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Gene: Ddit3 (DNA-damage inducible transcript 3) Mus musculus
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Symbol: Ddit3
Name: DNA-damage inducible transcript 3
RGD ID: 62396
Description: Exhibits several functions, including cAMP response element binding protein binding activity; molecular function regulator; and protein heterodimerization activity. Predicted to contribute to sequence-specific DNA binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway; negative regulation of cell differentiation; and regulation of transcription, DNA-templated. Localizes to CHOP-C/EBP complex; late endosome; and nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; liver; sensory organ; and urethra of female. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (R)-lipoic acid; (S)-amphetamine; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AltDDIT3; alternative DDIT3 proteins; C/EBP homoologous protein 10; C/EBP zeta; c/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; ch; chop; CHOP-; CHOP-10; CHOP10; DDIT-3; DNA damage-inducible transcript 3 protein; gadd15; gadd153; growth arrest and DNA-damage-inducible protein GADD153
Orthologs:
Homo sapiens (human) : DDIT3 (DNA damage inducible transcript 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ddit3 (DNA-damage inducible transcript 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddit3 (DNA damage inducible transcript 3)
Pan paniscus (bonobo/pygmy chimpanzee) : DDIT3 (DNA damage inducible transcript 3)
Canis lupus familiaris (dog) : DDIT3 (DNA damage inducible transcript 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ddit3 (DNA damage inducible transcript 3)
Sus scrofa (pig) : DDIT3 (DNA damage inducible transcript 3)
Chlorocebus sabaeus (African green monkey) : DDIT3 (DNA damage inducible transcript 3)
Heterocephalus glaber (naked mole-rat) : Ddit3 (DNA damage inducible transcript 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,126,662 - 127,132,160 (+)NCBI
GRCm3810127,290,793 - 127,296,291 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,290,829 - 127,293,753 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,290,774 - 127,296,288 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,727,849 - 126,733,344 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610126,693,759 - 126,699,235 (+)NCBImm8
Celera10129,683,104 - 129,688,599 (+)NCBICelera
Cytogenetic Map10D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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