Adipoq (adiponectin, C1Q and collagen domain containing) - Rat Genome Database

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Gene: Adipoq (adiponectin, C1Q and collagen domain containing) Mus musculus
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Symbol: Adipoq
Name: adiponectin, C1Q and collagen domain containing
RGD ID: 1552054
MGI Page MGI
Description: Enables hormone activity and identical protein binding activity. Involved in several processes, including detection of oxidative stress; negative regulation of cold-induced thermogenesis; and regulation of protein serine/threonine kinase activity. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including brown fat cell differentiation; negative regulation of gluconeogenesis; and positive regulation of glucose import. Located in endoplasmic reticulum and extracellular space. Is expressed in several structures, including adipose tissue; axial musculature; gut; male reproductive gland or organ; and serum. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cardiovascular system disease (multiple); non-alcoholic fatty liver disease; primary open angle glaucoma; and type 2 diabetes mellitus. Orthologous to human ADIPOQ (adiponectin, C1Q and collagen domain containing); PARTICIPATES IN adiponectin signaling pathway; type 2 diabetes mellitus pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 30 kDa adipocyte complement-related protein; 30kDa; a; Acd; Acdc; Acr; Acrp30; Ad; Adid; adip; adipo; adipocyte complement related protein; adipocyte complement-related 30 kDa protein; adipocyte, C1Q and collagen domain containing; adipocyte, C1q and collagen domain-containing protein; adipocyte-specific protein AdipoQ; adiponectin; adiponectin d; ap; apM1; APN; GBP2; GBP28
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391622,965,286 - 22,976,718 (+)NCBIGRCm39mm39
GRCm39 Ensembl1622,965,286 - 22,976,778 (+)Ensembl
GRCm381623,146,536 - 23,157,968 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1623,146,536 - 23,158,028 (+)EnsemblGRCm38mm10GRCm38
MGSCv371623,146,609 - 23,158,041 (+)NCBIGRCm37mm9NCBIm37
MGSCv361623,061,870 - 23,073,302 (+)NCBImm8
Celera1623,704,853 - 23,716,285 (+)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1613.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
3MC syndrome 1  (ISO)
Acute Lung Injury  (IDA,IMP)
Alcoholic Fatty Liver  (ISO)
Alzheimer's disease  (ISO)
amyloidosis  (ISO)
ankylosing spondylitis  (ISO)
asthma  (IMP)
atherosclerosis  (ISO)
autoimmune hepatitis  (ISO)
Behcet's disease  (ISO)
biliary atresia  (ISO)
bipolar disorder  (ISO)
brain infarction  (ISO)
breast cancer  (ISO)
cardiomyopathy  (IEP,ISO)
cardiovascular system disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (IDA,ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
Cognitive Dysfunction  (ISO)
colitis  (IMP,ISO)
congestive heart failure  (ISO)
coronary aneurysm  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary restenosis  (ISO)
Crohn's disease  (ISO)
dementia  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
diffuse scleroderma  (ISO)
dry eye syndrome  (IDA)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Myocarditis  (IMP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
familial hyperlipidemia  (ISO)
familial Mediterranean fever  (ISO)
fatty liver disease  (ISO)
Fetal Growth Retardation  (ISO)
gestational diabetes  (ISO)
Graft vs Host Disease  (ISO)
Graves' disease  (ISO)
hepatocellular carcinoma  (ISO)
heroin dependence  (ISO)
HIV-Associated Lipodystrophy Syndrome  (ISO)
Human Viral Hepatitis  (ISO)
Huntington's disease  (IEP)
Hyperemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
Hypertriglyceridemia  (ISO)
Hypoadiponectinemia  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
Insulin Resistance  (ISO)
Jaundice  (ISO)
Kawasaki disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
Mammary Neoplasms, Experimental  (IMP,ISO)
Masked Hypertension  (ISO)
Metabolic Syndrome  (IMP,ISO)
multiple sclerosis  (ISO)
Mycobacterium avium complex disease  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (IMP)
non-alcoholic fatty liver disease  (IEP,ISO)
obesity  (ISO)
Oxygen-Induced Retinopathy  (IDA)
