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Gene: Tnfsf11 (tumor necrosis factor (ligand) superfamily, member 11) Mus musculus
Symbol: Tnfsf11
Name: tumor necrosis factor (ligand) superfamily, member 11
Description: Exhibits identical protein binding activity and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including animal organ development; cellular response to cytokine stimulus; and positive regulation of cell communication. Predicted to localize to several cellular components, including extracellular space; integral component of membrane; and plasma membrane. Is expressed in genitourinary system; hemolymphoid system; hindlimb long bone; and lymphatic system. Used to study autosomal recessive osteopetrosis 2 and osteoporosis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF superfamily member 11); PARTICIPATES IN interleukin-6 signaling pathway; rheumatoid arthritis pathway; INTERACTS WITH (-)-anisomycin; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ly10; Ly109l; O; OD; ODF; OPG; OPG ligand; OPGL; osteoclast differentiation factor; osteoprotegerin ligand; R; RANKL; receptor activator of NF-kappaB ligand; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; TNF-related activation-induced cytokine; Tra; Trance; tumor necrosis factor ligand superfamily member 11; tumor necrosis factor-related activation-induced cytokine
Homo sapiens (human) : TNFSF11 (TNF superfamily member 11)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tnfsf11 (TNF superfamily member 11)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnfsf11 (TNF superfamily member 11)
Pan paniscus (bonobo/pygmy chimpanzee) : TNFSF11 (TNF superfamily member 11)
Canis lupus familiaris (dog) : TNFSF11 (TNF superfamily member 11)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnfsf11 (TNF superfamily member 11)
Sus scrofa (pig) : TNFSF11 (TNF superfamily member 11)
Chlorocebus sabaeus (African green monkey) : TNFSF11 (TNF superfamily member 11)
Heterocephalus glaber (naked mole-rat) : Tnfsf11 (TNF superfamily member 11)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1478,277,445 - 78,308,043 (-)EnsemblGRCm38mm10GRCm38
GRCm381478,277,446 - 78,308,043 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371478,677,253 - 78,707,850 (-)NCBIGRCm37mm9NCBIm37
MGSCv361477,009,005 - 77,042,170 (-)NCBImm8
Celera1475,790,488 - 75,821,164 (-)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1441.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tnfsf11
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1551655
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.