(+)-alpha-tocopherol multiple interactions ISO RGD:736793 6480464 [alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLC mRNA CTD PMID:24530478 (+)-schisandrin B increases activity ISO RGD:619868 6480464 schizandrin B analog results in increased activity of GCLC protein CTD PMID:21328628 (+)-schisandrin B multiple interactions ISO RGD:619868 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of GCLC mRNA] CTD PMID:31150632 (-)-epigallocatechin 3-gallate increases expression EXP 6480464 epigallocatechin gallate results in increased expression of GCLC mRNA CTD PMID:25585349 (2,4,5-trichlorophenoxy)acetic acid increases expression ISO RGD:736793 6480464 2 more ... CTD PMID:16426233 (2,4,5-trichlorophenoxy)acetic acid increases expression EXP 6480464 2 more ... CTD PMID:10377250 , PMID:16426233 (E)-cinnamyl alcohol increases expression ISO RGD:736793 6480464 cinnamyl alcohol results in increased expression of GCLC mRNA CTD PMID:20566472 (R)-lipoic acid increases expression ISO RGD:736793 6480464 Thioctic Acid results in increased expression of GCLC mRNA CTD PMID:16249512 , PMID:17940886 (R)-lipoic acid multiple interactions ISO RGD:619868 6480464 Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC mRNA], Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC protein] CTD PMID:27298056 (RS)-coclaurine multiple interactions EXP 6480464 [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 (RS)-norcoclaurine multiple interactions EXP 6480464 [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 (S)-coclaurine multiple interactions EXP 6480464 [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 (S)-naringenin multiple interactions ISO RGD:736793 6480464 NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLC protein] CTD PMID:31254498 (S)-naringenin increases expression ISO RGD:736793 6480464 naringenin results in increased expression of GCLC protein CTD PMID:31254498 (S)-nicotine multiple interactions EXP 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 1,1'-azobis(N,N-dimethylformamide) increases activity ISO RGD:619868 6480464 Diamide results in increased activity of GCLC protein CTD PMID:15115889 1,1'-azobis(N,N-dimethylformamide) increases expression ISO RGD:619868 6480464 Diamide results in increased expression of GCLC mRNA, Diamide results in increased expression of GCLC protein CTD PMID:15115889 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expression ISO RGD:619868 6480464 o, p'-DDT affects the expression of GCLC mRNA CTD PMID:17984292 1,2-dichloroethane multiple interactions EXP 6480464 [ethylene dichloride co-treated with Ethanol] results in increased expression of GCLC mRNA, [ethylene dichloride co-treated with Ethanol] results in increased expression of GCLC protein CTD PMID:30664321 1,3-benzothiazole-2-thiol increases expression ISO RGD:736793 6480464 captax results in increased expression of GCLC mRNA CTD PMID:20491607 1,3-dichloropropan-2-ol increases expression ISO RGD:619868 6480464 1, 3-dichloro-2-propanol results in increased expression of GCLC mRNA CTD PMID:26143167 1-bromopropane multiple interactions EXP 6480464 NFE2L2 promotes the reaction [1-bromopropane results in increased expression of GCLC mRNA] CTD PMID:20211940 1-bromopropane increases expression EXP 6480464 1-bromopropane results in increased expression of GCLC mRNA CTD PMID:20211940 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:736793 6480464 Dinitrochlorobenzene results in increased expression of GCLC mRNA CTD PMID:20146380 , PMID:20566472 1-fluoro-2,4-dinitrobenzene increases expression ISO RGD:736793 6480464 Dinitrofluorobenzene results in increased expression of GCLC mRNA CTD PMID:23999411 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression EXP 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions EXP 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 1-naphthyl isothiocyanate increases expression ISO RGD:619868 6480464 1-Naphthylisothiocyanate results in increased expression of GCLC mRNA CTD PMID:20551477 15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactions ISO RGD:736793 6480464 15-deoxy-delta(12 more ... CTD PMID:21728338 15-deoxy-Delta(12,14)-prostaglandin J2 increases expression ISO RGD:736793 6480464 15-deoxy-delta(12 more ... CTD PMID:21728338 17alpha-ethynylestradiol affects expression ISO RGD:736793 6480464 Ethinyl Estradiol affects the expression of GCLC mRNA CTD PMID:20170705 , PMID:26865667 17beta-estradiol multiple interactions ISO RGD:619868 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of GCLC mRNA CTD PMID:26496021 17beta-estradiol multiple interactions ISO RGD:736793 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of GCLC mRNA CTD PMID:30165855 17beta-estradiol increases expression ISO RGD:619868 6480464 Estradiol results in increased expression of GCLC mRNA CTD PMID:31119341 1H-pyrazole increases expression EXP 6480464 pyrazole results in increased expression of GCLC mRNA CTD PMID:17945193 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [2' more ... CTD PMID:31029725 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone increases expression EXP 6480464 2' more ... CTD PMID:31029725 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO RGD:736793 6480464 2 more ... CTD PMID:25659769 2,2',4,4'-Tetrabromodiphenyl ether multiple interactions ISO RGD:736793 6480464 [Eicosapentaenoic Acid analog co-treated with Docosahexaenoic Acids analog] promotes the reaction [2 more ... CTD PMID:25659769 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of GCLC mRNA more ... CTD PMID:16054899 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:736793 6480464 [Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in increased expression of GCLC mRNA CTD PMID:29704546 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of GCLC mRNA CTD PMID:20702594 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of GCLC mRNA CTD PMID:15328365 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:619868 6480464 Tetrachlorodibenzodioxin results in decreased expression of GCLC mRNA CTD PMID:21215274 , PMID:23238561 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:736793 6480464 Tetrachlorodibenzodioxin results in increased expression of GCLC mRNA CTD PMID:19542225 , PMID:21802500 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:619868 6480464 Tetrachlorodibenzodioxin results in increased expression of GCLC mRNA CTD PMID:16960034 2,3,7,8-Tetrachlorodibenzofuran affects expression EXP 6480464 2 more ... CTD PMID:20702594 2,4,6-trinitrobenzenesulfonic acid multiple interactions ISO RGD:619868 6480464 [Trinitrobenzenesulfonic Acid co-treated with Ethanol] results in increased expression of GCLC mRNA CTD PMID:10830784 2,4-dinitrotoluene affects expression ISO RGD:619868 6480464 2, 4-dinitrotoluene affects the expression of GCLC mRNA CTD PMID:21346803 2,6-di-tert-butyl-4-methylphenol increases expression EXP 6480464 Butylated Hydroxytoluene results in increased expression of GCLC protein CTD PMID:21536018 2,6-dinitrotoluene affects expression ISO RGD:619868 6480464 2, 6-dinitrotoluene affects the expression of GCLC mRNA CTD PMID:21346803 2-(chloromethyl)pyridine increases expression ISO RGD:736793 6480464 2-chloromethylpyridine results in increased expression of GCLC mRNA CTD PMID:26198647 2-acetamidofluorene increases expression ISO RGD:736793 6480464 2-Acetylaminofluorene results in increased expression of GCLC mRNA CTD PMID:16426233 2-acetamidofluorene multiple interactions ISO RGD:619868 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLC mRNA, [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GCLC mRNA CTD PMID:14656948 , PMID:16158176 2-acetamidofluorene increases expression EXP 6480464 2-Acetylaminofluorene results in increased expression of GCLC mRNA CTD PMID:16426233 2-amino-2-deoxy-D-glucopyranose increases expression EXP 6480464 Glucosamine analog results in increased expression of GCLC mRNA CTD PMID:21825963 2-butoxyethanol increases expression EXP 6480464 n-butoxyethanol results in increased expression of GCLC mRNA CTD PMID:19812364 2-chloroethanol multiple interactions ISO RGD:619868 6480464 allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC mRNA] more ... CTD PMID:31585129 2-chloroethanol increases expression ISO RGD:619868 6480464 Ethylene Chlorohydrin results in increased expression of GCLC mRNA, Ethylene Chlorohydrin results in increased expression of GCLC protein CTD PMID:31585129 2-hydroxypropanoic acid increases expression ISO RGD:736793 6480464 Lactic Acid results in increased expression of GCLC mRNA CTD PMID:20566472 2-nitrofluorene increases expression ISO RGD:619868 6480464 2-nitrofluorene results in increased expression of GCLC mRNA CTD PMID:14600272 , PMID:15890375 2-tert-butylhydroquinone multiple interactions EXP 6480464 [2-tert-butylhydroquinone results in increased activity of GCLC protein] which results in increased abundance of Glutathione more ... CTD PMID:19328227 more ... 2-tert-butylhydroquinone increases expression ISO RGD:736793 6480464 2-tert-butylhydroquinone results in increased expression of GCLC mRNA CTD PMID:27178040 , PMID:30806763 2-tert-butylhydroquinone increases expression ISO RGD:619868 6480464 2-tert-butylhydroquinone results in increased expression of GCLC mRNA CTD PMID:10978506 2-tert-butylhydroquinone increases activity EXP 6480464 2-tert-butylhydroquinone results in increased activity of GCLC protein CTD PMID:7955076 2-tert-butylhydroquinone affects expression ISO RGD:736793 6480464 2-tert-butylhydroquinone affects the expression of GCLC mRNA CTD PMID:15946948 2-tert-butylhydroquinone increases expression EXP 6480464 2-tert-butylhydroquinone results in increased expression of GCLC mRNA CTD PMID:12007577 more ... 3,3',4,4',5-pentachlorobiphenyl increases expression ISO RGD:619868 6480464 3 more ... CTD PMID:23196670 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:23994337 3,3',5,5'-tetrabromobisphenol A increases expression ISO RGD:736793 6480464 tetrabromobisphenol A results in increased expression of GCLC mRNA CTD PMID:30951941 3,3',5,5'-tetrabromobisphenol A multiple interactions ISO RGD:736793 6480464 Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased expression of GCLC mRNA] CTD PMID:30951941 3,4-methylenedioxymethamphetamine multiple interactions ISO RGD:619868 6480464 N-Methyl-3, 4-methylenedioxyamphetamine inhibits the reaction [sulforafan results in increased expression of GCLC mRNA] CTD PMID:21871945 3-chloropropane-1,2-diol decreases expression ISO RGD:619868 6480464 alpha-Chlorohydrin results in decreased expression of GCLC mRNA CTD PMID:28522335 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GCLC mRNA, Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GCLC mRNA] CTD PMID:16054899 3-nitropropanoic acid multiple interactions ISO RGD:619868 6480464 [naringin co-treated with 3-nitropropionic acid] results in increased expression of GCLC mRNA CTD PMID:22871521 3-phenylprop-2-enal multiple interactions ISO RGD:736793 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cinnamic aldehyde results in increased expression of GCLC protein] more ... CTD PMID:20351055 , PMID:21469739 3-phenylprop-2-enal increases expression ISO RGD:736793 6480464 cinnamic aldehyde results in increased expression of GCLC mRNA, cinnamic aldehyde results in increased expression of GCLC protein CTD PMID:17178418 more ... 3H-1,2-dithiole-3-thione multiple interactions ISO RGD:619868 6480464 [1, 2-dithiol-3-thione results in increased activity of GCLC protein] which results in decreased susceptibility to Acrolein CTD PMID:12535742 3H-1,2-dithiole-3-thione increases expression ISO RGD:736793 6480464 1, 2-dithiol-3-thione results in increased expression of GCLC mRNA CTD PMID:19073213 , PMID:19408115 3H-1,2-dithiole-3-thione increases expression EXP 6480464 1 more ... CTD PMID:18367636 , PMID:22959925 3H-1,2-dithiole-3-thione multiple interactions EXP 6480464 [1 more ... CTD PMID:18367636 , PMID:22495766 3H-1,2-dithiole-3-thione increases expression ISO RGD:619868 6480464 1, 2-dithiol-3-thione results in increased expression of GCLC mRNA CTD PMID:15946642 3H-1,2-dithiole-3-thione increases activity ISO RGD:619868 6480464 1, 2-dithiol-3-thione results in increased activity of GCLC protein CTD PMID:12535742 4,4'-methylene-bis-(2-chloroaniline) increases expression ISO RGD:736793 6480464 Methylenebis(chloroaniline) results in increased expression of GCLC mRNA CTD PMID:26198647 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression ISO RGD:619868 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GCLC mRNA CTD PMID:15890375 4-amino-2,6-dinitrotoluene affects expression ISO RGD:619868 6480464 4-amino-2, 6-dinitrotoluene affects the expression of GCLC mRNA CTD PMID:21346803 4-hydroxynon-2-enal increases expression EXP 6480464 4-hydroxy-2-nonenal results in increased expression of GCLC mRNA CTD PMID:19191707 4-hydroxynon-2-enal multiple interactions ISO RGD:619868 6480464 NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GCLC mRNA] CTD PMID:24291486 4-hydroxynon-2-enal increases expression ISO RGD:619868 6480464 4-hydroxy-2-nonenal results in increased expression of GCLC protein CTD PMID:24291486 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of GCLC mRNA CTD PMID:28973697 4-hydroxyphenyl retinamide increases expression ISO RGD:736793 6480464 Fenretinide results in increased expression of GCLC mRNA CTD PMID:21319187 4-hydroxyphenyl retinamide multiple interactions ISO RGD:736793 6480464 [Fenretinide co-treated with scriptaid] results in increased expression of GCLC mRNA, [Fenretinide co-treated with trichostatin A] results in increased expression of GCLC mRNA CTD PMID:21319187 4-nitro-1,2-phenylenediamine increases expression ISO RGD:736793 6480464 1, 2-diamino-4-nitrobenzene results in increased expression of GCLC mRNA CTD PMID:26198647 5-bromo-2'-deoxyuridine multiple interactions EXP 6480464 [Bromodeoxyuridine co-treated with furan] results in increased expression of GCLC mRNA CTD PMID:24910943 7,8-dihydroxycoumarin increases expression ISO RGD:736793 6480464 daphnetin results in increased expression of GCLC protein CTD PMID:30738023 [6]-Shogaol increases expression EXP 6480464 shogaol results in increased expression of GCLC mRNA CTD PMID:25148906 [6]-Shogaol increases expression ISO RGD:736793 6480464 shogaol metabolite results in increased expression of GCLC protein, shogaol results in increased expression of GCLC protein CTD PMID:25148906 [6]-Shogaol multiple interactions EXP 6480464 NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of GCLC mRNA] CTD PMID:25148906 acetaldehyde increases expression ISO RGD:619868 6480464 Acetaldehyde results in increased expression of GCLC mRNA CTD PMID:11439094 acetylcholine decreases response to substance ISO RGD:736793 6480464 GCLC promoter SNP results in decreased susceptibility to Acetylcholine CTD PMID:12598062 acrolein increases expression ISO RGD:619868 6480464 Acrolein results in increased expression of GCLC mRNA CTD PMID:25145656 acrolein multiple interactions ISO RGD:619868 6480464 [1, 2-dithiol-3-thione results in increased activity of GCLC protein] which results in decreased susceptibility to Acrolein CTD PMID:12535742 acrolein increases expression ISO RGD:736793 6480464 Acrolein results in increased expression of GCLC