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Gene: Gclc (glutamate-cysteine ligase, catalytic subunit) Mus musculus
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Description: Exhibits glutamate-cysteine ligase activity and protein heterodimerization activity. Involved in several processes, including glutathione biosynthetic process; negative regulation of apoptotic signaling pathway; and regulation of cellular protein metabolic process. Localizes to the cytosol and glutamate-cysteine ligase complex. Used to study cataract. Human ortholog(s) of this gene implicated in cystic fibrosis; hemolytic anemia; and myocardial infarction. Is expressed in several structures, including alimentary system; metanephros; respiratory system; sensory organ; and telencephalon. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; cysteine metabolic pathway; glutamic acid/glutamate metabolic pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (2,4,5-trichlorophenoxy)acetic acid; (RS)-coclaurine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D9Wsu168e; gamma GCS-HS; gamma-ECS; gamma-glutamylcysteine synthetase heavy subunit; GCS heavy chain; Ggcs-hs; GLCL-H; Glclc; glutamate cysteine ligase (gamma-glutamylcysteine synthetase), catalytic; glutamate--cysteine ligase catalytic subunit
Homo sapiens (human) : GCLC (glutamate-cysteine ligase catalytic subunit)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gclc (glutamate-cysteine ligase, catalytic subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gclc (glutamate-cysteine ligase catalytic subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : GCLC (glutamate-cysteine ligase catalytic subunit)
Canis lupus familiaris (dog) : GCLC (glutamate-cysteine ligase catalytic subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gclc (glutamate-cysteine ligase catalytic subunit)
Sus scrofa (pig) : GCLC (glutamate-cysteine ligase catalytic subunit)
Chlorocebus sabaeus (green monkey) : GCLC (glutamate-cysteine ligase catalytic subunit)
Heterocephalus glaber (naked mole-rat) : Gclc (glutamate-cysteine ligase catalytic subunit)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl977,754,535 - 77,794,485 (+)Ensembl
GRCm38977,754,535 - 77,794,489 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37977,602,617 - 77,641,458 (+)NCBIGRCm37mm9NCBIm37
MGSCv36977,540,494 - 77,579,335 (+)NCBImm8
Celera974,927,562 - 74,967,526 (+)NCBICelera
Cytogenetic Map9 E1NCBI
cM Map943.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Gclc
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10652
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.