Plekhh1 (pleckstrin homology domain containing, family H (with MyTH4 domain) member 1) - Rat Genome Database

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Gene: Plekhh1 (pleckstrin homology domain containing, family H (with MyTH4 domain) member 1) Mus musculus
Analyze
Symbol: Plekhh1
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
RGD ID: 408345569
MGI Page MGI
Description: Predicted to be located in cytoskeleton. Is expressed in genitourinary system. Orthologous to human PLEKHH1 (pleckstrin homology, MyTH4 and FERM domain containing H1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: D630024D12Rik; mKIAA1200; PH domain-containing family H member 1; pleckstrin homology domain-containing family H member 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391279,075,937 - 79,128,429 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1279,075,937 - 79,128,429 (+)EnsemblGRCm39 Ensembl
GRCm381279,029,163 - 79,081,655 (+)NCBIGRCm38GRCm38mm10GRCm38
Cytogenetic Map12C3NCBI
cM Map1235.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Plekhh1MouseLeber congenital amaurosis 13  ISOPLEKHH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Leber congenital amaurosis 13ClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Plekhh1MouseExperimental Liver Cirrhosis  ISOPLEKHH1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Plekhh1Mouse1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of PLEKHH1 mRNACTDPMID:22206623
Plekhh1Mouse1,2-dimethylhydrazine multiple interactionsEXP 6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of PLEKHH1 mRNA]CTDPMID:22206623
Plekhh1Mouse1-naphthyl isothiocyanate increases expressionISOPlekhh1 (Rattus norvegicus)64804641-Naphthylisothiocyanate results in increased expression of PLEKHH1 mRNACTDPMID:25380136
Plekhh1Mouse17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of PLEKHH1 mRNACTDPMID:19484750 and PMID:39298647
Plekhh1Mouse17beta-estradiol multiple interactionsISOPlekhh1 (Rattus norvegicus)6480464[bisphenol A co-treated with Estradiol] results in increased expression of PLEKHH1 mRNACTDPMID:26496021
Plekhh1Mouse17beta-estradiol increases expressionISOPLEKHH1 (Homo sapiens)6480464Estradiol results in increased expression of PLEKHH1 mRNACTDPMID:31614463
Plekhh1Mouse2,2',4,4'-Tetrabromodiphenyl ether affects expressionEXP 64804642 more ...CTDPMID:24680724
Plekhh1Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of PLEKHH1 mRNACTDPMID:26377647
Plekhh1Mouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISOPlekhh1 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in increased expression of PLEKHH1 mRNACTDPMID:33387578
Plekhh1Mouse2-methoxyethanol increases expressionISOPlekhh1 (Rattus norvegicus)6480464methyl cellosolve results in increased expression of PLEKHH1 mRNACTDPMID:21061450
Plekhh1Mouse4,4'-diaminodiphenylmethane increases expressionISOPlekhh1 (Rattus norvegicus)64804644 and 4'-diaminodiphenylmethane results in increased expression of PLEKHH1 mRNACTDPMID:25380136
Plekhh1Mouse4-hydroxyphenyl retinamide increases expressionEXP 6480464Fenretinide results in increased expression of PLEKHH1 mRNACTDPMID:28973697
Plekhh1Mouse6-propyl-2-thiouracil decreases expressionISOPlekhh1 (Rattus norvegicus)6480464Propylthiouracil results in decreased expression of PLEKHH1 mRNACTDPMID:24780913
Plekhh1Mouseacrylamide decreases expressionISOPLEKHH1 (Homo sapiens)6480464Acrylamide results in decreased expression of PLEKHH1 mRNACTDPMID:32763439
Plekhh1Mouseacrylamide decreases expressionISOPlekhh1 (Rattus norvegicus)6480464Acrylamide results in decreased expression of PLEKHH1 mRNACTDPMID:28959563
Plekhh1Mouseaflatoxin B1 increases expressionEXP 6480464Aflatoxin B1 results in increased expression of PLEKHH1 mRNACTDPMID:19770486
Plekhh1Mouseall-trans-retinoic acid decreases expressionISOPLEKHH1 (Homo sapiens)6480464Tretinoin results in decreased expression of PLEKHH1 mRNACTDPMID:33167477
Plekhh1Mouseall-trans-retinoic acid increases expressionISOPLEKHH1 (Homo sapiens)6480464Tretinoin results in increased expression of PLEKHH1 mRNACTDPMID:21934132
Plekhh1Mousearistolochic acid A decreases expressionISOPLEKHH1 (Homo sapiens)6480464aristolochic acid I results in decreased expression of PLEKHH1 mRNACTDPMID:33212167
Plekhh1Mousearsane multiple interactionsISOPLEKHH1 (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of PLEKHH1 mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of PLEKHH1 mRNACTDPMID:39836092

