Gsta1 (glutathione S-transferase, alpha 1 (Ya)) - Rat Genome Database

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Gene: Gsta1 (glutathione S-transferase, alpha 1 (Ya)) Mus musculus
Analyze
Symbol: Gsta1
Name: glutathione S-transferase, alpha 1 (Ya)
RGD ID: 1620118
MGI Page MGI
Description: Predicted to enable several functions, including anion binding activity; glutathione peroxidase activity; and glutathione transferase activity. Acts upstream of or within response to bacterium and response to stilbenoid. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; central nervous system; heart; skeleton; and urinary system. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3); PARTICIPATES IN glutathione conjugation pathway; glutathione metabolic pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,4-dioxane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 13-hydroperoxyoctadecadienoate peroxidase; androst-5-ene-3,17-dione isomerase; glutathione S-transferase A1; glutathione S-transferase Ya; glutathione S-transferase Ya1; GST class-alpha member 1; Gst2-; Gst2-1
RGD Orthologs
Human
Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39978,137,951 - 78,149,965 (+)NCBIGRCm39mm39
GRCm39 Ensembl978,137,938 - 78,149,966 (+)Ensembl
GRCm38978,230,669 - 78,242,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl978,230,656 - 78,242,684 (+)EnsemblGRCm38mm10GRCm38
MGSCv37978,078,476 - 78,090,490 (+)NCBIGRCm37mm9NCBIm37
MGSCv36978,016,370 - 78,028,355 (+)NCBImm8
Celera975,462,780 - 75,478,144 (+)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
asthma  (ISO)
hypertension  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-dioxane  (EXP)
1-Cyano-2-hydroxy-3-butene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-imidazole  (ISO)
1H-pyrazole  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetamidofluorene  (EXP)
2-nitrofluorene  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (EXP)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-bromo-2'-deoxyuridine  (EXP)
5-Hydroxythalidomide  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
aflatoxin B1 exo-8,9-epoxide  (ISO)
allopurinol  (EXP)
alpha-hexachlorocyclohexane  (ISO)
aminoguanidine  (EXP)
angelica lactone  (EXP)
anthracen-2-amine  (ISO)
antimycin A  (EXP)
arsenite(3-)  (EXP)
Azaspiracid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzoquinones  (EXP)
benzotriazole  (ISO)
benzyl isothiocyanate  (ISO)
benzylideneacetone  (EXP)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (ISO)
bifenthrin  (EXP)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
cafestol  (EXP,ISO)
captan  (EXP)
carbon nanotube  (EXP)
cefaloridine  (ISO)
chlorambucil  (ISO)
chlordecone  (EXP)
chlorogenic acid  (EXP)
chlorohydrocarbon  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP,ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyanocob(III)alamin  (EXP)
cycloheximide  (EXP)
cypermethrin  (EXP)
cyproconazole  (ISO)
decabromodiphenyl ether  (ISO)
Deoxycorticosterone acetate  (ISO)
dexamethasone  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diazinon  (ISO)
dichloroacetic acid  (EXP)
diclofenac  (ISO)
dieldrin  (ISO)
diethyl malate  (EXP)
diethyl maleate  (ISO)
dimercaprol  (EXP)
diuron  (ISO)
doramapimod  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
ethoxyquin  (EXP,ISO)
etofenprox  (ISO)
fenofibrate  (ISO)
fipronil  (ISO)
folic acid  (EXP)
folpet  (EXP)
furan  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP)
glutathione  (ISO)
glycine betaine  (EXP)
GW 4064  (EXP)
hydrogen peroxide  (EXP,ISO)
indole-3-methanol  (EXP,ISO)
indometacin  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
isopimpinellin  (EXP)
isothiocyanate  (EXP)
kahweol  (ISO)
L-ascorbic acid  (EXP)
L-cysteine  (ISO)
L-methionine  (EXP,ISO)
L-selenocysteine  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
lipopolysaccharide  (EXP)
Meclizine  (EXP)
melatonin  (ISO)
melphalan  (ISO)
menadione  (EXP,ISO)
mercury atom  (EXP)
mercury dichloride  (EXP)
mercury(0)  (EXP)
metacetamol  (EXP)
methapyrilene  (ISO)
methyl methacrylate  (EXP)
methylglyoxal  (ISO)
methylmercury chloride  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
ochratoxin A  (ISO)
oltipraz  (EXP,ISO)
omeprazole  (ISO)
oxfendazole  (ISO)
oxybenzone  (ISO)
oxycodone  (ISO)
ozone  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (EXP)
phlorizin  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
potassium bromate  (EXP)
potassium chloride  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (ISO)
propanal  (ISO)
propiconazole  (ISO)
Propiverine  (ISO)
pyrazinecarboxamide  (ISO)
pyrogallol  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sinigrin  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
spermidine  (EXP)
stilbene oxide  (ISO)
streptozocin  (ISO)
succimer  (EXP)
sulfasalazine  (EXP,ISO)
sulforaphane  (EXP)
taurine  (EXP)
tauroursodeoxycholic acid  (ISO)
tert-butyl ethyl ether  (ISO)
tetrachloromethane  (EXP,ISO)
thiazoles  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
triadimefon  (ISO)
triazines  (EXP)
triazoles  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP,ISO)
trimethylarsine oxide  (EXP)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (EXP)
tris(2-chloroethyl) phosphate  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1427837   PMID:1526290   PMID:1685137   PMID:1981995   PMID:2049074   PMID:2572508   PMID:2893339   PMID:3652905   PMID:6330685   PMID:8297798   PMID:8584275   PMID:8649810  
PMID:8884266   PMID:9441664   PMID:9606968   PMID:11851347   PMID:12020353   PMID:12466851   PMID:12477932   PMID:12557262   PMID:14610273   PMID:14672804   PMID:14681479   PMID:16141072  
PMID:16243960   PMID:16284450   PMID:16786188   PMID:17086191   PMID:19029078   PMID:21873635   PMID:22496890   PMID:23012479   PMID:23647087   PMID:24964013   PMID:27198676   PMID:32325033  


