Gclc (glutamate-cysteine ligase, catalytic subunit) - Rat Genome Database

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Gene: Gclc (glutamate-cysteine ligase, catalytic subunit) Mus musculus
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
RGD ID: 10652
Description: Enables glutamate-cysteine ligase activity. Acts upstream of or within several processes, including glutathione biosynthetic process; negative regulation of apoptotic signaling pathway; and regulation of protein metabolic process. Located in cytosol. Part of glutamate-cysteine ligase complex. Is expressed in several structures, including alimentary system; central nervous system; integumental system; sensory organ; and urinary system. Used to study cataract. Human ortholog(s) of this gene implicated in cystic fibrosis; glutamate-cysteine ligase deficiency; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: D9Wsu168; D9Wsu168e; gamma GCS-HS; gamma-ECS; gamma-glutamylcysteine synthetase heavy subunit; GCS heavy chain; Ggcs-hs; Glc; GLCL; GLCL-H; Glclc; glutamate cysteine ligase (gamma-glutamylcysteine synthetase), catalytic; glutamate--cysteine ligase catalytic subunit
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39977,661,817 - 77,701,771 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl977,661,817 - 77,701,767 (+)EnsemblGRCm39 Ensembl
GRCm38977,754,535 - 77,794,489 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl977,754,535 - 77,794,485 (+)EnsemblGRCm38mm10GRCm38
MGSCv37977,602,617 - 77,641,458 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36977,540,494 - 77,579,335 (+)NCBIMGSCv36mm8
Celera974,927,826 - 74,966,687 (+)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(2,4,5-trichlorophenoxy)acetic acid  (EXP,ISO)
(E)-cinnamyl alcohol  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(RS)-coclaurine  (EXP)
(RS)-norcoclaurine  (EXP)
(S)-coclaurine  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1-bromopropane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (EXP)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (ISO)
2-(chloromethyl)pyridine  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butoxyethanol  (EXP)
2-chloroethanol  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-nitropropanoic acid  (ISO)
3-O-Caffeoyl-1-O-methylquinic acid  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-nitro-1,2-phenylenediamine  (ISO)
4-phenyl-3-furoxancarbonitrile  (EXP,ISO)
5-(hydroxymethyl)cytosine  (ISO)
5-bromo-2'-deoxyuridine  (EXP)
5-methylcytosine  (ISO)
7,8-dihydroxycoumarin  (ISO)
[6]-Shogaol  (EXP,ISO)
acetaldehyde  (ISO)
acetic acid  (ISO)
acetylcholine  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (ISO)
alcohol  (EXP)
aldehydo-D-glucosamine  (EXP)
aldosterone  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
alloxan  (ISO)
allyl isothiocyanate  (EXP)
alpha,alpha-trehalose  (ISO)
alpha-D-galactose  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-linolenic acid  (ISO)
alpha-Solamarine  (EXP)
amlexanox  (EXP)
ampicillin  (ISO)
andrographolide  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimonite  (ISO)
antimony(0)  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (EXP)
arotinoid acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
astilbin  (ISO)
Augmentin  (ISO)
azathioprine  (ISO)
Bandrowski's base  (ISO)
Bardoxolone methyl  (ISO)
benzalkonium chloride  (ISO)
benzene  (EXP,ISO)
benzidine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoic acid  (ISO)
benzoquinones  (EXP)
berberine  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bleomycin A5  (ISO)
boric acid  (EXP,ISO)
bortezomib  (ISO)
bosentan  (ISO)
Brodifacoum  (ISO)
bromobenzene  (EXP)
Brusatol  (ISO)
buspirone  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
butane-2,3-dione  (ISO)
butylated hydroxyanisole  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP,ISO)
cadmium sulfide  (ISO)
cafestol  (ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
captan  (EXP)
carbamazepine  (ISO)
carbon disulfide  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
carnosic acid  (EXP,ISO)
Carnosol  (ISO)
celastrol  (ISO)
ceric oxide  (ISO)
cerium trichloride  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chlorogenic acid  (ISO)
chlorohydrocarbon  (ISO)
chloroprene  (EXP,ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
cholesterol  (EXP)
choline  (EXP)
chromium atom  (ISO)
chromium trinitrate  (ISO)
chromium(6+)  (EXP,ISO)
chrysin  (ISO)
cidofovir anhydrous  (ISO)
