TNFSF11 (TNF superfamily member 11) - Rat Genome Database

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Gene: TNFSF11 (TNF superfamily member 11) Canis lupus familiaris
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Symbol: TNFSF11
Name: TNF superfamily member 11
RGD ID: 12117362
Description: ENCODES a protein that exhibits tumor necrosis factor receptor superfamily binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); bone development (ortholog); bone resorption (ortholog); PARTICIPATES IN interleukin-6 signaling pathway; ASSOCIATED WITH Alveolar Bone Loss (ortholog); autosomal recessive osteopetrosis 2 (ortholog); B-Cell Chronic Lymphocytic Leukemia (ortholog); FOUND IN integral component of membrane (inferred); INTERACTS WITH resveratrol
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 11; tumor necrosis factor ligand superfamily member 11; tumor necrosis factor superfamily member 11
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1228,226,931 - 8,257,926 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl228,227,555 - 8,258,645 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha228,218,782 - 8,249,783 (-)NCBI
ROS_Cfam_1.0228,445,691 - 8,476,717 (-)NCBI
UMICH_Zoey_3.1228,136,967 - 8,174,247 (-)NCBI
UNSW_CanFamBas_1.0228,193,944 - 8,224,951 (-)NCBI
UU_Cfam_GSD_1.0228,205,225 - 8,236,245 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
resveratrol  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
bone development  (ISO)
bone resorption  (IEA,ISO)
calcium ion homeostasis  (IEA,ISO)
calcium-mediated signaling  (IEA)
cellular response to leukemia inhibitory factor  (IEA,ISO)
cytokine-mediated signaling pathway  (ISO)
ERK1 and ERK2 cascade  (IEA)
immune response  (IEA)
mammary gland alveolus development  (IEA,ISO)
mammary gland epithelial cell proliferation  (IEA,ISO)
monocyte chemotaxis  (IEA)
ossification  (IEA,ISO)
osteoclast development  (IEA,ISO)
osteoclast differentiation  (ISO)
osteoclast proliferation  (IEA,ISO)
paracrine signaling  (IEA,ISO)
positive regulation of bone resorption  (IEA,ISO)
positive regulation of corticotropin-releasing hormone secretion  (IEA)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling  (IEA)
positive regulation of fever generation by positive regulation of prostaglandin secretion  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of homotypic cell-cell adhesion  (IEA)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IEA,ISO)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of MAP kinase activity  (IEA)
positive regulation of NF-kappaB transcription factor activity  (IEA)
positive regulation of osteoclast development  (IEA,ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of protein kinase B signaling  (IEA,ISO)
positive regulation of T cell activation  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
regulation of actin binding  (IEA,ISO)
regulation of osteoclast differentiation  (ISO)
response to immobilization stress  (ISO)
response to radiation  (ISO)
TNFSF11-mediated signaling pathway  (ISO)
tooth eruption  (IEA,ISO)
tumor necrosis factor-mediated signaling pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:17338161   PMID:19674422   PMID:21239502   PMID:26254896   PMID:28554456  