1 to 20 of 77 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Plekhh1Mousebiological_process involved_inND 2290270 MGIGO_REF:0000015

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Plekhh1Mousecytoskeleton located_inIEAInterPro:IPR000299 and InterPro:IPR0008572290270 InterProGO_REF:0000002

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Plekhh1Mousemolecular_function enablesND 2290270 MGIGO_REF:0000015

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Plekhh1Mouseincreased circulating lipase level  IEA 5509061 MGI 
PMID:7671812   PMID:8889548   PMID:10349636   PMID:10725249   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12693553   PMID:14610273   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:17967808   PMID:18287559   PMID:18799693   PMID:21267068   PMID:25921334   PMID:38355793   PMID:39366945  



Plekhh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391279,075,937 - 79,128,429 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1279,075,937 - 79,128,429 (+)EnsemblGRCm39 Ensembl
GRCm381279,029,163 - 79,081,655 (+)NCBIGRCm38GRCm38mm10GRCm38
Cytogenetic Map12C3NCBI
cM Map1235.51NCBI
PLEKHH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381467,533,290 - 67,589,612 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1467,533,290 - 67,589,612 (+)EnsemblGRCh38hg38GRCh38
GRCh371468,000,007 - 68,056,329 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361467,069,761 - 67,126,008 (+)NCBINCBI36Build 36hg18NCBI36
Celera1448,059,079 - 48,115,320 (+)NCBICelera
Cytogenetic Map14q24.1NCBI
HuRef1448,169,751 - 48,225,996 (+)NCBIHuRef
CHM1_11467,938,650 - 67,994,902 (+)NCBICHM1_1
T2T-CHM13v2.01461,740,406 - 61,796,732 (+)NCBIT2T-CHM13v2.0
Plekhh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86103,572,304 - 103,621,729 (+)NCBIGRCr8
mRatBN7.2697,839,288 - 97,888,712 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl697,839,288 - 97,888,709 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx698,268,836 - 98,318,136 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0698,567,990 - 98,617,288 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0697,954,925 - 98,003,962 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06102,215,424 - 102,264,345 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6102,215,603 - 102,262,417 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06111,585,028 - 111,633,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46101,664,129 - 101,714,245 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16101,621,814 - 101,743,779 (+)NCBI
Celera696,226,252 - 96,275,106 (+)NCBICelera
Cytogenetic Map6q24NCBI
Plekhh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554662,618,585 - 2,653,771 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554662,616,627 - 2,653,804 (-)NCBIChiLan1.0ChiLan1.0
PLEKHH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21568,641,414 - 68,697,820 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11467,857,929 - 67,914,332 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01448,111,017 - 48,167,541 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11466,989,464 - 67,045,677 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1466,989,471 - 67,045,677 (+)Ensemblpanpan1.1panPan2
PLEKHH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1841,508,866 - 41,560,054 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl841,508,740 - 41,559,932 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha841,201,689 - 41,253,144 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0841,737,162 - 41,788,663 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl841,744,542 - 41,785,651 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1841,355,953 - 41,407,440 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0841,429,613 - 41,481,066 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0841,789,019 - 41,840,536 (+)NCBIUU_Cfam_GSD_1.0
Plekhh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864063,220,352 - 63,270,563 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649510,929,656 - 10,969,350 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649510,921,136 - 10,971,349 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12444,781,699 - 44,835,802 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2444,790,362 - 44,835,351 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605333,011,773 - 33,067,736 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plekhh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473433,413,087 - 33,449,932 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473433,411,271 - 33,456,003 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Plekhh1
1480 total Variants

1 to 10 of 25 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
14746976Manh73_mmandible shape 73 (mouse)126585713199857131Mouse
27226776Tibl6_mtibia length 6, 5 week (mouse)126064678692666774Mouse
1301337Cdcs8_mcytokine deficiency colitis susceptibility 8 (mouse)Not determined126468908398689229Mouse
1300633Cdcs7_mcytokine deficiency colitis susceptibility 7 (mouse)Not determined126468908398689229Mouse
27226771Tibl14_mtibia length 14, 10 week (mouse)126834677498766259Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
12832727Ahrq1_mairway hyperresponsiveness QTL 1 (mouse)125469591082665939Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse

