Fgg (fibrinogen gamma chain) - Rat Genome Database

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Gene: Fgg (fibrinogen gamma chain) Mus musculus
Analyze
Symbol: Fgg
Name: fibrinogen gamma chain
RGD ID: 10586
MGI Page MGI
Description: Predicted to enable several functions, including cell adhesion molecule binding activity; identical protein binding activity; and structural molecule activity. Predicted to be involved in several processes, including blood coagulation; negative regulation of apoptotic process; and positive regulation of secretion by cell. Predicted to act upstream of or within adaptive immune response; hemostasis; and innate immune response. Located in cell cortex. Is active in synapse. Is expressed in several structures, including cardiovascular system; chondrocranium; jaw; nephron; and notochord. Used to study congenital afibrinogenemia. Human ortholog(s) of this gene implicated in brain small vessel disease; congenital afibrinogenemia; and multiple myeloma. Orthologous to human FGG (fibrinogen gamma chain).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 3010002H13Rik; AI256424; fibrinogen gamma-chain; fibrinogen, gamma polypeptide; gamma-fibrinogen
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39382,915,031 - 82,922,363 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl382,915,031 - 82,922,356 (+)EnsemblGRCm39 Ensembl
GRCm38383,007,724 - 83,015,056 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,007,724 - 83,015,049 (+)EnsemblGRCm38mm10GRCm38
MGSCv37382,811,818 - 82,818,971 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36383,093,823 - 83,100,976 (+)NCBIMGSCv36mm8
Celera383,011,995 - 83,019,099 (+)NCBICelera
Cytogenetic Map3E3NCBI
cM Map336.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1-naphthyl isothiocyanate  (EXP)
1-Oleoyl-2-acetyl-sn-glycerol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
arachidonyl-2'-chloroethylamide  (EXP)
aristolochic acids  (ISO)
Azaspiracid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromobenzene  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
calcium silicate  (EXP)
carbon nanotube  (EXP,ISO)
carnosic acid  (EXP)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlorpyrifos  (EXP)
chromium trinitrate  (EXP)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
dabigatran  (EXP)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dienogest  (ISO)
diethyl maleate  (EXP)
diisopropyl fluorophosphate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP)
diquat  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
fenofibrate  (ISO)
fenthion  (EXP)
fructose  (EXP)
furan  (ISO)
gemcitabine  (ISO)
gestodene  (ISO)
glucose  (EXP)
glyphosate  (EXP)
graphene oxide  (EXP)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
inulin  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (EXP)
levonorgestrel  (ISO)
malathion  (ISO)
menadione  (ISO)
methidathion  (EXP)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (ISO)
natamycin  (EXP)
nefazodone  (ISO)
nitrofen  (ISO)
norethisterone  (ISO)
norgestimate  (ISO)
nystatin  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (EXP)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
quartz  (ISO)
quercetin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
titanium dioxide  (EXP,ISO)
tremolite asbestos  (EXP)
tributylstannane  (EXP)
Triptolide  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vitamin K  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Hepatic fibrinogen storage disease: identification of two novel mutations (p.Asp316Asn, fibrinogen Pisa and p.Gly366Ser, fibrinogen Beograd) impacting on the fibrinogen gamma-module. Asselta R, etal., J Thromb Haemost. 2015 Aug;13(8):1459-67. doi: 10.1111/jth.13021. Epub 2015 Jul 14.