Genomics

Comparative Map Data
TNFSF11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1228,226,931 - 8,257,926 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl228,227,555 - 8,258,645 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha228,218,782 - 8,249,783 (-)NCBI
ROS_Cfam_1.0228,445,691 - 8,476,717 (-)NCBI
UMICH_Zoey_3.1228,136,967 - 8,174,247 (-)NCBI
UNSW_CanFamBas_1.0228,193,944 - 8,224,951 (-)NCBI
UU_Cfam_GSD_1.0228,205,225 - 8,236,245 (-)NCBI
TNFSF11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1342,562,736 - 42,608,013 (+)EnsemblGRCh38hg38GRCh38
GRCh381342,562,736 - 42,608,013 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371343,136,872 - 43,182,149 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361342,043,795 - 42,080,148 (+)NCBINCBI36hg18NCBI36
Build 341342,043,794 - 42,080,148NCBI
Celera1324,194,611 - 24,239,896 (+)NCBI
Cytogenetic Map13q14.11NCBI
HuRef1323,940,423 - 23,985,716 (+)NCBIHuRef
CHM1_11343,104,338 - 43,149,624 (+)NCBICHM1_1
Tnfsf11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391478,514,886 - 78,545,483 (-)NCBIGRCm39mm39
GRCm39 Ensembl1478,514,885 - 78,545,483 (-)Ensembl
GRCm381478,277,446 - 78,308,043 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1478,277,445 - 78,308,043 (-)EnsemblGRCm38mm10GRCm38
MGSCv371478,677,253 - 78,707,850 (-)NCBIGRCm37mm9NCBIm37
MGSCv361477,009,005 - 77,042,170 (-)NCBImm8
Celera1475,790,488 - 75,821,164 (-)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1441.26NCBI
Tnfsf11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21553,674,990 - 53,705,171 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1553,673,877 - 53,705,445 (-)Ensembl
Rnor_6.01560,482,527 - 60,512,704 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1560,482,527 - 60,512,704 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01565,726,538 - 65,757,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01564,155,680 - 64,186,116 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41559,397,837 - 59,428,014 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11559,413,616 - 59,443,794 (-)NCBI
Celera1553,271,197 - 53,300,935 (-)NCBICelera
Cytogenetic Map15q11NCBI
Tnfsf11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955518430,642 - 462,705 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955518431,401 - 462,063 (+)NCBIChiLan1.0ChiLan1.0
TNFSF11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v01323,750,835 - 23,784,740 (+)NCBIMhudiblu_PPA_v0panPan3
Tnfsf11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945152,785,812 - 152,819,281 (+)NCBI
SpeTri2.0NW_0049367471,255,803 - 1,288,252 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFSF11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1124,466,586 - 24,505,422 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11124,468,011 - 24,505,421 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21125,117,332 - 25,154,855 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNFSF11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1320,717,884 - 20,761,520 (+)NCBI
ChlSab1.1 Ensembl320,727,592 - 20,760,408 (+)Ensembl
Vero_WHO_p1.0NW_02366605723,446,636 - 23,492,542 (-)NCBI
Tnfsf11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474812,527,221 - 12,555,551 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 6 1 5 3
Below cutoff 5 22 6 6 5 6 12 8 5 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000007513   ⟹   ENSCAFP00000006955
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl228,227,555 - 8,258,645 (-)Ensembl
RefSeq Acc Id: XM_038430799   ⟹   XP_038286727
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0228,445,691 - 8,476,717 (-)NCBI
RefSeq Acc Id: XM_038506956   ⟹   XP_038362884
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1228,136,967 - 8,174,247 (-)NCBI
RefSeq Acc Id: XM_038569367   ⟹   XP_038425295
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0228,205,225 - 8,236,245 (-)NCBI
RefSeq Acc Id: XM_038633534   ⟹   XP_038489462
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0228,193,944 - 8,224,951 (-)NCBI
RefSeq Acc Id: XM_846672   ⟹   XP_851765
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1228,226,931 - 8,257,926 (-)NCBI
Dog10K_Boxer_Tasha228,218,782 - 8,249,783 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038286727 (Get FASTA)   NCBI Sequence Viewer  
  XP_038362884 (Get FASTA)   NCBI Sequence Viewer  
  XP_038425295 (Get FASTA)   NCBI Sequence Viewer  
  XP_038489462 (Get FASTA)   NCBI Sequence Viewer  
  XP_851765 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_851765   ⟸   XM_846672
- UniProtKB: E2RCC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000006955   ⟸   ENSCAFT00000007513
RefSeq Acc Id: XP_038362884   ⟸   XM_038506956
RefSeq Acc Id: XP_038489462   ⟸   XM_038633534
RefSeq Acc Id: XP_038286727   ⟸   XM_038430799
RefSeq Acc Id: XP_038425295   ⟸   XM_038569367


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004675 Ensembl
NCBI Gene TNFSF11 ENTREZGENE
UniProt E2RCC9 ENTREZGENE
VGNC ID VGNC:57502 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-08 TNFSF11  TNF superfamily member 11    tumor necrosis factor superfamily member 11  Symbol and/or name change 5135510 APPROVED