cinnamyl alcohol  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
citraconic acid  (EXP,ISO)
clavulanic acid  (ISO)
Clivoline  (ISO)
clobetasol  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
coniferyl aldehyde  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumarin  (ISO)
crocidolite asbestos  (EXP)
cumene hydroperoxide  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (EXP,ISO)
cysteamine  (EXP)
deguelin  (ISO)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (ISO)
deoxynivalenol  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
dextromethorphan  (EXP)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenzoylmethane  (EXP)
dibutyl phthalate  (ISO)
dichloromethane  (EXP)
diclofenac  (ISO)
diethyl malate  (EXP)
diethyl maleate  (EXP,ISO)
diethyl sulfate  (ISO)
diethylstilbestrol  (ISO)
dihydrogen  (EXP)
dimethyl fumarate  (EXP,ISO)
dimethylarsinic acid  (ISO)
dinoseb  (EXP)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diprotium  (EXP)
diprotium oxide  (EXP)
diquat  (EXP,ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
diuron  (ISO)
domoic acid  (EXP)
dopamine  (ISO)
doramapimod  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
erastin  (ISO)
erdosteine  (EXP)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
Ethyl acrylate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
farnesal  (ISO)
farrerol  (EXP)
fenofibrate  (ISO)
ferrostatin-1  (EXP)
fipronil  (ISO)
flutamide  (EXP,ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
fumaraldehyde  (ISO)
furan  (EXP,ISO)
galactose  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-linolenic acid  (ISO)
gefitinib  (ISO)
genistein  (ISO)
ginsenoside Rg1  (EXP)
Ginsenoside Rh4  (EXP,ISO)
gliclazide  (ISO)
glutathione  (EXP,ISO)
Glutathione ethyl ester  (EXP)
glycerol 2-phosphate  (ISO)
guggulsterone  (EXP,ISO)
hemin  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hexadecanoic acid  (ISO)
hexane  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP,ISO)
hypochlorous acid  (EXP)
ibuprofen  (ISO)
ifosfamide  (ISO)
indometacin  (EXP,ISO)
iron atom  (ISO)
iron trichloride  (EXP)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) nitrilotriacetate  (EXP)
isoeugenol  (ISO)
isoniazide  (EXP,ISO)
isoprenaline  (EXP)
isorhamnetin  (EXP,ISO)
isothiocyanate  (EXP)
ivermectin  (ISO)
kaempferol  (EXP,ISO)
kahweol  (ISO)
ketamine  (ISO)
ketoprofen  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-cysteine  (ISO)
L-gamma-glutamyl-L-cysteine  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
Leonurine  (ISO)
levofloxacin  (ISO)
linalool  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP)
liquiritigenin  (ISO)
liquiritin  (ISO)
lithocholic acid  (EXP,ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
maneb  (ISO)
melatonin  (EXP)
meloxicam  (ISO)
menadione  (EXP,ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
mesalamine  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methyl non-2-ynoate  (ISO)
methyl salicylate  (ISO)
methylene blue  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
Methysticin  (EXP)
microcystin  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (EXP)
miquelianin  (ISO)
MK 571  (ISO)
monocrotaline  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methylformamide  (EXP)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
naphthalene  (EXP,ISO)
naphthalene-1,2-diol  (ISO)
naproxen  (ISO)
naringin  (ISO)
nefazodone  (ISO)
neoastilbin  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP,ISO)
nicotinamide  (ISO)
nicotine  (EXP)
nimesulide  (ISO)
nimustine  (ISO)
nitisinone  (EXP)
nitric oxide  (ISO)
nitrofurantoin  (ISO)
Nodularin  (ISO)
Nonidet P-40  (ISO)
notoginsenoside R1  (ISO)
ochratoxin A  (EXP,ISO)
oleanolic acid  (EXP,ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
para-Cresidine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorobutyric acid  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
perfluoroundecanoic acid  (EXP)
permethrin  (ISO)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (EXP)
phloroglucinol  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
Polpunonic acid  (EXP,ISO)
potassium chloride  (ISO)
potassium chromate  (EXP)
potassium dichromate  (EXP)
pravastatin  (EXP,ISO)
prazosin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP)
propacetamol  (EXP)
propan-2-ol  (ISO)
propanal  (ISO)
prostaglandin J2  (ISO)
puerarin  (EXP,ISO)
pyocyanine  (ISO)
pyrazines  (ISO)
Pyridostigmine bromide  (ISO)