mRNA CTD PMID:12084617 , PMID:28109747 actinomycin D multiple interactions ISO RGD:736793 6480464 Dactinomycin inhibits the reaction [Vitamin K 3 results in increased expression of GCLC mRNA] CTD PMID:11972604 actinomycin D multiple interactions ISO RGD:619868 6480464 Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein] CTD PMID:24437944 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of GCLC mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:736793 6480464 Aflatoxin B1 results in decreased methylation of GCLC gene CTD PMID:27153756 aflatoxin B1 increases expression ISO RGD:619868 6480464 Aflatoxin B1 results in increased expression of GCLC mRNA CTD PMID:15890375 more ... alachlor increases expression ISO RGD:619868 6480464 alachlor results in increased expression of GCLC protein CTD PMID:14563481 alcohol decreases expression EXP 6480464 Alcohols results in decreased expression of GCLC mRNA CTD PMID:18814483 alcohol multiple interactions EXP 6480464 Vitamin E inhibits the reaction [Alcohols results in increased expression of GCLC mRNA] CTD PMID:18814483 aldehydo-D-glucosamine increases expression EXP 6480464 Glucosamine analog results in increased expression of GCLC mRNA CTD PMID:21825963 aldosterone increases expression ISO RGD:619868 6480464 Aldosterone results in increased expression of GCLC protein CTD PMID:24512358 , PMID:25204689 aldosterone multiple interactions ISO RGD:619868 6480464 Spironolactone inhibits the reaction [Aldosterone results in increased expression of GCLC protein], tempol inhibits the reaction [Aldosterone results in increased expression of GCLC protein] CTD PMID:24512358 , PMID:25204689 all-trans-retinal increases expression ISO RGD:736793 6480464 Retinaldehyde results in increased expression of GCLC mRNA CTD PMID:25331497 , PMID:27751755 all-trans-retinoic acid decreases expression ISO RGD:619868 6480464 Tretinoin results in decreased expression of GCLC mRNA, Tretinoin results in decreased expression of GCLC protein CTD PMID:30267739 allyl isothiocyanate increases activity EXP 6480464 allyl isothiocyanate results in increased activity of GCLC protein CTD PMID:24036144 allyl isothiocyanate multiple interactions EXP 6480464 NFE2L2 protein affects the reaction [allyl isothiocyanate results in increased expression of GCLC mRNA] CTD PMID:24036144 allyl isothiocyanate increases expression EXP 6480464 allyl isothiocyanate results in increased expression of GCLC mRNA CTD PMID:24036144 alpha,alpha-trehalose multiple interactions ISO RGD:619868 6480464 Trehalose inhibits the reaction [cadmium acetate results in increased expression of GCLC protein] CTD PMID:29140578 alpha-D-galactose multiple interactions ISO RGD:619868 6480464 Saponins inhibits the reaction [Galactose results in decreased expression of GCLC mRNA] CTD PMID:25892055 alpha-D-galactose decreases expression ISO RGD:619868 6480464 Galactose results in decreased expression of GCLC mRNA CTD PMID:25892055 alpha-hexylcinnamaldehyde increases expression ISO RGD:736793 6480464 hexyl cinnamic aldehyde results in increased expression of GCLC mRNA CTD PMID:20566472 alpha-linolenic acid increases activity ISO RGD:736793 6480464 alpha-Linolenic Acid results in increased activity of GCLC protein CTD PMID:17092368 alpha-linolenic acid increases expression ISO RGD:736793 6480464 alpha-Linolenic Acid results in increased expression of GCLC mRNA CTD PMID:17092368 ampicillin decreases expression ISO RGD:736793 6480464 Ampicillin results in decreased expression of GCLC mRNA CTD PMID:21632981 , PMID:26198647 andrographolide increases expression ISO RGD:619868 6480464 andrographolide results in increased expression of GCLC mRNA, andrographolide results in increased expression of GCLC protein CTD PMID:25110055 , PMID:29355602 andrographolide multiple interactions EXP 6480464 andrographolide inhibits the reaction [Acetaminophen results in decreased expression of GCLC mRNA] CTD PMID:29355602 andrographolide increases expression ISO RGD:736793 6480464 andrographolide results in increased expression of GCLC protein CTD PMID:29355602 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:736793 6480464 pyrazolanthrone inhibits the reaction [[clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA] more ... CTD PMID:21469739 , PMID:25881548 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [Ozone results in increased expression of GCLC mRNA], pyrazolanthrone promotes the reaction [arsenite results in increased expression of GCLC mRNA] CTD PMID:17460151 , PMID:19328227 antimony(0) multiple interactions ISO RGD:736793 6480464 GCLC protein inhibits the reaction [ABCC1 protein results in decreased susceptibility to Antimony] CTD PMID:11560771 apigenin increases expression ISO RGD:619868 6480464 Apigenin results in increased expression of GCLC mRNA, Apigenin results in increased expression of GCLC protein CTD PMID:22864849 apigenin multiple interactions ISO RGD:619868 6480464 [Apigenin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide CTD PMID:22864849 apigenin increases expression ISO RGD:736793 6480464 Apigenin results in increased expression of GCLC mRNA CTD PMID:11864778 arachidonic acid increases activity ISO RGD:736793 6480464 Arachidonic Acid results in increased activity of GCLC protein CTD PMID:17092368 arachidonic acid increases expression ISO RGD:736793 6480464 Arachidonic Acid results in increased expression of GCLC mRNA CTD PMID:16704987 , PMID:17092368 Aroclor 1254 decreases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of GCLC mRNA CTD PMID:23650126 arsane increases expression ISO RGD:736793 6480464 Arsenic results in increased expression of GCLC mRNA, Arsenic results in increased expression of GCLC protein CTD PMID:18487201 , PMID:19945496 arsane affects response to substance ISO RGD:736793 6480464 GCLC gene SNP affects the susceptibility to Arsenic CTD PMID:29751399 arsane multiple interactions ISO RGD:736793 6480464 [GCLC gene SNP affects the susceptibility to Arsenic] which affects the abundance of Arsenicals CTD PMID:29751399 arsane increases expression EXP 6480464 Arsenic results in increased expression of GCLC mRNA CTD PMID:23000044 arsane multiple interactions EXP 6480464 NFE2L2 mRNA affects the reaction [Arsenic results in increased expression of GCLC mRNA] CTD PMID:23000044 arsenic atom increases expression ISO RGD:736793 6480464 Arsenic results in increased expression of GCLC mRNA, Arsenic results in increased expression of GCLC protein CTD PMID:18487201 , PMID:19945496 arsenic atom multiple interactions ISO RGD:736793 6480464 [GCLC gene SNP affects the susceptibility to Arsenic] which affects the abundance of Arsenicals CTD PMID:29751399 arsenic atom affects response to substance ISO RGD:736793 6480464 GCLC gene SNP affects the susceptibility to Arsenic CTD PMID:29751399 arsenic atom multiple interactions EXP 6480464 NFE2L2 mRNA affects the reaction [Arsenic results in increased expression of GCLC mRNA] CTD PMID:23000044 arsenic atom increases expression EXP 6480464 Arsenic results in increased expression of GCLC mRNA CTD PMID:23000044 arsenite(3-) multiple interactions EXP 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [arsenite results in increased expression of GCLC mRNA] more ... CTD PMID:15894712 , PMID:19328227 arsenite(3-) multiple interactions ISO RGD:736793 6480464 KEAP1 protein affects the reaction [arsenite results in increased expression of GCLC mRNA] more ... CTD PMID:22476201 arsenite(3-) increases expression ISO RGD:736793 6480464 arsenite results in increased expression of GCLC mRNA, arsenite results in increased expression of GCLC protein CTD PMID:22476201 arsenite(3-) increases expression EXP 6480464 arsenite results in increased expression of GCLC mRNA, arsenite results in increased expression of GCLC protein CTD PMID:15894712 , PMID:19328227 arsenous acid decreases expression ISO RGD:736793 6480464 Arsenic Trioxide results in decreased expression of GCLC protein CTD PMID:25341331 , PMID:25419056 arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of GCLC mRNA CTD PMID:29049341 arsenous acid increases expression ISO RGD:736793 6480464 Arsenic Trioxide results in increased expression of GCLC mRNA, Arsenic Trioxide results in increased expression of GCLC protein CTD PMID:19417148 more ... arsenous acid decreases response to substance ISO RGD:736793 6480464 GCLC protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 , PMID:29549912 arsenous acid multiple interactions EXP 6480464 NFE2L2 protein affects the reaction [Arsenic Trioxide results in increased expression of GCLC mRNA] CTD PMID:29049341 artesunate affects response to substance ISO RGD:736793 6480464 GCLC mRNA affects the susceptibility to artesunate CTD PMID:15796179 artesunate decreases response to substance ISO RGD:736793 6480464 GCLC mRNA results in decreased susceptibility to artesunate CTD PMID:15796179 astilbin multiple interactions ISO RGD:736793 6480464 astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] CTD PMID:29471006 azathioprine increases expression ISO RGD:736793 6480464 Azathioprine results in increased expression of GCLC mRNA CTD PMID:22623647 , PMID:26198647 Bandrowski's base increases expression ISO RGD:736793 6480464 Bandrowski's base results in increased expression of GCLC mRNA CTD PMID:20566472 benzalkonium chloride increases expression ISO RGD:736793 6480464 Benzalkonium Compounds results in increased expression of GCLC mRNA CTD PMID:30806763 benzene affects expression ISO RGD:619868 6480464 Benzene affects the expression of GCLC mRNA CTD PMID:15878777 benzidine increases expression ISO RGD:736793 6480464 benzidine results in increased expression of GCLC mRNA CTD PMID:26198647 benzo[a]pyrene multiple interactions ISO RGD:736793 6480464 [Cadmium Chloride co-treated with Benzo(a)pyrene] results in increased expression of GCLC mRNA CTD PMID:25170436 benzo[a]pyrene increases expression ISO RGD:736793 6480464 Benzo(a)pyrene results in increased expression of GCLC mRNA CTD PMID:20106945 more ... benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of GCLC mRNA CTD PMID:14625279 more ... benzo[a]pyrene multiple interactions EXP 6480464 [arsenite co-treated with Benzo(a)pyrene] results in increased expression of GCLC mRNA more ... CTD PMID:14625279 more ... benzo[a]pyrene diol epoxide I decreases expression ISO RGD:736793 6480464 7 more ... CTD PMID:19150397 benzoic acid increases expression ISO RGD:736793 6480464 Benzoic Acid results in increased expression of GCLC mRNA CTD PMID:20566472 benzoquinones increases expression EXP 6480464 Benzoquinones analog results in increased expression of GCLC protein CTD PMID:21651925 beta-D-glucosamine increases expression EXP 6480464 Glucosamine analog results in increased expression of GCLC mRNA CTD PMID:21825963 beta-naphthoflavone increases expression ISO RGD:736793 6480464 beta-Naphthoflavone results in increased expression of GCLC mRNA CTD PMID:16426233 beta-naphthoflavone increases expression EXP 6480464 beta-Naphthoflavone results in increased expression of GCLC mRNA CTD PMID:16426233 , PMID:23994337 bisphenol A affects expression ISO RGD:736793 6480464 bisphenol A affects the expression of GCLC mRNA CTD PMID:20170705 , PMID:30903817 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of GCLC mRNA CTD PMID:30547568 bisphenol A increases expression ISO RGD:736793 6480464 bisphenol A results in increased expression of GCLC CTD PMID:31207516 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of GCLC mRNA, bisphenol A results in increased expression of GCLC protein CTD PMID:28796629 bisphenol A increases expression ISO RGD:619868 6480464 bisphenol A results in increased expression of GCLC mRNA CTD PMID:25181051 bisphenol A multiple interactions ISO RGD:619868 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of GCLC mRNA CTD PMID:26496021 bleomycin A2 multiple interactions EXP 6480464 caffeic acid phenethyl ester inhibits the reaction [Bleomycin results in decreased expression of GCLC protein] CTD PMID:23570914 bleomycin A2 decreases expression EXP 6480464 Bleomycin results in decreased expression of GCLC protein CTD PMID:23570914 bleomycin A5 increases expression ISO RGD:736793 6480464 bleomycetin results in increased expression of GCLC mRNA CTD PMID:21040473 bosentan increases expression ISO RGD:736793 6480464 Bosentan results in increased expression of GCLC mRNA CTD PMID:29761207 Brodifacoum increases expression ISO RGD:619868 6480464 bromfenacoum results in increased expression of GCLC protein CTD PMID:28903499 bromobenzene increases expression EXP 6480464 bromobenzene results in increased expression of GCLC protein CTD PMID:18078705 Brusatol decreases expression ISO RGD:736793 6480464 brusatol results in decreased expression of GCLC protein CTD PMID:27639429 buspirone decreases expression ISO RGD:619868 6480464 Buspirone results in decreased expression of GCLC mRNA CTD PMID:24136188 buta-1,3-diene affects expression EXP 6480464 1, 3-butadiene affects the expression of GCLC mRNA CTD PMID:29038090 butanal decreases expression ISO RGD:736793 6480464 butyraldehyde results in decreased expression of GCLC mRNA CTD PMID:26079696 butane-2,3-dione increases expression ISO RGD:619868 6480464 Diacetyl results in increased expression of GCLC mRNA CTD PMID:25145656 butylated hydroxyanisole increases expression ISO RGD:736793 6480464 Butylated Hydroxyanisole results in increased expression of GCLC mRNA CTD PMID:16426233 butylated hydroxyanisole increases expression EXP 6480464 Butylated Hydroxyanisole results in increased expression of GCLC mRNA, Butylated Hydroxyanisole results in increased expression of GCLC protein CTD PMID:16426233 , PMID:25922074 cadmium atom increases expression ISO RGD:736793 6480464 Cadmium results in increased expression of GCLC mRNA CTD PMID:21120746 cadmium atom multiple interactions ISO RGD:736793 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GCLC protein, [GCLC results in decreased uptake of Cadmium] which results in decreased expression of SLC39A8 CTD PMID:18556457 , PMID:30359721 cadmium atom increases expression ISO RGD:619868 6480464 Cadmium results in increased expression of GCLC, Cadmium results in increased expression of GCLC mRNA CTD PMID:19879314 , PMID:25388156 cadmium dichloride multiple interactions ISO RGD:736793 6480464 [Cadmium Chloride co-treated with Benzo(a)pyrene] results in increased expression of GCLC mRNA more ... CTD PMID:18556457 more ... cadmium dichloride decreases expression ISO RGD:619868 6480464 Cadmium Chloride results in decreased expression of GCLC mRNA CTD PMID:25993096 cadmium dichloride increases expression ISO RGD:736793 6480464 Cadmium Chloride results in increased expression of GCLC mRNA, Cadmium Chloride results in increased expression of GCLC protein CTD PMID:24291162 more ... cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of GCLC mRNA, Cadmium Chloride results in increased expression of GCLC protein CTD PMID:22677785 , PMID:29486218 cadmium dichloride increases expression ISO RGD:619868 6480464 Cadmium Chloride results in increased expression of GCLC mRNA CTD PMID:11254161 cadmium dichloride multiple interactions ISO RGD:619868 6480464 Cadmium Chloride results in increased expression of and results in increased activity of GCLC protein, GCLC affects the reaction [NFE2L2 