Gclc (glutamate-cysteine ligase, catalytic subunit) - Rat Genome Database
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Gene: Gclc (glutamate-cysteine ligase, catalytic subunit) Mus musculus
Analyze
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
RGD ID: 10652
MGI Page MGI
Description: Is expressed in several structures, including alimentary system; metanephros; respiratory system; sensory organ; and telencephalon. Used to study cataract. Human ortholog(s) of this gene implicated in cystic fibrosis; glutamate-cysteine ligase deficiency; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; cysteine metabolic pathway; glutamic acid/glutamate metabolic pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (2,4,5-trichlorophenoxy)acetic acid; (RS)-coclaurine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D9Wsu168; D9Wsu168e; gamma GCS-HS; gamma-ECS; gamma-glutamylcysteine synthetase heavy subunit; GCS heavy chain; Ggcs-hs; Glc; GLCL; GLCL-H; Glclc; glutamate cysteine ligase (gamma-glutamylcysteine synthetase), catalytic; glutamate--cysteine ligase catalytic subunit
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39977,661,817 - 77,701,771 (+)NCBIGRCm39mm39
GRCm39 Ensembl977,661,817 - 77,701,767 (+)Ensembl
GRCm38977,754,535 - 77,794,489 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl977,754,535 - 77,794,485 (+)EnsemblGRCm38mm10GRCm38
MGSCv37977,602,617 - 77,641,458 (+)NCBIGRCm37mm9NCBIm37
MGSCv36977,540,494 - 77,579,335 (+)NCBImm8
Celera974,927,826 - 74,966,687 (+)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(2,4,5-trichlorophenoxy)acetic acid  (EXP,ISO)
(E)-cinnamyl alcohol  (ISO)
(R)-lipoic acid  (ISO)
(RS)-coclaurine  (EXP)
(RS)-norcoclaurine  (EXP)
(S)-coclaurine  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1-bromopropane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (EXP)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (ISO)
2-(chloromethyl)pyridine  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butoxyethanol  (EXP)
2-chloroethanol  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-nitropropanoic acid  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-nitro-1,2-phenylenediamine  (ISO)
5-bromo-2'-deoxyuridine  (EXP)
7,8-dihydroxycoumarin  (ISO)
[6]-Shogaol  (EXP,ISO)
acetaldehyde  (ISO)
acetylcholine  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (ISO)
alcohol  (EXP)
aldehydo-D-glucosamine  (EXP)
aldosterone  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (EXP)
alpha,alpha-trehalose  (ISO)
alpha-D-galactose  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-linolenic acid  (ISO)
amlexanox  (EXP)
ampicillin  (ISO)
andrographolide  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony(0)  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
astilbin  (ISO)
azathioprine  (ISO)
Bandrowski's base  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoic acid  (ISO)
benzoquinones  (EXP)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
bleomycin A5  (ISO)
boric acid  (EXP,ISO)
bosentan  (ISO)
Brodifacoum  (ISO)
bromobenzene  (EXP)
Brusatol  (ISO)
buspirone  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
butane-2,3-dione  (ISO)
butylated hydroxyanisole  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP,ISO)
cadmium sulfide  (ISO)
cafestol  (ISO)
caffeine  (EXP)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
captan  (EXP)
carbamazepine  (ISO)
carbon disulfide  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
carnosic acid  (EXP,ISO)
Carnosol  (ISO)
ceric oxide  (ISO)
cerium trichloride  (ISO)
chenodeoxycholic acid  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chlorogenic acid  (ISO)
chlorohydrocarbon  (ISO)
chloroprene  (EXP,ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
cholesterol  (EXP)
choline  (EXP)
chromium atom  (ISO)
chromium trinitrate  (ISO)
chromium(6+)  (EXP,ISO)
chrysin  (ISO)
cidofovir anhydrous  (ISO)
cinnamyl alcohol  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
citraconic acid  (EXP,ISO)
Clivoline  (ISO)
clobetasol  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
coniferyl aldehyde  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumarin  (ISO)
crocidolite asbestos  (EXP)
cumene hydroperoxide  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (EXP,ISO)
cysteamine  (EXP)
DDE  (ISO)
DDT  (ISO)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenzoylmethane  (EXP)
dibutyl phthalate  (ISO)
dichloromethane  (EXP)
diclofenac  (ISO)
diethyl malate  (EXP)
diethyl maleate  (EXP,ISO)
diethyl sulfate  (ISO)
diethylstilbestrol  (ISO)
dihydrogen  (EXP)
dimethyl fumarate  (EXP,ISO)
dinoseb  (EXP)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diprotium  (EXP)
diprotium oxide  (EXP)
diquat  (EXP,ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
diuron  (ISO)
domoic acid  (EXP)
dopamine  (ISO)
doramapimod  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
erdosteine  (EXP)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
Ethyl acrylate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
farnesal  (ISO)
farrerol  (EXP)
fenofibrate  (ISO)
fipronil  (ISO)
flutamide  (EXP,ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP,ISO)
