Egr4 (early growth response 4) - Rat Genome Database
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Gene: Egr4 (early growth response 4) Mus musculus
Analyze
Symbol: Egr4
Name: early growth response 4
RGD ID: 735818
MGI Page MGI
Description: Is expressed in several structures, including central nervous system; genitourinary system; and tooth. Orthologous to human EGR4 (early growth response 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: early growth response protein 4; EGR-4; NGF1-; NGF1-C; NGFI; NGFI-C; NGFIC; pAT1; pAT133
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,488,103 - 85,490,571 (-)NCBIGRCm39mm39
GRCm39 Ensembl685,488,103 - 85,490,571 (-)Ensembl
GRCm38685,511,121 - 85,513,589 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,511,121 - 85,513,589 (-)EnsemblGRCm38mm10GRCm38
MGSCv37685,461,116 - 85,463,536 (-)NCBIGRCm37mm9NCBIm37
MGSCv36685,476,780 - 85,479,200 (-)NCBImm8
Celera687,483,061 - 87,485,363 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map637.48NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trimethylbenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
6-propyl-2-thiouracil  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (ISO)
aripiprazole  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
carbon nanotube  (EXP)
carbonyl sulfide  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
decabromodiphenyl ether  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
fenvalerate  (ISO)
fluoxetine  (ISO)
glycidol  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (EXP)
ketamine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
maneb  (EXP)
methamphetamine  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (EXP,ISO)
naphthalenes  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentanal  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium bromate  (EXP)
Ptaquiloside  (EXP)
pyridaben  (EXP)
quercetin  (ISO)
rifampicin  (ISO)
SB 431542  (ISO)
SCH 23390  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
Soman  (ISO)
tributylstannane  (ISO)
trimellitic anhydride  (EXP)
undecane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

References

Additional References at PubMed
PMID:7774940   PMID:8188273   PMID:8504297   PMID:8751373   PMID:8889548   PMID:9858769   PMID:10349636   PMID:10529423   PMID:10866682   PMID:11042159   PMID:11076861   PMID:11180801  
PMID:11217851   PMID:11891986   PMID:12648095   PMID:16141072   PMID:16141073   PMID:17192429   PMID:18287559   PMID:19741146   PMID:20059953   PMID:20925118   PMID:21228173   PMID:21267068  
PMID:21837281   PMID:21873635  


Genomics

Comparative Map Data
Egr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,488,103 - 85,490,571 (-)NCBIGRCm39mm39
GRCm39 Ensembl685,488,103 - 85,490,571 (-)Ensembl
GRCm38685,511,121 - 85,513,589 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,511,121 - 85,513,589 (-)EnsemblGRCm38mm10GRCm38
MGSCv37685,461,116 - 85,463,536 (-)NCBIGRCm37mm9NCBIm37
MGSCv36685,476,780 - 85,479,200 (-)NCBImm8
Celera687,483,061 - 87,485,363 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map637.48NCBI
EGR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl273,290,929 - 73,293,701 (-)EnsemblGRCh38hg38GRCh38
GRCh38273,290,929 - 73,293,548 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37273,518,057 - 73,520,676 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36273,371,565 - 73,374,181 (-)NCBINCBI36hg18NCBI36
Build 34273,429,720 - 73,432,265NCBI
Celera273,368,884 - 73,371,656 (-)NCBI
Cytogenetic Map2p13.2NCBI
HuRef273,253,506 - 73,256,278 (-)NCBIHuRef
CHM1_1273,448,863 - 73,451,635 (-)NCBICHM1_1
Egr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24118,047,869 - 118,050,328 (-)NCBI
Rnor_6.0 Ensembl4117,293,620 - 117,296,082 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04117,293,620 - 117,296,082 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04181,870,041 - 181,872,503 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44119,765,289 - 119,767,612 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14120,009,769 - 120,012,093 (-)NCBI
Celera4107,029,479 - 107,031,938 (-)NCBICelera
RH 3.4 Map4690.8RGD
Cytogenetic Map4q34NCBI
Egr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542412,338,979 - 12,342,078 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542412,339,152 - 12,341,925 (+)NCBIChiLan1.0ChiLan1.0
EGR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A74,831,326 - 74,834,246 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A74,831,326 - 74,834,246 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A73,343,705 - 73,346,476 (-)NCBIMhudiblu_PPA_v0panPan3
EGR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1749,575,466 - 49,578,251 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11749,575,964 - 49,580,697 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Egr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649117,068,797 - 17,071,608 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl369,486,079 - 69,491,595 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1369,485,919 - 69,488,788 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2372,688,741 - 72,691,610 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EGR4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11433,879,707 - 33,882,669 (+)NCBI
ChlSab1.1 Ensembl1433,879,904 - 33,882,663 (+)Ensembl
Egr4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624762351,190 - 354,004 (+)NCBI

Position Markers
RH94566  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38685,511,170 - 85,511,308UniSTSGRCm38
MGSCv37685,461,164 - 85,461,302UniSTSGRCm37
Celera687,483,109 - 87,483,247UniSTS
Cytogenetic Map6C3UniSTS
cM Map636.5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:277
Count of miRNA genes:215
Interacting mature miRNAs:238
Transcripts:ENSMUST00000095759
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000095759   ⟹   ENSMUSP00000093433
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl685,511,121 - 85,513,589 (-)Ensembl
RefSeq Acc Id: NM_020596   ⟹   NP_065621
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,488,103 - 85,490,571 (-)NCBI
GRCm38685,511,121 - 85,513,589 (-)NCBI
MGSCv37685,461,116 - 85,463,536 (-)RGD
Celera687,483,061 - 87,485,363 (-)NCBI
cM Map6 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_065621 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD28267 (Get FASTA)   NCBI Sequence Viewer  
  BAE24779 (Get FASTA)   NCBI Sequence Viewer  
  EDK99137 (Get FASTA)   NCBI Sequence Viewer  
  Q9WUF2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_065621   ⟸   NM_020596
- UniProtKB: Q9WUF2 (UniProtKB/Swiss-Prot),   Q3URA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000093433   ⟸   ENSMUST00000095759
Protein Domains
C2H2-type

Promoters
RGD ID:6839216
Promoter ID:MM_KWN:46687
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000095759
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36685,463,471 - 85,463,971 (-)MPROMDB
RGD ID:6890236
Promoter ID:EPDNEW_M8569
Type:single initiation site
Name:Egr4_1
Description:Mus musculus early growth response 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38685,513,588 - 85,513,648EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99252 AgrOrtholog
Ensembl Genes ENSMUSG00000068300
  ENSMUSG00000071341 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000093433 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000095759 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13656 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:99252 ENTREZGENE
NCBI Gene 13656 ENTREZGENE
Pfam zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Egr4 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt EGR4_MOUSE UniProtKB/Swiss-Prot
  Q3URA9 ENTREZGENE, UniProtKB/TrEMBL
  Q9WUF2 ENTREZGENE