Perennial Allergic Rhinitis  (ISO)
peripheral artery disease  (ISO)
polycystic ovary syndrome  (ISO)
primary open angle glaucoma  (ISO)
proliferative diabetic retinopathy  (ISO)
prostate adenocarcinoma  (ISO)
pulmonary edema  (ISO)
pulmonary emphysema  (IMP)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IMP)
pulmonary tuberculosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Rett syndrome  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (IEP,IMP,ISO)
sleep apnea  (ISO)
Spinal Cord Injuries  (ISO)
Stroke  (IEP,ISO)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (IMP)
tongue squamous cell carcinoma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IMP,ISO)
ulcerative colitis  (ISO)
vascular disease  (ISO)
visual epilepsy  (IMP)
Weight Gain  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (ISO)
(R)-carnitine  (ISO)
(R)-lipoic acid  (ISO)
17alpha-ethynylestradiol  (ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butoxyethanol  (EXP)
2-deoxy-D-glucose  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-aminobenzamide  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4'-Methoxychalcone  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-methylumbelliferone  (EXP)
4-nonylphenol  (ISO)
5,6,7,8-tetrahydrobiopterin  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (EXP)
[6]-Shogaol  (EXP)
acarbose  (ISO)
acetaldehyde  (EXP,ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP,ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (ISO)
allopurinol  (ISO)
Aloe emodin  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (ISO)
avobenzone  (ISO)
benzamides  (EXP)
benzbromarone  (EXP,ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzyl parahydroxybenzoate  (EXP,ISO)
berberine  (EXP)
beta-carotene  (EXP)
beta-D-glucosamine  (EXP,ISO)
beta-hexachlorocyclohexane  (ISO)
bezafibrate  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bongkrekic acid  (ISO)
boric acid  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (EXP,ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
candesartan  (ISO)
capsaicin  (EXP)
capsazepine  (EXP)
carbon monoxide  (ISO)
carbon nanotube  (EXP)
carvacrol  (ISO)
carvedilol  (ISO)
cilazapril monohydrate  (ISO)
cimetidine  (ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (EXP)
conjugated linoleic acid  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
cortisone  (ISO)
cucurbitacin B  (EXP)
cucurbitacin I  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cyproterone acetate  (ISO)
cytarabine  (EXP)
D-glucose  (ISO)
DDE  (EXP)
deoxycholic acid  (EXP)
Deoxycorticosterone acetate  (ISO)
dexamethasone  (EXP,ISO)
dexamethasone phosphate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (ISO)
dicamba  (ISO)
diethyl sulfate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
disodium cromoglycate  (EXP)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP)
efavirenz  (ISO)
enalapril  (EXP)
equilin  (ISO)
ethanol  (EXP,ISO)
ethylparaben  (EXP)
fenofibrate  (ISO)
flavonoids  (ISO)
fructose  (EXP,ISO)
furan  (ISO)
Ganoderic acid A  (EXP)
gemcitabine  (ISO)
geraniol  (ISO)
gingerol  (EXP)
ginsenoside Re  (EXP)
glucagon  (EXP)
glucose  (ISO)
glycine  (EXP)
graphite  (EXP)
GW 6471  (EXP)
GW 7647  (EXP)
hemin  (ISO)
hesperetin  (ISO)
hexadecanoic acid  (ISO)
hispidulin  (EXP)
hydrochlorothiazide  (EXP)
hydrogen peroxide  (EXP)
hydroxytyrosol  (EXP)
Indeno[1,2,3-cd]pyrene  (EXP)
indinavir  (EXP,ISO)
indometacin  (EXP,ISO)
iron dextran  (EXP)
isoflavones  (ISO)
lamivudine  (EXP)
lead diacetate  (ISO)
letrozole  (ISO)
levonorgestrel  (ISO)
linoleic acid  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
liraglutide  (EXP)
lopinavir  (ISO)
losartan  (EXP)
lovastatin  (EXP)
LY294002  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
Melengestrol acetate  (ISO)
mercury dichloride  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP)
mifepristone  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotophos  (ISO)
monosodium L-glutamate  (EXP)
morin  (ISO)
N-acetyl-L-cysteine  (ISO)
naproxen  (EXP)
naringin  (EXP)
nelfinavir  (EXP,ISO)
nevirapine  (ISO)
nicotinamide  (EXP,ISO)
nicotinic acid  (EXP,ISO)
nitrofen  (ISO)
Nonylphenol  (EXP,ISO)
