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Gene: Ddit3 (DNA-damage inducible transcript 3) Mus musculus
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Description: Exhibits several functions, including DNA-binding transcription factor activity; protein heterodimerization activity; and transcription coactivator activity. Predicted to contribute to sequence-specific DNA binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway; negative regulation of cell differentiation; and regulation of transcription, DNA-templated. Localizes to the CHOP-C/EBP complex and late endosome. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Is expressed in several structures, including central nervous system; dorsal root ganglion; liver; sensory organ; and urethra of female. Orthologous to human DDIT3 (DNA damage inducible transcript 3); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (R)-lipoic acid; (S)-amphetamine; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C/EBP homoologous protein 10; C/EBP zeta; c/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; chop; CHOP-10; CHOP10; DDIT-3; DNA damage-inducible transcript 3 protein; gadd153; growth arrest and DNA-damage-inducible protein GADD153
Homo sapiens (human) : DDIT3 (DNA damage inducible transcript 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ddit3 (DNA-damage inducible transcript 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddit3 (DNA damage inducible transcript 3)
Pan paniscus (bonobo/pygmy chimpanzee) : DDIT3 (DNA damage inducible transcript 3)
Canis lupus familiaris (dog) : DDIT3 (DNA damage inducible transcript 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ddit3 (DNA damage inducible transcript 3)
Sus scrofa (pig) : DDIT3 (DNA damage inducible transcript 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3810127,290,793 - 127,296,291 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3710126,727,849 - 126,733,344 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610126,693,759 - 126,699,235 (+)NCBImm8
Celera10129,683,104 - 129,688,599 (+)NCBICelera
Cytogenetic Map10 D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ddit3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62396
Created: 2001-04-26
Species: Mus musculus
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.