protein results in decreased susceptibility to Cadmium Chloride] CTD PMID:11254161 , PMID:19682480 cadmium dichloride decreases uptake ISO RGD:736793 6480464 GCLC results in decreased uptake of Cadmium Chloride CTD PMID:18556457 cadmium dichloride decreases response to substance ISO RGD:736793 6480464 GCLC results in decreased susceptibility to Cadmium Chloride CTD PMID:18556457 cadmium sulfate multiple interactions ISO RGD:736793 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GCLC mRNA CTD PMID:18654764 cadmium sulfate increases expression EXP 6480464 cadmium sulfate results in increased expression of GCLC mRNA CTD PMID:16221973 cadmium sulfate increases expression ISO RGD:736793 6480464 cadmium sulfate results in increased expression of GCLC mRNA CTD PMID:12064557 cadmium sulfide decreases expression ISO RGD:736793 6480464 cadmium sulfide results in decreased expression of GCLC mRNA CTD PMID:27866839 cafestol multiple interactions ISO RGD:619868 6480464 [cafestol co-treated with kahweol] inhibits the reaction [ochratoxin A results in decreased expression of GCLC protein] CTD PMID:17110534 caffeine multiple interactions EXP 6480464 [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 calcitriol multiple interactions ISO RGD:619868 6480464 [Calcium co-treated with Calcitriol] affects the expression of GCLC mRNA CTD PMID:15913539 calcium atom multiple interactions ISO RGD:619868 6480464 [Calcium co-treated with Calcitriol] affects the expression of GCLC mRNA CTD PMID:15913539 calcium(0) multiple interactions ISO RGD:619868 6480464 [Calcium co-treated with Calcitriol] affects the expression of GCLC mRNA CTD PMID:15913539 carbamazepine affects expression ISO RGD:736793 6480464 Carbamazepine affects the expression of GCLC mRNA CTD PMID:24752500 carbon disulfide increases expression ISO RGD:619868 6480464 Carbon Disulfide results in increased expression of GCLC mRNA CTD PMID:27530093 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon analog results in increased expression of GCLC mRNA, Nanotubes, Carbon results in increased expression of GCLC mRNA CTD PMID:25554681 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of GCLC mRNA, Nanotubes, Carbon results in decreased expression of GCLC mRNA CTD PMID:25620056 carmustine multiple interactions ISO RGD:619868 6480464 [Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GCLC protein, [Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of GCLC protein CTD PMID:12967637 , PMID:16288907 carnosic acid increases expression ISO RGD:736793 6480464 salvin results in increased expression of GCLC protein CTD PMID:26577515 , PMID:26686574 carnosic acid multiple interactions ISO RGD:619868 6480464 salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLC protein] CTD PMID:25446857 carnosic acid increases expression EXP 6480464 salvin results in increased expression of GCLC mRNA CTD PMID:18329808 carnosic acid multiple interactions ISO RGD:736793 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLC protein] more ... CTD PMID:25446857 more ... Carnosol increases expression ISO RGD:736793 6480464 carnosol results in increased expression of GCLC mRNA CTD PMID:20116392 ceric oxide decreases expression ISO RGD:619868 6480464 ceric oxide results in decreased expression of GCLC mRNA CTD PMID:29463257 cerium trichloride increases expression ISO RGD:736793 6480464 cerous chloride results in increased expression of GCLC mRNA CTD PMID:28954213 cerium trichloride multiple interactions ISO RGD:736793 6480464 [cerous chloride co-treated with lanthanum chloride] results in increased expression of GCLC mRNA CTD PMID:28954213 chenodeoxycholic acid increases expression ISO RGD:736793 6480464 Chenodeoxycholic Acid results in increased expression of GCLC protein CTD PMID:17724089 chenodeoxycholic acid multiple interactions ISO RGD:736793 6480464 [Chenodeoxycholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione CTD PMID:17724089 chlorambucil multiple interactions ISO RGD:736793 6480464 [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Chlorambucil CTD PMID:10900222 chloroacetaldehyde increases expression ISO RGD:736793 6480464 chloroacetaldehyde results in increased expression of GCLC mRNA CTD PMID:25596134 chlorogenic acid increases expression ISO RGD:736793 6480464 Chlorogenic Acid results in increased expression of GCLC mRNA CTD PMID:29136249 chlorogenic acid multiple interactions ISO RGD:736793 6480464 Chlorogenic Acid promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA] CTD PMID:29136249 chlorohydrocarbon decreases activity ISO RGD:736793 6480464 Hydrocarbons, Chlorinated analog results in decreased activity of GCLC protein CTD PMID:24355586 chlorohydrocarbon multiple interactions ISO RGD:736793 6480464 Acetylcysteine inhibits the reaction [Hydrocarbons, Chlorinated analog results in increased expression of GCLC protein] CTD PMID:24355586 chloroprene increases expression ISO RGD:619868 6480464 Chloroprene results in increased expression of GCLC mRNA CTD PMID:23125180 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of GCLC mRNA CTD PMID:23125180 chlorpromazine decreases expression ISO RGD:619868 6480464 Chlorpromazine results in decreased expression of GCLC mRNA CTD PMID:25596134 cholesterol increases expression EXP 6480464 Cholesterol results in increased expression of GCLC protein CTD PMID:29486218 choline multiple interactions EXP 6480464 [Choline deficiency co-treated with Methionine deficiency] results in increased expression of GCLC mRNA, NFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of GCLC mRNA] CTD PMID:20350562 chromium atom multiple interactions ISO RGD:736793 6480464 [chromous chloride results in increased abundance of Chromium] which results in decreased expression of GCLC protein CTD PMID:30359721 chromium trinitrate increases expression ISO RGD:736793 6480464 chromium nitrate results in increased expression of GCLC mRNA CTD PMID:20491607 chromium(6+) multiple interactions EXP 6480464 [Arsenates co-treated with chromium hexavalent ion] results in increased expression of GCLC mRNA more ... CTD PMID:19895865 , PMID:25820237 chromium(6+) increases expression ISO RGD:619868 6480464 chromium hexavalent ion results in increased expression of GCLC protein CTD PMID:18306314 chrysin multiple interactions ISO RGD:619868 6480464 [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]] more ... CTD PMID:22864849 chrysin increases expression ISO RGD:619868 6480464 chrysin results in increased expression of GCLC mRNA, chrysin results in increased expression of GCLC protein CTD PMID:22864849 cidofovir anhydrous decreases expression ISO RGD:736793 6480464 Cidofovir results in decreased expression of GCLC mRNA CTD PMID:25596134 cinnamyl alcohol increases expression ISO RGD:736793 6480464 cinnamyl alcohol results in increased expression of GCLC mRNA CTD PMID:20566472 ciprofibrate decreases activity ISO RGD:619868 6480464 ciprofibrate results in decreased activity of GCLC protein CTD PMID:7676460 ciprofibrate decreases expression ISO RGD:619868 6480464 ciprofibrate results in decreased expression of GCLC mRNA CTD PMID:7676460 cisplatin multiple interactions ISO RGD:736793 6480464 astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] more ... CTD PMID:17628013 more ... cisplatin decreases response to substance ISO RGD:736793 6480464 GCLC protein results in decreased susceptibility to Cisplatin CTD PMID:29549912 cisplatin increases expression ISO RGD:736793 6480464 Cisplatin results in increased expression of GCLC mRNA CTD PMID:27480280 , PMID:28959534 cisplatin decreases expression ISO RGD:736793 6480464 Cisplatin results in decreased expression of GCLC mRNA CTD PMID:25596134 , PMID:29471006 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of GCLC mRNA, Cisplatin results in increased expression of GCLC protein CTD PMID:20605904 cisplatin multiple interactions EXP 6480464 NFE2L2 protein promotes the reaction [Cisplatin results in increased expression of GCLC mRNA], NFE2L2 protein promotes the reaction [Cisplatin results in increased expression of GCLC protein] CTD PMID:20605904 cisplatin increases phosphorylation EXP 6480464 Cisplatin results in increased phosphorylation of GCLC protein CTD PMID:22006019 citraconic acid increases expression ISO RGD:619868 6480464 citraconic acid results in increased expression of GCLC protein CTD PMID:27277809 citraconic acid increases expression EXP 6480464 citraconic acid results in increased expression of GCLC mRNA CTD PMID:27277809 Clivoline multiple interactions ISO RGD:736793 6480464 [clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA, pyrazolanthrone inhibits the reaction [[clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA] CTD PMID:25881548 clobetasol decreases expression ISO RGD:736793 6480464 Clobetasol results in decreased expression of GCLC mRNA CTD PMID:16882163 clodronic acid decreases expression ISO RGD:736793 6480464 Clodronic Acid results in decreased expression of GCLC mRNA CTD PMID:25596134 cobalt dichloride multiple interactions ISO RGD:736793 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GCLC mRNA more ... CTD PMID:18654764 , PMID:29966676 cobalt dichloride increases expression ISO RGD:736793 6480464 cobaltous chloride results in increased expression of GCLC mRNA CTD PMID:19320972 , PMID:29966676 cobalt dichloride increases expression ISO RGD:619868 6480464 cobaltous chloride results in increased expression of GCLC mRNA CTD PMID:24386269 cocaine increases expression EXP 6480464 Cocaine results in increased expression of GCLC mRNA CTD PMID:30393195 cocaine multiple interactions EXP 6480464 PRKCD protein affects the reaction [Cocaine results in increased expression of GCLC mRNA], rottlerin promotes the reaction [Cocaine results in increased expression of GCLC mRNA] CTD PMID:30393195 coniferyl aldehyde increases expression ISO RGD:736793 6480464 coniferaldehyde results in increased expression of GCLC mRNA CTD PMID:26275128 conjugated linoleic acid increases activity ISO RGD:736793 6480464 Linoleic Acids, Conjugated results in increased activity of GCLC protein CTD PMID:17092368 conjugated linoleic acid multiple interactions ISO RGD:736793 6480464 [Linoleic Acids, Conjugated results in increased activity of GCLC protein] which results in decreased susceptibility to tert-Butylhydroperoxide CTD PMID:17092368 conjugated linoleic acid increases expression ISO RGD:736793 6480464 Linoleic Acids, Conjugated results in increased expression of GCLC mRNA CTD PMID:17092368 copper atom decreases expression ISO RGD:619868 6480464 Copper results in decreased expression of GCLC mRNA CTD PMID:22465980 copper atom multiple interactions ISO RGD:736793 6480464 [NSC 689534 binds to Copper] which results in increased expression of GCLC mRNA more ... CTD PMID:19747488 , PMID:20971185 copper atom increases expression ISO RGD:736793 6480464 Copper results in increased expression of GCLC mRNA CTD PMID:19747488 copper(0) decreases expression ISO RGD:619868 6480464 Copper results in decreased expression of GCLC mRNA CTD PMID:22465980 copper(0) multiple interactions ISO RGD:736793 6480464 [NSC 689534 binds to Copper] which results in increased expression of GCLC mRNA more ... CTD PMID:19747488 , PMID:20971185 copper(0) increases expression ISO RGD:736793 6480464 Copper results in increased expression of GCLC mRNA CTD PMID:19747488 copper(II) chloride increases expression ISO RGD:736793 6480464 cupric chloride results in increased expression of GCLC mRNA CTD PMID:17211630 copper(II) sulfate increases expression ISO RGD:736793 6480464 Copper Sulfate results in increased expression of GCLC mRNA CTD PMID:19549813 cortisol increases expression ISO RGD:619868 6480464 Hydrocortisone results in increased expression of GCLC mRNA CTD PMID:10978506 coumarin increases expression ISO RGD:619868 6480464 coumarin results in increased expression of GCLC mRNA CTD PMID:18480146 crocidolite asbestos increases expression EXP 6480464 Asbestos, Crocidolite results in increased expression of GCLC mRNA, Asbestos, Crocidolite results in increased expression of GCLC protein CTD PMID:15520183 crocidolite asbestos multiple interactions EXP 6480464 [GCLC protein co-treated with GCLM protein] inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA] more ... CTD PMID:15520183 cumene hydroperoxide increases expression EXP 6480464 cumene hydroperoxide results in increased expression of GCLC mRNA CTD PMID:30547568 curcumin increases activity ISO RGD:736793 6480464 Curcumin results in increased activity of GCLC protein CTD PMID:10514034 curcumin multiple interactions EXP 6480464 NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA] CTD PMID:29571711 curcumin increases expression ISO RGD:736793 6480464 Curcumin analog results in increased expression of GCLC mRNA, Curcumin results in increased expression of GCLC mRNA CTD PMID:23710286 , PMID:23954767 curcumin multiple interactions ISO RGD:736793 6480464 Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GCLC mRNA] more ... CTD PMID:23954767 , PMID:31521693 curcumin increases expression ISO RGD:619868 6480464 Curcumin results in increased expression of GCLC mRNA, Curcumin results in increased expression of GCLC protein CTD PMID:17602960 more ... curcumin multiple interactions ISO RGD:619868 6480464 Curcumin results in increased activity of [GCLC protein binds to GCLM protein] CTD PMID:17602960 curcumin increases expression EXP 6480464 Curcumin results in increased expression of GCLC mRNA CTD PMID:19168576 more ... cyanidin 3-O-beta-D-glucoside multiple interactions ISO RGD:736793 6480464 [IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with cyanidin 3-O-glucoside] results in increased expression of GCLC mRNA CTD PMID:27818126 cycloheximide multiple interactions EXP 6480464 Cycloheximide inhibits the reaction [arsenite results in increased activity of [GCLC protein binds to GCLM protein]] more ... CTD PMID:17628625 , PMID:19328227 cycloheximide multiple interactions ISO RGD:619868 6480464 Cycloheximide inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein] CTD PMID:24437944 cyclophosphamide decreases expression EXP 6480464 Cyclophosphamide results in decreased expression of GCLC mRNA, Cyclophosphamide results in decreased expression of GCLC protein CTD PMID:27633142 cyclophosphamide multiple interactions EXP 6480464 Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of GCLC protein] CTD PMID:27633142 cyclosporin A decreases expression ISO RGD:619868 6480464 Cyclosporine results in decreased expression of GCLC mRNA CTD PMID:11589784 , PMID:25596134 cyclosporin A increases expression ISO RGD:736793 6480464 Cyclosporine results in increased expression of GCLC mRNA CTD PMID:20106945 more ... cylindrospermopsin increases expression ISO RGD:736793 6480464 cylindrospermopsin results in increased expression of GCLC mRNA CTD PMID:23726867 cylindrospermopsin increases expression EXP 6480464 cylindrospermopsin results in increased expression of GCLC mRNA CTD PMID:20936652 cysteamine decreases activity EXP 6480464 Cysteamine results in decreased activity of GCLC protein CTD PMID:15282320 cysteamine multiple interactions EXP 6480464 [Cysteamine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione CTD PMID:15282320 DDE multiple interactions ISO RGD:736793 6480464 Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC mRNA] more ... CTD PMID:25263748 DDE decreases expression ISO RGD:736793 6480464 Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC mRNA, Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC protein CTD PMID:25263748 DDT increases expression ISO RGD:736793 6480464 DDT results in increased expression of GCLC mRNA CTD PMID:26198647 DDT increases expression ISO RGD:619868 6480464 DDT results in increased expression of GCLC mRNA CTD PMID:29477483 deoxycholic acid multiple interactions ISO RGD:736793 6480464 [Deoxycholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA CTD PMID:17724089 Deoxycorticosterone acetate multiple interactions ISO RGD:619868 6480464 [Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of GCLC mRNA CTD PMID:22228705 dexamethasone multiple interactions EXP 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GCLC mRNA, Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GCLC mRNA] CTD PMID:16054899 dexamethasone multiple interactions ISO RGD:619868 6480464 [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA more ... CTD PMID:27028516 dextran sulfate multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of GCLC mRNA CTD PMID:29950665 diallyl disulfide multiple interactions ISO RGD:619868 6480464 diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA] CTD PMID:24293383 Diallyl sulfide multiple interactions ISO RGD:619868 6480464 allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC mRNA], allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC protein] CTD PMID:31585129 diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of GCLC mRNA CTD PMID:29049341 diarsenic trioxide decreases response to substance ISO RGD:736793 6480464 GCLC protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 , PMID:29549912 diarsenic trioxide multiple interactions EXP 6480464 NFE2L2 protein affects the reaction [Arsenic Trioxide results in increased expression of GCLC mRNA] CTD PMID:29049341 diarsenic trioxide decreases expression ISO RGD:736793 6480464 Arsenic Trioxide results in decreased expression of GCLC protein CTD PMID:25341331 , PMID:25419056 diarsenic trioxide increases expression ISO RGD:736793 6480464 Arsenic Trioxide results in increased expression of GCLC mRNA, Arsenic Trioxide results in increased expression of GCLC protein CTD PMID:19417148 more ... diazinon increases expression ISO RGD:736793 6480464 Diazinon results in increased expression of GCLC mRNA CTD PMID:26198647 dibenzoylmethane increases expression EXP 6480464 dibenzoylmethane results in increased expression of GCLC mRNA CTD PMID:17942926 dibenzoylmethane multiple interactions EXP 6480464 [sulforafan co-treated with dibenzoylmethane] results in increased expression of GCLC mRNA CTD PMID:17942926 dibutyl phthalate increases expression ISO RGD:619868 6480464 Dibutyl Phthalate results in increased expression of GCLC mRNA CTD PMID:21266533 diclofenac decreases expression ISO RGD:619868 6480464 Diclofenac results in decreased expression of GCLC mRNA CTD PMID:17202759 diclofenac affects expression ISO RGD:736793 6480464 Diclofenac affects the expression of GCLC mRNA CTD PMID:24752500 diclofenac affects response to substance ISO RGD:619868 6480464 GCLC protein affects the susceptibility to Diclofenac CTD PMID:19481141 diethyl malate affects expression EXP 6480464 diethyl malate affects the expression of GCLC mRNA CTD PMID:24814887 diethyl maleate increases expression ISO RGD:619868 6480464 diethyl maleate results in increased expression of GCLC mRNA, diethyl maleate results in increased expression of GCLC protein CTD PMID:10978506 more ... diethyl maleate increases expression EXP 6480464 diethyl maleate results in increased expression of GCLC mRNA, diethyl maleate results in increased expression of GCLC protein CTD PMID:10915739 , PMID:25270620 diethyl maleate increases activity ISO RGD:619868 6480464 diethyl maleate results in increased activity of GCLC protein CTD PMID:15115889 diethyl maleate increases activity EXP 6480464 diethyl maleate results in increased activity of GCLC protein CTD PMID:10915739 diethyl sulfate increases expression ISO RGD:736793 6480464 diethyl sulfate results in increased expression of GCLC mRNA CTD PMID:20491607 diethylstilbestrol increases expression ISO RGD:619868 6480464 Diethylstilbestrol results in increased expression of GCLC mRNA CTD PMID:15890375 diethylstilbestrol increases expression ISO RGD:736793 6480464 Diethylstilbestrol results in increased expression of GCLC mRNA CTD PMID:26198647 dimethyl fumarate multiple interactions EXP 6480464 NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLC mRNA] CTD PMID:27277809 dimethyl fumarate increases expression EXP 6480464 Dimethyl Fumarate results in increased expression of GCLC mRNA CTD PMID:27277809 , PMID:30248482 dimethyl fumarate increases expression ISO RGD:619868 6480464 Dimethyl Fumarate results in increased expression of GCLC protein CTD PMID:27277809 dinoseb increases expression EXP 6480464 dinoseb results in increased expression of GCLC mRNA CTD PMID:30547568 dioxygen multiple interactions ISO RGD:619868 6480464 [Oxygen deficiency co-treated with Oxygen] results in increased expression of GCLC protein more ... CTD PMID:25773745 dioxygen increases expression ISO RGD:736793 6480464 Oxygen deficiency results in increased expression of GCLC mRNA CTD PMID:25596134 , PMID:29966676 dioxygen multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Oxygen] results in increased expression of GCLC mRNA CTD PMID:25922074 dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate increases expression ISO RGD:736793 6480464 Antimony Potassium Tartrate results in increased expression of GCLC mRNA, Antimony Potassium Tartrate results in increased expression of GCLC protein CTD PMID:28713220 diquat increases expression EXP 6480464 Diquat results in increased expression of GCLC mRNA CTD PMID:16962985 diquat multiple interactions EXP 6480464 [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA CTD PMID:22762311 diquat decreases activity ISO RGD:619868 6480464 Diquat results in decreased activity of GCLC protein CTD PMID:7676460 diquat decreases expression ISO RGD:619868 6480464 Diquat results in decreased expression of GCLC mRNA CTD PMID:7676460 disodium selenite increases expression EXP 6480464 Sodium Selenite results in increased expression of GCLC mRNA CTD PMID:18449455 disodium selenite increases expression ISO RGD:736793 6480464 Sodium Selenite results in increased expression of GCLC mRNA CTD PMID:24383545 disulfiram increases expression ISO RGD:736793 6480464 Disulfiram results in increased expression of GCLC mRNA CTD PMID:20566472 diuron increases expression ISO RGD:619868 6480464 Diuron results in increased expression of GCLC mRNA CTD PMID:21551480 domoic acid increases expression EXP 6480464 domoic acid results in increased expression of GCLC mRNA, domoic acid results in increased expression of GCLC protein CTD PMID:23315585 dopamine multiple interactions ISO RGD:736793 6480464 Dopamine promotes the reaction [Zinc deficiency results in increased cleavage of GCLC protein] CTD PMID:23377617 doramapimod increases expression EXP 6480464 BIRB 796 results in increased expression of GCLC mRNA CTD PMID:21328587 dorsomorphin multiple interactions ISO RGD:736793 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:24211276 , PMID:27188386 doxorubicin multiple interactions ISO RGD:619868 6480464 Doxorubicin promotes the reaction [RTKI cpd results in decreased expression of GCLC protein] more ... CTD PMID:18371937 , PMID:30588110 doxorubicin decreases response to substance ISO RGD:736793 6480464 GCLC protein results in decreased susceptibility to Doxorubicin CTD PMID:29549912 doxorubicin decreases expression ISO RGD:619868 6480464 Doxorubicin results in decreased expression of GCLC mRNA, Doxorubicin results in decreased expression of GCLC protein CTD PMID:18371937 more ... doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of GCLC protein CTD PMID:26822305 doxorubicin multiple interactions EXP 6480464 ABCC1 gene mutant form promotes the reaction [Doxorubicin results in increased expression of GCLC protein] CTD PMID:26822305 doxorubicin multiple interactions ISO RGD:736793 6480464 [GCLC protein co-treated with GCLM protein] promotes the reaction [GSTP1 protein results in decreased susceptibility to Doxorubicin], GCLC protein inhibits the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin] CTD PMID:10900222 , PMID:11560771 elemental selenium multiple interactions ISO RGD:619868 6480464 [Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of GCLC mRNA CTD PMID:11444866 endosulfan increases expression ISO RGD:619868 6480464 Endosulfan results in increased expression of GCLC mRNA CTD PMID:29391264 enzyme inhibitor multiple interactions ISO RGD:736793 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GCLC protein CTD PMID:23301498 erdosteine increases expression EXP 6480464 erdosteine results in increased expression of GCLC protein CTD PMID:26193055 etacrynic acid multiple interactions ISO RGD:736793 6480464 [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Ethacrynic Acid CTD PMID:10900222 ethanol increases expression ISO RGD:619868 6480464 Ethanol results in increased expression of GCLC mRNA CTD PMID:10978506 ethanol affects splicing EXP 6480464 Ethanol affects the splicing of GCLC mRNA CTD PMID:30319688 ethanol multiple interactions EXP 6480464 [ethylene dichloride co-treated with Ethanol] results in increased expression of GCLC mRNA more ... CTD PMID:27983966 , PMID:30664321 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of GCLC mRNA CTD PMID:27983966 ethanol multiple interactions ISO RGD:619868 6480464 [Trinitrobenzenesulfonic Acid co-treated with Ethanol] results in increased expression of GCLC mRNA CTD PMID:10830784 ethanol increases expression ISO RGD:736793 6480464 Ethanol results in increased expression of GCLC mRNA CTD PMID:19133322 ethanol multiple interactions ISO RGD:736793 6480464 CYP2E1 protein promotes the reaction [Ethanol results in increased expression of GCLC mRNA] CTD PMID:19133322 Ethyl acrylate increases expression ISO RGD:736793 6480464 ethyl acrylate results in increased expression of GCLC mRNA CTD PMID:26198647 etoposide multiple interactions ISO RGD:736793 6480464 [GCLC protein co-treated with GCLM protein] promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide], [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Etoposide CTD PMID:10900222 eugenol increases expression ISO RGD:736793 6480464 Eugenol results in increased expression of GCLC mRNA CTD PMID:20566472 more ... farnesal increases expression ISO RGD:736793 6480464 farnesal results in increased expression of GCLC mRNA CTD PMID:20491607 farrerol increases expression EXP 6480464 farrerol results in increased expression of GCLC mRNA CTD PMID:26111761 fenofibrate decreases expression ISO RGD:619868 6480464 Fenofibrate results in decreased expression of GCLC mRNA CTD PMID:25596134 fipronil increases expression ISO RGD:619868 6480464 fipronil results in increased expression of GCLC mRNA CTD PMID:23962444 flutamide increases expression EXP 6480464 Flutamide results in increased expression of GCLC mRNA CTD PMID:17702527 flutamide increases expression ISO RGD:619868 6480464 Flutamide results in increased expression of GCLC mRNA CTD PMID:24136188 flutamide affects response to substance ISO RGD:619868 6480464 GCLC protein affects the susceptibility to Flutamide CTD PMID:19481141 formaldehyde increases expression ISO RGD:736793 6480464 Formaldehyde results in increased expression of GCLC mRNA CTD PMID:20491607 fulvestrant multiple interactions ISO RGD:619868 6480464 fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein] CTD PMID:24437944 furan multiple interactions EXP 6480464 [Bromodeoxyuridine co-treated with furan] results in increased expression of GCLC mRNA CTD PMID:24910943 furan increases expression ISO RGD:619868 6480464 furan results in increased expression of GCLC mRNA CTD PMID:27402187 furan increases expression EXP 6480464 furan results in increased expression of GCLC mRNA CTD PMID:24183702 , PMID:24910943 galactose multiple interactions ISO RGD:619868 6480464 Saponins inhibits the reaction [Galactose results in decreased expression of GCLC mRNA] CTD PMID:25892055 galactose decreases expression ISO RGD:619868 6480464 Galactose results in decreased expression of GCLC mRNA CTD PMID:25892055 gamma-hexachlorocyclohexane increases expression ISO RGD:736793 6480464 Hexachlorocyclohexane results in increased expression of GCLC mRNA CTD PMID:26198647 gamma-linolenic acid increases activity ISO RGD:736793 6480464 gamma-Linolenic Acid results in increased activity of GCLC protein CTD PMID:17092368 gamma-linolenic acid increases expression ISO RGD:736793 6480464 gamma-Linolenic Acid results in increased expression of GCLC mRNA CTD PMID:17092368 gefitinib affects response to substance ISO RGD:736793 6480464 GCLC protein affects the susceptibility to gefitinib CTD PMID:15496427 genistein multiple interactions ISO RGD:619868 6480464 [Genistein co-treated with Methoxychlor] results in increased expression of GCLC mRNA CTD PMID:21782745 genistein affects expression ISO RGD:736793 6480464 Genistein affects the expression of GCLC mRNA CTD PMID:26865667 genistein increases expression ISO RGD:619868 6480464 Genistein results in increased expression of GCLC mRNA CTD PMID:21782745 ginsenoside Rg1 increases expression EXP 6480464 ginsenoside Rg1 results in increased expression of GCLC mRNA CTD PMID:29964319 ginsenoside Rg1 multiple interactions EXP 6480464 ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA], NFE2L2 protein affects the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]] CTD PMID:29964319 gliclazide multiple interactions ISO RGD:619868 6480464 Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA], Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein] CTD PMID:21439372 glutathione increases abundance EXP 6480464 GCLC mRNA results in increased abundance of Glutathione, GCLC protein results in increased abundance of Glutathione CTD PMID:19914271 more ... glutathione increases expression ISO RGD:619868 6480464 Glutathione deficiency results in increased expression of GCLC mRNA CTD PMID:15345336 , PMID:20621112 glutathione affects chemical synthesis ISO RGD:736793 6480464 GCLC polymorphism affects the chemical synthesis of Glutathione CTD PMID:16599007 glutathione increases abundance ISO RGD:736793 6480464 GCLC results in increased abundance of Glutathione CTD PMID:18556457 glutathione multiple interactions ISO RGD:619868 6480464 [HGF protein results in increased activity of GCLC protein] which results in increased chemical synthesis of Glutathione CTD PMID:10544272 glutathione multiple interactions ISO RGD:736793 6480464 [[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione more ... CTD PMID:11673643 more ... glutathione multiple interactions EXP 6480464 [2-tert-butylhydroquinone results in increased activity of GCLC protein] which results in increased abundance of Glutathione more ... CTD PMID:14978233 more ... glycerol 2-phosphate multiple interactions ISO RGD:619868 6480464 [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA more ... CTD PMID:27028516 guggulsterone