norethisterone  (ISO)
norgestrel  (ISO)
nuarimol  (ISO)
octadecanoic acid  (EXP)
olanzapine  (EXP)
oleic acid  (ISO)
oleuropein  (ISO)
orientin  (EXP)
orlistat  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (EXP)
PCB138  (EXP,ISO)
pencycuron  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
Phenylamil  (EXP)
phosphatidylcholine  (EXP)
picolinic acid  (ISO)
pioglitazone  (EXP,ISO)
piperine  (ISO)
pirinixic acid  (EXP)
pluronic P-123  (ISO)
Poloxamer  (ISO)
prednisone  (ISO)
prochloraz  (ISO)
progesterone  (EXP,ISO)
propylparaben  (EXP)
protein kinase inhibitor  (EXP,ISO)
quercetin  (EXP,ISO)
raffinose  (EXP)
raloxifene  (EXP)
ramipril  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
rimonabant  (EXP)
risperidone  (EXP)
ritonavir  (EXP,ISO)
rotenone  (ISO)
Rutamarin  (EXP)
ruthenium red  (EXP)
salicylic acid  (ISO)
sapropterin  (ISO)
saquinavir  (EXP)
sarpogrelate  (ISO)
SB 203580  (ISO)
scopoletin  (ISO)
serpentine asbestos  (EXP)
sildenafil citrate  (EXP)
silicon dioxide  (EXP)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
Sodium oleate  (ISO)
spironolactone  (ISO)
stavudine  (EXP,ISO)
stilben-4-ol  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (EXP)
telmisartan  (EXP,ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
Thiocarbohydrazide  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
tolylfluanid  (ISO)
topiramate  (EXP)
triamcinolone  (ISO)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triflumizole  (EXP,ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
troglitazone  (EXP,ISO)
tungsten  (EXP)
tunicamycin  (EXP)
umbelliferone  (EXP)
valproic acid  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vanadyl sulfate  (EXP)
vinclozolin  (ISO)
vitamin E  (ISO)
warfarin  (ISO)
XL147  (EXP)
zidovudine  (EXP,ISO)
zinc molecular entity  (ISO)
zinc protoporphyrin  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brown fat cell differentiation  (IDA)
cellular response to cAMP  (ISO)
cellular response to epinephrine stimulus  (ISO)
cellular response to insulin stimulus  (IGI,ISO)
cellular response to xenobiotic stimulus  (IDA)
circadian rhythm  (ISO)
detection of oxidative stress  (IMP)
fatty acid beta-oxidation  (IMP)
fatty acid oxidation  (IDA)
gene expression  (IDA)
glucose homeostasis  (IDA,IMP)
glucose metabolic process  (IDA,IMP)
low-density lipoprotein particle clearance  (ISO)
negative regulation of blood pressure  (ISO)
negative regulation of cell migration  (IDA)
negative regulation of cold-induced thermogenesis  (IMP)
negative regulation of DNA biosynthetic process  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of fat cell differentiation  (IDA,ISO)
negative regulation of gluconeogenesis  (IDA)
negative regulation of granulocyte differentiation  (ISO)
negative regulation of heterotypic cell-cell adhesion  (ISO)
negative regulation of hormone secretion  (ISO)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
negative regulation of inflammatory response  (IDA)
negative regulation of intracellular protein transport  (ISO)
negative regulation of low-density lipoprotein receptor activity  (ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
negative regulation of macrophage differentiation  (ISO)
negative regulation of MAP kinase activity  (IDA)
negative regulation of metanephric mesenchymal cell migration  (IDA)
negative regulation of phagocytosis  (ISO)
negative regulation of platelet-derived growth factor receptor signaling pathway  (IDA,ISO)
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway  (IDA)
negative regulation of protein autophosphorylation  (ISO)
negative regulation of receptor binding  (ISO)
negative regulation of synaptic transmission  (ISO)
negative regulation of transcription, DNA-templated  (IMP,ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of cAMP-dependent protein kinase activity  (IMP,ISO)
positive regulation of cholesterol efflux  (ISO)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of fatty acid metabolic process  (IMP)
positive regulation of glucose import  (IDA)
positive regulation of glycogen (starch) synthase activity  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IDA)