2. Molecular characterization of 7 patients affected by dys- or hypo-dysfibrinogenemia: Identification of a novel mutation in the fibrinogen Bbeta chain causing a gain of glycosylation. Asselta R, etal., Thromb Res. 2015 Jul;136(1):168-74. doi: 10.1016/j.thromres.2015.05.007. Epub 2015 May 14.
3. Novel fibrinogen gamma375 Arg-->Trp mutation (fibrinogen aguadilla) causes hepatic endoplasmic reticulum storage and hypofibrinogenemia. Brennan SO, etal., Hepatology. 2002 Sep;36(3):652-8.
4. Abnormal expression of Smurf2 during the process of rat liver fibrosis. Cai Y, etal., Chin J Dig Dis. 2006;7(4):237-45.
5. Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study. Carty CL, etal., Thromb Haemost. 2008 Feb;99(2):388-95.
6. Quantitative organellar proteomics analysis of rough endoplasmic reticulum from normal and acute pancreatitis rat pancreas. Chen X, etal., J Proteome Res. 2010 Feb 5;9(2):885-96.
7. Profiling of gender-specific rat plasma proteins associated with susceptibility or resistance to diet-induced obesity. Choi JW, etal., J Proteomics. 2012 Feb 2;75(4):1386-400. doi: 10.1016/j.jprot.2011.11.012. Epub 2011 Nov 20.
8. [Comparative plasma proteomic analysis of patients with multiple myeloma treated with bortezomib-based regimens]. Cumova J, etal., Klin Onkol. 2012;25(1):17-25.
9. Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury. Gralinski LE, etal., mBio. 2013 Aug 6;4(4). pii: mBio.00271-13. doi: 10.1128/mBio.00271-13.
10. Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping. Haefliger JA, etal., J Biol Chem 1992 Jan 25;267(3):2057-64.
11. Identification of a novel splicing mutation in the fibrinogen gamma chain gene leading to dysfibrinogenaemia in a Chinese pedigree. Huang D, etal., Pathology. 2015 Feb;47(2):145-50. doi: 10.1097/PAT.0000000000000213.
12. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
13. Haemostatic abnormalities persist despite glycaemic improvement by insulin therapy in lean type 2 diabetic patients. Knobl P, etal., Thromb Haemost. 1994 Jun;71(6):692-7.
14. Fibrinogen beta-derived Bbeta(15-42) peptide protects against kidney ischemia/reperfusion injury. Krishnamoorthy A, etal., Blood. 2011 Aug 18;118(7):1934-42. Epub 2011 Jun 17.
15. Fibrinogen Hangzhou: congenital dysfibrinogenemia caused by the novel missense mutation in FGG (gamma308Asn-->Thr). Liao Z, etal., Clin Chim Acta. 2014 Jan 20;428:106-9.
16. Basic mechanisms and regulation of fibrinolysis. Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
17. Gene and pseudogene of the mouse cation-dependent mannose 6-phosphate receptor. Genomic organization, expression, and chromosomal localization. Ludwig T, etal., J Biol Chem 1992 Jun 15;267(17):12211-9.
18. A G-to-A mutation in IVS-3 of the human gamma fibrinogen gene causing afibrinogenemia due to abnormal RNA splicing. Margaglione M, etal., Blood 2000 Oct 1;96(7):2501-5.
19. Novel fibrinogen mutation (gamma 313 Ser-->Asn) associated with hypofibrinogenemia in two unrelated families. Meyer M, etal., Blood Coagul Fibrinolysis. 2006 Jan;17(1):63-7.
20. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
21. MGDs mouse GO annotations MGD data from the GO Consortium
22. MGD IEA MGD IEA
23. Fibrinogen and fibrin structure and functions. Mosesson MW J Thromb Haemost. 2005 Aug;3(8):1894-904.
24. Plasma fibrinogen gamma' chain content in the thrombotic microangiopathy syndrome. Mosesson MW, etal., J Thromb Haemost. 2007 Jan;5(1):62-9. Epub 2006 Oct 13.
25. Expression and analysis of a split premature termination codon in FGG responsible for congenital afibrinogenemia: escape from RNA surveillance mechanisms in transfected cells. Neerman-Arbez M, etal., Blood. 2004 Dec 1;104(12):3618-23. Epub 2004 Jul 29.
26. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
31. Mouse MP Annotation Import Pipeline RGD automated import pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Mice lacking factor VII develop normally but suffer fatal perinatal bleeding. Rosen ED, etal., Nature 1997 Nov 20;390(6657):290-4.
35. The responses of rat liver glucocorticoid receptors and genes for tyrosine aminotransferase, alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy-, dexamethasone- and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokines. Sevaljevic L, etal., Biol Signals Recept. 2001 Sep-Oct;10(5):299-309.
36. Fibrinogen Seoul (FGG Ala341Asp): a novel mutation associated with hypodysfibrinogenemia. Song KS, etal., Clin Appl Thromb Hemost. 2006 Jul;12(3):338-43.
37. Molecular basis of quantitative fibrinogen disorders in 27 patients from India. Sumitha E, etal., Haemophilia. 2013 Jul;19(4):611-8. doi: 10.1111/hae.12143. Epub 2013 Apr 8.
38. Proteomic analysis of plasma from rats following total parenteral nutrition-induced liver injury. Tsai JJ, etal., Proteomics. 2015 Nov;15(22):3865-74. doi: 10.1002/pmic.201500128.
39. Haplotypes of the fibrinogen gene and cerebral small vessel disease: the Rotterdam scan study. van Oijen M, etal., J Neurol Neurosurg Psychiatry. 2008 Jul;79(7):799-803. Epub 2007 Oct 19.
40. Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Warden CH, etal., Genomics 1993 Nov;18(2):295-307.
41. Proteomics of microparticles after experimental pulmonary embolism. Watts JA, etal., Thromb Res. 2011 Oct 17.
42. A novel fibrinogen mutation (gamma Thr277Arg) causes hereditary hypofibrinogenemia in a Chinese family. Zhu L, etal., Blood Coagul Fibrinolysis. 2013 Sep;24(6):642-4. doi: 10.1097/MBC.0b013e32835facdc.
43. Novel mutations (gammaTrp208Leu and gammaLys232Thr) leading to congenital hypofibrinogenemia in two unrelated Chinese families. Zhu L, etal., Blood Coagul Fibrinolysis. 2014 Dec;25(8):894-7. doi: 10.1097/MBC.0000000000000156.
Additional References at PubMed
PMID:1535334   PMID:1617215   PMID:1628813   PMID:2071145   PMID:2450406   PMID:2903254   PMID:7527354   PMID:7835895   PMID:8075500   PMID:8114702   PMID:8223273   PMID:8244376  
PMID:8404042   PMID:8428520   PMID:8431640   PMID:8467710   PMID:8827514   PMID:8918453   PMID:9096311   PMID:9143490   PMID:9537422   PMID:9788960   PMID:9819035   PMID:10349636  
PMID:10393836   PMID:10438476   PMID:10501977   PMID:10749569   PMID:10829076   PMID:10980108   PMID:11018075   PMID:11042159   PMID:11076861   PMID:11159184   PMID:11409899   PMID:11460467  
PMID:11891199   PMID:12218060   PMID:12426405   PMID:12477932   PMID:12750384   PMID:12766619   PMID:12819125   PMID:12855554   PMID:14644995   PMID:15173886   PMID:15257013   PMID:15304068  
PMID:15489334   PMID:15747579   PMID:15914557   PMID:16051597   PMID:16141072   PMID:16141073   PMID:16434491   PMID:16452087   PMID:16707424   PMID:16949567   PMID:16981239   PMID:17155952  
PMID:17339406   PMID:17932565   PMID:18287559   PMID:18337830   PMID:18593877   PMID:19056689   PMID:19059206   PMID:19167351   PMID:19332769   PMID:20152176   PMID:20233870   PMID:20876456  
PMID:21136017   PMID:21267068   PMID:21305474   PMID:21873635   PMID:22008794   PMID:22159717   PMID:22381526   PMID:22815383   PMID:23145320   PMID:23187627   PMID:23299312   PMID:24664548  
PMID:24916154   PMID:24983320   PMID:25353084   PMID:25614284   PMID:26921287   PMID:27140400   PMID:27561317   PMID:28071719   PMID:28378742   PMID:28737512   PMID:29495105   PMID:30737131  
PMID:30992366   PMID:31101623   PMID:31675530   PMID:32325033   PMID:33311441   PMID:34183396   PMID:35041705   PMID:36920550   PMID:37062522   PMID:37291385  


