Get3 (guided entry of tail-anchored proteins factor 3, ATPase) - Rat Genome Database
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Gene: Get3 (guided entry of tail-anchored proteins factor 3, ATPase) Mus musculus
Analyze
Symbol: Get3
Name: guided entry of tail-anchored proteins factor 3, ATPase
RGD ID: 1620065
MGI Page MGI
Description: Predicted to have ATPase activity. Predicted to be involved in posttranslational protein targeting to endoplasmic reticulum membrane and tail-anchored membrane protein insertion into ER membrane. Predicted to localize to GET complex; nucleolus; and nucleoplasm. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and vibrissa. Orthologous to human GET3 (guided entry of tail-anchored proteins factor 3, ATPase); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1810048H22Rik; A; ArsA; arsA arsenite transporter, ATP-binding, homolog 1 (bacterial); arsenical pump-driving ATPase; arsenite-stimulated ATPase; arsenite-translocating ATPase; Asna1; ATPase Asna1; ATPase GET3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,744,558 - 85,751,916 (-)NCBIGRCm39mm39
GRCm38885,017,929 - 85,025,287 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl885,017,931 - 85,025,281 (-)EnsemblGRCm38mm10GRCm38
MGSCv37887,541,830 - 87,549,177 (-)NCBIGRCm37mm9NCBIm37
MGSCv36887,908,036 - 87,915,383 (-)NCBImm8
Celera889,312,886 - 89,320,055 (-)NCBICelera
Cytogenetic Map8C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11239426   PMID:11470536   PMID:12466851   PMID:12477932   PMID:14610273   PMID:14651920   PMID:15188402   PMID:15489334  
PMID:15782199   PMID:16141072   PMID:16141073   PMID:16797549   PMID:17967808   PMID:18477612   PMID:18799693   PMID:21267068   PMID:21873635   PMID:24457600   PMID:24885147   PMID:26438609  
PMID:26496610   PMID:27458190   PMID:29180572   PMID:30595499   PMID:32325033   PMID:32968282  


Genomics

Comparative Map Data
Get3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,744,558 - 85,751,916 (-)NCBIGRCm39mm39
GRCm38885,017,929 - 85,025,287 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl885,017,931 - 85,025,281 (-)EnsemblGRCm38mm10GRCm38
MGSCv37887,541,830 - 87,549,177 (-)NCBIGRCm37mm9NCBIm37
MGSCv36887,908,036 - 87,915,383 (-)NCBImm8
Celera889,312,886 - 89,320,055 (-)NCBICelera
Cytogenetic Map8C3NCBI
GET3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1912,737,139 - 12,748,323 (+)EnsemblGRCh38hg38GRCh38
GRCh381912,737,106 - 12,748,323 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371912,848,306 - 12,859,137 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,709,306 - 12,720,137 (+)NCBINCBI36hg18NCBI36
Build 341912,709,305 - 12,720,137NCBI
Celera1912,738,017 - 12,748,848 (+)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,421,428 - 12,432,073 (+)NCBIHuRef
CHM1_11912,848,768 - 12,859,600 (+)NCBICHM1_1
Get3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01926,133,024 - 26,142,637 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1926,133,027 - 26,141,111 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01937,108,647 - 37,116,734 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,786,390 - 24,794,477 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11924,791,225 - 24,799,303 (+)NCBI
Celera1922,688,066 - 22,696,153 (+)NCBICelera
Cytogenetic Map19q11NCBI
Get3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,836,294 - 31,843,104 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,836,294 - 31,843,046 (+)NCBIChiLan1.0ChiLan1.0
GET3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11913,045,570 - 13,055,908 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,045,570 - 13,055,908 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01912,299,706 - 12,310,923 (+)NCBIMhudiblu_PPA_v0panPan3
GET3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2049,392,662 - 49,398,664 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12049,392,662 - 49,398,662 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Get3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366591,851,953 - 1,858,176 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GET3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,249,566 - 66,260,954 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,251,381 - 66,261,135 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,632,155 - 66,641,634 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GET3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl611,426,787 - 11,437,119 (+)Ensembl
ChlSab1.1611,426,857 - 11,437,343 (+)NCBI
Get3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624901361,364 - 368,249 (+)NCBI

