Phex (phosphate regulating endopeptidase homolog, X-linked) - Rat Genome Database

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Gene: Phex (phosphate regulating endopeptidase homolog, X-linked) Mus musculus
Analyze
Symbol: Phex
Name: phosphate regulating endopeptidase homolog, X-linked
RGD ID: 11097
MGI Page MGI
Description: Predicted to enable metalloendopeptidase activity. Acts upstream of or within bone mineralization; odontogenesis; and organophosphate metabolic process. Located in Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Is expressed in several structures, including chondrocranium; epidermis; limb; liver; and tooth. Used to study X-linked dominant hypophosphatemic rickets and otitis media. Human ortholog(s) of this gene implicated in X-linked dominant hypophosphatemic rickets. Orthologous to human PHEX (phosphate regulating endopeptidase homolog X-linked); INTERACTS WITH (2E,4E)-hexa-2,4-dienoic acid; 1,4-dioxane; 17beta-hydroxy-5alpha-androstan-3-one.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Gy; HPD; HPDR; HPDR1; Hyp; metalloendopeptidase homolog; metalloendopeptidase homolog PEX; Metalloendopeptidase homolog PEX (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein); PEX; phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets); phosphate regulating neutral endopeptidase; phosphate-regulating neutral endopeptidase PHEX; vitamin D-resistant hypophosphatemic rickets protein; X-linked hypophosphatemia protein; X-linked phosphate regulating endopeptidase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X155,945,071 - 156,198,282 (-)NCBIGRCm39mm39
GRCm39 EnsemblX155,945,071 - 156,198,308 (-)Ensembl
GRCm38X157,162,075 - 157,415,286 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX157,162,075 - 157,415,312 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X153,596,618 - 153,853,218 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X152,502,794 - 152,759,383 (-)NCBImm8
CeleraX140,419,752 - 140,667,816 (-)NCBICelera
Cytogenetic MapXF4NCBI
cM MapX72.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(2E,4E)-hexa-2,4-dienoic acid  (EXP)
1,4-dioxane  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-diaminotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
3-methylcholanthrene  (EXP)
7,12-dimethyltetraphene  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
aflatoxin M1  (ISO)
alachlor  (ISO)
all-trans-retinoic acid  (EXP)
aluminium oxide  (ISO)
ammonium chloride  (ISO)
anthracene-1,8,9-triol  (EXP)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (EXP,ISO)
biphenyl-2-ol  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (EXP)
cadmium dichloride  (EXP)
caffeine  (EXP)
calcitriol  (EXP,ISO)
carbon nanotube  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
DDT  (ISO)
dextran sulfate  (EXP)
dibutyl phthalate  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (EXP)
erythrosin B  (EXP)
fenvalerate  (ISO)
glycerol 2-phosphate  (ISO)
iron dichloride  (EXP)
iron trichloride  (EXP)
levamisole  (ISO)
Mezerein  (EXP)
nitrofen  (ISO)
oxaliplatin  (ISO)
paraquat  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
phosphonoformic acid  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP)
propionic acid  (EXP)
saccharin  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
styrene oxide  (EXP)
thyroxine  (EXP)
tin(II) chloride (anhydrous)  (EXP)
topotecan  (ISO)
tributylstannane  (EXP)
XL147  (EXP)
zinc dichloride  (EXP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal acetabulum morphology  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone structure  (IAGP)
abnormal caudal vertebrae morphology  (IAGP)
abnormal chondrocyte physiology  (IAGP)
abnormal circulating calcium level  (IAGP)
abnormal circulating phosphate level  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal costochondral joint morphology  (IAGP)
abnormal cranial suture morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal femur morphology  (IAGP)
abnormal fibrocartilage morphology  (IAGP)
abnormal gait  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal inner ear morphology  (IAGP)
abnormal intestinal absorption  (IAGP)
abnormal joint morphology  (IAGP)
abnormal limb bone morphology  (IAGP)
abnormal limb long bone morphology  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal long bone metaphysis morphology  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal obturator foramen morphology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal osteocyte lacuna morphology  (IAGP)
abnormal osteocyte lacunocanalicular system morphology  (IAGP)
abnormal osteoid morphology  (IAGP)
