway; negative regulation of dendritic spine morphogenesis; and synapse pruning. Localizes to the glutamatergic synapse. Is expressed in several structures, including brain; eye; female reproductive system; forelimb; and liver. Orthologous to human NGEF (neuronal guanine nucleotide exchange factor); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: eph-interacting exchange protein; ephexin; ephexin-1; Tims2; transforming immortalised mammary epithelial sequence 2
Orthologs:
Homo sapiens (human) : NGEF (neuronal guanine nucleotide exchange factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ngef (neuronal guanine nucleotide exchange factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ngef (neuronal guanine nucleotide exchange factor)
Pan paniscus (bonobo/pygmy chimpanzee) : NGEF (neuronal guanine nucleotide exchange factor)
Canis lupus familiaris (dog) : NGEF (neuronal guanine nucleotide exchange factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ngef (neuronal guanine nucleotide exchange factor)
Sus scrofa (pig) : NGEF (neuronal guanine nucleotide exchange factor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl187,476,834 - 87,573,870 (-)Ensembl
GRCm38187,476,829 - 87,573,870 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37189,373,404 - 89,470,445 (-)NCBIGRCm37mm9NCBIm37
MGSCv36189,308,005 - 89,341,517 (-)NCBImm8
Celera190,442,498 - 90,539,911 (-)NCBICelera
Cytogenetic Map1 DNCBI
cM Map144.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ngef
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319182
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.