Symbol:
Egr4
Name:
early growth response 4
Description:
ENCODES a protein that exhibits RNA polymerase II regulatory region sequence-specific DNA binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH abnormal male germ cell apoptosis; abnormal male meiosis; abnormal seminiferous tubule epithelium morphology; ASSOCIATED WITH middle cerebral artery infarction (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; benzo[a]pyrene
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
early growth response protein 4; EGR-4; NGF1-C; NGFI-C; NGFIC; pAT133
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
EGR4 (early growth response 4) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Egr4 (early growth response 4) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Egr4 (early growth response 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
EGR4 (early growth response 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
EGR4 (early growth response 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Egr4 (early growth response 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
EGR4 (early growth response 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Egr4 (early growth response 4)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
EGR4 (early growth response 4)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
egr4 (early growth response 4)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, PANTHER, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
egrh-1
Alliance
DIOPT (Ensembl Compara, PANTHER, Roundup)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 6 85,511,121 - 85,513,589 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 6 85,461,116 - 85,463,536 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 6 85,476,780 - 85,479,200 (-) NCBI mm8 Celera 6 87,483,061 - 87,485,363 (-) NCBI Celera Cytogenetic Map 6 C3 NCBI cM Map 6 37.48 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
1,2,4-trimethylbenzene increases expression ISO RGD:2546 6480464 pseudocumene results in increased expression of EGR4 protein CTD PMID:17337753 1-naphthyl isothiocyanate decreases expression ISO RGD:2546 6480464 1-Naphthylisothiocyanate results in decreased expression of EGR4 mRNA CTD PMID:12832660 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO RGD:2546 6480464 2 more ... CTD PMID:27291303 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of EGR4 mRNA CTD PMID:26377647 3,4-methylenedioxymethamphetamine decreases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of EGR4 mRNA CTD PMID:20188158 6-propyl-2-thiouracil decreases expression ISO RGD:2546 6480464 Propylthiouracil results in decreased expression of EGR4 mRNA CTD PMID:24780913 acetylsalicylic acid decreases expression ISO RGD:735817 6480464 Aspirin results in decreased expression of EGR4 mRNA CTD PMID:11906190 aflatoxin B1 decreases methylation ISO RGD:735817 6480464 Aflatoxin B1 results in decreased methylation of EGR4 gene CTD PMID:27153756 ammonium chloride affects expression ISO RGD:2546 6480464 Ammonium Chloride affects the expression of EGR4 mRNA CTD PMID:16483693 aripiprazole increases expression ISO RGD:2546 6480464 Aripiprazole results in increased expression of EGR4 mRNA CTD PMID:17868501 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of EGR4 mRNA CTD PMID:27195522 benzo[a]pyrene diol epoxide I affects expression ISO RGD:735817 6480464 7 more ... CTD PMID:20382639 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:735817 6480464 Diethylhexyl Phthalate results in decreased expression of EGR4 mRNA CTD PMID:31163220 bisphenol A multiple interactions EXP 6480464 [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of EGR4 mRNA] CTD PMID:27082013 bisphenol A affects methylation EXP 6480464 bisphenol A affects the methylation of EGR4 promoter CTD PMID:27334623 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of EGR4 mRNA CTD PMID:27082013 butanal increases expression ISO RGD:735817 6480464 butyraldehyde results in increased expression of EGR4 mRNA CTD PMID:26079696 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon results in increased expression of EGR4 mRNA CTD PMID:25554681 carbonyl