abnormal otic capsule morphology  (IAGP)
abnormal patella morphology  (IAGP)
abnormal pelvic girdle bone morphology  (IAGP)
abnormal postnatal growth/weight/body size  (IAGP)
abnormal renal glucose reabsorption  (IAGP)
abnormal renal phosphate reabsorption  (IAGP)
abnormal rib morphology  (IAGP)
abnormal scala tympani morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal temporal bone morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal urine nucleotide level  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal vestibular saccule morphology  (IAGP)
abnormal vitamin D level  (IAGP)
camptomelia  (IAGP)
circling  (IAGP)
cochlear ganglion degeneration  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mass  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone mineralization  (IAGP)
decreased bone resorption  (IAGP)
decreased chondrocyte apoptosis  (IAGP)
decreased circulating alkaline phosphatase level  (IAGP)
decreased circulating C-reactive protein level  (IAGP)
decreased circulating calcium level  (IAGP)
decreased circulating parathyroid hormone level  (IAGP)
decreased circulating phosphate level  (IAGP)
decreased circulating potassium level  (IAGP)
decreased compact bone thickness  (IAGP)
decreased cranium height  (IAGP)
decreased diameter of femur  (IAGP)
decreased intestinal calcium absorption  (IAGP)
decreased length of long bones  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased total body fat amount  (IAGP)
decreased urine calcium level  (IAGP)
decreased vitamin D level  (IAGP)
disorganized long bone epiphyseal plate  (IAGP)
disproportionate dwarf  (IAGP)
distended Reissner membrane  (IAGP)
domed cranium  (IAGP)
ear inflammation  (IAGP)
enthesitis  (IAGP)
exostosis  (IAGP)
head bobbing  (IAGP)
impaired hearing  (IAGP)
increased activity of parathyroid  (IAGP)
increased bone mineral density  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating parathyroid hormone level  (IAGP)
increased circulating phosphate level  (IAGP)
increased diameter of femur  (IAGP)
increased diameter of long bones  (IAGP)
increased long bone epiphyseal plate size  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased susceptibility to otitis media  (IAGP)
increased urine creatinine level  (IAGP)
increased urine phosphate level  (IAGP)
increased width of hypertrophic chondrocyte zone  (IAGP)
long femur  (IAGP)
maternal effect  (IAGP)
oliguria  (IAGP)
organ of Corti degeneration  (IAGP)
osteomalacia  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
rickets  (IAGP)
short femur  (IAGP)
short fibula  (IAGP)
short frontal bone  (IAGP)
short humerus  (IAGP)
short limbs  (IAGP)
short mandible  (IAGP)
short maxilla  (IAGP)
short nasal bone  (IAGP)
short premaxilla  (IAGP)
short radius  (IAGP)
short tail  (IAGP)
short tibia  (IAGP)
short ulna  (IAGP)
small caudal vertebrae  (IAGP)
small clavicle  (IAGP)
small cranium  (IAGP)
small vertebrae  (IAGP)
unilateral deafness  (IAGP)
References

Additional References at PubMed
PMID:188049   PMID:221535   PMID:566613   PMID:908280   PMID:1290161   PMID:1309337   PMID:1315116   PMID:1352307   PMID:1528020   PMID:1547718   PMID:1612032   PMID:1685478  
PMID:1962291   PMID:2177024   PMID:2982272   PMID:2994997   PMID:3015770   PMID:3145795   PMID:3425609   PMID:3460077   PMID:3863638   PMID:3940855   PMID:6090101   PMID:6479099  
PMID:6583703   PMID:6892799   PMID:6893581   PMID:6896304   PMID:6896684   PMID:7365241   PMID:7502704   PMID:7573493   PMID:7611412   PMID:7611447   PMID:7671167   PMID:7785464  
PMID:7853101   PMID:7873297   PMID:7900834   PMID:7962329   PMID:8070635   PMID:8082056   PMID:8108466   PMID:8113402   PMID:8137741   PMID:8141332   PMID:8266820   PMID:8304442  
PMID:8390690   PMID:8405991   PMID:8518105   PMID:8635692   PMID:8691720   PMID:8717533   PMID:8770917   PMID:8772486   PMID:8812412   PMID:8833143   PMID:8914019   PMID:8927512  
PMID:8940337   PMID:9077527   PMID:9141502   PMID:9262518   PMID:9269633   PMID:9333128   PMID:9362326   PMID:9421395   PMID:9467015   PMID:9467016   PMID:9503026   PMID:9524191  
PMID:9545633   PMID:9736774   PMID:9753616   PMID:9755091   PMID:9803442   PMID:10069185   PMID:10087298   PMID:10349636   PMID:10920247   PMID:10934642   PMID:11018258   PMID:11023830  
PMID:11042159   PMID:11076861   PMID:11159866   PMID:11217851   PMID:11517178   PMID:11713245   PMID:11811562   PMID:12110521   PMID:12194021   PMID:12220505   PMID:12414538   PMID:12456809  
PMID:12466851   PMID:12477932   PMID:12619927   PMID:12791601   PMID:12865326   PMID:12900584   PMID:12952859   PMID:14751570   PMID:15050894   PMID:15054142   PMID:15459188   PMID:15579309  
