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Gene: Ddit3 (DNA-damage inducible transcript 3) Mus musculus
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Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Description: Exhibits several functions, including DNA-binding transcription factor activity; protein heterodimerization activity; and transcription coactivator activity. Predicted to contribute to sequence-specific DNA binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway; negative regulation of cell differentiation; and regulation of transcription, DNA-templated. Localizes to the CHOP-C/EBP complex and late endosome. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Is expressed in several structures, including central nervous system; dorsal root ganglion; liver; sensory organ; and urethra of female. Orthologous to human DDIT3 (DNA damage inducible transcript 3); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (R)-lipoic acid; (S)-amphetamine; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C/EBP homoologous protein 10; C/EBP zeta; c/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; chop; CHOP-10; CHOP10; DDIT-3; DNA damage-inducible transcript 3 protein; gadd153; growth arrest and DNA-damage-inducible protein GADD153
Orthologs:
Homo sapiens (human) : DDIT3 (DNA damage inducible transcript 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ddit3 (DNA-damage inducible transcript 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddit3 (DNA damage inducible transcript 3)
Pan paniscus (bonobo/pygmy chimpanzee) : DDIT3 (DNA damage inducible transcript 3)
Canis lupus familiaris (dog) : DDIT3 (DNA damage inducible transcript 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ddit3 (DNA damage inducible transcript 3)
Sus scrofa (pig) : DDIT3 (DNA damage inducible transcript 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3810127,290,793 - 127,296,291 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3710126,727,849 - 126,733,344 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610126,693,759 - 126,699,235 (+)NCBImm8
Celera10129,683,104 - 129,688,599 (+)NCBICelera
Cytogenetic Map10 D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ddit3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62396
Created: 2001-04-26
Species: Mus musculus
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.