Alox5ap (arachidonate 5-lipoxygenase activating protein) - Rat Genome Database

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Gene: Alox5ap (arachidonate 5-lipoxygenase activating protein) Mus musculus
Analyze
Symbol: Alox5ap
Name: arachidonate 5-lipoxygenase activating protein
RGD ID: 736461
MGI Page MGI
Description: Predicted to enable several functions, including arachidonate binding activity; glutathione peroxidase activity; and glutathione transferase activity. Predicted to contribute to arachidonate 5-lipoxygenase activity. Acts upstream of or within leukotriene biosynthetic process and leukotriene production involved in inflammatory response. Located in nucleus. Is expressed in cerebral cortex; hemolymphoid system; limb long bone; liver; and vertebra. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); asthma; brain infarction (multiple); breast cancer; and cerebral palsy. Orthologous to human ALOX5AP (arachidonate 5-lipoxygenase activating protein).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: arachidonate 5 lipoxygenase activating protein; arachidonate 5-lipoxygenase-activating protein; F; Flap; MK-886-binding protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395149,201,814 - 149,224,963 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5149,201,577 - 149,224,963 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385149,265,004 - 149,288,153 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5149,264,767 - 149,288,153 (+)Ensemblmm10GRCm38
MGSCv375150,076,634 - 150,099,623 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365149,575,407 - 149,596,895 (+)NCBIMGSCv36mm8
Celera5147,280,239 - 147,303,063 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.18NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP,ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
acetamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
Azoxymethane  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
captan  (EXP)
carbon nanotube  (EXP)
chlordecone  (EXP)
choline  (EXP)
cisplatin  (EXP,ISO)
clopidogrel  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-penicillamine  (ISO)
DDE  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
folic acid  (EXP)
folpet  (EXP)
furan  (ISO)
herbicide  (ISO)
hexachlorobenzene  (ISO)
histamine  (ISO)
hydrogen peroxide  (ISO)
imidazopyrazole  (ISO)
indinavir  (EXP)
kainic acid  (ISO)
L-methionine  (EXP)
lamivudine  (EXP)
leukotriene B4  (ISO)
leukotriene C4  (ISO)
lipopolysaccharide  (EXP)
lithium chloride  (ISO)
medroxyprogesterone acetate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrobenzenes  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
Phenelzine  (EXP)
phenobarbital  (EXP)
picrotoxin  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
saquinavir  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tributylstannane  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
tungsten  (EXP)
vinclozolin  (ISO)
warfarin  (ISO)
zidovudine  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
endoplasmic reticulum  (IBA,IEA,ISO)
endoplasmic reticulum membrane  (IEA)
membrane  (IEA)
nuclear envelope  (IBA,IEA,ISO,ISS)
nuclear membrane  (IEA,ISO,ISS)
nucleus  (IDA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. 5-Lipoxygenase-activating protein: a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation. Back M, etal., Circ Res. 2007 Apr 13;100(7):946-9. Epub 2007 Mar 22.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses. Byrum RS, etal., J Exp Med. 1997 Mar 17;185(6):1065-75.
4. In situ amplification of 5-lipoxygenase and 5-lipoxygenase-activating protein in allergic airway inflammation and inhibition by leukotriene blockade. Chu SJ, etal., J Immunol. 2000 Oct 15;165(8):4640-8.
5. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Dixon RA, etal., Nature 1990 Jan 18;343(6255):282-4.
6. Increased expression of cytosolic phospholipase A2, 5-lipoxygenase and 5-lipoxygenase-activating protein in rat peritoneal macrophages during ovalbumin-induced sensitization. Escoubet-Lozach L, etal., Clin Exp Allergy 2001 Jul;31(7):1094-104.
7. Decreased paraoxonase-2 expression in human carotids during the progression of atherosclerosis. Fortunato G, etal., Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):594-600. Epub 2008 Feb 7.
8. Candidate genes and cerebral palsy: a population-based study. Gibson CS, etal., Pediatrics. 2008 Nov;122(5):1079-85.
9. Collagen-induced arthritis is reduced in 5-lipoxygenase-activating protein-deficient mice. Griffiths RJ, etal., J Exp Med. 1997 Mar 17;185(6):1123-9.
10. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Helgadottir A, etal., Nat Genet. 2004 Mar;36(3):233-9. Epub 2004 Feb 8.
11. The importance of leukotrienes in airway inflammation in a mouse model of asthma. Henderson WR Jr, etal., J Exp Med. 1996 Oct 1;184(4):1483-94.