pyrroloquinoline quinone  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (EXP,ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
selenocystine  (ISO)
selenomethionine  (ISO)
sevoflurane  (EXP)
silicon atom  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
silver(1+) nitrate  (ISO)
SL-327  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium cholate  (EXP)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
spironolactone  (ISO)
staurosporine  (ISO)
stavudine  (ISO)
streptozocin  (EXP,ISO)
styrene  (EXP)
succimer  (ISO)
sulforaphane  (EXP,ISO)
sulindac  (ISO)
sunitinib  (ISO)
suprofen  (ISO)
T-2 toxin  (EXP)
tamoxifen  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP,ISO)
thapsigargin  (ISO)
thiabendazole  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trans-isoeugenol  (ISO)
triacsin C  (ISO)
tributylstannane  (EXP)
trichostatin A  (ISO)
trimethyltin  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (EXP)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
usnic acid  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
vanillin  (ISO)
vincristine  (ISO)
vitamin E  (EXP,ISO)
water  (EXP)
withaferin A  (EXP)
XAV939  (ISO)
yohimbine  (EXP)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc oxide  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
blood vessel diameter maintenance  (ISO)
cell redox homeostasis  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to thyroxine stimulus  (ISO)
cysteine metabolic process  (ISO)
glutamate metabolic process  (ISO)
glutathione biosynthetic process  (IBA,IDA,IMP,ISO)
glutathione metabolic process  (IMP)
L-ascorbic acid metabolic process  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IGI)
negative regulation of hepatic stellate cell activation  (ISO)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (IGI)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein ubiquitination  (IMP)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IMP)
regulation of mitochondrial depolarization  (IGI)
response to activity  (ISO)
response to arsenic-containing substance  (IMP)
response to auditory stimulus  (ISO)
response to cadmium ion  (ISO)
response to heat  (ISO)
response to hormone  (ISO)
response to human chorionic gonadotropin  (ISO)
response to interleukin-1  (ISO)
response to nitrosative stress  (ISO)
response to nutrient  (ISO)
response to oxidative stress  (ISO)
response to xenobiotic stimulus  (IMP)

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Knock down of gamma-glutamylcysteine synthetase in rat causes acetaminophen-induced hepatotoxicity. Akai S, etal., J Biol Chem. 2007 Aug 17;282(33):23996-4003. Epub 2007 Jun 15.
2. The molecular basis of a case of gamma-glutamylcysteine synthetase deficiency. Beutler E, etal., Blood 1999 Oct 15;94(8):2890-4.
3. Schisandra Chinensis Baillon regulates the gene expression of phase II antioxidant/detoxifying enzymes in hepatic damage induced rats. Jang HI, etal., Nutr Res Pract. 2014 Jun;8(3):272-7. doi: 10.4162/nrp.2014.8.3.272. Epub 2014 May 15.
4. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, etal., Hum Mol Genet 1998 Nov;7(12):1967-78.
5. Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction. Koide S, etal., J Am Coll Cardiol 2003 Feb 19;41(4):539-45.
6. Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers. Kuo MT, etal., Cancer Res. 1996 Aug 15;56(16):3642-4.
7. Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study. Marson FA, etal., BMC Med Genet. 2014 Mar 4;15:27. doi: 10.1186/1471-2350-15-27.
8. Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease. McKone EF, etal., Am J Respir Crit Care Med. 2006 Aug 15;174(4):415-9. Epub 2006 May 11.
9. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
10. MGDs mouse GO annotations MGD data from the GO Consortium
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis. Ramani K, etal., J Biol Chem. 2012 Oct 19;287(43):36341-55. doi: 10.1074/jbc.M112.370775. Epub 2012 Aug 31.
15. Mouse MP Annotation Import Pipeline RGD automated import pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. A missense mutation in the heavy subunit of gamma-glutamylcysteine synthetase gene causes hemolytic anemia. Ristoff E, etal., Blood. 2000 Apr 1;95(7):2193-6.
19. Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3. Tsuchiya K, etal., Genomics 1995 Dec 10;30(3):630-2.
20. The critical role of the cellular thiol homeostasis in cadmium perturbation of the lung extracellular matrix. Zhao Y, etal., Toxicology. 2010 Jan 12;267(1-3):60-9. Epub 2009 Oct 29.