galactose  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-linolenic acid  (ISO)
gefitinib  (ISO)
genistein  (ISO)
ginsenoside Rg1  (EXP)
gliclazide  (ISO)
glutathione  (EXP,ISO)
glycerol 2-phosphate  (ISO)
guggulsterone  (EXP,ISO)
hemin  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hexadecanoic acid  (ISO)
hexane  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
hypochlorous acid  (EXP)
ibuprofen  (ISO)
ifosfamide  (ISO)
indometacin  (ISO)
iron atom  (ISO)
iron trichloride  (EXP)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) nitrilotriacetate  (EXP)
isoeugenol  (ISO)
isoniazide  (EXP)
isoprenaline  (EXP)
isorhamnetin  (EXP,ISO)
isothiocyanate  (EXP)
kaempferol  (EXP,ISO)
kahweol  (ISO)
ketamine  (ISO)
ketoprofen  (ISO)
L-ascorbic acid  (ISO)
L-cysteine  (ISO)
L-gamma-glutamyl-L-cysteine  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
levofloxacin  (ISO)
linalool  (ISO)
lipoic acid  (ISO)
liquiritigenin  (ISO)
liquiritin  (ISO)
lithocholic acid  (EXP,ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
maneb  (ISO)
melatonin  (EXP)
meloxicam  (ISO)
menadione  (EXP,ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
mesalamine  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methyl non-2-ynoate  (ISO)
methyl salicylate  (ISO)
methylene blue  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
Methysticin  (EXP)
microcystin  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (EXP)
miquelianin  (ISO)
MK 571  (ISO)
monocrotaline  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methylformamide  (EXP)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
naphthalene  (EXP,ISO)
naphthalene-1,2-diol  (ISO)
naproxen  (ISO)
naringin  (ISO)
nefazodone  (ISO)
neoastilbin  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP,ISO)
nicotinamide  (ISO)
nicotine  (EXP)
nimesulide  (ISO)
nimustine  (ISO)
nitisinone  (EXP)
nitric oxide  (ISO)
Nodularin  (ISO)
Nonidet P-40  (ISO)
notoginsenoside R1  (ISO)
ochratoxin A  (EXP,ISO)
oleanolic acid  (EXP,ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
para-Cresidine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
perfluoroundecanoic acid  (EXP)
permethrin  (ISO)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (EXP)
phloroglucinol  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
Polpunonic acid  (EXP,ISO)
potassium chloride  (ISO)
potassium chromate  (EXP)
potassium dichromate  (EXP)
pravastatin  (EXP,ISO)
prazosin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
Pristimerin  (ISO)
progesterone  (EXP)
propacetamol  (EXP)
propan-2-ol  (ISO)
propanal  (ISO)
prostaglandin J2  (ISO)
pyocyanine  (ISO)
pyrazines  (ISO)
Pyridostigmine bromide  (ISO)
pyrroloquinoline quinone  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
selenocystine  (ISO)
selenomethionine  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
silver(1+) nitrate  (ISO)
SL-327  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium cholate  (EXP)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
spironolactone  (ISO)
staurosporine  (ISO)
stavudine  (ISO)
streptozocin  (ISO)
styrene  (EXP)
succimer  (ISO)
sulforaphane  (EXP,ISO)
sulindac  (ISO)
sunitinib  (ISO)
suprofen  (ISO)
T-2 toxin  (EXP)
tamoxifen  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP,ISO)
thiabendazole  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trans-isoeugenol  (ISO)
triacsin C  (ISO)
tributylstannane  (EXP)
trichostatin A  (ISO)
trimethyltin  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (EXP)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
usnic acid  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
vanillin  (ISO)
vincristine  (ISO)
vitamin E  (EXP,ISO)
water  (EXP)
yohimbine  (EXP)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc oxide  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
blood vessel diameter maintenance  (ISO)
cell redox homeostasis  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to thyroxine stimulus  (ISO)
cysteine metabolic process  (ISO)
glutamate metabolic process  (ISO)
glutathione biosynthetic process  (IBA,IDA,IMP,ISO)
glutathione metabolic process  (IMP)
L-ascorbic acid metabolic process  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IGI)
negative regulation of hepatic stellate cell activation  (ISO)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (IGI)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein ubiquitination  (IMP)
negative regulation of transcription, DNA-templated  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IMP)
regulation of mitochondrial depolarization  (IGI)
response to activity  (ISO)
response to arsenic-containing substance  (IMP)
response to auditory stimulus  (ISO)
response to cadmium ion  (ISO)
response to heat  (ISO)
response to hormone  (ISO)
response to human chorionic gonadotropin  (ISO)
response to interleukin-1  (ISO)
response to nitrosative stress  (ISO)
response to nutrient  (ISO)
response to oxidative stress  (ISO)
response to xenobiotic stimulus  (IMP)

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:7578676   PMID:9223101   PMID:9224945   PMID:10349636   PMID:10421798   PMID:10725249   PMID:10805773   PMID:10922068   PMID:10966520   PMID:11032771   PMID:11042159   PMID:11076861  
