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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551655
Species: Mus musculus
RGD Object: Gene
Symbol: Tnfsf11
Name: tumor necrosis factor (ligand) superfamily, member 11
Acc ID: CHEBI:16827
Term: corticosterone
Definition: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Chemical ID: MESH:D003345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfsf11decreases expressionISOTnfsf11 (Rattus norvegicus)6480464CTDCorticosterone results in decreased expression of TNFSF11 mRNAPMID:29981921
Tnfsf11increases expressionISOTnfsf11 (Rattus norvegicus)6480464CTDCorticosterone results in increased expression of TNFSF11 mRNAPMID:17476578
Tnfsf11multiple interactionsISOTnfsf11 (Rattus norvegicus)6480464CTD[Corticosterone co-treated with PTH protein] results in decreased expression of TNFSF11 mRNA; Mifepristone inhibits the reaction [Corticosterone results in decreased expression of TNFSF11 mRNA]PMID:17476578 PMID:29981921
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