1 to 10 of 25 rows






Ensembl Acc Id: ENSMUST00000039928   ⟹   ENSMUSP00000049460
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1279,075,937 - 79,128,429 (+)Ensembl
Ensembl Acc Id: ENSMUST00000217954   ⟹   ENSMUSP00000151944
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1279,076,468 - 79,097,080 (+)Ensembl
Ensembl Acc Id: ENSMUST00000219946
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1279,114,383 - 79,128,422 (+)Ensembl
Ensembl Acc Id: ENSMUST00000219956   ⟹   ENSMUSP00000151747
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1279,082,410 - 79,127,403 (+)Ensembl
RefSeq Acc Id: NM_181073   ⟹   NP_851418
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391279,075,937 - 79,128,429 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006515646   ⟹   XP_006515709
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391279,075,943 - 79,128,423 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036157303   ⟹   XP_036013196
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391279,082,415 - 79,128,423 (+)NCBI
Sequence:
RefSeq Acc Id: NP_851418   ⟸   NM_181073
- UniProtKB: Q99JL2 (UniProtKB/Swiss-Prot),   Q8K334 (UniProtKB/Swiss-Prot),   Q8BWF3 (UniProtKB/Swiss-Prot),   Q80TI1 (UniProtKB/Swiss-Prot),   Q3UPN4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006515709   ⟸   XM_006515646
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_036013196   ⟸   XM_036157303
- Peptide Label: isoform X1
- UniProtKB: Q99JL2 (UniProtKB/Swiss-Prot),   Q8K334 (UniProtKB/Swiss-Prot),   Q8BWF3 (UniProtKB/Swiss-Prot),   Q80TI1 (UniProtKB/Swiss-Prot),   Q3UPN4 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000151747   ⟸   ENSMUST00000219956
Ensembl Acc Id: ENSMUSP00000049460   ⟸   ENSMUST00000039928
FERM   MyTH4   PH

RGD ID:8678634
Promoter ID:EPDNEW_M17347
Type:initiation region
Name:Plekhh1_1
Description:Mus musculus pleckstrin homology domain containing, family Hmember 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381279,029,175 - 79,029,235EPDNEW


1 to 40 of 47 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000060716 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000039928 ENTREZGENE
  ENSMUST00000039928.7 UniProtKB/Swiss-Prot
  ENSMUST00000219956 ENTREZGENE
  ENSMUST00000219956.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.80.10 UniProtKB/Swiss-Prot
  MyTH4 domain UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
  Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) UniProtKB/Swiss-Prot
InterPro Band_41_domain UniProtKB/Swiss-Prot
  FERM/acyl-CoA-bd_prot_sf UniProtKB/Swiss-Prot
  FERM_2 UniProtKB/Swiss-Prot
  FERM_central UniProtKB/Swiss-Prot
  FERM_domain UniProtKB/Swiss-Prot
  MyTH4_dom UniProtKB/Swiss-Prot
  MyTH4_dom_sf UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
KEGG Report mmu:211945 UniProtKB/Swiss-Prot
MGD MGI:2144989 ENTREZGENE
NCBI Gene Plekhh1 ENTREZGENE
PANTHER PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 1 UniProtKB/Swiss-Prot
  PLEKHH PROTEIN UniProtKB/Swiss-Prot
Pfam FERM_M UniProtKB/Swiss-Prot
  MyTH4 UniProtKB/Swiss-Prot
  PF00169 UniProtKB/Swiss-Prot
  RA_2 UniProtKB/Swiss-Prot
PhenoGen Plekhh1 PhenoGen
PROSITE FERM_3 UniProtKB/Swiss-Prot
  MYTH4 UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
SMART B41 UniProtKB/Swiss-Prot
  MyTH4 UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  Second domain of FERM UniProtKB/Swiss-Prot
UniProt A0A1W2P874_MOUSE UniProtKB/TrEMBL
  PKHH1_MOUSE UniProtKB/Swiss-Prot
  Q3UPN4 ENTREZGENE
  Q80TI1 ENTREZGENE
1 to 40 of 47 rows