Genomics

Comparative Map Data
Gsta1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39978,137,951 - 78,149,965 (+)NCBIGRCm39mm39
GRCm39 Ensembl978,137,938 - 78,149,966 (+)Ensembl
GRCm38978,230,669 - 78,242,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl978,230,656 - 78,242,684 (+)EnsemblGRCm38mm10GRCm38
MGSCv37978,078,476 - 78,090,490 (+)NCBIGRCm37mm9NCBIm37
MGSCv36978,016,370 - 78,028,355 (+)NCBImm8
Celera975,462,780 - 75,478,144 (+)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.65NCBI
GSTA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl652,831,655 - 52,840,843 (-)EnsemblGRCh38hg38GRCh38
GRCh38652,831,692 - 52,846,245 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37652,696,540 - 52,710,893 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,804,499 - 52,818,852 (-)NCBINCBI36hg18NCBI36
Build 34652,804,498 - 52,818,852NCBI
Celera654,358,301 - 54,372,656 (-)NCBI
Cytogenetic Map6p12.2NCBI
HuRef652,527,978 - 52,542,334 (-)NCBIHuRef
CHM1_1652,698,651 - 52,713,008 (-)NCBICHM1_1
Gsta5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2879,105,561 - 79,117,472 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl879,105,661 - 79,117,472 (+)Ensembl
Rnor_6.0885,553,659 - 85,564,914 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl885,553,734 - 85,565,179 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0885,111,369 - 85,122,622 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4883,202,554 - 83,211,997 (+)NCBIRGSC3.4rn4RGSC3.4
Celera878,852,562 - 78,862,243 (+)NCBICelera
Cytogenetic Map8q31NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94452089278520980Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94892377482923895Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94892377482923895Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse
14746993Manh66_mmandible shape 66 (mouse)94990676683906766Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95024403884244166Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95212317899910428Mouse
12790990Tgl7_mtriglyceride 7 (mouse)95465267888652678Mouse
10043877Adip21_madiposity 21 (mouse)Not determined95653182690531973Mouse
4141676Neogq1_mneonatal growth QTL 1 (mouse)Not determined95789776486239920Mouse
1301172Fembrs6_mfemur breaking strength 6 (mouse)Not determined95911710593117252Mouse
1301803Stheal9_msoft tissue heal 9 (mouse)Not determined95911710593117252Mouse
5491195Mobq8_mmultigenic obesity QTL 8 (mouse)Not determined95946266493462846Mouse
1300848Skull13_mskull morphology 13 (mouse)Not determined95946266493462846Mouse
1301456Adip5_madiposity 5 (mouse)Not determined95946266493462846Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
1301611Lrnx3_mlearning contextual 3 (mouse)Not determined96224248596242599Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
11081165Psl6_mpromotion susceptibility QTL 6 (mouse)96513390995640755Mouse
1301290Smgd1_msubmucosal gland distribution 1 (mouse)Not determined96592377486695914Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966207024100207122Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967124167101124167Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968897510102897652Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968897510102897652Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969239845103239920Mouse
10412174Habiir4_mhyperoxic acute lung injury imprinted region 4 (mouse)Not determined96936046598819654Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969546513103546645Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1301914Ksc1_mkeratinocyte stem cell locus 1 (mouse)Not determined97550175580091050Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976117105101528921Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:158
Count of miRNA genes:121
Interacting mature miRNAs:124
Transcripts:ENSMUST00000098537, ENSMUST00000127192
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000098537   ⟹   ENSMUSP00000096139
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl978,137,938 - 78,149,966 (+)Ensembl
GRCm38.p6 Ensembl978,230,656 - 78,242,684 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127192
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl978,142,285 - 78,149,877 (+)Ensembl
GRCm38.p6 Ensembl978,235,003 - 78,242,595 (+)Ensembl
RefSeq Acc Id: NM_008181   ⟹   NP_032207
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39978,137,951 - 78,149,965 (+)NCBI
GRCm38978,230,669 - 78,242,683 (+)ENTREZGENE
MGSCv37978,078,476 - 78,090,490 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032207 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI32573 (Get FASTA)   NCBI Sequence Viewer  
  AAI32577 (Get FASTA)   NCBI Sequence Viewer  
  P13745 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_032207   ⟸   NM_008181
- UniProtKB: P13745 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000096139   ⟸   ENSMUST00000098537
Protein Domains
GST C-terminal   GST N-terminal

Promoters
RGD ID:8670258
Promoter ID:EPDNEW_M13160
Type:initiation region
Name:Gm3776_1
Description:Mus musculus predicted gene 3776 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38978,230,689 - 78,230,749EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1095417 AgrOrtholog
Ensembl Genes ENSMUSG00000074183 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000096139 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000098537 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot
  GST_alpha UniProtKB/Swiss-Prot
  GST_C UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report mmu:14857 UniProtKB/Swiss-Prot
MGD MGI:1095417 ENTREZGENE
NCBI Gene 14857 ENTREZGENE
Pfam GST_C UniProtKB/Swiss-Prot
  GST_N UniProtKB/Swiss-Prot
PhenoGen Gsta1 PhenoGen
PRINTS GSTRNSFRASEA UniProtKB/Swiss-Prot
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
UniProt GSTA1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2RTN4 UniProtKB/Swiss-Prot