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Gene: TNFSF11 (TNF superfamily member 11) Homo sapiens
Symbol: TNFSF11
Name: TNF superfamily member 11
RGD ID: 1347343
Description: Exhibits cytokine activity. Involved in several processes, including positive regulation of MAPK cascade; positive regulation of cell-cell adhesion; and regulation of transcription, DNA-templated. Predicted to localize to extracellular region and plasma membrane. Implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Biomarker of myocardial infarction.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD254; hRANKL2; ODF; OPGL; OPTB2; osteoclast differentiation factor; osteoprotegerin ligand; RANKL; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; sOdf; TNF-related activation-induced cytokine; TNLG6B; TRANCE; tumor necrosis factor (ligand) superfamily member 11; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand 6B; tumor necrosis factor ligand superfamily member 11; tumor necrosis factor superfamily member 11
Mus musculus (house mouse) : Tnfsf11 (tumor necrosis factor (ligand) superfamily, member 11)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tnfsf11 (TNF superfamily member 11)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnfsf11 (TNF superfamily member 11)
Pan paniscus (bonobo/pygmy chimpanzee) : TNFSF11 (TNF superfamily member 11)
Canis lupus familiaris (dog) : TNFSF11 (TNF superfamily member 11)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnfsf11 (TNF superfamily member 11)
Sus scrofa (pig) : TNFSF11 (TNF superfamily member 11)
Chlorocebus sabaeus (African green monkey) : TNFSF11 (TNF superfamily member 11)
Heterocephalus glaber (naked mole-rat) : Tnfsf11 (TNF superfamily member 11)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1342,562,736 - 42,608,013 (+)EnsemblGRCh38hg38GRCh38
GRCh381342,562,736 - 42,608,013 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371343,136,872 - 43,182,149 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361342,043,795 - 42,080,148 (+)NCBINCBI36hg18NCBI36
Build 341342,043,794 - 42,080,148NCBI
Celera1324,194,611 - 24,239,896 (+)NCBI
Cytogenetic Map13q14.11NCBI
HuRef1323,940,423 - 23,985,716 (+)NCBIHuRef
CHM1_11343,104,338 - 43,149,624 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TNFSF11
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1347343
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.