Position Markers
RH129284  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38885,017,946 - 85,018,103UniSTSGRCm38
MGSCv37887,541,845 - 87,542,002UniSTSGRCm37
Celera889,312,901 - 89,313,058UniSTS
Cytogenetic Map8C3-D1UniSTS
UniSTS:235944  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38885,020,690 - 85,020,915UniSTSGRCm38
MGSCv37887,544,589 - 87,544,814UniSTSGRCm37
Celera889,315,639 - 89,315,864UniSTS
Cytogenetic Map8C3-D1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse
1301766Desp1_mdespair 1 (mouse)Not determined884759576118759741Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:286
Count of miRNA genes:238
Interacting mature miRNAs:261
Transcripts:ENSMUST00000064314
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001357202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001357203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC163703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF039405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF061177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK007827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY230823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY631769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000064314   ⟹   ENSMUSP00000065337
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl885,017,931 - 85,025,281 (-)Ensembl
RefSeq Acc Id: ENSMUST00000209834   ⟹   ENSMUSP00000147483
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl885,018,810 - 85,025,266 (-)Ensembl
RefSeq Acc Id: ENSMUST00000211221
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl885,024,623 - 85,025,263 (-)Ensembl
RefSeq Acc Id: ENSMUST00000211702
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl885,019,848 - 85,024,868 (-)Ensembl
RefSeq Acc Id: NM_001357202   ⟹   NP_001344131
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39885,744,558 - 85,751,916 (-)NCBI
GRCm38885,017,929 - 85,025,287 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001357203   ⟹   NP_001344132
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39885,744,558 - 85,751,916 (-)NCBI
GRCm38885,017,929 - 85,025,287 (-)NCBI
Sequence:
RefSeq Acc Id: NM_019652   ⟹   NP_062626
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39885,744,558 - 85,751,916 (-)NCBI
GRCm38885,017,929 - 85,025,287 (-)NCBI
MGSCv37887,541,830 - 87,549,177 (-)RGD
Celera889,312,886 - 89,320,055 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062626   ⟸   NM_019652
- Peptide Label: isoform 1
- UniProtKB: O54984 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001344132   ⟸   NM_001357203
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001344131   ⟸   NM_001357202
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000065337   ⟸   ENSMUST00000064314
RefSeq Acc Id: ENSMUSP00000147483   ⟸   ENSMUST00000209834
Protein Domains
ArsA_ATPase

Promoters
RGD ID:8667801
Promoter ID:EPDNEW_M11896
Type:multiple initiation site
Name:Asna1_1
Description:Mus musculus arsA arsenite transporter, ATP-binding, homolog1 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38885,025,279 - 85,025,339EPDNEW
RGD ID:6842802
Promoter ID:MM_KWN:55127
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000064314
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36887,549,006 - 87,549,687 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1928379 AgrOrtholog
Ensembl Genes ENSMUSG00000052456 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000065337 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000147483 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000064314 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000209834 UniProtKB/TrEMBL
InterPro Anion-transp_ATPase-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_ArsA/GET3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_ArsA/GET3_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56495 UniProtKB/Swiss-Prot
MGD MGI:1928379 ENTREZGENE
NCBI Gene 56495 ENTREZGENE
PANTHER PTHR10803 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10803:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ArsA_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Get3 PhenoGen
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs GET3_arsA_TRC40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.41475 ENTREZGENE
UniProt A0A1B0GRE1_MOUSE UniProtKB/TrEMBL
  ASNA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8C1Q1_MOUSE UniProtKB/TrEMBL
  Q8VEI6_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TAQ4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-04-07 Get3  guided entry of tail-anchored proteins factor 3, ATPase  Asna1  arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)  Symbol and/or name change 5135510 APPROVED