increases expression EXP 6480464 pregna-4 more ... CTD PMID:22851183 guggulsterone increases expression ISO RGD:736793 6480464 pregna-4 more ... CTD PMID:22851183 hemin increases expression ISO RGD:736793 6480464 Hemin results in increased expression of GCLC mRNA CTD PMID:16631525 Hexachloro-1,3-butadiene decreases expression ISO RGD:619868 6480464 hexachlorobutadiene results in decreased expression of GCLC mRNA CTD PMID:21905055 Hexachloro-1,3-butadiene increases expression ISO RGD:619868 6480464 hexachlorobutadiene results in increased expression of GCLC mRNA CTD PMID:21905055 hexadecanoic acid increases expression ISO RGD:619868 6480464 Palmitic Acid results in increased expression of GCLC mRNA CTD PMID:28027979 hexane increases expression ISO RGD:736793 6480464 n-hexane results in increased expression of GCLC mRNA CTD PMID:20566472 hydrogen chloride increases expression EXP 6480464 Hydrochloric Acid results in increased expression of GCLC mRNA CTD PMID:29618784 hydrogen chloride multiple interactions EXP 6480464 NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GCLC mRNA] CTD PMID:29618784 hydrogen peroxide affects expression ISO RGD:736793 6480464 Hydrogen Peroxide affects the expression of GCLC mRNA CTD PMID:20044591 hydrogen peroxide multiple interactions ISO RGD:619868 6480464 Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA] more ... CTD PMID:24437944 , PMID:27028516 hydrogen peroxide affects expression ISO RGD:619868 6480464 Hydrogen Peroxide affects the expression of GCLC protein CTD PMID:24437944 hydrogen peroxide multiple interactions ISO RGD:736793 6480464 4-((alpha-L-rhamnosyloxy)benzyl)isothiocyanate inhibits the reaction [Hydrogen Peroxide results in decreased expression of GCLC mRNA] more ... CTD PMID:24866057 , PMID:31521693 hydrogen peroxide decreases expression ISO RGD:736793 6480464 Hydrogen Peroxide results in decreased expression of GCLC mRNA, Hydrogen Peroxide results in decreased expression of GCLC protein CTD PMID:24866057 , PMID:31521693 hydrogen peroxide increases expression ISO RGD:736793 6480464 Hydrogen Peroxide results in increased expression of GCLC mRNA CTD PMID:12598062 more ... hydrogen peroxide multiple interactions EXP 6480464 GCLC protein inhibits the reaction [Hydrogen Peroxide results in decreased abundance of Glutathione] more ... CTD PMID:19914271 , PMID:31494107 hydrogen peroxide decreases response to substance EXP 6480464 GCLC protein results in decreased susceptibility to Hydrogen Peroxide CTD PMID:19914271 hydroquinone increases expression EXP 6480464 hydroquinone results in increased expression of GCLC mRNA, hydroquinone results in increased expression of GCLC protein CTD PMID:30547568 hypochlorous acid multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA] more ... CTD PMID:17980396 hypochlorous acid affects expression EXP 6480464 Hypochlorous Acid affects the expression of GCLC mRNA CTD PMID:18648578 hypochlorous acid increases expression EXP 6480464 Hypochlorous Acid results in increased expression of GCLC mRNA CTD PMID:17980396 ibuprofen increases expression ISO RGD:736793 6480464 Ibuprofen results in increased expression of GCLC mRNA CTD PMID:11909699 ifosfamide decreases expression ISO RGD:736793 6480464 Ifosfamide results in decreased expression of GCLC mRNA CTD PMID:25596134 indometacin multiple interactions ISO RGD:736793 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Indomethacin results in increased expression of GCLC mRNA] more ... CTD PMID:11909699 indometacin increases expression ISO RGD:736793 6480464 Indomethacin results in increased expression of GCLC mRNA, Indomethacin results in increased expression of GCLC protein CTD PMID:11820781 , PMID:11909699 iron atom increases activity ISO RGD:619868 6480464 Iron results in increased activity of GCLC protein CTD PMID:17189828 iron atom decreases expression ISO RGD:736793 6480464 Iron results in decreased expression of GCLC mRNA CTD PMID:19073151 iron atom multiple interactions ISO RGD:736793 6480464 Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GCLC mRNA] CTD PMID:19073151 iron trichloride multiple interactions EXP 6480464 [ferric chloride co-treated with TNF protein] results in increased expression of GCLC protein CTD PMID:19900513 iron(0) increases activity ISO RGD:619868 6480464 Iron results in increased activity of GCLC protein CTD PMID:17189828 iron(0) multiple interactions ISO RGD:736793 6480464 Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GCLC mRNA] CTD PMID:19073151 iron(0) decreases expression ISO RGD:736793 6480464 Iron results in decreased expression of GCLC mRNA CTD PMID:19073151 iron(2+) sulfate (anhydrous) multiple interactions ISO RGD:736793 6480464 ferrous sulfate promotes the reaction [SNCA protein results in decreased expression of GCLC protein] CTD PMID:27424009 iron(2+) sulfate (anhydrous) decreases expression ISO RGD:736793 6480464 ferrous sulfate results in decreased expression of GCLC protein CTD PMID:27424009 iron(III) nitrilotriacetate increases expression EXP 6480464 ferric nitrilotriacetate results in increased expression of GCLC mRNA CTD PMID:18617210 isoeugenol increases expression ISO RGD:736793 6480464 isoeugenol results in increased expression of GCLC mRNA CTD PMID:20566472 isoniazide decreases expression EXP 6480464 Isoniazid results in decreased expression of GCLC mRNA CTD PMID:24128855 isoniazide multiple interactions EXP 6480464 Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GCLC mRNA] CTD PMID:24128855 isoprenaline decreases expression EXP 6480464 Isoproterenol results in decreased expression of GCLC mRNA CTD PMID:21335049 isorhamnetin multiple interactions ISO RGD:736793 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] more ... CTD PMID:24211276 isorhamnetin multiple interactions ISO RGD:619868 6480464 [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA, [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein CTD PMID:25716194 isorhamnetin increases expression ISO RGD:619868 6480464 3-methylquercetin results in increased expression of GCLC mRNA, 3-methylquercetin results in increased expression of GCLC protein CTD PMID:25716194 isorhamnetin multiple interactions EXP 6480464 [3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein CTD PMID:24211276 isothiocyanate increases expression EXP 6480464 Isothiocyanates results in increased expression of GCLC protein CTD PMID:15570060 kaempferol increases expression ISO RGD:736793 6480464 kaempferol results in increased expression of GCLC mRNA CTD PMID:11864778 kaempferol multiple interactions EXP 6480464 kaempferol affects the reaction [propacetamol affects the expression of GCLC protein] CTD PMID:29574133 kahweol multiple interactions ISO RGD:619868 6480464 [cafestol co-treated with kahweol] inhibits the reaction [ochratoxin A results in decreased expression of GCLC protein] CTD PMID:17110534 ketamine increases expression ISO RGD:619868 6480464 Ketamine results in increased expression of GCLC mRNA CTD PMID:20080153 ketoprofen increases expression ISO RGD:736793 6480464 Ketoprofen results in increased expression of GCLC mRNA CTD PMID:11909699 L-ascorbic acid multiple interactions ISO RGD:619868 6480464 [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA more ... CTD PMID:27028516 , PMID:31585129 L-cysteine multiple interactions ISO RGD:619868 6480464 Cysteine promotes the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine] CTD PMID:15115889 L-gamma-glutamyl-L-cysteine multiple interactions ISO RGD:619868 6480464 Buthionine Sulfoximine inhibits the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine] more ... CTD PMID:15115889 L-gamma-glutamyl-L-cysteine increases chemical synthesis ISO RGD:619868 6480464 GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine CTD PMID:15115889 L-methionine multiple interactions EXP 6480464 [Choline deficiency co-treated with Methionine deficiency] results in increased expression of GCLC mRNA, NFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of GCLC mRNA] CTD PMID:20350562 lead diacetate multiple interactions ISO RGD:736793 6480464 NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of GCLC mRNA] CTD PMID:26498409 lead diacetate increases expression ISO RGD:736793 6480464 lead acetate results in increased expression of GCLC mRNA CTD PMID:26498409 lead(II) chloride multiple interactions ISO RGD:736793 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GCLC mRNA CTD PMID:18654764 lead(II) chloride decreases expression ISO RGD:736793 6480464 lead chloride results in decreased expression of GCLC protein CTD PMID:30359721 lead(II) chloride increases expression ISO RGD:736793 6480464 lead chloride results in increased expression of GCLC mRNA CTD PMID:18654764 leflunomide increases expression ISO RGD:619868 6480464 leflunomide results in increased expression of GCLC mRNA CTD PMID:24136188 levofloxacin decreases expression ISO RGD:619868 6480464 Levofloxacin results in decreased expression of GCLC mRNA CTD PMID:24136188 linalool increases expression ISO RGD:736793 6480464 linalool results in increased expression of GCLC mRNA CTD PMID:20491607 lipoic acid increases expression ISO RGD:736793 6480464 Thioctic Acid results in increased expression of GCLC mRNA CTD PMID:16249512 , PMID:17940886 lipoic acid multiple interactions ISO RGD:619868 6480464 Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC mRNA], Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC protein] CTD PMID:27298056 liquiritigenin multiple interactions ISO RGD:619868 6480464 liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA] CTD PMID:29908794 liquiritigenin increases expression ISO RGD:619868 6480464 liquiritigenin results in increased expression of GCLC protein CTD PMID:29908794 liquiritin increases expression ISO RGD:619868 6480464 liquiritin results in increased expression of GCLC protein CTD PMID:29908794 liquiritin multiple interactions ISO RGD:619868 6480464 liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA] CTD PMID:29908794 lithocholic acid increases expression EXP 6480464 Lithocholic Acid results in increased expression of GCLC mRNA, Lithocholic Acid results in increased expression of GCLC protein CTD PMID:20977460 lithocholic acid decreases expression EXP 6480464 Lithocholic Acid results in decreased expression of GCLC mRNA CTD PMID:29794447 lithocholic acid increases expression ISO RGD:736793 6480464 Lithocholic Acid results in increased expression of GCLC protein CTD PMID:17724089 lithocholic acid multiple interactions ISO RGD:736793 6480464 [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA more ... CTD PMID:17724089 , PMID:20146260 lithocholic acid affects expression ISO RGD:736793 6480464 Lithocholic Acid affects the expression of GCLC mRNA, Lithocholic Acid affects the expression of GCLC protein CTD PMID:20146260 lithocholic acid multiple interactions EXP 6480464 [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA more ... CTD PMID:17724089 more ... luteolin multiple interactions ISO RGD:619868 6480464 [Luteolin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide CTD PMID:22864849 luteolin increases expression ISO RGD:619868 6480464 Luteolin results in increased expression of GCLC mRNA, Luteolin results in increased expression of GCLC protein CTD PMID:22864849 LY294002 multiple interactions ISO RGD:736793 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cinnamic aldehyde results in increased expression of GCLC protein] more ... CTD PMID:19073151 more ... LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]] CTD PMID:25895139 LY294002 multiple interactions ISO RGD:619868 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Plant Extracts results in increased expression of GCLC mRNA] CTD PMID:20399244 , PMID:25773745 LY294002 decreases expression ISO RGD:736793 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of GCLC mRNA CTD PMID:19073151 maneb increases expression ISO RGD:736793 6480464 [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of GCLC mRNA CTD PMID:21402726 maneb increases activity ISO RGD:619868 6480464 Maneb results in increased activity of GCLC protein CTD PMID:15527874 melatonin multiple interactions EXP 6480464 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]] more ... CTD PMID:25550330 meloxicam multiple interactions ISO RGD:736793 6480464 meloxicam inhibits the reaction [Paraquat results in decreased expression of GCLC protein] CTD PMID:20851755 menadione increases activity ISO RGD:736793 6480464 Vitamin K 3 results in increased activity of GCLC protein CTD PMID:11972604 menadione increases expression ISO RGD:736793 6480464 Vitamin K 3 results in increased expression of GCLC mRNA CTD PMID:11972604 , PMID:23410634 menadione increases expression EXP 6480464 Vitamin K 3 results in increased expression of GCLC mRNA CTD PMID:25270620 menadione multiple interactions ISO RGD:736793 6480464 Dactinomycin inhibits the reaction [Vitamin K 3 results in increased expression of GCLC mRNA] CTD PMID:11972604 mercury atom increases expression ISO RGD:736793 6480464 Mercury results in increased expression of GCLC mRNA CTD PMID:17547211 mercury atom multiple interactions ISO RGD:736793 6480464 [Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of GCLC protein, GCLC gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury] CTD PMID:19515364 , PMID:30359721 mercury atom affects response to substance ISO RGD:736793 6480464 GCLC gene SNP affects the susceptibility to Mercury CTD PMID:22236634 mercury dibromide increases expression ISO RGD:736793 6480464 mercuric bromide results in increased expression of GCLC mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO RGD:736793 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLC mRNA CTD PMID:27188386 mercury dichloride decreases response to substance ISO RGD:736793 6480464 GCLC protein results in decreased susceptibility to Mercuric Chloride CTD PMID:24118919 mercury dichloride multiple interactions ISO RGD:736793 6480464 [Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of GCLC protein CTD PMID:30359721 mercury dichloride increases expression ISO RGD:736793 6480464 Mercuric Chloride results in increased expression of GCLC mRNA CTD PMID:24118919 mercury(0) increases expression ISO RGD:736793 6480464 Mercury results in increased expression of GCLC mRNA CTD PMID:17547211 mercury(0) multiple interactions ISO RGD:736793 6480464 [Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of GCLC protein, GCLC gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury] CTD PMID:19515364 , PMID:30359721 mercury(0) affects response to substance ISO RGD:736793 6480464 GCLC gene SNP affects the susceptibility to Mercury CTD PMID:22236634 mesalamine multiple interactions ISO RGD:736793 6480464 [IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Mesalamine] results in increased expression of GCLC mRNA CTD PMID:27818126 metformin increases expression ISO RGD:619868 6480464 Metformin results in increased expression of GCLC mRNA CTD PMID:25596134 methapyrilene increases expression ISO RGD:619868 6480464 Methapyrilene results in increased expression of GCLC mRNA, Methapyrilene results in increased expression of GCLC protein CTD PMID:15890375 more ... methimazole increases expression ISO RGD:736793 6480464 Methimazole results in increased