Additional References at PubMed
PMID:7578676   PMID:9223101   PMID:9224945   PMID:10349636   PMID:10421798   PMID:10725249   PMID:10805773   PMID:10922068   PMID:10966520   PMID:11032771   PMID:11042159   PMID:11076861  
PMID:11118286   PMID:11217851   PMID:11933164   PMID:12063408   PMID:12363041   PMID:12384496   PMID:12466851   PMID:12477932   PMID:14681479   PMID:15288121   PMID:15336720   PMID:15489334  
PMID:15629866   PMID:16081425   PMID:16141072   PMID:16141073   PMID:16324789   PMID:16403949   PMID:16840778   PMID:17000861   PMID:17189825   PMID:17464988   PMID:17559975   PMID:17785990  
PMID:18094238   PMID:18691715   PMID:18799693   PMID:19521566   PMID:19914271   PMID:20061376   PMID:20128681   PMID:20300111   PMID:20332089   PMID:20463017   PMID:20696779   PMID:21267068  
PMID:21389693   PMID:21554947   PMID:21657237   PMID:21677750   PMID:21873635   PMID:22249522   PMID:22634145   PMID:23045016   PMID:23226398   PMID:23237955   PMID:23671099   PMID:26199344  
PMID:26808544   PMID:27125672   PMID:27140233   PMID:27472077   PMID:28158580   PMID:28177569   PMID:28423341   PMID:28457937   PMID:28525556   PMID:28827139   PMID:28951044   PMID:29618580  
PMID:30198844   PMID:30333137   PMID:30753104   PMID:30938680   PMID:31220272   PMID:32213345   PMID:32325033   PMID:34198827   PMID:34359856   PMID:35379825   PMID:36243294  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39977,661,817 - 77,701,771 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl977,661,817 - 77,701,767 (+)EnsemblGRCm39 Ensembl
GRCm38977,754,535 - 77,794,489 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl977,754,535 - 77,794,485 (+)EnsemblGRCm38mm10GRCm38
MGSCv37977,602,617 - 77,641,458 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36977,540,494 - 77,579,335 (+)NCBIMGSCv36mm8
Celera974,927,826 - 74,966,687 (+)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38653,497,341 - 53,545,101 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl653,497,341 - 53,616,970 (-)EnsemblGRCh38hg38GRCh38
GRCh37653,362,139 - 53,409,899 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36653,470,098 - 53,517,790 (-)NCBINCBI36Build 36hg18NCBI36
Build 34653,470,097 - 53,517,790NCBI
Celera655,024,301 - 55,071,990 (-)NCBICelera
Cytogenetic Map6p12.1NCBI
HuRef653,193,712 - 53,241,391 (-)NCBIHuRef
CHM1_1653,363,932 - 53,411,726 (-)NCBICHM1_1
T2T-CHM13v2.0653,337,262 - 53,385,020 (-)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2878,629,899 - 78,668,547 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl878,630,127 - 78,668,544 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx884,117,437 - 84,155,850 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0882,394,078 - 82,432,491 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0880,216,769 - 80,255,182 (+)NCBIRnor_WKY
Rnor_6.0885,059,051 - 85,097,471 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl885,059,051 - 85,097,468 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0884,627,768 - 84,666,188 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4882,724,429 - 82,762,848 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1882,743,482 - 82,781,899 (+)NCBI
Celera878,379,669 - 78,418,088 (+)NCBICelera
Cytogenetic Map8q31NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554112,593,541 - 2,616,539 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554112,593,523 - 2,617,553 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1654,687,315 - 54,738,111 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl654,687,315 - 54,734,994 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0653,052,145 - 53,102,794 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11220,999,815 - 21,047,779 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1221,000,792 - 21,047,779 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1220,898,243 - 20,947,109 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01221,495,557 - 21,544,499 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1221,496,624 - 21,545,459 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11220,996,643 - 21,045,520 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01221,104,936 - 21,153,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01221,243,198 - 21,292,135 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494656,541,439 - 56,588,950 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364767,371,149 - 7,418,958 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364767,371,270 - 7,418,756 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl727,209,565 - 27,253,530 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1727,209,565 - 27,253,535 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2731,702,759 - 31,747,437 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11719,012,994 - 19,060,617 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1719,013,026 - 19,060,659 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604453,368,286 - 53,415,900 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624850749,050 - 793,959 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624850749,046 - 793,654 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:334
Count of miRNA genes:252
Interacting mature miRNAs:288
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94883105682831177Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94883105682831177Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
14746993Manh66_mmandible shape 66 (mouse)94981404883814048Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95015132084151448Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95203447899792481Mouse
12790990Tgl7_mtriglyceride 7 (mouse)95455996088559960Mouse
10043877Adip21_madiposity 21 (mouse)Not determined95643910890439255Mouse
4141676Neogq1_mneonatal growth QTL 1 (mouse)Not determined95780504786121973Mouse