12. The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility. Holloway JW, etal., Allergy. 2008 Aug;63(8):1046-53. Epub 2008 Jun 10.
13. Hyperoxia increases protein mass of 5-lipoxygenase and its activating protein, flap, and leukotriene B(4) output in newborn rat lungs. Hosford GE, etal., Exp Lung Res. 2002 Dec;28(8):671-84.
14. Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4. Jame AJ, etal., Clin Exp Allergy. 2007 Jun;37(6):880-92.
15. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
16. Polymorphisms in the 5-lipoxygenase activating protein (ALOX5AP) gene are not associated with asthma in an Australian population. Kedda MA, etal., Clin Exp Allergy. 2005 Mar;35(3):332-8.
17. Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein mRNAs in the peripheral blood leukocytes of asthmatics. Koshino T, etal., Biochem Biophys Res Commun. 1998 Jun 18;247(2):510-3.
18. Novel polymorphism of the 5-lipoxygenase activating protein (FLAP) promoter gene associated with asthma. Koshino T, etal., Mol Cell Biol Res Commun. 1999 Jul;2(1):32-5.
19. Differential gene signatures in rat mammary tumors induced by DMBA and those induced by fractionated gamma radiation. Lee HJ, etal., Radiat Res. 2008 Nov;170(5):579-90.
20. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. Lemaitre RN, etal., Atherosclerosis. 2009 Jun;204(2):e58-63. Epub 2008 Nov 1.
21. Association of three-gene interaction among MTHFR, ALOX5AP and NOTCH3 with thrombotic stroke: a multicenter case-control study. Liu J, etal., Hum Genet. 2009 Jun;125(5-6):649-56. Epub 2009 Apr 17.
22. Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2 -ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation. Lorrain DS, etal., J Pharmacol Exp Ther. 2009 Dec;331(3):1042-50. Epub 2009 Sep 11.
23. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
24. MGDs mouse GO annotations MGD data from the GO Consortium
25. MGD IEA MGD IEA
26. Increased 5-lipoxygenase activating protein in immune-mediated experimental nephritis. Montero A, etal., J Nephrol. 2003 Sep-Oct;16(5):682-90.
27. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. Placenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell disease. Patel N, etal., Blood. 2009 Jan 29;113(5):1129-38. Epub 2008 Oct 22.
30. Mouse MP Annotation Import Pipeline RGD automated import pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population. Sayers I, etal., Clin Exp Allergy. 2003 Aug;33(8):1103-10.
34. Rhinovirus infection increases 5-lipoxygenase and cyclooxygenase-2 in bronchial biopsy specimens from nonatopic subjects. Seymour ML, etal., J Infect Dis. 2002 Feb 15;185(4):540-4. Epub 2002 Jan 31.
35. Increased urinary leukotriene E4 excretion in obstructive sleep apnea: effects of obesity and hypoxia. Stanke-Labesque F, etal., J Allergy Clin Immunol. 2009 Aug;124(2):364-70, 370.e1-2. Epub 2009 Jul 12.
36. Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy. Sveinbjornsson B, etal., FASEB J. 2008 Oct;22(10):3525-36. Epub 2008 Jun 30.
37. 5-Lipoxygenase pathway gene polymorphisms: lack of association with asthma in a Spanish population. Torres-Galvan SM, etal., J Investig Allergol Clin Immunol. 2009;19(6):453-8.
38. Associations of genetic polymorphisms of arachidonate 5-lipoxygenase-activating protein with risk of coronary artery disease in a European-American population. Tsai AK, etal., Atherosclerosis. 2009 Jun 18.
39. The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos. Via M, etal., Clin Exp Allergy. 2010 Apr;40(4):582-9. Epub 2010 Jan 11.
40. Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats. Voelkel NF, etal., J Clin Invest 1996 Jun 1;97(11):2491-8.
41. 5-lipoxygenase and 5-lipoxygenase-activating protein gene polymorphisms, dietary linoleic acid, and risk for breast cancer. Wang J, etal., Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2748-54.
42. Nasal mucosal expression of the leukotriene and prostanoid pathways in seasonal and perennial allergic rhinitis. Westergren VS, etal., Clin Exp Allergy. 2009 Jun;39(6):820-8. Epub 2009 Apr 2.
43. 5-Lipoxygenase and 5-lipoxygenase activating protein (FLAP) immunoreactivity in lungs from patients with primary pulmonary hypertension. Wright L, etal., Am J Respir Crit Care Med. 1998 Jan;157(1):219-29.
44. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics Xu XW, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Oct;24(5):491-4.
45. Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome. Yamada Y, etal., Int J Mol Med. 2008 Jun;21(6):801-8.
46. Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus. Yoshida T, etal., Int J Mol Med. 2009 Apr;23(4):529-37.
Additional References at PubMed
PMID:1480129   PMID:7493652   PMID:8706658   PMID:8889548   PMID:10349636   PMID:10779800   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11130978   PMID:12477932   PMID:14610273  
PMID:15489334   PMID:15616590   PMID:15894604   PMID:16141072   PMID:16141073   PMID:16200066   PMID:16930777   PMID:19075240   PMID:19358825   PMID:19965960   PMID:20207999   PMID:21052705  
PMID:21267068   PMID:21308776   PMID:21873635   PMID:22493243   PMID:23250985   PMID:23357209   PMID:24301651   PMID:24641614   PMID:27129215   PMID:27207555   PMID:29174564   PMID:29311656  
PMID:30418981   PMID:30649890   PMID:34321999  


Genomics

Comparative Map Data
Alox5ap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395149,201,814 - 149,224,963 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5149,201,577 - 149,224,963 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385149,265,004 - 149,288,153 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5149,264,767 - 149,288,153 (+)Ensemblmm10GRCm38
MGSCv375150,076,634 - 150,099,623 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365149,575,407 - 149,596,895 (+)NCBIMGSCv36mm8
Celera5147,280,239 - 147,303,063 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.18NCBI
ALOX5AP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381330,713,485 - 30,764,426 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1330,713,478 - 30,764,426 (+)Ensemblhg38GRCh38
GRCh371331,287,622 - 31,338,563 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361330,207,669 - 30,236,556 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341330,207,668 - 30,236,556NCBI
Celera1312,378,644 - 12,407,516 (+)NCBICelera
Cytogenetic Map13q12.3NCBI
HuRef1312,105,618 - 12,156,585 (+)NCBIHuRef
CHM1_11331,255,200 - 31,306,135 (+)NCBICHM1_1
T2T-CHM13v2.01329,935,580 - 29,986,538 (+)NCBIT2T-CHM13v2.0
Alox5ap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,785,254 - 10,809,295 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1210,785,257 - 10,817,038 (-)EnsemblGRCr8
mRatBN7.2125,748,941 - 5,772,986 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl125,748,944 - 5,772,986 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx126,415,168 - 6,438,995 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,038,642 - 7,062,468 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0126,066,300 - 6,090,127 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0126,854,930 - 6,879,112 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl126,854,920 - 6,879,154 (-)Ensemblrn6Rnor6.0
Rnor_5.0128,950,727 - 8,974,708 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4126,245,808 - 6,269,796 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera127,507,392 - 7,531,448 (-)NCBICelera
RGSC_v3.1126,245,808 - 6,269,796 (-)NCBI
Cytogenetic Map12p11NCBI
Alox5ap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543115,069,089 - 15,097,580 (-)Ensembl
ChiLan1.0NW_00495543115,071,535 - 15,097,496 (-)NCBIChiLan1.0ChiLan1.0
ALOX5AP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21430,318,849 - 30,348,046 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11321,425,689 - 21,454,792 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01312,012,399 - 12,041,557 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11330,425,510 - 30,476,607 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1330,425,510 - 30,476,607 (+)EnsemblpanPan2panpan1.1
ALOX5AP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,320,868 - 9,351,056 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,320,864 - 9,351,836 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha259,363,720 - 9,390,082 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
Alox5ap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945170,449,329 - 170,475,151 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647225,477,010 - 25,502,840 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647225,477,094 - 25,502,823 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALOX5AP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl117,411,644 - 7,438,108 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1117,371,328 - 7,438,111 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,222,771 - 7,287,566 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALOX5AP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.139,618,030 - 9,642,990 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl39,617,949 - 9,643,184 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605734,722,809 - 34,747,583 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alox5ap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247767,475,200 - 7,506,283 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247767,475,269 - 7,646,805 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Alox5ap