sulfide decreases expression ISO RGD:2546 6480464 carbonyl sulfide results in decreased expression of EGR4 mRNA CTD PMID:19395590 cocaine increases expression ISO RGD:2546 6480464 Cocaine results in increased expression of EGR4 mRNA CTD PMID:27899881 copper(II) sulfate increases expression ISO RGD:735817 6480464 Copper Sulfate results in increased expression of EGR4 mRNA CTD PMID:19549813 crocidolite asbestos increases expression ISO RGD:735817 6480464 Asbestos, Crocidolite results in increased expression of EGR4 mRNA CTD PMID:18687144 cyclophosphamide decreases expression ISO RGD:2546 6480464 Cyclophosphamide results in decreased expression of EGR4 mRNA CTD PMID:27281708 cyclosporin A increases expression ISO RGD:735817 6480464 Cyclosporine results in increased expression of EGR4 mRNA CTD PMID:25562108 cylindrospermopsin increases expression ISO RGD:735817 6480464 cylindrospermopsin results in increased expression of EGR4 mRNA CTD PMID:24921660 decabromodiphenyl ether decreases expression ISO RGD:2546 6480464 decabromobiphenyl ether results in decreased expression of EGR4 mRNA CTD PMID:23640034 disodium selenite decreases expression ISO RGD:735817 6480464 Sodium Selenite results in decreased expression of EGR4 mRNA CTD PMID:18175754 dorsomorphin multiple interactions ISO RGD:735817 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 entinostat multiple interactions ISO RGD:735817 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EGR4 mRNA CTD PMID:27188386 entinostat decreases expression ISO RGD:735817 6480464 entinostat results in decreased expression of EGR4 mRNA CTD PMID:26272509 ethanol affects expression EXP 6480464 Ethanol affects the expression of EGR4 mRNA CTD PMID:30319688 fluoxetine decreases expression ISO RGD:2546 6480464 Fluoxetine results in decreased expression of EGR4 mRNA CTD PMID:17033635 glycidol decreases expression ISO RGD:2546 6480464 glycidol results in decreased expression of EGR4 mRNA CTD PMID:24915197 hydrogen peroxide affects expression ISO RGD:735817 6480464 Hydrogen Peroxide affects the expression of EGR4 mRNA CTD PMID:20044591 ketamine decreases expression ISO RGD:2546 6480464 Ketamine results in decreased expression of EGR4 mRNA CTD PMID:20080153 lead(0) decreases expression ISO RGD:735817 6480464 Lead results in decreased expression of EGR4 mRNA CTD PMID:19921347 lead(2+) decreases expression ISO RGD:735817 6480464 Lead results in decreased expression of EGR4 mRNA CTD PMID:19921347 leflunomide increases expression ISO RGD:735817 6480464 leflunomide results in increased expression of EGR4 mRNA CTD PMID:28988120 maneb multiple interactions EXP 6480464 [Paraquat co-treated with Maneb] affects the expression of EGR4 mRNA CTD PMID:22563483 methamphetamine increases expression ISO RGD:2546 6480464 Methamphetamine results in increased expression of EGR4 mRNA CTD PMID:19564919 methamphetamine multiple interactions ISO RGD:2546 6480464 [Methamphetamine co-treated with SCH 23390] results in increased expression of EGR4 mRNA CTD PMID:19564919 methotrexate decreases expression ISO RGD:735817 6480464 Methotrexate results in decreased expression of EGR4 mRNA CTD PMID:24449571 methyl methanesulfonate increases expression ISO RGD:735817 6480464 Methyl Methanesulfonate results in increased expression of EGR4 mRNA CTD PMID:23649840 methylmercury chloride increases expression ISO RGD:735817 6480464 methylmercuric chloride results in increased expression of EGR4 mRNA CTD PMID:28001369 mono(2-ethylhexyl) phthalate increases expression ISO RGD:2546 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of EGR4 mRNA CTD PMID:16809437 morphine multiple interactions EXP 6480464 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3 more ... CTD PMID:22454534 morphine increases expression EXP 6480464 Morphine results in increased expression of EGR4 mRNA CTD PMID:22454534 morphine increases expression ISO RGD:2546 6480464 Morphine results in increased expression of EGR4 mRNA CTD PMID:22454534 morphine multiple interactions ISO RGD:2546 6480464 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3, 4-difluorobenzamide inhibits the reaction [Morphine results in increased expression