PMID:15615882   PMID:15833911   PMID:15843468   PMID:15940367   PMID:15976027   PMID:16005844   PMID:16084134   PMID:16123154   PMID:16141072   PMID:16141073   PMID:16144964   PMID:16449303  
PMID:16597685   PMID:16762607   PMID:16829211   PMID:17251516   PMID:17615144   PMID:17638577   PMID:17710565   PMID:17848631   PMID:17942069   PMID:18172553   PMID:18597632   PMID:18753255  
PMID:19082853   PMID:19419310   PMID:19556340   PMID:19584304   PMID:19656036   PMID:19737523   PMID:19775205   PMID:19933269   PMID:19952276   PMID:19966287   PMID:20204609   PMID:20440000  
PMID:20583265   PMID:20817730   PMID:21075853   PMID:21139072   PMID:21177780   PMID:21267068   PMID:21308778   PMID:21312267   PMID:21507898   PMID:21677750   PMID:21873635   PMID:22006791  
PMID:22093826   PMID:22161748   PMID:22334725   PMID:22527485   PMID:22609228   PMID:22886699   PMID:22930691   PMID:22991293   PMID:23028440   PMID:23038738   PMID:23128355   PMID:23174213  
PMID:23266491   PMID:23652555   PMID:23700148   PMID:23895994   PMID:24269824   PMID:24470103   PMID:24601885   PMID:24710520   PMID:24797667   PMID:24839967   PMID:25089825   PMID:25460577  
PMID:25568170   PMID:26234751   PMID:26336161   PMID:26588476   PMID:26784541   PMID:26792657   PMID:27035636   PMID:27929669   PMID:28728941   PMID:28764922   PMID:29561836   PMID:29635291  
PMID:29735309   PMID:29878089   PMID:29977226   PMID:30096468   PMID:30120363   PMID:30247553   PMID:31202927   PMID:31484825   PMID:32325033   PMID:33072734  


Genomics

Comparative Map Data
Phex
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X155,945,071 - 156,198,282 (-)NCBIGRCm39mm39
GRCm39 EnsemblX155,945,071 - 156,198,308 (-)Ensembl
GRCm38X157,162,075 - 157,415,286 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX157,162,075 - 157,415,312 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X153,596,618 - 153,853,218 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X152,502,794 - 152,759,383 (-)NCBImm8
CeleraX140,419,752 - 140,667,816 (-)NCBICelera
Cytogenetic MapXF4NCBI
cM MapX72.38NCBI
PHEX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX22,032,325 - 22,494,713 (+)EnsemblGRCh38hg38GRCh38
GRCh38X22,032,325 - 22,251,310 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X22,050,443 - 22,269,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X21,960,842 - 22,176,399 (+)NCBINCBI36hg18NCBI36
Build 34X21,810,215 - 22,025,985NCBI
CeleraX26,171,770 - 26,387,304 (+)NCBI
Cytogenetic MapXp22.11NCBI
HuRefX19,791,354 - 20,006,299 (+)NCBIHuRef
CHM1_1X22,081,373 - 22,297,157 (+)NCBICHM1_1
Phex
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X37,607,553 - 37,856,183 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX37,610,760 - 37,854,469 (+)Ensembl
Rnor_6.0X40,460,047 - 40,717,982 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX40,460,047 - 40,717,982 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X40,772,810 - 41,031,710 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X58,911,144 - 59,168,857 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X58,964,612 - 59,222,310 (+)NCBI
CeleraX38,233,227 - 38,472,933 (+)NCBICelera
Cytogenetic MapXq21NCBI
Phex
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555092,357,263 - 2,546,802 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555092,357,263 - 2,546,802 (+)NCBIChiLan1.0ChiLan1.0
PHEX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X22,017,678 - 22,235,560 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX22,017,681 - 22,232,501 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X14,663,847 - 14,859,294 (+)NCBIMhudiblu_PPA_v0panPan3
PHEX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X17,830,714 - 18,038,755 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX17,829,158 - 18,035,775 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X17,788,714 - 17,997,786 (+)NCBI
UMICH_Zoey_3.1X17,822,506 - 18,032,213 (+)NCBI
UNSW_CanFamBas_1.0X17,844,194 - 18,054,186 (+)NCBI
UU_Cfam_GSD_1.0X17,904,817 - 18,114,749 (+)NCBI
Phex
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X10,843,339 - 11,033,426 (+)NCBI
SpeTri2.0NW_0049366242,124,479 - 2,312,847 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHEX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX18,203,174 - 18,418,004 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X18,199,396 - 18,420,985 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X19,362,855 - 19,605,399 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PHEX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X20,507,619 - 20,733,367 (+)NCBI
ChlSab1.1 EnsemblX20,522,498 - 20,734,599 (+)Ensembl
