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Gene: Hand1 (heart and neural crest derivatives expressed 1) Mus musculus
Symbol: Hand1
Name: heart and neural crest derivatives expressed 1
Description: Exhibits several functions, including bHLH transcription factor binding activity; protein dimerization activity; and transcription coactivator activity. Predicted to contribute to transcription regulatory region DNA binding activity. Involved in several processes, including animal organ development; mesoderm formation; and regulation of transcription, DNA-templated. Localizes to the nucleolus and nucleoplasm. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; heart and pericardium; and nervous system. Orthologous to human HAND1 (heart and neural crest derivatives expressed 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alcohol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: bHLHa27; eHAND; Ehand1; extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; heart and neural crest derivatives expressed transcript 1; heart- and neural crest derivatives-expressed protein 1; helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast; Hxt; Th1; thing-1; Thing1
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381157,828,713 - 57,832,147 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371157,642,215 - 57,645,649 (-)NCBIGRCm37mm9NCBIm37
MGSCv361157,644,908 - 57,648,342 (-)NCBImm8
Celera1162,581,753 - 62,585,188 (-)NCBICelera
Cytogenetic Map11 B1.3NCBI
cM Map1135.27NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Hand1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737011
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.