1207 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:347
Count of miRNA genes:290
Interacting mature miRNAs:314
Transcripts:ENSMUST00000071130, ENSMUST00000130144
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
13504734Ifvrq4_minfluenza virus resistance QTL 4 (mouse)5139985755151658149Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
13504735Ifvrq7_minfluenza virus resistance QTL 7 (mouse)5139509801151658149Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse
13504737Ifvrq5_minfluenza virus resistance QTL 5 (mouse)5139509801151658149Mouse

Markers in Region
Alox5ap  
Mouse AssemblyChrPosition (strand)SourceJBrowse
cM Map5 UniSTS
Alox5ap  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G3UniSTS
cM Map5 UniSTS
Alox5ap  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000071130   ⟹   ENSMUSP00000071130
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5149,201,577 - 149,224,963 (+)Ensembl
GRCm38.p6 Ensembl5149,264,767 - 149,288,153 (+)Ensembl
Ensembl Acc Id: ENSMUST00000200806   ⟹   ENSMUSP00000144472
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5149,202,157 - 149,224,537 (+)Ensembl
GRCm38.p6 Ensembl5149,265,347 - 149,287,727 (+)Ensembl
Ensembl Acc Id: ENSMUST00000200928   ⟹   ENSMUSP00000144115
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5149,215,821 - 149,224,560 (+)Ensembl
GRCm38.p6 Ensembl5149,279,011 - 149,287,750 (+)Ensembl
Ensembl Acc Id: ENSMUST00000202629
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5149,224,225 - 149,224,854 (+)Ensembl
GRCm38.p6 Ensembl5149,287,415 - 149,288,044 (+)Ensembl
RefSeq Acc Id: NM_001308462   ⟹   NP_001295391
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395149,201,814 - 149,224,963 (+)NCBI
GRCm385149,265,004 - 149,288,153 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009663   ⟹   NP_033793
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395149,201,814 - 149,224,963 (+)NCBI
GRCm385149,265,004 - 149,288,153 (+)NCBI
MGSCv375150,076,634 - 150,099,623 (+)RGD
Celera5147,280,239 - 147,303,063 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033793   ⟸   NM_009663
- Peptide Label: isoform 1
- UniProtKB: Q9D138 (UniProtKB/Swiss-Prot),   P30355 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001295391   ⟸   NM_001308462
- Peptide Label: isoform 2
- Sequence:
Ensembl Acc Id: ENSMUSP00000071130   ⟸   ENSMUST00000071130
Ensembl Acc Id: ENSMUSP00000144115   ⟸   ENSMUST00000200928
Ensembl Acc Id: ENSMUSP00000144472   ⟸   ENSMUST00000200806

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30355-F1-model_v2 AlphaFold P30355 1-161 view protein structure

Promoters
RGD ID:6888862
Promoter ID:EPDNEW_M7882
Type:initiation region
Name:Alox5ap_1
Description:Mus musculus arachidonate 5-lipoxygenase activating protein ,transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385149,265,044 - 149,265,104EPDNEW
RGD ID:6837067
Promoter ID:MM_KWN:44951
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:NM_009663,   OTTMUST00000071392
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365150,076,399 - 150,076,899 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107505 AgrOrtholog
Ensembl Genes ENSMUSG00000060063 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000071130 ENTREZGENE
  ENSMUST00000071130.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.550 UniProtKB/Swiss-Prot
InterPro 5_LipOase_AP UniProtKB/Swiss-Prot
  FLAP/GST2/LTC4S_CS UniProtKB/Swiss-Prot
  MAPEG UniProtKB/Swiss-Prot
  MAPEG-like_dom_sf UniProtKB/Swiss-Prot
  Membr-assoc_MAPEG UniProtKB/Swiss-Prot
KEGG Report mmu:11690 UniProtKB/Swiss-Prot
MGD MGI:107505 ENTREZGENE
NCBI Gene 11690 ENTREZGENE
PANTHER ARACHIDONATE 5-LIPOXYGENASE-ACTIVATING PROTEIN UniProtKB/Swiss-Prot
  MICROSOMAL GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot
Pfam MAPEG UniProtKB/Swiss-Prot
PhenoGen Alox5ap PhenoGen
PRINTS 5LPOXGNASEAP UniProtKB/Swiss-Prot
PROSITE FLAP_GST2_LTC4S UniProtKB/Swiss-Prot
Superfamily-SCOP SSF161084 UniProtKB/Swiss-Prot
UniProt A0A0J9YUC8_MOUSE UniProtKB/TrEMBL
  A0A0J9YV38_MOUSE UniProtKB/TrEMBL
  AL5AP_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9D138 ENTREZGENE
UniProt Secondary Q9D138 UniProtKB/Swiss-Prot