expression of GCLC mRNA CTD PMID:20144635 methotrexate affects expression EXP 6480464 Methotrexate affects the expression of GCLC mRNA CTD PMID:18502557 methoxychlor multiple interactions ISO RGD:619868 6480464 [Genistein co-treated with Methoxychlor] results in increased expression of GCLC mRNA CTD PMID:21782745 methoxychlor increases expression ISO RGD:619868 6480464 Methoxychlor results in increased expression of GCLC mRNA CTD PMID:21782745 methyl non-2-ynoate increases expression ISO RGD:736793 6480464 2-nonynoic acid methyl ester results in increased expression of GCLC mRNA CTD PMID:20491607 methyl salicylate increases expression ISO RGD:736793 6480464 methyl salicylate results in increased expression of GCLC mRNA CTD PMID:20566472 methylene blue multiple interactions EXP 6480464 [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA, NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA] CTD PMID:24556215 methylene blue increases expression EXP 6480464 Methylene Blue results in increased expression of GCLC mRNA CTD PMID:24556215 methylisothiazolinone increases expression ISO RGD:736793 6480464 2-methyl-4-isothiazolin-3-one results in increased expression of GCLC mRNA CTD PMID:30806763 methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of GCLC mRNA CTD PMID:20061341 methylmercury chloride increases expression ISO RGD:619868 6480464 methylmercuric chloride results in increased expression of GCLC mRNA, methylmercuric chloride results in increased expression of GCLC protein CTD PMID:27298056 methylmercury chloride multiple interactions ISO RGD:619868 6480464 Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC mRNA], Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC protein] CTD PMID:27298056 methylmercury chloride increases expression ISO RGD:736793 6480464 methylmercuric chloride results in increased expression of GCLC mRNA CTD PMID:24118919 , PMID:28001369 methylmercury chloride decreases response to substance ISO RGD:736793 6480464 GCLC protein results in decreased susceptibility to methylmercuric chloride CTD PMID:24118919 Methysticin increases expression EXP 6480464 methysticin results in increased expression of GCLC mRNA CTD PMID:28448946 microcystin increases expression ISO RGD:619868 6480464 Microcystins analog results in increased expression of GCLC mRNA CTD PMID:24964298 microcystin multiple interactions ISO RGD:619868 6480464 Buthionine Sulfoximine inhibits the reaction [Microcystins analog results in increased expression of GCLC mRNA] CTD PMID:24964298 microcystin-LR increases expression EXP 6480464 cyanoginosin LR results in increased expression of GCLC mRNA CTD PMID:17654400 microcystin-LR decreases expression ISO RGD:736793 6480464 cyanoginosin LR results in decreased expression of GCLC mRNA CTD PMID:30940545 microcystin-LR multiple interactions ISO RGD:736793 6480464 cyanoginosin LR results in decreased expression of and results in increased phosphorylation of GCLC protein, GCLC protein inhibits the reaction [cyanoginosin LR results in decreased activity of CAT protein] CTD PMID:30940545 mifepristone multiple interactions EXP 6480464 Acetaminophen promotes the reaction [Mifepristone results in increased activity of [GCLC protein binds to GCLM protein]], Mifepristone results in increased activity of [GCLC protein binds to GCLM protein] CTD PMID:16840778 mifepristone increases expression EXP 6480464 Mifepristone results in increased expression of GCLC protein CTD PMID:16840778 miquelianin multiple interactions ISO RGD:619868 6480464 [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA, [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein CTD PMID:25716194 MK 571 multiple interactions ISO RGD:736793 6480464 [verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12, 14)-prostaglandin J2 results in increased expression of GCLC protein] CTD PMID:21728338 monocrotaline decreases expression ISO RGD:619868 6480464 Monocrotaline results in decreased expression of GCLC mRNA CTD PMID:29908794 monocrotaline multiple interactions ISO RGD:619868 6480464 liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA], liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA] CTD PMID:29908794 N,N-diethyl-m-toluamide multiple interactions ISO RGD:619868 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GCLC mRNA CTD PMID:28659758 N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide multiple interactions ISO RGD:736793 6480464 N-(3, 5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Copper results in increased expression of GCLC mRNA] CTD PMID:19747488 N-acetyl-L-cysteine multiple interactions ISO RGD:736793 6480464 Acetylcysteine inhibits the reaction [15-deoxy-delta(12 more ... CTD PMID:11820781 more ... N-acetyl-L-cysteine multiple interactions ISO RGD:619868 6480464 Acetylcysteine inhibits the reaction [decamethrin results in increased expression of GCLC mRNA], Acetylcysteine inhibits the reaction [decamethrin results in increased expression of GCLC protein] CTD PMID:17540521 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [2' more ... CTD PMID:17980396 more ... N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:736793 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC mRNA], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC protein] CTD PMID:25263748 N-methylformamide affects expression EXP 6480464 methylformamide affects the expression of GCLC mRNA, methylformamide analog affects the expression of GCLC mRNA CTD PMID:17040096 N-methylnicotinate multiple interactions ISO RGD:736793 6480464 trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA] CTD PMID:24015256 N-nitrosodiethylamine multiple interactions ISO RGD:619868 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLC mRNA more ... CTD PMID:14656948 more ... N-nitrosodiethylamine increases expression ISO RGD:619868 6480464 Diethylnitrosamine results in increased expression of GCLC mRNA CTD PMID:19638242 N-nitrosodimethylamine increases expression ISO RGD:736793 6480464 Dimethylnitrosamine results in increased expression of GCLC mRNA CTD PMID:17547211 N-nitrosodimethylamine decreases expression ISO RGD:619868 6480464 Dimethylnitrosamine results in decreased expression of GCLC protein CTD PMID:23485615 N-nitrosodimethylamine multiple interactions ISO RGD:619868 6480464 Plant Extracts inhibits the reaction [Dimethylnitrosamine results in decreased expression of GCLC protein] CTD PMID:23485615 N-nitrosodimethylamine increases expression ISO RGD:619868 6480464 Dimethylnitrosamine results in increased expression of GCLC mRNA CTD PMID:14600272 , PMID:15890375 N-tosyl-L-phenylalanyl chloromethyl ketone increases expression EXP 6480464 Tosylphenylalanyl Chloromethyl Ketone results in increased expression of GCLC mRNA CTD PMID:22851183 N-tosyl-L-phenylalanyl chloromethyl ketone increases expression ISO RGD:736793 6480464 Tosylphenylalanyl Chloromethyl Ketone results in increased expression of GCLC mRNA CTD PMID:22851183 naphthalene multiple interactions EXP 6480464 Buthionine Sulfoximine inhibits the reaction [GCLC protein results in decreased susceptibility to naphthalene] more ... CTD PMID:10900227 , PMID:12805647 naphthalene decreases expression EXP 6480464 naphthalene results in decreased expression of GCLC mRNA CTD PMID:31020322 naphthalene increases expression ISO RGD:619868 6480464 naphthalene analog results in increased expression of GCLC mRNA, naphthalene results in increased expression of GCLC mRNA CTD PMID:24563378 , PMID:24976557 naphthalene increases activity EXP 6480464 naphthalene results in increased activity of GCLC protein CTD PMID:10900227 naphthalene decreases response to substance EXP 6480464 GCLC protein results in decreased susceptibility to naphthalene CTD PMID:10900227 , PMID:12805647 naphthalene-1,2-diol increases expression ISO RGD:736793 6480464 1, 2-dihydroxynaphthalene analog results in increased expression of GCLC mRNA CTD PMID:25807370 naproxen increases expression ISO RGD:736793 6480464 Naproxen results in increased expression of GCLC mRNA CTD PMID:11909699 naringin multiple interactions ISO RGD:619868 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein] more ... CTD PMID:22871521 , PMID:25773745 naringin increases expression ISO RGD:619868 6480464 naringin results in increased expression of GCLC mRNA, naringin results in increased expression of GCLC protein CTD PMID:22871521 , PMID:25773745 nefazodone increases expression ISO RGD:619868 6480464 nefazodone results in increased expression of GCLC mRNA CTD PMID:24136188 neoastilbin multiple interactions ISO RGD:736793 6480464 astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] CTD PMID:29471006 nickel dichloride affects expression ISO RGD:619868 6480464 nickel chloride affects the expression of GCLC mRNA CTD PMID:22110744 nickel dichloride increases expression ISO RGD:736793 6480464 nickel chloride results in increased expression of GCLC mRNA CTD PMID:17547211 , PMID:21111804 nickel sulfate increases expression EXP 6480464 nickel sulfate results in increased expression of GCLC mRNA CTD PMID:16100012 nickel sulfate increases expression ISO RGD:736793 6480464 nickel sulfate results in increased expression of GCLC mRNA CTD PMID:20491607 , PMID:20566472 nicotinamide multiple interactions ISO RGD:619868 6480464 [Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA more ... CTD PMID:21439372 nicotine multiple interactions EXP 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 nimesulide increases expression ISO RGD:619868 6480464 nimesulide results in increased expression of GCLC mRNA CTD PMID:24136188 nimustine increases expression ISO RGD:736793 6480464 Nimustine results in increased expression of GCLC mRNA CTD PMID:9393752 nitisinone multiple interactions EXP 6480464 [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLC mRNA CTD PMID:12899938 nitric oxide decreases expression ISO RGD:619868 6480464 Nitric Oxide deficiency results in decreased expression of GCLC mRNA, Nitric Oxide deficiency results in decreased expression of GCLC protein CTD PMID:19631198 Nodularin affects expression ISO RGD:736793 6480464 nodularin affects the expression of GCLC mRNA CTD PMID:30562542 Nonidet P-40 decreases expression ISO RGD:736793 6480464 Nonidet P-40 results in decreased expression of GCLC mRNA CTD PMID:26552463 notoginsenoside R1 multiple interactions ISO RGD:619868 6480464 Cycloheximide inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein] more ... CTD PMID:24437944 notoginsenoside R1 increases expression ISO RGD:619868 6480464 notoginsenoside R1 results in increased expression of GCLC protein CTD PMID:24437944 ochratoxin A multiple interactions ISO RGD:619868 6480464 [cafestol co-treated with kahweol] inhibits the reaction [ochratoxin A results in decreased expression of GCLC protein] CTD PMID:17110534 ochratoxin A increases expression ISO RGD:736793 6480464 ochratoxin A results in increased expression of GCLC mRNA CTD PMID:30291945 ochratoxin A multiple interactions ISO RGD:736793 6480464 AHR protein affects the reaction [ochratoxin A results in increased expression of GCLC mRNA], NR1I2 protein affects the reaction [ochratoxin A results in increased expression of GCLC mRNA] CTD PMID:30291945 ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of GCLC mRNA CTD PMID:30291945 ochratoxin A decreases expression ISO RGD:619868 6480464 ochratoxin A results in decreased expression of GCLC mRNA, ochratoxin A results in decreased expression of GCLC protein CTD PMID:16251485 more ... oleanolic acid increases expression ISO RGD:619868 6480464 Oleanolic Acid results in increased expression of GCLC mRNA CTD PMID:18706400 oleanolic acid increases expression EXP 6480464 Oleanolic Acid results in increased expression of GCLC mRNA, Oleanolic Acid results in increased expression of GCLC protein CTD PMID:18706400 more ... oxaliplatin decreases expression ISO RGD:619868 6480464 oxaliplatin results in decreased expression of GCLC mRNA CTD PMID:25729387 oxaliplatin multiple interactions ISO RGD:619868 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of GCLC mRNA, [Topotecan co-treated with oxaliplatin] results in decreased expression of GCLC mRNA CTD PMID:25729387 oxidopamine multiple interactions ISO RGD:619868 6480464 salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLC protein] CTD PMID:25446857 oxidopamine decreases expression ISO RGD:736793 6480464 Oxidopamine results in decreased expression of GCLC protein CTD PMID:25446857 oxidopamine multiple interactions ISO RGD:736793 6480464 salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLC protein] CTD PMID:25446857 oxidopamine decreases expression ISO RGD:619868 6480464 Oxidopamine results in decreased expression of GCLC protein CTD PMID:25446857 oxidopamine increases expression ISO RGD:619868 6480464 Oxidopamine results in increased expression of GCLC mRNA, Oxidopamine results in increased expression of GCLC protein CTD PMID:21397656 ozone multiple interactions EXP 6480464 [NOTCH3 gene mutant form affects the susceptibility to Ozone] which results in increased expression of GCLC mRNA more ... CTD PMID:17460151 more ... ozone increases expression EXP 6480464 Ozone results in increased expression of GCLC mRNA CTD PMID:17095637 p-chloromercuribenzoic acid increases expression ISO RGD:736793 6480464 p-Chloromercuribenzoic Acid results in increased expression of GCLC mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions ISO RGD:736793 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLC mRNA CTD PMID:27188386 para-Cresidine increases expression ISO RGD:736793 6480464 cresidine results in increased expression of GCLC mRNA CTD PMID:26198647 paracetamol increases expression ISO RGD:736793 6480464 Acetaminophen results in increased expression of GCLC mRNA CTD PMID:21420995 more ... paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of GCLC mRNA CTD PMID:25818464 , PMID:29355602 paracetamol decreases response to substance EXP 6480464 GCLC protein results in decreased susceptibility to Acetaminophen CTD PMID:18642143 , PMID:24661219 paracetamol decreases expression ISO RGD:736793 6480464 Acetaminophen results in decreased expression of GCLC mRNA CTD PMID:27761495 paracetamol decreases expression ISO RGD:619868 6480464 Acetaminophen results in decreased expression of GCLC mRNA CTD PMID:26767949 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of GCLC mRNA, Acetaminophen results in increased expression of GCLC protein CTD PMID:10915739 more ... paracetamol increases expression ISO RGD:619868 6480464 Acetaminophen results in increased expression of GCLC mRNA CTD PMID:11245408 more ... paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of GCLC mRNA CTD PMID:15606129 more ... paracetamol affects response to substance ISO RGD:619868 6480464 GCLC protein affects the susceptibility to Acetaminophen CTD PMID:17573345 paracetamol decreases activity EXP 6480464 Acetaminophen results in decreased activity of GCLC protein CTD PMID:10915739 paracetamol multiple interactions EXP 6480464 [Acetaminophen co-treated with Tobacco Smoke Pollution] results in increased expression of GCLC mRNA more ... CTD PMID:15122755 more ... paracetamol multiple interactions ISO RGD:736793 6480464 Chlorogenic Acid promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA] more ... CTD PMID:25881548 , PMID:29136249 paraquat increases expression EXP 6480464 Paraquat results in increased expression of GCLC mRNA CTD PMID:17215068 paraquat increases expression ISO RGD:619868 6480464 Paraquat results in increased expression of GCLC mRNA CTD PMID:26598004 , PMID:28467894 paraquat decreases expression ISO RGD:736793 6480464 Paraquat results in decreased expression of GCLC mRNA, Paraquat results in decreased expression of GCLC protein CTD PMID:20851755 , PMID:24866057 paraquat multiple interactions ISO RGD:736793 6480464 [alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLC mRNA more ... CTD PMID:20851755 more ... paraquat affects expression ISO RGD:619868 6480464 Paraquat affects the expression of GCLC mRNA CTD PMID:16854511 perfluorononanoic acid decreases expression EXP 6480464 perfluoro-n-nonanoic acid results in decreased expression of GCLC mRNA CTD PMID:23567314 perfluorooctane-1-sulfonic acid increases expression EXP 6480464 perfluorooctane sulfonic acid results in increased expression of GCLC mRNA CTD PMID:26548598 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of GCLC mRNA CTD PMID:23567314 , PMID:30547568 perfluoroundecanoic acid decreases expression EXP 6480464 perfluoro-n-undecanoic acid results in decreased expression of GCLC mRNA CTD PMID:23567314 permethrin multiple interactions ISO RGD:619868 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GCLC mRNA CTD PMID:28659758 phenethyl caffeate multiple interactions EXP 6480464 caffeic acid phenethyl ester inhibits the reaction [Bleomycin results in decreased expression of GCLC protein] CTD PMID:23570914 phenethyl isothiocyanate increases expression ISO RGD:736793 6480464 phenethyl isothiocyanate results in increased expression of GCLC mRNA CTD PMID:20442190 phenobarbital decreases expression EXP 6480464 Phenobarbital results in decreased expression of GCLC mRNA CTD PMID:19270015 phenobarbital decreases expression ISO RGD:619868 6480464 Phenobarbital results in decreased expression of GCLC mRNA CTD PMID:19162173 phenol increases expression ISO RGD:736793 6480464 Phenol results in increased expression of GCLC mRNA CTD PMID:26198647 phenylmercury acetate increases expression ISO RGD:736793 6480464 Phenylmercuric Acetate results in increased expression of GCLC mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:736793 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLC mRNA CTD PMID:27188386 phlorizin decreases expression EXP 6480464 Phlorhizin results in decreased expression of GCLC mRNA CTD PMID:22538082 phloroglucinol increases expression EXP 6480464 Phloroglucinol results in increased expression of GCLC protein CTD PMID:20188716 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:736793 6480464 [Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA CTD PMID:18154958 phorbol 13-acetate 12-myristate increases expression ISO RGD:736793 6480464 Tetradecanoylphorbol Acetate results in increased expression of GCLC mRNA CTD PMID:18154958 , PMID:26198647 phorbol 13-acetate 12-myristate increases expression EXP 6480464 Tetradecanoylphorbol Acetate results in increased expression of GCLC mRNA CTD PMID:17200146 phosgene affects expression EXP 6480464 Phosgene affects the expression of GCLC mRNA CTD PMID:16300373 piperonyl butoxide increases expression ISO RGD:619868 6480464 Piperonyl Butoxide results in increased expression of GCLC mRNA CTD PMID:15890375 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of GCLC mRNA CTD PMID:17426115 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of GCLC mRNA CTD PMID:18445702 pirinixic acid increases expression ISO RGD:619868 6480464 pirinixic acid results in increased expression of GCLC mRNA CTD PMID:15890375 , PMID:19162173 Polpunonic acid increases expression ISO RGD:736793 6480464 maytenonic acid results in increased expression of GCLC mRNA CTD PMID:27751938 Polpunonic acid increases expression EXP 6480464 maytenonic acid results in increased expression of GCLC mRNA CTD PMID:27751938 potassium chloride multiple interactions ISO RGD:619868 6480464 [Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of GCLC mRNA CTD PMID:22228705 potassium chromate multiple interactions EXP 6480464 [Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of GCLC mRNA] CTD PMID:14625279 potassium dichromate multiple interactions EXP 6480464 [Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of GCLC mRNA] CTD PMID:14625279 pravastatin increases expression EXP 6480464 Pravastatin results in increased expression of GCLC mRNA CTD PMID:27225895 pravastatin decreases expression ISO RGD:619868 6480464 Pravastatin results in decreased expression of GCLC mRNA CTD PMID:27225895 prazosin multiple interactions EXP 6480464 Prazosin inhibits the reaction [Acetaminophen results in increased expression of GCLC mRNA] CTD PMID:18071297 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:619868 6480464 Pregnenolone Carbonitrile results in increased expression of GCLC mRNA CTD PMID:19162173 pregnenolone 16alpha-carbonitrile decreases expression EXP 6480464 Pregnenolone Carbonitrile results in decreased expression of GCLC mRNA CTD PMID:28903501 Pristimerin multiple interactions ISO RGD:619868 6480464 pristimerin inhibits the reaction [Doxorubicin results in decreased expression of GCLC mRNA], pristimerin inhibits the reaction [Doxorubicin results in decreased expression of GCLC protein] CTD PMID:30588110 progesterone decreases expression EXP 6480464 Progesterone results in decreased expression of GCLC mRNA CTD PMID:22238285 propacetamol affects expression EXP 6480464 propacetamol affects the expression of GCLC protein CTD PMID:29574133 propacetamol multiple interactions EXP 6480464 kaempferol affects the reaction [propacetamol affects the expression of GCLC protein] CTD PMID:29574133 propan-2-ol increases expression ISO RGD:736793 6480464 2-Propanol results in increased expression of GCLC mRNA CTD PMID:20566472 propanal decreases expression ISO RGD:736793 6480464 propionaldehyde results in decreased expression of GCLC mRNA CTD PMID:26079696 prostaglandin J2 increases expression ISO RGD:619868 6480464 9-deoxy-delta-9-prostaglandin D2 results in increased expression of GCLC mRNA, 9-deoxy-delta-9-prostaglandin D2 results in increased expression of GCLC protein CTD PMID:18332871 pyocyanine increases expression ISO RGD:736793 6480464 Pyocyanine results in increased expression of GCLC mRNA CTD PMID:24015256 pyocyanine multiple interactions ISO RGD:736793 6480464 [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA, trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA] CTD PMID:24015256 pyrazines increases expression ISO RGD:736793 6480464 Pyrazines analog results in increased expression of GCLC mRNA CTD PMID:25056784 Pyridostigmine bromide multiple interactions ISO RGD:619868 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GCLC mRNA CTD PMID:28659758 pyrroloquinoline quinone multiple interactions ISO RGD:619868 6480464 PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of GCLC mRNA] CTD PMID:26276080 quercetin increases expression ISO RGD:736793 6480464 Quercetin results in increased expression of GCLC mRNA, Quercetin results in increased expression of GCLC protein CTD PMID:11864778 more ... quercetin increases expression ISO RGD:619868 6480464 Quercetin results in increased expression of GCLC mRNA, Quercetin results in increased expression of GCLC protein CTD PMID:19798679 more ... quercetin multiple interactions ISO RGD:619868 6480464 [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA more ... CTD PMID:19798679 more ... quercetin multiple interactions ISO RGD:736793 6480464 [clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA more ... CTD PMID:25881548 quercetin increases expression EXP 6480464 Quercetin results in increased expression of GCLC mRNA CTD PMID:19183254 quercetin affects expression ISO RGD:619868 6480464 Quercetin affects the expression of GCLC mRNA CTD PMID:18178720 rac-lactic acid increases expression ISO RGD:736793 6480464 Lactic Acid results in increased expression of GCLC mRNA CTD PMID:20566472 reactive oxygen species multiple interactions ISO RGD:736793 6480464 [[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione, [[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein CTD PMID:21728338 reactive oxygen species affects expression ISO RGD:736793 6480464 Reactive Oxygen Species affects the expression of GCLC mRNA CTD PMID:25800948 reactive oxygen species multiple interactions ISO RGD:619868 6480464 [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]] CTD PMID:22864849 resorcinol increases expression ISO RGD:736793 6480464 resorcinol results in increased expression of GCLC mRNA CTD PMID:30806763 resveratrol increases expression ISO RGD:736793 6480464 resveratrol results in increased expression of GCLC mRNA CTD PMID:11909699 more ... resveratrol multiple interactions ISO RGD:619868 6480464 resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA], resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein] CTD PMID:21439372 resveratrol increases expression ISO RGD:619868 6480464 resveratrol results in increased expression of GCLC mRNA CTD PMID:15882976 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of GCLC mRNA CTD PMID:21520053 resveratrol multiple interactions ISO RGD:736793 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [resveratrol results in increased expression of GCLC mRNA] more ... CTD PMID:11909699 more ... rosuvastatin calcium multiple interactions ISO RGD:736793 6480464 [Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA CTD PMID:18154958 rosuvastatin calcium increases expression ISO RGD:736793 6480464 Rosuvastatin Calcium results in increased expression of GCLC mRNA CTD PMID:18154958 rotenone increases expression EXP 6480464 Rotenone results in increased expression of GCLC mRNA CTD PMID:17657281 rotenone decreases expression ISO RGD:619868 6480464 Rotenone results in decreased expression of GCLC mRNA CTD PMID:26276080 rotenone multiple interactions ISO RGD:619868 6480464 PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of GCLC mRNA] CTD PMID:26276080 rottlerin multiple interactions ISO RGD:736793 6480464 rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein], rottlerin inhibits the reaction [Plant Extracts results in increased expression of GCLC protein] CTD PMID:24211276 , PMID:30626086 rottlerin multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]] more ... CTD PMID:25895139 more ... rottlerin multiple interactions ISO RGD:619868 6480464 rottlerin inhibits the reaction [naringin results in increased expression of GCLC protein] CTD PMID:25773745 S-adenosyl-L-methioninate multiple interactions ISO RGD:736793 6480464 S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA], S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]] CTD PMID:20146260 S-adenosyl-L-methionine multiple interactions ISO RGD:736793 6480464 S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA], S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]] CTD PMID:20146260 S-butyl-DL-homocysteine (S,R)-sulfoximine decreases activity EXP 6480464 Buthionine Sulfoximine results in decreased activity of GCLC protein CTD PMID:15707499 , PMID:7955076 S-butyl-DL-homocysteine (S,R)-sulfoximine increases expression ISO RGD:619868 6480464 Buthionine Sulfoximine results in increased expression of GCLC mRNA CTD PMID:10978506 , PMID:23585199 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO RGD:736793 6480464 Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione], Buthionine Sulfoximine inhibits the reaction [GCLC results in decreased susceptibility to Cadmium Chloride] CTD PMID:17724089 , PMID:18556457 S-butyl-DL-homocysteine (S,R)-sulfoximine decreases activity ISO RGD:619868 6480464 Buthionine Sulfoximine results in decreased activity of GCLC protein CTD PMID:12433058 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO RGD:619868 6480464 [Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GCLC protein more ... CTD PMID:12967637 more ... S-butyl-DL-homocysteine (S,R)-sulfoximine increases expression EXP 6480464 Buthionine Sulfoximine results in increased expression of GCLC mRNA CTD PMID:17980396 , PMID:18449455 S-butyl-DL-homocysteine (S,R)-sulfoximine increases activity EXP 6480464 Buthionine Sulfoximine results in increased activity of GCLC protein CTD PMID:10915739 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions EXP 6480464 [Buthionine Sulfoximine results in decreased activity of GCLC protein] inhibits the reaction [indenoindole results in increased abundance of Glutathione] more ... CTD PMID:10900227 more ... SB 203580 multiple interactions ISO RGD:736793 6480464 SB 203580 inhibits the reaction [Plant Extracts results in increased expression of GCLC protein], SB 203580 inhibits the reaction [sodium arsenite results in increased expression of GCLC protein] CTD PMID:25201354 , PMID:30626086 SB 203580 multiple interactions EXP 6480464 SB 203580 inhibits the reaction [2' more ... CTD PMID:31029725 SB 431542 multiple interactions ISO RGD:736793 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 selenium atom multiple interactions ISO RGD:619868 6480464 [Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of GCLC mRNA CTD PMID:11444866 selenocystine increases expression ISO RGD:736793 6480464 selenocystine results in increased expression of GCLC mRNA CTD PMID:22807314 selenocystine multiple interactions ISO RGD:736793 6480464 NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of GCLC mRNA] CTD PMID:22807314 selenomethionine increases expression ISO RGD:736793 6480464 Selenomethionine results in increased expression of GCLC mRNA CTD PMID:22807314 silicon dioxide decreases expression ISO RGD:736793 6480464 Silicon Dioxide analog results in decreased expression of GCLC mRNA CTD PMID:25895662 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of GCLC mRNA CTD PMID:23221170 silver atom multiple interactions ISO RGD:736793 6480464 NFE2L2 protein affects the reaction [Silver results in increased expression of GCLC mRNA] CTD PMID:22546375 silver atom increases expression EXP 6480464 Silver results in increased expression of GCLC mRNA CTD PMID:27131904 silver atom increases expression ISO RGD:736793 6480464 Silver results in increased expression of GCLC mRNA CTD PMID:22036727 more ... silver(0) multiple interactions ISO RGD:736793 6480464 NFE2L2 protein affects the reaction [Silver results in increased expression of GCLC mRNA] CTD PMID:22546375 silver(0) increases expression EXP 6480464 Silver results in increased expression of GCLC mRNA CTD PMID:27131904 silver(0) increases expression ISO RGD:736793 6480464 Silver results in increased expression of GCLC mRNA CTD PMID:22036727 more ... silver(1+) nitrate decreases expression ISO RGD:736793 6480464 Silver Nitrate results in decreased expression of GCLC mRNA CTD PMID:19733233 SL-327 multiple interactions EXP 6480464 SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]] CTD PMID:25550330 sodium arsenate increases expression ISO RGD:736793 6480464 sodium arsenate results in increased expression of GCLC mRNA CTD PMID:12727804 sodium arsenite increases expression ISO RGD:736793 6480464 sodium arsenite results in increased expression of GCLC mRNA, sodium arsenite results in increased expression