Vero_WHO_p1.0NW_02366605622,362,964 - 22,589,561 (+)NCBI
Phex
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248296,960,740 - 7,151,752 (+)NCBI

Position Markers
AI848741  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38197,425,707 - 7,425,841UniSTSGRCm38
GRCm38X157,364,995 - 157,365,130UniSTSGRCm38
MGSCv37X153,802,927 - 153,803,062UniSTSGRCm37
MGSCv37197,500,197 - 7,500,331UniSTSGRCm37
Celera197,197,455 - 7,197,589UniSTS
CeleraX140,617,055 - 140,617,190UniSTS
Cytogenetic MapXF4UniSTS
Cytogenetic Map19AUniSTS
cM MapX65.4UniSTS
Whitehead/MRC_RH1932.02UniSTS
U49908  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X157,163,567 - 157,163,661UniSTSGRCm38
MGSCv37X153,598,110 - 153,598,204UniSTSGRCm37
CeleraX140,421,244 - 140,421,338UniSTS
Cytogenetic MapXF4UniSTS
cM MapX65.4UniSTS
Whitehead/MRC_RHX1809.28UniSTS
Phex  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X157,162,273 - 157,162,364UniSTSGRCm38
MGSCv37X153,596,816 - 153,596,907UniSTSGRCm37
CeleraX140,419,950 - 140,420,041UniSTS
Cytogenetic MapXF4UniSTS
cM MapX65.4UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX103012242163975945Mouse
1301209Cia19_mcollagen induced arthritis 19 (mouse)Not determinedX122083468161430042Mouse
10412164Cmv2_mcytomegalovirus resistance 2 (mouse)Not determinedX126902153160902273Mouse
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX134639291166515599Mouse
1302000Pgia25_mproteoglycan induced arthritis 2 (mouse)Not determinedX145691384171031299Mouse
10401118Pgia39_mproteoglycan induced arthritis 39 (mouse)Not determinedX145691384171031299Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2034
Count of miRNA genes:599
Interacting mature miRNAs:755
Transcripts:ENSMUST00000079945, ENSMUST00000135713, ENSMUST00000138396
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000079945   ⟹   ENSMUSP00000078863
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX155,945,071 - 156,198,282 (-)Ensembl
GRCm38.p6 EnsemblX157,162,075 - 157,415,286 (-)Ensembl
RefSeq Acc Id: ENSMUST00000135713   ⟹   ENSMUSP00000121281
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX155,945,071 - 155,948,658 (-)Ensembl
GRCm38.p6 EnsemblX157,162,075 - 157,165,662 (-)Ensembl
RefSeq Acc Id: ENSMUST00000138396   ⟹   ENSMUSP00000122953
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX156,003,401 - 156,198,308 (-)Ensembl
GRCm38.p6 EnsemblX157,220,405 - 157,415,312 (-)Ensembl
RefSeq Acc Id: NM_011077   ⟹   NP_035207
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X155,945,071 - 156,198,282 (-)NCBI
GRCm38X157,162,075 - 157,415,286 (-)NCBI
MGSCv37X153,596,618 - 153,853,218 (-)RGD
CeleraX140,419,752 - 140,667,816 (-)RGD
cM MapX ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035207   ⟸   NM_011077
- UniProtKB: P70669 (UniProtKB/Swiss-Prot),   Q3TYM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000078863   ⟸   ENSMUST00000079945
RefSeq Acc Id: ENSMUSP00000122953   ⟸   ENSMUST00000138396
RefSeq Acc Id: ENSMUSP00000121281   ⟸   ENSMUST00000135713
Promoters
RGD ID:13681706
Promoter ID:EPDNEW_M25002
Type:single initiation site
Name:Phex_1
Description:Mus musculus phosphate regulating endopeptidase homolog, X-linked, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X157,415,312 - 157,415,372EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107489 AgrOrtholog
Ensembl Genes ENSMUSG00000057457 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000078863 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000121281 UniProtKB/TrEMBL
  ENSMUSP00000122953 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000079945 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000135713 UniProtKB/TrEMBL
  ENSMUST00000138396 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1380.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13_dom_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18675 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107489 ENTREZGENE
NCBI Gene 18675 ENTREZGENE
PANTHER PTHR11733 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Phex PhenoGen
PRINTS NEPRILYSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEPRILYSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
UniProt A2AC80_MOUSE UniProtKB/TrEMBL
  A2ICR0_MOUSE UniProtKB/TrEMBL
  F6S0V7_MOUSE UniProtKB/TrEMBL
  P70669 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3TYM9 ENTREZGENE, UniProtKB/TrEMBL
  Q9ERK6_MOUSE UniProtKB/TrEMBL
UniProt Secondary P97439 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-06-24 Phex  phosphate regulating endopeptidase homolog, X-linked    phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)  Symbol and/or name change 5135510 APPROVED