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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551655
Species: Mus musculus
RGD Object: Gene
Symbol: Tnfsf11
Name: tumor necrosis factor (ligand) superfamily, member 11
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfsf11multiple interactionsEXP 6480464CTDFulvestrant inhibits the reaction [dioscin results in increased expression of TNFSF11 mRNA]; Fulvestrant inhibits the reaction [naringenin-6-C-glucoside results in decreased expression of TNFSF11 mRNA]PMID:21864313 PMID:24742230
Tnfsf11multiple interactionsISOTNFSF11 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] affects the methylation of TNFSF11 gene; Fulvestrant inhibits the reaction [daidzein results in decreased expression of TNFSF11 mRNA]; Fulvestrant inhibits the reaction [daidzein results in decreased expression of TNFSF11 protein]PMID:27576059 PMID:31601247
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