Genomics

Comparative Map Data
Fgg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39382,915,031 - 82,922,363 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl382,915,031 - 82,922,356 (+)EnsemblGRCm39 Ensembl
GRCm38383,007,724 - 83,015,056 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,007,724 - 83,015,049 (+)EnsemblGRCm38mm10GRCm38
MGSCv37382,811,818 - 82,818,971 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36383,093,823 - 83,100,976 (+)NCBIMGSCv36mm8
Celera383,011,995 - 83,019,099 (+)NCBICelera
Cytogenetic Map3E3NCBI
cM Map336.94NCBI
FGG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384154,604,136 - 154,612,656 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4154,604,134 - 154,612,967 (-)EnsemblGRCh38hg38GRCh38
GRCh374155,525,288 - 155,533,808 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364155,744,736 - 155,753,352 (-)NCBINCBI36Build 36hg18NCBI36
Build 344155,883,339 - 155,891,408NCBI
Celera4152,856,249 - 152,864,865 (-)NCBICelera
Cytogenetic Map4q32.1NCBI
HuRef4151,265,862 - 151,274,478 (-)NCBIHuRef
CHM1_14155,503,216 - 155,511,832 (-)NCBICHM1_1
T2T-CHM13v2.04157,935,943 - 157,944,463 (-)NCBIT2T-CHM13v2.0
Fgg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82170,652,929 - 170,660,372 (+)NCBIGRCr8
mRatBN7.22168,354,880 - 168,362,325 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2168,355,013 - 168,362,322 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2175,545,169 - 175,552,469 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02173,566,102 - 173,573,404 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02168,167,520 - 168,174,818 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02181,987,080 - 181,994,523 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2181,987,217 - 181,994,514 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02201,401,700 - 201,409,143 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42174,727,312 - 174,734,594 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12174,677,417 - 174,684,698 (+)NCBI
Celera2162,381,731 - 162,389,018 (+)NCBICelera
Cytogenetic Map2q34NCBI
Fgg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554718,786,910 - 8,795,013 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554718,786,910 - 8,794,947 (+)NCBIChiLan1.0ChiLan1.0
FGG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23152,516,571 - 152,539,442 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14152,872,009 - 152,886,596 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04146,970,671 - 146,979,348 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14158,788,761 - 158,797,460 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4158,788,966 - 158,797,237 (-)Ensemblpanpan1.1panPan2
FGG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11552,261,215 - 52,270,077 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1552,261,217 - 52,269,964 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1552,605,731 - 52,614,513 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01552,948,278 - 52,957,065 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1552,948,283 - 52,957,026 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11552,203,172 - 52,211,960 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01552,307,741 - 52,316,537 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01552,622,568 - 52,631,351 (-)NCBIUU_Cfam_GSD_1.0
Fgg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530138,194,766 - 38,203,257 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365761,343,661 - 1,352,143 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365761,343,657 - 1,352,085 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl874,553,105 - 74,563,688 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1874,553,040 - 74,562,151 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2878,850,804 - 78,859,881 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17101,148,457 - 101,157,245 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7101,148,058 - 101,157,111 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603780,803,057 - 80,811,786 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248585,827,316 - 5,838,170 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248585,828,334 - 5,836,382 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

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Variants in Fgg
231 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:46
Interacting mature miRNAs:53
Transcripts:ENSMUST00000048486
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
1357585Manln3_mmandible length 3 (mouse)Not determined35262550986625745Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
13464139Nhdlq17_mnon-HDL QTL 17 (mouse)35292318386923183Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1300895Hdl5_mHDL level 5 (mouse)Not determined34949500583495118Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
1301917Tshp4_mtooth shape 4 (mouse)Not determined35262550986625745Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
1301824Susp_msuppressor of superoxide production (mouse)Not determined34949500583495118Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1300593Skull4_mskull morphology 4 (mouse)Not determined35262550986625745Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35890730792907307Mouse
4141079Ath23_matherosclerosis 23 (mouse)Not determined4935758183357581Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse

Markers in Region
AI256424  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38383,014,921 - 83,015,009UniSTSGRCm38
MGSCv37382,818,843 - 82,818,931UniSTSGRCm37
Celera383,018,971 - 83,019,059UniSTS
Cytogenetic Map3E3UniSTS
cM Map341.3UniSTS
Whitehead/MRC_RH3804.92UniSTS
Fgg  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38383,012,909 - 83,014,192UniSTSGRCm38
Celera383,016,959 - 83,018,242UniSTS
Cytogenetic Map3E3UniSTS
cM Map336.94UniSTS


Expression


Sequence


Ensembl Acc Id: ENSMUST00000048486   ⟹   ENSMUSP00000037018
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl382,915,031 - 82,922,356 (+)Ensembl
GRCm38.p6 Ensembl383,007,724 - 83,015,049 (+)Ensembl
Ensembl Acc Id: ENSMUST00000194175   ⟹   ENSMUSP00000141648
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl382,915,168 - 82,922,012 (+)Ensembl
GRCm38.p6 Ensembl383,007,861 - 83,014,705 (+)Ensembl
RefSeq Acc Id: NM_001317105   ⟹   NP_001304034
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39382,915,031 - 82,922,024 (+)NCBI
GRCm38383,007,724 - 83,014,717 (+)NCBI
Sequence:
RefSeq Acc Id: NM_133862   ⟹   NP_598623
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39382,915,031 - 82,922,363 (+)NCBI
GRCm38383,007,724 - 83,015,056 (+)NCBI
MGSCv37382,811,818 - 82,818,971 (+)RGD
Celera383,011,995 - 83,019,099 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_598623   ⟸   NM_133862
- Peptide Label: isoform 1 precursor
- UniProtKB: Q8WUR3 (UniProtKB/Swiss-Prot),   Q91ZP0 (UniProtKB/Swiss-Prot),   Q8VCM7 (UniProtKB/Swiss-Prot),   Q3UEM7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001304034   ⟸   NM_001317105
- Peptide Label: isoform 2 precursor
- UniProtKB: Q3UER8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000037018   ⟸   ENSMUST00000048486
Ensembl Acc Id: ENSMUSP00000141648   ⟸   ENSMUST00000194175
Protein Domains
Fibrinogen C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VCM7-F1-model_v2 AlphaFold Q8VCM7 1-436 view protein structure

Promoters
RGD ID:6833779
Promoter ID:MM_KWN:34682
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_133862,   UC008PPD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36382,811,621 - 82,812,121 (+)MPROMDB
RGD ID:6847745
Promoter ID:MM_ACW:32097
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:FGG.CSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36382,816,471 - 82,816,971 (+)MPROMDB
RGD ID:6880968
Promoter ID:EPDNEW_M3935
Type:initiation region
Name:Fgg_1
Description:Mus musculus fibrinogen gamma chain , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38383,007,861 - 83,007,921EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95526 AgrOrtholog
Ensembl Genes ENSMUSG00000033860 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000048486 ENTREZGENE
  ENSMUST00000048486.13 UniProtKB/Swiss-Prot
  ENSMUST00000194175 ENTREZGENE
  ENSMUST00000194175.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.215.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fibrinogen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_a/b/g_coil_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:99571 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95526 ENTREZGENE
NCBI Gene 99571 ENTREZGENE
PANTHER FIBRINOGEN ALPHA CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FIBRINOGEN GAMMA CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Fib_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fgg PhenoGen
PROSITE FIBRINOGEN_C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FIBRINOGEN_C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FBG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fib_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Fibrinogen coiled-coil and central regions UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56496 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt FIBG_MOUSE UniProtKB/Swiss-Prot
  Q3UEM7 ENTREZGENE, UniProtKB/TrEMBL
  Q3UER8 ENTREZGENE, UniProtKB/TrEMBL
  Q8VCM7 ENTREZGENE
  Q8WUR3 ENTREZGENE
  Q91ZP0 ENTREZGENE
UniProt Secondary Q8WUR3 UniProtKB/Swiss-Prot
  Q91ZP0 UniProtKB/Swiss-Prot