positive regulation of interleukin-8 production  (ISO)
positive regulation of lipid transporter activity  (ISO)
positive regulation of metanephric glomerular visceral epithelial cell development  (IMP)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of myeloid cell apoptotic process  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein kinase A signaling  (ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of renal albumin absorption  (IMP,ISO)
positive regulation of signal transduction  (IDA)
protein localization to plasma membrane  (ISO)
regulation of glucose metabolic process  (ISO)
response to activity  (ISO)
response to bacterium  (IEP)
response to ethanol  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (IDA,IMP)
response to hypoxia  (ISO)
response to linoleic acid  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
response to sucrose  (ISO)
response to tumor necrosis factor  (ISO)
response to xenobiotic stimulus  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal abdominal fat pad morphology  (IAGP)
abnormal cardiovascular system morphology  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal coat appearance  (IAGP)
abnormal energy homeostasis  (IAGP)
abnormal gas homeostasis  (IAGP)
abnormal gluconeogenesis  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal glucose tolerance  (IAGP)
abnormal heart morphology  (IEA)
abnormal hormone level  (IAGP)
abnormal inguinal fat pad morphology  (IAGP)
abnormal lactation  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal lipid level  (IAGP)
abnormal nitric oxide homeostasis  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal osteoclast morphology  (IAGP)
abnormal respiratory electron transport chain  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal tumor morphology  (IAGP)
abnormal urine homeostasis  (IAGP)
abnormal vascular wound healing  (IAGP)
abnormal vasodilation  (IAGP)
abnormal white adipose tissue morphology  (IAGP)
albuminuria  (IAGP)
cardiac hypertrophy  (IAGP)
congestive heart failure  (IAGP)
decreased body weight  (IAGP)
decreased bone mass  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone ossification  (IAGP)
decreased bone trabecula number  (IAGP)
decreased carbon dioxide production  (IAGP)
decreased circulating adiponectin level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased energy expenditure  (IAGP)
decreased fatty acid beta-oxidation  (IAGP)
decreased food intake  (IAGP)
decreased heart rate  (IAGP)
decreased insulin secretion  (IAGP)
decreased liver cholesterol level  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased oxygen consumption  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased susceptibility to diet-induced hepatic steatosis  (IAGP)
decreased susceptibility to induced hypothermia  (IAGP)
decreased systemic arterial blood pressure  (IAGP)
decreased total body fat amount  (IAGP)
decreased total fat pad weight  (IAGP)
decreased trabecular bone volume  (IAGP)
decreased ventricle muscle contractility  (IAGP)
dilated heart left ventricle  (IAGP)
enlarged heart  (IEA)
fused podocyte foot processes  (IAGP)
hemorrhage  (IAGP)
hyperglycemia  (IAGP)
impaired glucose tolerance  (IAGP)
increased adiponectin level  (IAGP)
increased body weight  (IAGP)
increased bone mass  (IAGP)
increased bone mineral density  (IAGP)
increased bone ossification  (IAGP)
increased bone strength  (IAGP)
increased carbon dioxide production  (IAGP)
increased circulating adiponectin level  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating osteocalcin level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased compact bone thickness  (IAGP)
increased core body temperature  (IAGP)
increased energy expenditure  (IAGP)
increased food intake  (IAGP)
increased leukocyte cell number  (IAGP)
increased liver triglyceride level  (IAGP)
increased lung weight  (IAGP)
increased mammary gland tumor incidence  (IAGP)
increased metastatic potential  (IAGP)
increased noradrenaline level  (IAGP)
increased osteoblast cell number  (IAGP)
increased oxygen consumption  (IAGP)