of GCLC protein CTD PMID:12441363 more ... sodium arsenite affects methylation ISO RGD:736793 6480464 sodium arsenite affects the methylation of GCLC gene CTD PMID:28589171 sodium arsenite increases expression ISO RGD:619868 6480464 sodium arsenite results in increased expression of GCLC mRNA, sodium arsenite results in increased expression of GCLC protein CTD PMID:12210719 , PMID:21465251 sodium arsenite affects expression ISO RGD:619868 6480464 sodium arsenite affects the expression of GCLC mRNA CTD PMID:25625412 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of GCLC mRNA, sodium arsenite results in increased expression of GCLC protein CTD PMID:16014739 more ... sodium arsenite multiple interactions EXP 6480464 [GCLM co-treated with GCLC] inhibits the reaction [sodium arsenite results in increased activity of and results in increased cleavage of CASP3 protein], [GCLM co-treated with GCLC] inhibits the reaction [sodium arsenite results in increased activity of CASP9 protein] CTD PMID:20006689 sodium arsenite increases activity ISO RGD:736793 6480464 sodium arsenite results in increased activity of GCLC protein CTD PMID:12441363 sodium arsenite multiple interactions ISO RGD:736793 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of GCLC protein] more ... CTD PMID:20805060 more ... sodium cholate multiple interactions EXP 6480464 [Cholesterol, Dietary co-treated with Sodium Cholate] results in increased expression of GCLC protein, MET gene mutant form inhibits the reaction [[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased expression of GCLC protein] CTD PMID:27394961 sodium dichromate increases expression ISO RGD:619868 6480464 sodium bichromate results in increased expression of GCLC mRNA CTD PMID:22561333 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of GCLC mRNA CTD PMID:22155349 sodium dichromate decreases expression EXP 6480464 sodium bichromate results in decreased expression of GCLC mRNA CTD PMID:22155349 sodium dodecyl sulfate increases expression ISO RGD:736793 6480464 Sodium Dodecyl Sulfate results in increased expression of GCLC mRNA CTD PMID:20566472 sodium fluoride decreases expression EXP 6480464 Sodium Fluoride results in decreased expression of GCLC mRNA CTD PMID:27862939 spironolactone multiple interactions ISO RGD:619868 6480464 Spironolactone inhibits the reaction [Aldosterone results in increased expression of GCLC protein] CTD PMID:24512358 , PMID:25204689 staurosporine multiple interactions ISO RGD:736793 6480464 Staurosporine promotes the reaction [MYC protein binds to GCLC promoter] CTD PMID:17628013 stavudine increases expression ISO RGD:619868 6480464 Stavudine results in increased expression of GCLC mRNA CTD PMID:18299183 streptozocin multiple interactions ISO RGD:619868 6480464 [Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA more ... CTD PMID:21439372 styrene increases activity EXP 6480464 Styrene results in increased activity of GCLC protein CTD PMID:16971035 succimer multiple interactions ISO RGD:736793 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of GCLC mRNA CTD PMID:26378955 sulforaphane multiple interactions EXP 6480464 [sulforafan co-treated with dibenzoylmethane] results in increased expression of GCLC mRNA more ... CTD PMID:17942926 more ... sulforaphane increases expression EXP 6480464 sulforafan results in increased expression of GCLC mRNA, sulforafan results in increased expression of GCLC protein CTD PMID:17942926 more ... sulforaphane increases expression ISO RGD:736793 6480464 sulforafan results in increased expression of GCLC mRNA, sulforafan results in increased expression of GCLC protein CTD PMID:20442190 more ... sulforaphane increases expression ISO RGD:619868 6480464 sulforafan results in increased expression of GCLC mRNA, sulforafan results in increased expression of GCLC protein CTD PMID:21871945 , PMID:22558124 sulforaphane multiple interactions ISO RGD:619868 6480464 N-Methyl-3, 4-methylenedioxyamphetamine inhibits the reaction [sulforafan results in increased expression of GCLC mRNA] CTD PMID:21871945 sulforaphane multiple interactions ISO RGD:736793 6480464 alpha-methylepinine promotes the reaction [sulforafan results in increased expression of GCLC mRNA] more ... CTD PMID:21871945 more ... sulindac multiple interactions ISO RGD:736793 6480464 Acetylcysteine inhibits the reaction [Sulindac results in increased expression of GCLC protein] CTD PMID:11820781 sulindac increases expression ISO RGD:736793 6480464 Sulindac results in increased expression of GCLC protein CTD PMID:11820781 sulindac affects expression ISO RGD:736793 6480464 Sulindac affects the expression of GCLC mRNA CTD PMID:15946948 sunitinib increases expression ISO RGD:736793 6480464 Sunitinib results in increased expression of GCLC mRNA CTD PMID:31533062 suprofen increases expression ISO RGD:736793 6480464 Suprofen results in increased expression of GCLC mRNA CTD PMID:11909699 T-2 Toxin decreases expression EXP 6480464 T-2 Toxin results in decreased expression of GCLC mRNA CTD PMID:20854872 tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of GCLC mRNA CTD PMID:20937368 tert-butyl hydroperoxide multiple interactions ISO RGD:736793 6480464 [Linoleic Acids, Conjugated results in increased activity of GCLC protein] which results in decreased susceptibility to tert-Butylhydroperoxide CTD PMID:17092368 tert-butyl hydroperoxide decreases expression EXP 6480464 tert-Butylhydroperoxide results in decreased expression of GCLC mRNA CTD PMID:30547568 tert-butyl hydroperoxide increases expression ISO RGD:736793 6480464 tert-Butylhydroperoxide results in increased expression of GCLC mRNA CTD PMID:23410634 , PMID:27509014 tert-butyl hydroperoxide multiple interactions ISO RGD:619868 6480464 [Apigenin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide more ... CTD PMID:22864849 tert-butyl hydroperoxide decreases response to substance ISO RGD:619868 6480464 GCLC protein results in decreased susceptibility to tert-Butylhydroperoxide CTD PMID:12425961 tetrachloromethane affects expression EXP 6480464 Carbon Tetrachloride affects the expression of GCLC mRNA CTD PMID:17484886 tetrachloromethane increases expression ISO RGD:619868 6480464 Carbon Tetrachloride results in increased expression of GCLC mRNA CTD PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA] more ... CTD PMID:21725986 more ... tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of GCLC mRNA, Carbon Tetrachloride results in decreased expression of GCLC protein CTD PMID:27477297 , PMID:29964319 tetrachloromethane multiple interactions ISO RGD:619868 6480464 diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA], schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of GCLC mRNA] CTD PMID:24293383 , PMID:31150632 tetrachloromethane decreases expression ISO RGD:619868 6480464 Carbon Tetrachloride results in decreased expression of GCLC mRNA CTD PMID:24293383 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of GCLC mRNA, Carbon Tetrachloride results in increased expression of GCLC protein CTD PMID:10915739 more ... tetrachloromethane decreases activity EXP 6480464 Carbon Tetrachloride results in decreased activity of GCLC protein CTD PMID:10915739 tetramethylpyrazine increases expression ISO RGD:736793 6480464 tetramethylpyrazine analog results in increased expression of GCLC mRNA, tetramethylpyrazine analog results in increased expression of GCLC protein CTD PMID:25056784 tetramethylpyrazine multiple interactions EXP 6480464 NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]] more ... CTD PMID:27477297 thiabendazole increases activity EXP 6480464 Thiabendazole results in increased activity of GCLC protein CTD PMID:11019651 thiabendazole multiple interactions EXP 6480464 [Thiabendazole co-treated with Buthionine Sulfoximine] results in increased activity of GCLC protein CTD PMID:11019651 thioacetamide increases expression ISO RGD:619868 6480464 Thioacetamide results in increased expression of GCLC mRNA, Thioacetamide results in increased expression of GCLC protein CTD PMID:10486302 more ... thioacetamide multiple interactions ISO RGD:619868 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of GCLC mRNA CTD PMID:28943392 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of GCLC mRNA CTD PMID:23557971 titanium dioxide multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of GCLC mRNA, Grape Seed Proanthocyanidins inhibits the reaction [titanium dioxide results in decreased expression of GCLC protein] CTD PMID:28780322 , PMID:29950665 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of GCLC protein CTD PMID:28780322 topotecan decreases expression ISO RGD:619868 6480464 Topotecan results in decreased expression of GCLC mRNA CTD PMID:25729387 topotecan multiple interactions ISO RGD:619868 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of GCLC mRNA, [Topotecan co-treated with oxaliplatin] results in decreased expression of GCLC mRNA CTD PMID:25729387 trans-isoeugenol increases expression ISO RGD:736793 6480464 isoeugenol results in increased expression of GCLC mRNA CTD PMID:20566472 triacsin C increases expression ISO RGD:736793 6480464 triacsin C results in increased expression of GCLC mRNA CTD PMID:16704987 tributylstannane multiple interactions EXP 6480464 PRKCD gene mutant form promotes the reaction [tributyltin results in increased expression of GCLC mRNA] CTD PMID:25895139 trichostatin A increases expression ISO RGD:736793 6480464 trichostatin A results in increased expression of GCLC mRNA CTD PMID:21319187 trichostatin A multiple interactions ISO RGD:736793 6480464 [Fenretinide co-treated with trichostatin A] results in increased expression of GCLC mRNA CTD PMID:21319187 trimethyltin increases expression EXP 6480464 trimethyltin results in increased expression of GCLC mRNA CTD PMID:25895139 trimethyltin multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]], rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA] CTD PMID:25895139 Triptolide multiple interactions ISO RGD:619868 6480464 NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of GCLC protein] CTD PMID:25169008 Triptolide decreases expression EXP 6480464 triptolide results in decreased expression of GCLC protein CTD PMID:25169008 Triptolide decreases expression ISO RGD:619868 6480464 triptolide results in decreased expression of GCLC protein CTD PMID:25169008 troglitazone increases expression ISO RGD:736793 6480464 troglitazone results in increased expression of GCLC mRNA CTD PMID:19140230 trovafloxacin decreases expression ISO RGD:619868 6480464 trovafloxacin results in decreased expression of GCLC mRNA CTD PMID:24136188 trovafloxacin multiple interactions EXP 6480464 [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of GCLC mRNA CTD PMID:18930950 tunicamycin increases expression EXP 6480464 Tunicamycin results in increased expression of GCLC mRNA CTD PMID:22959925 tunicamycin multiple interactions EXP 6480464 NFE2L2 mRNA affects the reaction [Tunicamycin results in increased expression of GCLC mRNA] CTD PMID:22959925 tyrphostin AG 1478 multiple interactions ISO RGD:619868 6480464 Doxorubicin promotes the reaction [RTKI cpd results in decreased expression of GCLC protein] CTD PMID:18371937 tyrphostin AG 1478 decreases expression ISO RGD:619868 6480464 RTKI cpd results in decreased expression of GCLC protein CTD PMID:18371937 urethane increases expression ISO RGD:736793 6480464 Urethane results in increased expression of GCLC mRNA CTD PMID:28818685 ursodeoxycholic acid multiple interactions ISO RGD:736793 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GCLC mRNA] more ... CTD PMID:19073151 , PMID:20146260 ursodeoxycholic acid multiple interactions EXP 6480464 NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of GCLC mRNA] CTD PMID:18687751 ursodeoxycholic acid increases expression ISO RGD:736793 6480464 Ursodeoxycholic Acid results in increased expression of GCLC mRNA CTD PMID:19073151 ursodeoxycholic acid increases expression EXP 6480464 Ursodeoxycholic Acid results in increased expression of GCLC mRNA, Ursodeoxycholic Acid results in increased expression of GCLC protein CTD PMID:18687751 usnic acid increases expression ISO RGD:736793 6480464 usnic acid results in increased expression of GCLC mRNA, usnic acid results in increased expression of GCLC protein CTD PMID:27369375 usnic acid multiple interactions ISO RGD:736793 6480464 NFE2L2 protein promotes the reaction [usnic acid results in increased expression of GCLC protein] CTD PMID:27369375 valdecoxib increases expression ISO RGD:619868 6480464 valdecoxib results in increased expression of GCLC mRNA CTD PMID:24136188 valproic acid increases expression ISO RGD:736793 6480464 Valproic Acid results in increased expression of GCLC mRNA CTD PMID:25716160 vanillin increases expression ISO RGD:736793 6480464 vanillin results in increased expression of GCLC mRNA CTD PMID:17178418 vincristine multiple interactions ISO RGD:736793 6480464 [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Vincristine CTD PMID:10900222 vitamin E multiple interactions ISO RGD:736793 6480464 [alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLC mRNA CTD PMID:24530478 vitamin E multiple interactions ISO RGD:619868 6480464 [Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of GCLC mRNA, Vitamin E affects the reaction [[REL binds to GCLC promoter] which affects the expression of GCLC mRNA] CTD PMID:11444866 , PMID:16298738 vitamin E affects expression ISO RGD:619868 6480464 Vitamin E affects the expression of GCLC mRNA, Vitamin E affects the expression of GCLC protein CTD PMID:16298738 vitamin E multiple interactions EXP 6480464 Vitamin E inhibits the reaction [Alcohols results in increased expression of GCLC mRNA] CTD PMID:18814483 yohimbine multiple interactions EXP 6480464 [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 zinc atom multiple interactions ISO RGD:736793 6480464 acetyl-valyl-isoleucyl-aspartyl-aldehyde inhibits the reaction [Zinc deficiency results in increased cleavage of GCLC protein] more ... CTD PMID:23377617 zinc atom decreases expression ISO RGD:736793 6480464 Zinc deficiency results in decreased expression of GCLC mRNA CTD PMID:23377617 zinc atom decreases expression ISO RGD:619868 6480464 Zinc deficiency results in decreased expression of GCLC mRNA, Zinc deficiency results in decreased expression of GCLC protein CTD PMID:23377617 zinc dichloride multiple interactions ISO RGD:736793 6480464 zinc chloride promotes the reaction [SLC39A2 protein results in increased expression of GCLC mRNA] CTD PMID:18385089 zinc oxide multiple interactions EXP 6480464 Zinc Oxide affects the splicing of and results in increased expression of GCLC mRNA CTD PMID:30500950 zinc(0) multiple interactions ISO RGD:736793 6480464 acetyl-valyl-isoleucyl-aspartyl-aldehyde inhibits the reaction [Zinc deficiency results in increased cleavage of GCLC protein] more ... CTD PMID:23377617 zinc(0) decreases expression ISO RGD:619868 6480464 Zinc deficiency results in decreased expression of GCLC mRNA, Zinc deficiency results in decreased expression of GCLC protein CTD PMID:23377617 zinc(0) decreases expression ISO RGD:736793 6480464 Zinc deficiency results in decreased expression of GCLC mRNA CTD PMID:23377617
Gene-Chemical Interaction Annotations