PMID:11118286   PMID:11217851   PMID:11933164   PMID:12063408   PMID:12363041   PMID:12384496   PMID:12466851   PMID:12477932   PMID:14681479   PMID:15288121   PMID:15336720   PMID:15489334  
PMID:15629866   PMID:16081425   PMID:16141072   PMID:16141073   PMID:16324789   PMID:16403949   PMID:16840778   PMID:17000861   PMID:17189825   PMID:17464988   PMID:17559975   PMID:17785990  
PMID:18094238   PMID:18691715   PMID:18799693   PMID:19521566   PMID:19914271   PMID:20061376   PMID:20128681   PMID:20300111   PMID:20332089   PMID:20463017   PMID:20696779   PMID:21267068  
PMID:21389693   PMID:21554947   PMID:21657237   PMID:21677750   PMID:21873635   PMID:22249522   PMID:22634145   PMID:23045016   PMID:23226398   PMID:23237955   PMID:23671099   PMID:26808544  
PMID:27125672   PMID:27140233   PMID:27472077   PMID:28158580   PMID:28177569   PMID:28423341   PMID:28457937   PMID:28525556   PMID:28827139   PMID:28951044   PMID:29618580   PMID:30198844  
PMID:30333137   PMID:30753104   PMID:30938680   PMID:31220272   PMID:32325033  


Genomics

Comparative Map Data
Gclc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39977,661,817 - 77,701,771 (+)NCBIGRCm39mm39
GRCm39 Ensembl977,661,817 - 77,701,767 (+)Ensembl
GRCm38977,754,535 - 77,794,489 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl977,754,535 - 77,794,485 (+)EnsemblGRCm38mm10GRCm38
MGSCv37977,602,617 - 77,641,458 (+)NCBIGRCm37mm9NCBIm37
MGSCv36977,540,494 - 77,579,335 (+)NCBImm8
Celera974,927,826 - 74,966,687 (+)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.36NCBI
GCLC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl653,497,341 - 53,616,970 (-)EnsemblGRCh38hg38GRCh38
GRCh38653,497,341 - 53,545,101 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37653,362,139 - 53,409,899 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36653,470,098 - 53,517,790 (-)NCBINCBI36hg18NCBI36
Build 34653,470,097 - 53,517,790NCBI
Celera655,024,301 - 55,071,990 (-)NCBI
Cytogenetic Map6p12.1NCBI
HuRef653,193,712 - 53,241,391 (-)NCBIHuRef
CHM1_1653,363,932 - 53,411,726 (-)NCBICHM1_1
Gclc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2878,629,899 - 78,668,547 (+)NCBI
Rnor_6.0 Ensembl885,059,051 - 85,097,468 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0885,059,051 - 85,097,471 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0884,627,768 - 84,666,188 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4882,724,429 - 82,762,848 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1882,743,482 - 82,781,899 (+)NCBI
Celera878,379,669 - 78,418,088 (+)NCBICelera
Cytogenetic Map8q31NCBI
Gclc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554112,593,541 - 2,616,539 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554112,593,523 - 2,617,553 (+)NCBIChiLan1.0ChiLan1.0
GCLC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1654,687,315 - 54,738,111 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl654,687,315 - 54,734,994 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0653,052,145 - 53,102,794 (-)NCBIMhudiblu_PPA_v0panPan3
GCLC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1221,000,792 - 21,047,779 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11220,999,815 - 21,047,779 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Gclc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364767,371,270 - 7,418,756 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCLC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl727,209,564 - 27,253,535 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1727,209,565 - 27,253,535 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2731,702,759 - 31,747,437 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GCLC
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11719,012,994 - 19,060,617 (+)NCBI
ChlSab1.1 Ensembl1719,013,026 - 19,060,659 (+)Ensembl
Gclc
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624850749,046 - 793,654 (-)NCBI

Position Markers
RH124736  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38977,794,074 - 77,794,346UniSTSGRCm38
MGSCv37977,641,881 - 77,642,153UniSTSGRCm37
Celera974,967,111 - 74,967,383UniSTS
Cytogenetic Map9D-EUniSTS
Gclc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9D-EUniSTS
cM Map942.0UniSTS
UniSTS:224467  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38977,793,393 - 77,793,590UniSTSGRCm38
MGSCv37977,641,200 - 77,641,397UniSTSGRCm37
Celera974,966,429 - 74,966,626UniSTS
Cytogenetic Map9D-EUniSTS
D9Wsu168e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38977,794,008 - 77,794,207UniSTSGRCm38
MGSCv37977,641,815 - 77,642,014UniSTSGRCm37
Celera974,967,045 - 74,967,244UniSTS
Cytogenetic Map9D-EUniSTS
cM Map942.0UniSTS
Gclc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9D-EUniSTS
Gclc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9D-EUniSTS
cM Map942.0UniSTS
Gclc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9D-EUniSTS
Gclc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9D-EUniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94452089278520980Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94892377482923895Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94892377482923895Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse
14746993Manh66_mmandible shape 66 (mouse)94990676683906766Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95024403884244166Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95212317899910428Mouse
12790990Tgl7_mtriglyceride 7 (mouse)95465267888652678Mouse
10043877Adip21_madiposity 21 (mouse)Not determined95653182690531973Mouse
4141676Neogq1_mneonatal growth QTL 1 (mouse)Not determined95789776486239920Mouse
1301172Fembrs6_mfemur breaking strength 6 (mouse)Not determined95911710593117252Mouse
1301803Stheal9_msoft tissue heal 9 (mouse)Not determined95911710593117252Mouse
5491195Mobq8_mmultigenic obesity QTL 8 (mouse)Not determined95946266493462846Mouse
1300848Skull13_mskull morphology 13 (mouse)Not determined95946266493462846Mouse
1301456Adip5_madiposity 5 (mouse)Not determined95946266493462846Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
1301611Lrnx3_mlearning contextual 3 (mouse)Not determined96224248596242599Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
11081165Psl6_mpromotion susceptibility QTL 6 (mouse)96513390995640755Mouse
1301290Smgd1_msubmucosal gland distribution 1 (mouse)Not determined96592377486695914Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966207024100207122Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967124167101124167Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968897510102897652Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968897510102897652Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969239845103239920Mouse
10412174Habiir4_mhyperoxic acute lung injury imprinted region 4 (mouse)Not determined96936046598819654Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969546513103546645Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1301914Ksc1_mkeratinocyte stem cell locus 1 (mouse)Not determined97550175580091050Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976117105101528921Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:334
Count of miRNA genes:252
Interacting mature miRNAs:288
Transcripts:ENSMUST00000034905
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034905   ⟹   ENSMUSP00000034905
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl977,754,535 - 77,794,485 (+)Ensembl
RefSeq Acc Id: ENSMUST00000216315
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl977,763,983 - 77,781,262 (+)Ensembl
RefSeq Acc Id: ENSMUST00000216848
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl977,766,142 - 77,779,545 (+)Ensembl
RefSeq Acc Id: NM_010295   ⟹   NP_034425
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39977,661,817 - 77,701,771 (+)NCBI
GRCm38977,754,535 - 77,794,489 (+)NCBI
MGSCv37977,602,617 - 77,641,458 (+)RGD
Celera974,927,562 - 74,967,526 (+)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_151778
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39977,661,817 - 77,701,771 (+)NCBI
GRCm38977,754,535 - 77,794,489 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006510812   ⟹   XP_006510875
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39977,671,364 - 77,701,771 (+)NCBI
GRCm38977,764,082 - 77,794,485 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034425   ⟸   NM_010295
- UniProtKB: P97494 (UniProtKB/Swiss-Prot),   Q3TEF1 (UniProtKB/TrEMBL),   Q3UNA7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006510875   ⟸   XM_006510812
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000034905   ⟸   ENSMUST00000034905

Promoters
RGD ID:6844546
Promoter ID:MM_KWN:58128
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000049815
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36977,602,261 - 77,602,761 (+)MPROMDB
RGD ID:8670236
Promoter ID:EPDNEW_M13149
Type:initiation region
Name:Gclc_1
Description:Mus musculus glutamate-cysteine ligase, catalytic subunit , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13150  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38977,754,535 - 77,754,595EPDNEW
RGD ID:8670238
Promoter ID:EPDNEW_M13150
Type:initiation region
Name:Gclc_2
Description:Mus musculus glutamate-cysteine ligase, catalytic subunit , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13149  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38977,754,728 - 77,754,788EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104990 AgrOrtholog
Ensembl Genes ENSMUSG00000032350 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000034905 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034905 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gln_synth/guanido_kin_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14629 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104990 ENTREZGENE
NCBI Gene 14629 ENTREZGENE
PANTHER PTHR11164 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gclc PhenoGen
Superfamily-SCOP SSF55931 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt GSH1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TEF1 ENTREZGENE, UniProtKB/TrEMBL
  Q3UNA7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O09166 UniProtKB/Swiss-Prot
  Q8VCS5 UniProtKB/Swiss-Prot