increased percent body fat/body weight  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased susceptibility to diet-induced hepatic steatosis  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased susceptibility to weight gain  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased total body fat amount  (IAGP)
increased total fat pad weight  (IAGP)
increased trabecular bone thickness  (IAGP)
increased trabecular bone volume  (IAGP)
increased tumor growth/size  (IAGP)
increased urine adrenaline level  (IAGP)
increased vascular endothelial cell adhesion  (IAGP)
insulin resistance  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
maternal effect  (IAGP)
oxidative stress  (IAGP)
premature hair loss  (IAGP)
pulmonary edema  (IAGP)
pulmonary vascular congestion  (IAGP)
vascular restenosis  (IAGP)
References

References - curated
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PMID:24780611   PMID:24792183   PMID:24809933   PMID:24816832   PMID:24836538   PMID:24852843   PMID:24876128   PMID:24911638   PMID:24942043   PMID:25028793   PMID:25037058   PMID:25051362  
PMID:25071024   PMID:25071026   PMID:25154876   PMID:25180179   PMID:25187370   PMID:25187480   PMID:25190567   PMID:25240468   PMID:25331877   PMID:25339419   PMID:25448847   PMID:25491932  
PMID:25514086   PMID:25590242   PMID:25620282   PMID:25694398   PMID:25698374   PMID:25704819   PMID:25712519   PMID:25739441   PMID:25785965   PMID:25794851   PMID:25815422   PMID:25888509  
PMID:25900100   PMID:25905437   PMID:25910275   PMID:25915851   PMID:25956568   PMID:25957229   PMID:25961840   PMID:26020520   PMID:26037251   PMID:26052006   PMID:26060250   PMID:26121241  
PMID:26137442   PMID:26139044   PMID:26166748   PMID:26173479   PMID:26196305   PMID:26243869   PMID:26330614   PMID:26332085   PMID:26399931   PMID:26407855   PMID:26417088   PMID:26417690  
PMID:26462929   PMID:26476732   PMID:26611106   PMID:26687997   PMID:26812237   PMID:26826036   PMID:26888756   PMID:26906634   PMID:26909947   PMID:26965176   PMID:26984772   PMID:27050429  
PMID:27053360   PMID:27094728   PMID:27140617   PMID:27187175   PMID:27264953   PMID:27317261   PMID:27384302   PMID:27404230   PMID:27408775   PMID:27495989   PMID:27573244   PMID:27666676  
PMID:27681418   PMID:27700136   PMID:27702590   PMID:27720679   PMID:27882945   PMID:27914707   PMID:28051329   PMID:28062540   PMID:28071719   PMID:28073830   PMID:28156058   PMID:28188334  
PMID:28199833   PMID:28216285   PMID:28240307   PMID:28258220   PMID:28324027   PMID:28325833   PMID:28364022   PMID:28380381   PMID:28387990   PMID:28463682   PMID:28480607   PMID:28595178  
PMID:28600493   PMID:28606559   PMID:28755973   PMID:28763559   PMID:28790184   PMID:28825851   PMID:28931940   PMID:28963101   PMID:28964716   PMID:29018142   PMID:29022894   PMID:29058611  
PMID:29115433   PMID:29180355   PMID:29184485   PMID:29224189   PMID:29263115   PMID:29267271   PMID:29356901   PMID:29414510   PMID:29445073   PMID:29539416   PMID:29688375   PMID:29706566  
PMID:29728617   PMID:29766204   PMID:29925443   PMID:29991592   PMID:30041041   PMID:30076527   PMID:30077007   PMID:30221582   PMID:30254407   PMID:30307150   PMID:30333718   PMID:30352954  
PMID:30471430   PMID:30474186   PMID:30550785   PMID:30626897   PMID:30792196   PMID:30794695   PMID:30927046   PMID:30934765   PMID:30944152   PMID:31125082   PMID:31134096   PMID:31167128  
PMID:31176759   PMID:31222110   PMID:31233501   PMID:31253725   PMID:31310580   PMID:31433978   PMID:31502564   PMID:31503545   PMID:31578352   PMID:31585050   PMID:31836511   PMID:32023207  
PMID:32244188   PMID:32325033   PMID:32559849   PMID:32632018   PMID:32634201   PMID:32644041   PMID:32652137   PMID:32724116   PMID:32774242   PMID:32877748   PMID:32879136   PMID:32956869  
PMID:32958254   PMID:33104171   PMID:33261886   PMID:33284092   PMID:33334822   PMID:33359123   PMID:33527775   PMID:33553430   PMID:33727658   PMID:33846639   PMID:33904399   PMID:33989084  
PMID:34038729   PMID:34162682   PMID:34378533  


Genomics

Comparative Map Data
Adipoq
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391622,965,286 - 22,976,718 (+)NCBIGRCm39mm39
GRCm39 Ensembl1622,965,286 - 22,976,778 (+)Ensembl
GRCm381623,146,536 - 23,157,968 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1623,146,536 - 23,158,028 (+)EnsemblGRCm38mm10GRCm38
