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Gene: Gclc (glutamate-cysteine ligase, catalytic subunit) Mus musculus
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Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Description: Exhibits glutamate-cysteine ligase activity and protein heterodimerization activity. Involved in several processes, including glutathione biosynthetic process; negative regulation of apoptotic signaling pathway; and regulation of cellular protein metabolic process. Localizes to the cytosol and glutamate-cysteine ligase complex. Used to study cataract. Human ortholog(s) of this gene implicated in cystic fibrosis; hemolytic anemia; and myocardial infarction. Is expressed in several structures, including alimentary system; metanephros; respiratory system; sensory organ; and telencephalon. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; cysteine metabolic pathway; glutamic acid/glutamate metabolic pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (2,4,5-trichlorophenoxy)acetic acid; (RS)-coclaurine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D9Wsu168e; gamma GCS-HS; gamma-ECS; gamma-glutamylcysteine synthetase heavy subunit; GCS heavy chain; Ggcs-hs; GLCL-H; Glclc; glutamate cysteine ligase (gamma-glutamylcysteine synthetase), catalytic; glutamate--cysteine ligase catalytic subunit
Orthologs:
Homo sapiens (human) : GCLC (glutamate-cysteine ligase catalytic subunit)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gclc (glutamate-cysteine ligase, catalytic subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gclc (glutamate-cysteine ligase catalytic subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : GCLC (glutamate-cysteine ligase catalytic subunit)
Canis lupus familiaris (dog) : GCLC (glutamate-cysteine ligase catalytic subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gclc (glutamate-cysteine ligase catalytic subunit)
Sus scrofa (pig) : GCLC (glutamate-cysteine ligase catalytic subunit)
Chlorocebus sabaeus (green monkey) : GCLC (glutamate-cysteine ligase catalytic subunit)
Heterocephalus glaber (naked mole-rat) : Gclc (glutamate-cysteine ligase catalytic subunit)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl977,754,535 - 77,794,485 (+)Ensembl
GRCm38977,754,535 - 77,794,489 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37977,602,617 - 77,641,458 (+)NCBIGRCm37mm9NCBIm37
MGSCv36977,540,494 - 77,579,335 (+)NCBImm8
Celera974,927,562 - 74,967,526 (+)NCBICelera
Cytogenetic Map9 E1NCBI
cM Map943.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Gclc
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10652
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.