of EGR4 mRNA] CTD PMID:22454534 morphine affects response to substance EXP 6480464 EGR4 protein affects the susceptibility to Morphine CTD PMID:22454534 naphthalenes increases expression ISO RGD:2546 6480464 Naphthalenes results in increased expression of EGR4 protein CTD PMID:17337753 p-chloromercuribenzoic acid multiple interactions ISO RGD:735817 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EGR4 mRNA CTD PMID:27188386 paracetamol increases expression ISO RGD:735817 6480464 Acetaminophen results in increased expression of EGR4 mRNA CTD PMID:26690555 paraquat multiple interactions EXP 6480464 [Paraquat co-treated with Maneb] affects the expression of EGR4 mRNA CTD PMID:22563483 paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of EGR4 mRNA CTD PMID:22563483 pentanal increases expression ISO RGD:735817 6480464 pentanal results in increased expression of EGR4 mRNA CTD PMID:26079696 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:735817 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of EGR4 mRNA CTD PMID:16979875 potassium bromate multiple interactions EXP 6480464 [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of EGR4 mRNA], [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of EGR4 mRNA] CTD PMID:27082013 potassium bromate affects expression EXP 6480464 potassium bromate affects the expression of EGR4 mRNA CTD PMID:27082013 Ptaquiloside increases expression EXP 6480464 ptaquiloside results in increased expression of EGR4 mRNA CTD PMID:23274088 pyridaben decreases expression EXP 6480464 pyridaben results in decreased expression of EGR4 mRNA CTD PMID:22563483 quercetin increases expression ISO RGD:735817 6480464 Quercetin results in increased expression of EGR4 mRNA CTD PMID:21632981 rifampicin multiple interactions ISO RGD:735817 6480464 [Rifampin co-treated with NR1I2 protein] results in increased expression of EGR4 mRNA CTD PMID:21127053 SB 431542 multiple interactions ISO RGD:735817 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 SCH 23390 multiple interactions ISO RGD:2546 6480464 [Methamphetamine co-treated with SCH 23390] results in increased expression of EGR4 mRNA CTD PMID:19564919 SCH 23390 decreases expression ISO RGD:2546 6480464 SCH 23390 results in decreased expression of EGR4 mRNA CTD PMID:19564919 silicon dioxide increases expression ISO RGD:735817 6480464 Silicon Dioxide analog results in increased expression of EGR4 mRNA CTD PMID:23806026 , PMID:25895662 silver atom increases expression ISO RGD:735817 6480464 Silver results in increased expression of EGR4 mRNA CTD PMID:26551752 silver(0) increases expression ISO RGD:735817 6480464 Silver results in increased expression of EGR4 mRNA CTD PMID:26551752 silver(1+) increases expression ISO RGD:735817 6480464 Silver results in increased expression of EGR4 mRNA CTD PMID:26551752 Soman increases expression ISO RGD:2546 6480464 Soman results in increased expression of EGR4 mRNA CTD PMID:19281266 trimellitic anhydride increases expression EXP 6480464 trimellitic anhydride results in increased expression of EGR4 mRNA CTD PMID:19042947 undecane increases expression ISO RGD:2546 6480464 undecane results in increased expression of EGR4 protein CTD PMID:17337753 valproic acid increases expression ISO RGD:735817 6480464 Valproic Acid results in increased expression of EGR4 mRNA CTD PMID:24383497 valproic acid decreases expression ISO RGD:2546 6480464 Valproic Acid results in decreased expression of EGR4 mRNA CTD PMID:29427782 valproic acid decreases expression ISO RGD:735817 6480464 Valproic Acid results in decreased expression of EGR4 mRNA CTD PMID:28001369 vinclozolin affects expression ISO RGD:2546 6480464 vinclozolin affects the expression of EGR4 mRNA CTD PMID:19015723 zinc atom multiple interactions ISO RGD:735817 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of EGR4 mRNA CTD PMID:16979875 zinc(0) multiple interactions ISO RGD:735817 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of EGR4 mRNA CTD PMID:16979875 zoledronic acid increases expression ISO RGD:735817 6480464 zoledronic acid results in increased expression of EGR4 mRNA CTD PMID:20977926 
Gene-Chemical Interaction Annotations