MGSCv371623,146,609 - 23,158,041 (+)NCBIGRCm37mm9NCBIm37
MGSCv361623,061,870 - 23,073,302 (+)NCBImm8
Celera1623,704,853 - 23,716,285 (+)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1613.96NCBI
ADIPOQ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3186,842,704 - 186,858,463 (+)EnsemblGRCh38hg38GRCh38
GRCh383186,842,710 - 186,858,463 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373186,560,499 - 186,576,252 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363188,043,157 - 188,058,946 (+)NCBINCBI36hg18NCBI36
Build 343188,043,164 - 188,058,952NCBI
Celera3184,996,682 - 185,012,474 (+)NCBI
Cytogenetic Map3q27.3NCBI
HuRef3183,969,546 - 183,985,186 (+)NCBIHuRef
CHM1_13186,523,992 - 186,539,778 (+)NCBICHM1_1
Adipoq
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21177,721,912 - 77,735,644 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1177,721,912 - 77,735,564 (-)Ensembl
Rnor_6.01181,330,845 - 81,344,488 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1181,330,293 - 81,344,488 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01184,363,940 - 84,382,663 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41179,908,291 - 79,911,065 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11179,965,888 - 79,968,654 (-)NCBI
Celera1176,596,543 - 76,599,824 (-)NCBICelera
Cytogenetic Map11q23NCBI
Adipoq
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542020,912,348 - 20,914,402 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542020,911,181 - 20,922,992 (-)NCBIChiLan1.0ChiLan1.0
ADIPOQ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13192,341,471 - 192,354,885 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3192,341,320 - 192,354,885 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03183,876,051 - 183,889,723 (+)NCBIMhudiblu_PPA_v0panPan3
ADIPOQ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13419,398,310 - 19,410,519 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3419,354,825 - 19,409,844 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3423,492,088 - 23,493,907 (+)NCBI
ROS_Cfam_1.03419,309,590 - 19,321,861 (+)NCBI
UMICH_Zoey_3.13419,349,075 - 19,350,894 (+)NCBI
UNSW_CanFamBas_1.03419,348,981 - 19,350,799 (+)NCBI
UU_Cfam_GSD_1.03419,582,218 - 19,584,037 (+)NCBI
Adipoq
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602117,076,470 - 117,087,548 (-)NCBI
SpeTri2.0NW_0049365783,168,599 - 3,179,369 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADIPOQ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13124,633,684 - 124,646,648 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113124,633,906 - 124,646,237 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213134,076,753 - 134,077,342 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADIPOQ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11581,128,427 - 81,142,779 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1581,129,795 - 81,147,391 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604154,621,772 - 54,634,568 (+)NCBIVero_WHO_p1.0
Adipoq
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473069,941,963 - 69,959,266 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Adipoq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381623,157,594 - 23,157,644UniSTSGRCm38
MGSCv371623,157,667 - 23,157,717UniSTSGRCm37
Celera1623,715,911 - 23,715,961UniSTS
Cytogenetic Map16B3-B4UniSTS
cM Map1616.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124445989Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124445989Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128616494Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129856336Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130249113Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130996708Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16350000040000000Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16350000051600000Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16350000064800000Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16400000064800000Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16450000044700000Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16482756438827664Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16595650239956690Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16595650239956690Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16595650239956690Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16595650239956690Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16665914535200846Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16672511565669666Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16731904229406653Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16840730242407302Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16860000091100000Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined161006288144062881Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161203007246030171Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161240654246406653Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161498410348984214Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161570409149704294Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162020057985803938Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162211802156118212Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2295650257773713Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:159
Interacting mature miRNAs:166
Transcripts:ENSMUST00000023593, ENSMUST00000171309
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000023593   ⟹   ENSMUSP00000023593
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1622,965,286 - 22,976,778 (+)Ensembl
GRCm38.p6 Ensembl1623,146,536 - 23,158,028 (+)Ensembl
RefSeq Acc Id: ENSMUST00000171309   ⟹   ENSMUSP00000126793
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1622,965,396 - 22,976,042 (+)Ensembl
GRCm38.p6 Ensembl1623,146,646 - 23,157,292 (+)Ensembl
RefSeq Acc Id: NM_009605   ⟹   NP_033735
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391622,965,286 - 22,976,718 (+)NCBI
GRCm381623,146,536 - 23,157,968 (+)ENTREZGENE
MGSCv371623,146,609 - 23,158,041 (+)RGD
Celera1623,704,853 - 23,716,285 (+)RGD
cM Map16 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033735   ⟸   NM_009605
- Peptide Label: precursor
- UniProtKB: Q60994 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000126793   ⟸   ENSMUST00000171309
RefSeq Acc Id: ENSMUSP00000023593   ⟸   ENSMUST00000023593
Protein Domains
C1q   Collagen-like

Promoters
RGD ID:6826752
Promoter ID:MM_KWN:20578
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6
Transcripts:NM_009605
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361623,146,329 - 23,146,829 (+)MPROMDB
RGD ID:8685840
Promoter ID:EPDNEW_M20951
Type:initiation region
Name:Adipoq_1
Description:Mus musculus adiponectin, C1Q and collagen domain containing, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381623,146,604 - 23,146,664EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:106675 AgrOrtholog
Ensembl Genes ENSMUSG00000022878 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000023593 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000126793 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023593 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000171309 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Adiponectin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C1q_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Collagen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11450 UniProtKB/Swiss-Prot
MGD MGI:106675 ENTREZGENE
NCBI Gene 11450 ENTREZGENE
PANTHER PTHR15427:SF20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1q UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Collagen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ADIPOQ RGD
PhenoGen Adipoq PhenoGen
PRINTS COMPLEMNTC1Q UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE C1Q UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART C1Q UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ADIPO_MOUSE UniProtKB/Swiss-Prot
  E9PWU4_MOUSE UniProtKB/TrEMBL
  Q60994 ENTREZGENE
  Q8BRW2_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q62400 UniProtKB/Swiss-Prot
  Q6GTX4 UniProtKB/Swiss-Prot
  Q9DC68 UniProtKB/Swiss-Prot