1301803Stheal9_msoft tissue heal 9 (mouse)Not determined95902438793024534Mouse
1301172Fembrs6_mfemur breaking strength 6 (mouse)Not determined95902438793024534Mouse
1301456Adip5_madiposity 5 (mouse)Not determined95936994693370128Mouse
1300848Skull13_mskull morphology 13 (mouse)Not determined95936994693370128Mouse
5491195Mobq8_mmultigenic obesity QTL 8 (mouse)Not determined95936994693370128Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959897283109089068Mouse
1301611Lrnx3_mlearning contextual 3 (mouse)Not determined96214976796149881Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
11081165Psl6_mpromotion susceptibility QTL 6 (mouse)96504119195522808Mouse
1301290Smgd1_msubmucosal gland distribution 1 (mouse)Not determined96583105686577967Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966089077100089175Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967006220101006220Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968779563102779705Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968779563102779705Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969121898103121973Mouse
10412174Habiir4_mhyperoxic acute lung injury imprinted region 4 (mouse)Not determined96926774798701707Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969428566103428698Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972859058106859205Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972859058106859205Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974250230108250378Mouse
1301914Ksc1_mkeratinocyte stem cell locus 1 (mouse)Not determined97540903779998332Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975682646114303447Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975682646114303447Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976024387101406120Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976417989110418183Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38977,794,074 - 77,794,346UniSTSGRCm38
MGSCv37977,641,881 - 77,642,153UniSTSGRCm37
Celera974,967,111 - 74,967,383UniSTS
Cytogenetic Map9D-EUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9D-EUniSTS
cM Map942.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38977,793,393 - 77,793,590UniSTSGRCm38
MGSCv37977,641,200 - 77,641,397UniSTSGRCm37
Celera974,966,429 - 74,966,626UniSTS
Cytogenetic Map9D-EUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38977,794,008 - 77,794,207UniSTSGRCm38
MGSCv37977,641,815 - 77,642,014UniSTSGRCm37
Celera974,967,045 - 74,967,244UniSTS
Cytogenetic Map9D-EUniSTS
cM Map942.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9D-EUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9D-EUniSTS
cM Map942.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9D-EUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9D-EUniSTS



Reference Sequences
RefSeq Acc Id: ENSMUST00000034905   ⟹   ENSMUSP00000034905
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl977,661,817 - 77,701,767 (+)Ensembl
GRCm38.p6 Ensembl977,754,535 - 77,794,485 (+)Ensembl
RefSeq Acc Id: ENSMUST00000216315
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl977,671,265 - 77,688,544 (+)Ensembl
GRCm38.p6 Ensembl977,763,983 - 77,781,262 (+)Ensembl
RefSeq Acc Id: ENSMUST00000216848
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl977,673,424 - 77,686,827 (+)Ensembl
GRCm38.p6 Ensembl977,766,142 - 77,779,545 (+)Ensembl
RefSeq Acc Id: NM_010295   ⟹   NP_034425
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39977,661,817 - 77,701,771 (+)NCBI
GRCm38977,754,535 - 77,794,489 (+)NCBI
MGSCv37977,602,617 - 77,641,458 (+)RGD
Celera974,927,562 - 74,967,526 (+)ENTREZGENE
RefSeq Acc Id: NR_151778
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39977,661,817 - 77,701,771 (+)NCBI
GRCm38977,754,535 - 77,794,489 (+)NCBI
RefSeq Acc Id: XM_006510812   ⟹   XP_006510875
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39977,671,364 - 77,701,771 (+)NCBI
GRCm38977,764,082 - 77,794,485 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_034425   ⟸   NM_010295
- UniProtKB: Q8VCS5 (UniProtKB/Swiss-Prot),   P97494 (UniProtKB/Swiss-Prot),   Q3TEF1 (UniProtKB/TrEMBL),   Q3UNA7 (UniProtKB/TrEMBL),   A0A8C6IEA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006510875   ⟸   XM_006510812
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000034905   ⟸   ENSMUST00000034905

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97494-F1-model_v2 AlphaFold P97494 1-637 view protein structure

RGD ID:6844546
Promoter ID:MM_KWN:58128
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Mouse AssemblyChrPosition (strand)Source
MGSCv36977,602,261 - 77,602,761 (+)MPROMDB
RGD ID:8670236
Promoter ID:EPDNEW_M13149
Type:initiation region
Description:Mus musculus glutamate-cysteine ligase, catalytic subunit , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13150  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38977,754,535 - 77,754,595EPDNEW
RGD ID:8670238
Promoter ID:EPDNEW_M13150
Type:initiation region
Description:Mus musculus glutamate-cysteine ligase, catalytic subunit , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13149  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38977,754,728 - 77,754,788EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104990 AgrOrtholog
Ensembl Genes ENSMUSG00000032350 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000034905 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034905 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gln_synth/guanido_kin_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14629 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR11164 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gclc PhenoGen
Superfamily-SCOP SSF55931 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary O09166 UniProtKB/Swiss-Prot
  Q8VCS5 UniProtKB/Swiss-Prot